-
1
-
-
68549106083
-
E-cadherin, b-catenin, and ZEB1 in malignant progression of cancer
-
Schmalhofer O, Brabletz S, Brabletz T. E-cadherin, b-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 2009;28: 151-66.
-
(2009)
Cancer Metastasis Rev
, vol.28
, pp. 151-166
-
-
Schmalhofer, O.1
Brabletz, S.2
Brabletz, T.3
-
2
-
-
77956230322
-
The ZEB/miR-200 feedback loop: A motor of cellular plasticity in development and cancer?
-
Brabletz S, Brabletz T. The ZEB/miR-200 feedback loop: a motor of cellular plasticity in development and cancer? EMBO Rep 2010; 11: 670-7.
-
(2010)
EMBO Rep
, vol.11
, pp. 670-677
-
-
Brabletz, S.1
Brabletz, T.2
-
3
-
-
84867578091
-
EMT-activating transcription factors in cancer: Beyond EMT and tumor invasiveness
-
Sanchez-Tillo E, Liu Y, de Barrios O, Siles L, Fanlo L, Cuatrecasas M, et al. EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness. Cell Mol Life Sci 2012;69: 3429-56.
-
(2012)
Cell Mol Life Sci
, vol.69
, pp. 3429-3456
-
-
Sanchez-Tillo, E.1
Liu, Y.2
De Barrios, O.3
Siles, L.4
Fanlo, L.5
Cuatrecasas, M.6
-
4
-
-
82755165972
-
Expanding roles of ZEB factors in tumorigenesis and tumor progression
-
Sanchez-Tillo E, Siles L, de Barrios O, Cuatrecasas M, Vaquero E, Castells A, et al. Expanding roles of ZEB factors in tumorigenesis and tumor progression. Am J Cancer Res 2011;1: 897-912.
-
(2011)
Am J Cancer Res
, vol.1
, pp. 897-912
-
-
Sanchez-Tillo, E.1
Siles, L.2
De Barrios, O.3
Cuatrecasas, M.4
Vaquero, E.5
Castells, A.6
-
5
-
-
78549244727
-
ZEB1-responsive genes in non-small cell lung cancer
-
Gemmill RM, Roche J, Potiron VA, Nasarre P, Mitas M, Coldren CD, et al. ZEB1-responsive genes in non-small cell lung cancer. Cancer Lett 2011;300: 66-78.
-
(2011)
Cancer Lett
, vol.300
, pp. 66-78
-
-
Gemmill, R.M.1
Roche, J.2
Potiron, V.A.3
Nasarre, P.4
Mitas, M.5
Coldren, C.D.6
-
6
-
-
39049160267
-
The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
-
Spaderna S, Schmalhofer O, Wahlbuhl M, Dimmler A, Bauer K, Sultan A, et al. The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res 2008;68: 537-44.
-
(2008)
Cancer Res
, vol.68
, pp. 537-544
-
-
Spaderna, S.1
Schmalhofer, O.2
Wahlbuhl, M.3
Dimmler, A.4
Bauer, K.5
Sultan, A.6
-
7
-
-
73049110243
-
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
-
Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A, et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 2009;11: 1487-95.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 1487-1495
-
-
Wellner, U.1
Schubert, J.2
Burk, U.C.3
Schmalhofer, O.4
Zhu, F.5
Sonntag, A.6
-
8
-
-
84871385387
-
ZEB/miR-200 feedback loop: At the crossroads of signal transduction in cancer
-
Hill L, Browne G, Tulchinsky E. ZEB/miR-200 feedback loop: at the crossroads of signal transduction in cancer. Int J Cancer 2013;132: 745-54.
-
(2013)
Int J Cancer
, vol.132
, pp. 745-754
-
-
Hill, L.1
Browne, G.2
Tulchinsky, E.3
-
9
-
-
34548496683
-
Differential regulation of epithelial and mesenchymal markers by dEF1 proteins in epithelial mesenchymal transition induced by TGF-b
-
Shirakihara T, Saitoh M, Miyazono K. Differential regulation of epithelial and mesenchymal markers by dEF1 proteins in epithelial mesenchymal transition induced by TGF-b. Mol Biol Cell 2007;18: 3533-44.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 3533-3544
-
-
Shirakihara, T.1
Saitoh, M.2
Miyazono, K.3
-
10
-
-
65549141305
-
Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the Notch signaling pathway
-
Wang Z, Li Y, Kong D, Banerjee S, Ahmad A, Azmi AS, et al. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the Notch signaling pathway. Cancer Res 2009;69: 2400-7.
-
(2009)
Cancer Res
, vol.69
, pp. 2400-2407
-
-
Wang, Z.1
Li, Y.2
Kong, D.3
Banerjee, S.4
Ahmad, A.5
Azmi, A.S.6
-
11
-
-
82755198488
-
B-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness
-
Sanchez-Tillo E, de Barrios O, Siles L, Cuatrecasas M, Castells A, Postigo A. b-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness. Proc Natl Acad Sci USA 2011;108: 19204-9.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 19204-19209
-
-
Sanchez-Tillo, E.1
De Barrios, O.2
Siles, L.3
Cuatrecasas, M.4
Castells, A.5
Postigo, A.6
-
12
-
-
33748116186
-
A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer
-
Spaderna S, Schmalhofer O, Hlubek F, Berx G, Eger A, Merkel S, et al.A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology 2006;131: 830-40.
-
(2006)
Gastroenterology
, vol.131
, pp. 830-840
-
-
Spaderna, S.1
Schmalhofer, O.2
Hlubek, F.3
Berx, G.4
Eger, A.5
Merkel, S.6
-
13
-
-
0035964349
-
Variable b-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
-
Brabletz T, Jung A, Reu S, Porzner M, Hlubek F, Kunz-Schughart LA, et al. Variable b-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci USA 2001;98: 10356-61.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10356-10361
-
-
Brabletz, T.1
Jung, A.2
Reu, S.3
Porzner, M.4
Hlubek, F.5
Kunz-Schughart, L.A.6
-
14
-
-
77953743748
-
ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
-
Sanchez-Tillo E, Lazaro A, Torrent R, Cuatrecasas M, Vaquero EC, Castells A, et al. ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. Oncogene 2010;29: 3490-500.
-
(2010)
Oncogene
, vol.29
, pp. 3490-3500
-
-
Sanchez-Tillo, E.1
Lazaro, A.2
Torrent, R.3
Cuatrecasas, M.4
Vaquero, E.C.5
Castells, A.6
-
15
-
-
79953163995
-
Proteolytic networks in cancer
-
Mason SD, Joyce JA. Proteolytic networks in cancer. Trends Cell Biol 2011;21: 228-37.
-
(2011)
Trends Cell Biol
, vol.21
, pp. 228-237
-
-
Mason, S.D.1
Joyce, J.A.2
-
16
-
-
16844386886
-
Plasminogen activation and cancer
-
Danø K, Behrendt N, Høyer-Hansen G, Johnsen M, Lund LR, Ploug M, et al. Plasminogen activation and cancer. Thromb Haemost 2005;93: 676-81.
-
(2005)
Thromb Haemost
, vol.93
, pp. 676-681
-
-
Danø, K.1
Behrendt, N.2
Høyer-Hansen, G.3
Johnsen, M.4
Lund, L.R.5
Ploug, M.6
-
17
-
-
0036559388
-
Significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 (PAI-1) expression in human colorectal carcinomas
-
Papadopoulou S, Scorilas A, Yotis J, Arnogianaki N, Plataniotis G, Agnanti N, et al. Significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 (PAI-1) expression in human colorectal carcinomas. Tumor Biol 2002;23: 170-8.
-
(2002)
Tumor Biol
, vol.23
, pp. 170-178
-
-
Papadopoulou, S.1
Scorilas, A.2
Yotis, J.3
Arnogianaki, N.4
Plataniotis, G.5
Agnanti, N.6
-
18
-
-
62449284577
-
Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases
-
Illemann M, Bird N, Majeed A, Laerum OD, Lund LR, Danø K, et al. Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. Int J Cancer 2009;124: 1860-70.
-
(2009)
Int J Cancer
, vol.124
, pp. 1860-1870
-
-
Illemann, M.1
Bird, N.2
Majeed, A.3
Laerum, O.D.4
Lund, L.R.5
Danø, K.6
-
19
-
-
0034667385
-
Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1
-
Gutierrez LS, Schulman A, Brito-Robinson T, Noria F, Ploplis VA, Castellino FJ. Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. Cancer Res 2000;60: 5839-47.
-
(2000)
Cancer Res
, vol.60
, pp. 5839-5847
-
-
Gutierrez, L.S.1
Schulman, A.2
Brito-Robinson, T.3
Noria, F.4
Ploplis, V.A.5
Castellino, F.J.6
-
20
-
-
0034885886
-
Stable transfection of urokinase-type plasminogen activator antisense construct modulates invasion of human glioblastoma cells
-
Mohanam S, Jasti SL, Kondraganti SR, Chandrasekar N, Kin Y, Fuller GN, et al. Stable transfection of urokinase-type plasminogen activator antisense construct modulates invasion of human glioblastoma cells. Clin Cancer Res 2001;7: 2519-26.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2519-2526
-
-
Mohanam, S.1
Jasti, S.L.2
Kondraganti, S.R.3
Chandrasekar, N.4
Kin, Y.5
Fuller, G.N.6
-
21
-
-
12144289397
-
Plasminogen activator inhibitor-I and tumour growth, invasion, and metastasis
-
Durand MK, Bødker JS, Christensen A, Dupont DM, Hansen M, Jensen JK, et al. Plasminogen activator inhibitor-I and tumour growth, invasion, and metastasis. Thromb Haemost 2004;91: 438-49.
-
(2004)
Thromb Haemost
, vol.91
, pp. 438-449
-
-
Durand, M.K.1
Bødker, J.S.2
Christensen, A.3
Dupont, D.M.4
Hansen, M.5
Jensen, J.K.6
-
22
-
-
0031902286
-
Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
-
Bajou K, Noël A, Gerard RD, Masson V, Brunner N, Holst-Hansen C, et al. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nat Med 1998;4: 923-8.
-
(1998)
Nat Med
, vol.4
, pp. 923-928
-
-
Bajou, K.1
Noël, A.2
Gerard, R.D.3
Masson, V.4
Brunner, N.5
Holst-Hansen, C.6
-
23
-
-
0028821827
-
Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor-associated angiogenesis, and metastasis to lung and liver in an athymic mouse model
-
Soff GA, Sanderowitz J, Gately S, Verrusio E, Weiss I, Brem S, et al. Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor-associated angiogenesis, and metastasis to lung and liver in an athymic mouse model. J Clin Invest 1995;96: 2593-600.
-
(1995)
J Clin Invest
, vol.96
, pp. 2593-2600
-
-
Soff, G.A.1
Sanderowitz, J.2
Gately, S.3
Verrusio, E.4
Weiss, I.5
Brem, S.6
-
24
-
-
10744221160
-
B-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors
-
Hiendlmeyer E, Regus S, Wassermann S, Hlubek F, Haynl A, Dimmler A, et al. b-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors. Cancer Res 2004;64: 1209-14.
-
(2004)
Cancer Res
, vol.64
, pp. 1209-1214
-
-
Hiendlmeyer, E.1
Regus, S.2
Wassermann, S.3
Hlubek, F.4
Haynl, A.5
Dimmler, A.6
-
25
-
-
78651388566
-
Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer
-
Shimizu M, Cohen B, Goldvasser P, Berman H, Virtanen C, Reedijk M. Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer. Cancer Res 2011;71: 277-86.
-
(2011)
Cancer Res
, vol.71
, pp. 277-286
-
-
Shimizu, M.1
Cohen, B.2
Goldvasser, P.3
Berman, H.4
Virtanen, C.5
Reedijk, M.6
-
26
-
-
57349083077
-
Transcriptional regulation of the plasminogen activator inhibitor type 1 with an emphasis on negative regulation
-
Nagamine Y. Transcriptional regulation of the plasminogen activator inhibitor type 1 with an emphasis on negative regulation. Thromb Haemost 2008;100: 1007-13.
-
(2008)
Thromb Haemost
, vol.100
, pp. 1007-1013
-
-
Nagamine, Y.1
-
27
-
-
0031594268
-
DEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages
-
Takagi T, Moribe H, Kondoh H, Higashi Y. dEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development 1998;125: 21-31.
-
(1998)
Development
, vol.125
, pp. 21-31
-
-
Takagi, T.1
Moribe, H.2
Kondoh, H.3
Higashi, Y.4
-
28
-
-
0037416148
-
Nuclear export of the APC tumour suppressor controls b-catenin function in transcription
-
Rosin-Arbesfeld R, Cliffe A, Brabletz T, Bienz M. Nuclear export of the APC tumour suppressor controls b-catenin function in transcription. EMBO J 2003;22: 1101-13.
-
(2003)
EMBO J
, vol.22
, pp. 1101-1113
-
-
Rosin-Arbesfeld, R.1
Cliffe, A.2
Brabletz, T.3
Bienz, M.4
-
29
-
-
0028168794
-
The d-crystallin enhancer-binding protein dEF1 is a repressor of E2-box-mediated gene activation
-
Sekido R, Murai K, Funahashi J, Kamachi Y, Fujisawa-Sehara A, Nabeshima Y, et al. The d-crystallin enhancer-binding protein dEF1 is a repressor of E2-box-mediated gene activation. Mol Cell Biol 1994;14: 5692-700.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 5692-5700
-
-
Sekido, R.1
Murai, K.2
Funahashi, J.3
Kamachi, Y.4
Fujisawa-Sehara, A.5
Nabeshima, Y.6
-
30
-
-
0038324070
-
Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
-
Postigo A, Depp JL, Taylor JJ, Kroll KL. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J 2003;22: 2453-62.
-
(2003)
EMBO J
, vol.22
, pp. 2453-2462
-
-
Postigo, A.1
Depp, J.L.2
Taylor, J.J.3
Kroll, K.L.4
-
31
-
-
0038324071
-
Opposing functions of ZEB proteins in the regulation of the TGFb/BMP signaling pathway
-
Postigo A. Opposing functions of ZEB proteins in the regulation of the TGFb/BMP signaling pathway. EMBO J 2003;22: 2443-52.
-
(2003)
EMBO J
, vol.22
, pp. 2443-2452
-
-
Postigo, A.1
-
32
-
-
0347917028
-
The urokinase plasminogen activator system: Role in malignancy
-
Duffy MJ. The urokinase plasminogen activator system: role in malignancy. Curr Pharm Des 2004;10: 39-49.
-
(2004)
Curr Pharm des
, vol.10
, pp. 39-49
-
-
Duffy, M.J.1
-
33
-
-
80052265739
-
Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty?
-
Matthews H, Ranson M, Kelso MJ. Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty? Int J Cancer 2011;129: 2051-61.
-
(2011)
Int J Cancer
, vol.129
, pp. 2051-2061
-
-
Matthews, H.1
Ranson, M.2
Kelso, M.J.3
-
34
-
-
34547610957
-
Urokinase plasminogen activation receptor induces epithelial-mesenchymal transition in hypoxic breast cancer cells
-
Lester RD, Jo M, Montel V, Takimoto S, Gonias SL. Urokinase plasminogen activation receptor induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol 2007;178: 425-36.
-
(2007)
J Cell Biol
, vol.178
, pp. 425-436
-
-
Lester, R.D.1
Jo, M.2
Montel, V.3
Takimoto, S.4
Gonias, S.L.5
-
35
-
-
69249111313
-
Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling
-
Jo M, Lester RD, Montel V, Eastman B, Takimoto S, Gonias SL. Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling. J Biol Chem 2009;284: 22825-33.
-
(2009)
J Biol Chem
, vol.284
, pp. 22825-22833
-
-
Jo, M.1
Lester, R.D.2
Montel, V.3
Eastman, B.4
Takimoto, S.5
Gonias, S.L.6
-
36
-
-
47249109051
-
Nuclear translocation of urokinase-type plasminogen activator
-
Stepanova V, Lebedeva T, Kuo A, Yarovoi S, Tkachuk S, Zaitsev S, et al. Nuclear translocation of urokinase-type plasminogen activator. Blood 2008;112: 100-11.
-
(2008)
Blood
, vol.112
, pp. 100-111
-
-
Stepanova, V.1
Lebedeva, T.2
Kuo, A.3
Yarovoi, S.4
Tkachuk, S.5
Zaitsev, S.6
-
37
-
-
79954455085
-
Suppression of the uPAR-uPA system retards angiogenesis, invasion, and in vivo tumor development in pancreatic cancer cells
-
Gorantla B, Asuthkar S, Rao JS, Patel J, Gondi CS. Suppression of the uPAR-uPA system retards angiogenesis, invasion, and in vivo tumor development in pancreatic cancer cells. Mol Cancer Res 2011;9: 377-89.
-
(2011)
Mol Cancer Res
, vol.9
, pp. 377-389
-
-
Gorantla, B.1
Asuthkar, S.2
Rao, J.S.3
Patel, J.4
Gondi, C.S.5
-
38
-
-
0035976964
-
Id2 is a target of the b-catenin/T cell factor pathway in colon carcinoma
-
Rockman SP, Currie SA, Ciavarella M, Vincan E, Dow C, Thomas RJ, et al. Id2 is a target of the b-catenin/T cell factor pathway in colon carcinoma. J Biol Chem 2001;276: 45113-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 45113-45119
-
-
Rockman, S.P.1
Currie, S.A.2
Ciavarella, M.3
Vincan, E.4
Dow, C.5
Thomas, R.J.6
-
39
-
-
80053458622
-
Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells
-
Bekes EM, Deryugina EI, Kupriyanova TA, Zajac E, Botkjaer KA, Andreasen PA, et al. Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells. Neoplasia 2011;13: 806-21.
-
(2011)
Neoplasia
, vol.13
, pp. 806-821
-
-
Bekes, E.M.1
Deryugina, E.I.2
Kupriyanova, T.A.3
Zajac, E.4
Botkjaer, K.A.5
Andreasen, P.A.6
-
40
-
-
84863236117
-
ZEB2 upregulates integrin a5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells
-
Nam EH, Lee Y, Park YK, Lee JW, Kim S. ZEB2 upregulates integrin a5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells. Carcinogenesis 2012;33: 563-71.
-
(2012)
Carcinogenesis
, vol.33
, pp. 563-571
-
-
Nam, E.H.1
Lee, Y.2
Park, Y.K.3
Lee, J.W.4
Kim, S.5
-
41
-
-
50349100870
-
Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53
-
Shetty S, Shetty P, Idell S, Velusamy T, Bhandary YP, Shetty RS. Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53. J Biol Chem 2008;283: 19570-80.
-
(2008)
J Biol Chem
, vol.283
, pp. 19570-19580
-
-
Shetty, S.1
Shetty, P.2
Idell, S.3
Velusamy, T.4
Bhandary, Y.P.5
Shetty, R.S.6
-
42
-
-
77956643809
-
Post-transcriptional regulation of plasminogen activator inhibitor type-1 expression in human pleural mesothelial cells
-
Shetty S, Velusamy T, Shetty RS, Marudamuthu AS, Shetty SK, Florova G, et al. Post-transcriptional regulation of plasminogen activator inhibitor type-1 expression in human pleural mesothelial cells. Am J Respir Cell Mol Biol 2010;43: 358-67.
-
(2010)
Am J Respir Cell Mol Biol
, vol.43
, pp. 358-367
-
-
Shetty, S.1
Velusamy, T.2
Shetty, R.S.3
Marudamuthu, A.S.4
Shetty, S.K.5
Florova, G.6
-
44
-
-
81855169565
-
Cancer invasion and the microenvironment: Plasticity and reciprocity
-
Friedl P, Alexander S. Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 2011;147: 992-1009.
-
(2011)
Cell
, vol.147
, pp. 992-1009
-
-
Friedl, P.1
Alexander, S.2
|