In silico approaches for the identification of optimal culture condition for tissue engineered bone substitutes

Current Analytical Chemistry

Volumn 9, Issue 1, 2013, Pages 16-28

  Kahlig, A ^a   Hansmann, J ^a   Groeber, F ^a   Schwarz, T ^c   Weyhmuller J ^c   Illig, A ^c   Kleinhans, C ^a   Walles, H ^b,c  

^a UNIVERSITY OF STUTTGART   (Germany)

^b FRAUNHOFER INSTITUTE FOR INTERFACIAL ENGINEERING AND BIOTECHNOLOGY IGB   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Bone; Diffusion; Flow; Metabolic rates; Modelling; MSC; Scaffold; Simulation; Tissue engineering; Young's modulus

Indexed keywords

BONE; CELL ENGINEERING; COMPUTATION THEORY; COMPUTATIONAL METHODS; DIFFUSION IN LIQUIDS; ELASTIC MODULI; ENDOTHELIAL CELLS; GLUCOSE; SCAFFOLDS (BIOLOGY); SHEAR STRESS; STEM CELLS; STOCHASTIC MODELS; STOCHASTIC SYSTEMS;

BONE GRAFT; FLOW; IN-VITRO; MESENCHYMAL STEM CELL; METABOLIC RATES; MODELING; SIMULATION; TISSUE-ENGINEERED BONES; TISSUES ENGINEERINGS; YOUNG MODULUS;

CELL CULTURE;

EID: 84874891650     PISSN: 15734110     EISSN: None     Source Type: Journal    
DOI: 10.2174/157341113804486563     Document Type: Article

References (82)

1. Ai-Aql, Z. S.; Alagl, A. S.; Graves, D. T.; Gerstenfeld, L. C.; Einhorn, T. A., Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. Journal of dental research 2008, 87 (2), 107-18.
2. Dimitriou, R.; Jones, E.; McGonagle, D.; Giannoudis, P. V., Bone regeneration: current concepts and future directions. BMC medicine 2011, 9, 66.
3. Greenwald, A. S.; Boden, S. D.; Goldberg, V. M.; Khan, Y.; Laurencin, C. T.; Rosier, R. N., Bone-graft substitutes: facts, fictions, and applications. The Journal of bone and joint surgery. American volume 2001, 83-A Suppl 2 Pt 2, 98-103.
4. Calori, G. M.; Mazza, E.; Colombo, M.; Ripamonti, C., The use of bone-graft substitutes in large bone defects: Any specific needs? Injury 2011, 42 Suppl 2, S56-63.
5. Bernhardt, A.; Lode, A.; Peters, F.; Gelinsky, M., Novel ceramic bone replacement material Osbone (R) in a comparative in vitro study with osteoblasts. Clin Oral Implan Res 2011, 22 (6), 651-657.
6. Boccaccini, A. R.; Blaker, J. J., Bioactive composite materials for tissue engineering scaffolds. Expert review of medical devices 2005, 2 (3), 303-17.
7. Blaker, J. J.; Maquet, V.; Jerome, R.; Boccaccini, A. R.; Nazhat, S. N., Mechanical properties of highly porous PDLLA/Bioglass composite foams as scaffolds for bone tissue engineering. Acta biomaterialia 2005, 1 (6), 643-52.
8. Tsigkou, O.; Pomerantseva, I.; Spencer, J. A.; Redondo, P. A.; Hart, A. R.; O'Doherty, E.; Lin, Y.; Friedrich, C. C.; Daheron, L.; Lin, C. P.; Sundback, C. A.; Vacanti, J. P.; Neville, C., Engineered vascularized bone grafts. Proceedings of the National Academy of Sciences of the United States of America 2010, 107 (8), 3311-6.
9. Bohner, M., Resorbable biomaterials as bone graft substitutes. Mater Today 2010, 13 (1-2), 24-30.
10. Eglin, D.; Alini, M., Degradable polymeric materials for osteosynthesis: tutorial. European cells & materials 2008, 16, 80-91.
11. Habibovic, P.; de Groot, K., Osteoinductive biomaterials--properties and relevance in bone repair. Journal of tissue engineering and regenerative medicine 2007, 1 (1), 25-32.
12. Habibovic, P.; Gbureck, U.; Doillon, C. J.; Bassett, D. C.; van Blitterswijk, C. A.; Barralet, J. E., Osteoconduction and osteoinduction of low-temperature 3D printed bioceramic implants. Biomaterials 2008, 29 (7), 944-53.
13. Hamanishi, C.; Kitamoto, K.; Ohura, K.; Tanaka, S.; Doi, Y., Selfsetting, bioactive, and biodegradable TTCP-DCPD apatite cement. Journal of biomedical materials research 1996, 32 (3), 383-9.
14. Heini, P. F.; Berlemann, U., Bone substitutes in vertebroplasty. European spine journal: official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2001, 10 Suppl 2, S205-13.
15. Ikenaga, M.; Hardouin, P.; Lemaitre, J.; Andrianjatovo, H.; Flautre, B., Biomechanical characterization of a biodegradable calcium phosphate hydraulic cement: a comparison with porous biphasic calcium phosphate ceramics. Journal of biomedical materials research 1998, 40 (1), 139-44.
16. Suzuki, O.; Imaizumi, H.; Kamakura, S.; Katagiri, T., Bone regeneration by synthetic octacalcium phosphate and its role in biological mineralization. Current medicinal chemistry 2008, 15 (3), 305-13.
17. Tamimi, F.; Torres, J.; Kathan, C.; Baca, R.; Clemente, C.; Blanco, L.; Lopez Cabarcos, E., Bone regeneration in rabbit calvaria with novel monetite granules. Journal of biomedical materials research. Part A 2008, 87 (4), 980-5.
18. Teitelbaum, S. L., Bone resorption by osteoclasts. Science 2000, 289 (5484), 1504-8.
19. Yamada, S.; Heymann, D.; Bouler, J. M.; Daculsi, G., Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/beta-tricalcium phosphate ratios. Biomaterials 1997, 18 (15), 1037-41.
20. Zberg, B.; Uggowitzer, P. J.; Loffler, J. F., MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants. Nature materials 2009, 8 (11), 887-91.
21. Eberli, D., Tissue Engineering. Eberli, D., Ed. In-teh: Croatia, 2010.
22. Stock, U. A.; Vacanti, J. P., Tissue engineering: current state and prospects. Annual review of medicine 2001, 52, 443-51.
23. Groeber, F.; Holeiter, M.; Hampel, M.; Hinderer, S.; Schenke-Layland, K., Skin tissue engineering--in vivo and in vitro applications. Advanced drug delivery reviews 2011, 63 (4-5), 352-66.
24. Walles, T.; Giere, B.; Hofmann, M.; Schanz, J.; Hofmann, F.; Mertsching, H.; Macchiarini, P., Experimental generation of a tissue-engineered functional and vascularized trachea. The Journal of thoracic and cardiovascular surgery 2004, 128 (6), 900-6.
25. Iwasa, J.; Engebretsen, L.; Shima, Y.; Ochi, M., Clinical application of scaffolds for cartilage tissue engineering. Knee surgery, sports traumatology, arthroscopy: official journal of the ESSKA 2009, 17 (6), 561-77.
26. Kershen, R. T.; Atala, A., New advances in injectable therapies for the treatment of incontinence and vesicoureteral reflux. The Urologic clinics of North America 1999, 26 (1), 81-94, viii.
27. Walles, T.; Weimer, M.; Linke, K.; Michaelis, J.; Mertsching, H., The potential of bioartificial tissues in oncology research and treatment. Onkologie 2007, 30 (7), 388-94.
28. Ponec, M., Skin constructs for replacement of skin tissues for in vitro testing. Advanced drug delivery reviews 2002, 54 Suppl 1, S19-30.
29. Frohlich, M.; Grayson, W. L.; Wan, L. Q.; Marolt, D.; Drobnic, M.; Vunjak-Novakovic, G., Tissue engineered bone grafts: biological requirements, tissue culture and clinical relevance. Current stem cell research & therapy 2008, 3 (4), 254-64.
30. Damron, T. A., Use of 3D beta-tricalcium phosphate (Vitoss) scaffolds in repairing bone defects. Nanomedicine (Lond) 2007, 2 (6), 763-75.
31. Kadow-Romacker, A.; Greiner, S.; Schmidmaier, G.; Wildemann, B., Effect of {beta}-tricalcium phosphate coated with zoledronic acid on human osteoblasts and human osteoclasts in vitro. Journal of biomaterials applications 2011.
32. Caplan, A. I., Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of cellular physiology 2007, 213 (2), 341-7.
33. Bianco, P.; Riminucci, M.; Gronthos, S.; Robey, P. G., Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 2001, 19 (3), 180-92.
34. Bonfield, T. L.; Caplan, A. I., Adult mesenchymal stem cells: an innovative therapeutic for lung diseases. Discovery medicine 2010, 9 (47), 337-45.
35. Bianco, P.; Robey, P. G., Stem cells in tissue engineering. Nature 2001, 414 (6859), 118-21.
36. Klein-Nulend, J.; Bacabac, R. G.; Mullender, M. G., Mechanobiology of bone tissue. Pathologie-biologie 2005, 53 (10), 576-80.
37. Knothe Tate, M. L.; Steck, R.; Forwood, M. R.; Niederer, P., In vivo demonstration of load-induced fluid flow in the rat tibia and its potential implications for processes associated with functional adaptation. The Journal of experimental biology 2000, 203 (Pt 18), 2737-45.
38. Klein-Nulend, J.; Burger, E. H.; Semeins, C. M.; Raisz, L. G.; Pilbeam, C. C., Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 1997, 12 (1), 45-51.
39. Raggatt, L. J.; Partridge, N. C., Cellular and molecular mechanisms of bone remodeling. The Journal of biological chemistry 2010, 285 (33), 25103-8.
40. Gurkan, U. A.; Akkus, O., The mechanical environment of bone marrow: a review. Annals of biomedical engineering 2008, 36 (12), 1978-91.
41. Liu, L.; Yuan, W.; Wang, J., Mechanisms for osteogenic differentiation of human mesenchymal stem cells induced by fluid shear stress. Biomechanics and modeling in mechanobiology 2010, 9 (6), 659-70.
42. Fritton, S. P.; Weinbaum, S., Fluid and Solute Transport in Bone: Flow-Induced Mechanotransduction. Annual review of fluid mechanics 2009, 41, 347-374.
43. Goulet, G. C.; Hamilton, N.; Cooper, D.; Coombe, D.; Tran, D.; Martinuzzi, R.; Zernicke, R. F., Influence of vascular porosity on fluid flow and nutrient transport in loaded cortical bone. Journal of biomechanics 2008, 41 (10), 2169-75.
44. Mullender, M.; El Haj, A. J.; Yang, Y.; van Duin, M. A.; Burger, E. H.; Klein-Nulend, J., Mechanotransduction of bone cells in vitro: mechanobiology of bone tissue. Medical & biological engineering & computing 2004, 42 (1), 14-21.
45. Portner, R.; Nagel-Heyer, S.; Goepfert, C.; Adamietz, P.; Meenen, N. M., Bioreactor design for tissue engineering. Journal of bioscience and bioengineering 2005, 100 (3), 235-45.
46. Wendt, D.; Jakob, M.; Martin, I., Bioreactor-based engineering of osteochondral grafts: from model systems to tissue manufacturing. Journal of bioscience and bioengineering 2005, 100 (5), 489-94.
47. Schmid, J.; Wallkamm, B.; Hammerle, C. H.; Gogolewski, S.; Lang, N. P., The significance of angiogenesis in guided bone regeneration. A case report of a rabbit experiment. Clin Oral Implants Res 1997, 8 (3), 244-8.
48. Hunter, J., A treatise on the blood, inflammation, and gun-shot wounds. 1794. Clinical orthopaedics and related research 2007, 458, 27-34.
49. Kanczler, J. M.; Oreffo, R. O., Osteogenesis and angiogenesis: the potential for engineering bone. European cells & materials 2008, 15, 100-14.
50. Novosel, E. C.; Kleinhans, C.; Kluger, P. J., Vascularization is the key challenge in tissue engineering. Advanced drug delivery reviews 2011, 63 (4-5), 300-11.
51. Nomi, M.; Atala, A.; Coppi, P. D.; Soker, S., Principals of neovascularization for tissue engineering. Molecular aspects of medicine 2002, 23 (6), 463-83.
52. Ribatti, D.; Vacca, A.; Presta, M., The discovery of angiogenic factors: a historical review. General pharmacology 2000, 35 (5), 227-31.
53. Shweiki, D.; Itin, A.; Soffer, D.; Keshet, E., Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992, 359 (6398), 843-5.
54. Longabaugh, W. J.; Davidson, E. H.; Bolouri, H., Computational representation of developmental genetic regulatory networks. Developmental Biology 2005, 283 (1), 1-16.
55. Diaz-Zuccarini, V.; Lawford, P. V., An in-silico future for the engineering of functional tissues and organs. Organogenesis 2010, 6 (4), 245-51.
56. Cinbiz, M. N.; Tigli, R. S.; Beskardes, I. G.; Gumusderelioglu, M.; Colak, U., Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering. Journal of biotechnology 2010, 150 (3), 389-95.
57. Geris, L.; Van Liedekerke, P.; Smeets, B.; Tijskens, E.; Ramon, H., A cell based modelling framework for skeletal tissue engineering applications. Journal of biomechanics 2010, 43 (5), 887-92.
58. Grayson, W. L.; Marolt, D.; Bhumiratana, S.; Frohlich, M.; Guo, X. E.; Vunjak-Novakovic, G., Optimizing the medium perfusion rate in bone tissue engineering bioreactors. Biotechnology and bioengineering 2010.
59. Grayson, W. L.; Marolt, D.; Bhumiratana, S.; Frohlich, M.; Guo, X. E.; Vunjak-Novakovic, G., Optimizing the medium perfusion rate in bone tissue engineering bioreactors. Biotechnology and bioengineering 2011, 108 (5), 1159-70.
60. Knothe Tate, M. L., Top down and bottom up engineering of bone. Journal of biomechanics 2011, 44 (2), 304-12.
61. Lesman, A.; Blinder, Y.; Levenberg, S., Modeling of flow-induced shear stress applied on 3D cellular scaffolds: Implications for vascular tissue engineering. Biotechnology and bioengineering 2010, 105 (3), 645-54.
62. Milan, J. L.; Planell, J. A.; Lacroix, D., Computational modelling of the mechanical environment of osteogenesis within a polylactic acid-calcium phosphate glass scaffold. Biomaterials 2009, 30 (25), 4219-26.
63. Porter, B.; Zauel, R.; Stockman, H.; Guldberg, R.; Fyhrie, D., 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor. Journal of biomechanics 2005, 38 (3), 543-9.
64. Sanz-Herrera, J. A.; Garcia-Aznar, J. M.; Doblare, M., A mathematical model for bone tissue regeneration inside a specific type of scaffold. Biomechanics and modeling in mechanobiology 2008, 7 (5), 355-66.
65. Walles, T.; Herden, T.; Haverich, A.; Mertsching, H., Influence of scaffold thickness and scaffold composition on bioartificial graft survival. Biomaterials 2003, 24 (7), 1233-9.
66. Ferrara, N., Vascular endothelial growth factor and the regulation of angiogenesis. Recent progress in hormone research 2000, 55, 15-35; discussion 35-6.
67. Ferrara, N.; Gerber, H. P.; LeCouter, J., The biology of VEGF and its receptors. Nature medicine 2003, 9 (6), 669-76.
68. Ley, C. D.; Olsen, M. W.; Lund, E. L.; Kristjansen, P. E., Angiogenic synergy of bFGF and VEGF is antagonized by Angiopoietin-2 in a modified in vivo Matrigel assay. Microvascular research 2004, 68 (3), 161-8.
69. Rousseau, S.; Houle, F.; Huot, J., Integrating the VEGF signals leading to actin-based motility in vascular endothelial cells. Trends in cardiovascular medicine 2000, 10 (8), 321-7.
70. Ferrara, N.; Henzel, W. J., Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochemical and biophysical research communications 1989, 161 (2), 851-8.
71. Schanz, J. E. Etablierung einer biologischen vaskularisierten Matrix als Grundlage für ein in vitro Lebertestsystem. Universitätsbibliothek der Universität Stuttgart, Stuttgart, 2008.
72. van Mourik, A. M.; Daffertshofer, A.; Beek, P. J., Estimating Kramers-Moyal coefficients in short and non-stationary data sets. Physics Letters A 2006, 351 (1-2), 13-17.
73. Holy, C. E.; Shoichet, M. S.; Davies, J. E., Engineering threedimensional bone tissue in vitro using biodegradable scaffolds: investigating initial cell-seeding density and culture period. Journal of biomedical materials research 2000, 51 (3), 376-82.
74. Yeatts, A. B.; Fisher, J. P., Bone tissue engineering bioreactors: dynamic culture and the influence of shear stress. Bone 2011, 48 (2), 171-81.
75. Zhao, F.; Chella, R.; Ma, T., Effects of shear stress on 3-D human mesenchymal stem cell construct development in a perfusion bioreactor system: Experiments and hydrodynamic modeling. Biotechnology and bioengineering 2007, 96 (3), 584-95.
76. Deligianni, D. D.; Katsala, N. D.; Koutsoukos, P. G.; Missirlis, Y. F., Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength. Biomaterials 2001, 22 (1), 87-96.
77. Pattappa, G.; Heywood, H. K.; de Bruijn, J. D.; Lee, D. A., The metabolism of human mesenchymal stem cells during proliferation and differentiation. Journal of cellular physiology 2011, 226 (10), 2562-70.
78. Desquiret, V.; Gueguen, N.; Malthiery, Y.; Ritz, P.; Simard, G., Mitochondrial effects of dexamethasone imply both membrane and cytosolic-initiated pathways in HepG2 cells. The international journal of biochemistry & cell biology 2008, 40 (8), 1629-41.
79. Roussel, D.; Dumas, J. F.; Simard, G.; Malthiery, Y.; Ritz, P., Kinetics and control of oxidative phosphorylation in rat liver mitochondria after dexamethasone treatment. The Biochemical journal 2004, 382 (Pt 2), 491-9.
80. Weinbaum, S.; Cowin, S. C.; Zeng, Y., A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. Journal of biomechanics 1994, 27 (3), 339-60.
81. Risken, H.; Frank, T., The Fokker-Planck Equation Methods of Solutions and Applications. 1989; Vol. 3.
82. Stokes, C. L.; Lauffenburger, D. A., Analysis of the roles of microvessel endothelial cell random motility and chemotaxis in angiogenesis. Journal of theoretical biology 1991, 152 (3), 377-403.