18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: A first-in-human study of radiochemical safety, biokinetics, and radiation dosimetry

Journal of Nuclear Medicine

Volumn 54, Issue 3, 2013, Pages 388-396

  Wong, Dean F ^a   Waterhouse, Rikki ^b   Kuwabara, Hiroto ^a   Kim, Jongho ^a   Brašíc, James R ^a   Chamroonrat, Wichana ^a   Stabins, Michael ^c   Holt, Daniel P ^a   Dannals, Robert F ^a   Hamill, Terence G ^d   Mozley, P David ^d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

3 fluoro 5 (pyridin 3 yl)ethynyl benzonitrile (FPEB); 18F FPEB; Human radiation dosimetry; Metabotropic glutamate receptor subtype 5 (mGluR5); Neuroreceptors; Positron emission tomography (PET); Radioligand

Indexed keywords

3 FLUORO 5 [(PYRIDIN 3 YL)ETHYNYL]BENZONITRILE F 18; METABOTROPIC RECEPTOR 5; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; 3 FLUORO 5 ((PYRIDIN 3 YL)ETHYNYL)BENZONITRILE; 3-FLUORO-5-((PYRIDIN-3-YL)ETHYNYL)BENZONITRILE; DIAGNOSTIC AGENT; FLUORINE; METABOTROPIC RECEPTOR; NITRILE; PYRIDINE DERIVATIVE;

ADULT; ARTICLE; BRAIN REGION; CAUDATE NUCLEUS; CEREBELLUM; COMPUTER PROGRAM; DOSIMETRY; DRUG ACCUMULATION; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; DRUG UPTAKE; ELECTROCARDIOGRAPHY; FEMALE; FIRST IN HUMAN STUDY; HUMAN; HUMAN EXPERIMENT; IMAGE RECONSTRUCTION; INSULA; LABORATORY TEST; MALE; MATHEMATICAL MODEL; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPEN STUDY; PILOT STUDY; PONS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION DOSE; RADIATION SAFETY; RADIOCHEMISTRY; SIDE EFFECT; TEST RETEST RELIABILITY; THALAMUS; VITAL SIGN; VOLUNTEER; BIOLOGICAL MODEL; BRAIN; COMPUTER ASSISTED DIAGNOSIS; DRUG ANTAGONISM; METABOLISM; METHODOLOGY; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING; TISSUE DISTRIBUTION; WHOLE BODY IMAGING;

ADULT; BRAIN; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MODELS, BIOLOGICAL; NITRILES; PILOT PROJECTS; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RADIATION DOSAGE; RADIOPHARMACEUTICALS; RECEPTORS, METABOTROPIC GLUTAMATE; TISSUE DISTRIBUTION; WHOLE BODY IMAGING;

MLCS; MLOWN;

EID: 84874881790     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.112.107995     Document Type: Article

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