PET imaging of neurokinin-1 receptors with [18F]SPA-RQ in human subjects: Assessment of reference tissue models and their test-retest reproducibility

Synapse

Volumn 61, Issue 4, 2007, Pages 242-251

  Yasuno, Fumihiko ^a   Sanabria, Sandra M ^b   Burns, Donald ^b   Hargreaves, Richard J ^b   Ghose, Subroto ^c   Ichise, Masanori ^d   Chin, Frederick T ^a   Morse, Cheryl L ^a   Pike, Victor W ^a   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Noninvasive quantification; Parametric image; Positron emission tomography

Indexed keywords

FLUORINE 18; NEUROKININ 1 RECEPTOR; SUBSTANCE P ANTAGONIST; TRACER;

ADULT; ARTICLE; BLOOD SAMPLING; CALCULATION; CORRELATION COEFFICIENT; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MEASUREMENT; NEUROIMAGING; NORMAL HUMAN; PARAMETER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR DENSITY; RELIABILITY; REPRODUCIBILITY; SCANNING ELECTROCHEMICAL MICROSCOPY; SIMULATION; TEST RETEST RELIABILITY;

ADULT; BRAIN; BRAIN MAPPING; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LINEAR MODELS; MALE; MIDDLE AGED; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, NEUROKININ-1; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TETRAZOLES; TIME FACTORS;

EID: 33846963540     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20361     Document Type: Article

References (30)

1. Caberlotto L, Hurd YL, Murdock P, Wahlin JP, Melotto S, Corsi M, Carletti R. 2003. Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain. Eur J Neurosci 17:1736-1746.
2. Carson RE. 1993. PET parameter estimation using linear integration methods: Bias and variability consideration. In: Uemura K, Lassen N, Jones T, editors. Quantification of brain function: tracer kinetics and image analysis in brain PET. Amsterdam: Elsevier Science. p 81-89.
3. 18F]SPA-RQ for imaging human brain NK1 receptors with PET. J Labelled Compd Radiopharm 49:17-31.
4. De Felipe C, Herrero JF, O'Brien JA, Palmer JA, Doyle CA, Smith AJ, Laird JM, Belmonte C, Cervero F, Hunt SP. 1998. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature 392:394-397.
5. Fleiss J. 1986. The design and analysis of clinical experiments. New York: Wiley.
6. 3H]GR205171 displays similar NK1 receptor binding profile in gerbil and human brain. Br J Pharmacol 148:39-45.
7. Hesketh PJ, Grunberg SM, Gralla RJ, Warr DG, Roila F, de Wit R, Chawla SP, Carides AD, Ianus J, Elmer ME, Evans JK, Beck K, Reines S, Horgan KJ; APSG. 2003. The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: A multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin - The Aprepitant Protocol 052 Study Group. J Clin Oncol 21:4112-4119.
8. Hietala J, Nyman MJ, Eskola O, Laakso A, Gronroos T, Oikonen V, Bergman J, Haaparanta M, Forsback S, Marjamaki P, Lehikoinen P, Goldberg M, Burns D, Hamill T, Eng WS, Coimbra A, Hargreaves R, Solin O. 2005. Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain. Mol Imaging Biol 7:262-272.
9. 11C-raclopride. Nucl Med Commun 24:1207-1214.
10. Ichise M, Toyama H, Innis RB, Carson RE. 2002. Strategies to improve neuroreceptor parameter estimation by linear regression analysis. J Cereb Blood Flow Metab 22:1271-1281.
11. Ichise M, Liow JS, Lu JQ, Takano A, Model K, Toyama H, Suhara T, Suzuki K, Innis RB, Carson RE. 2003. Linearized reference tissue parametric imaging methods: Application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab 23:1096-1112.
12. 11C]DAA1106. J Cereb Blood Flow Metab (in press).
13. 11C]DASB: Test-retest reproducibility using a multilinear reference tissue parametric imaging method. J Nucl Med 47:208-214.
14. Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Carlson EJ, Hargreaves RJ, Rupniak NM. 1998. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281:1640-1645.
15. Lammertsma AA, Hume SP. 1996. Simplified reference tissue model for PET receptor studies. Neuroimage 4:153-158.
16. 11C-methyl]-(-)cocaine PET studies in human subjects. J Cereb Blood Flow Metab 10:740-747.
17. Meyer JH, Gunn RN, Myers R, Grasby PM. 1999. Assessment of spatial normalization of PET ligand images using ligand-specific templates. Neuroimage 9:545-553.
18. Morcuende S, Gadd CA, Peters M, Moss A, Harris EA, Sheasby A, Fisher AS, De Felipe C, Mantyh PW, Rupniak NM, Giese KP, Hunt SP. 2003. Increased neurogenesis and brain-derived neurotrophic factor in neurokinin-1 receptor gene knockout mice. Eur J Neurosci 18:1828-1836.
19. Murtra P, Sheasby AM, Hunt SP, De Felipe C. 2000. Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature 405:180-183.
20. 18F]SPA-RQ. Int J Neuropsychopharmacol 30:1-11.
21. Rioux L, Joyce JN. 1993. Substance P receptors are differentially affected in Parkinson's and Alzheimer's disease. J Neural Transm Park Dis Dement Sect 6:199-210.
22. Santarelli L, Gobbi G, Debs PC, Sibille ET, Blier P, Hen R, Heath MJ. 2001. Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci USA 98. 1912-1917.
23. Saria A. 1999. The tachykinin NK1 receptor in the brain: Pharmacology and putative functions. Eur J Pharmacol 375:51-60.
24. 11C]WAY-100635 binding parameters with reference tissue models: Effect of violations of model assumptions. Nucl Med Biol 27:487-492.
25. 18F]altanserin in the human brain. Synapse 30:380-392.
26. 18F]SPA-RQ. Mol Imaging Biol 6:373-384.
27. Stumm R, Culmsee C, Schafer MK, Krieglstein J, Weihe E. 2001. Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium. J Neurosci 21:798-811.
28. 11C]FLB 457 binding in extrastriatal regions. Nucl Med Commun 22:1215-1221.
29. 11C]FLB 457 - A test-retest analysis. Eur J Nucl Med 27:1666-1673.
30. Yasuno F, Hasnine AH, Suhara T, Ichimiya T, Sudo Y, Inoue M, Takano A, Ou T, Ando T, Toyama H. 2002. Template-based method for multiple volumes of interest of human brain PET images. Neuroimage 16:577-586.