Biodistribution and radiation dosimetry of a positron emission tomographic ligand, 18F-SP203, to image metabotropic glutamate subtype 5 receptors in humans

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 37, Issue 10, 2010, Pages 1943-1949

  Kimura, Yasuyuki ^a   Siméon, Fabrice G ^a   Hatazawa, Jun ^b   Mozley, P David ^c   Pike, Victor W ^a   Innis, Robert B ^a   Fujita, Masahiro ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Defluorination; Dosimetry; MGluR5; PET

Indexed keywords

3 FLUORO 5 (2 (2 18F (FLUOROMETHYL)THIAZOL 4 YL)ETHYNYL)BENZONITRILE; METABOTROPIC RECEPTOR 5; TRACER; UNCLASSIFIED DRUG; 3 FLUORO 5 (2 (2 (FLUOROMETHYL)THIAZOL 4 YL)ETHYNYL)BENZONITRILE; 3-FLUORO-5-(2-(2-(FLUOROMETHYL)THIAZOL-4-YL)ETHYNYL)BENZONITRILE; DIAGNOSTIC AGENT; FLUORINE; LIGAND; METABOTROPIC RECEPTOR; NITRILE; THIAZOLE DERIVATIVE;

ADULT; ARTICLE; BLADDER WALL; BONE MARROW; BONE STRUCTURE; DEFLUORINATION; DOSIMETRY; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG URINE LEVEL; FEMALE; GALLBLADDER; HUMAN; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; RADIATION ABSORPTION; RADIATION EXPOSURE; RADIOACTIVITY; URINALYSIS; WHOLE BODY IMAGING; BONE; CHEMISTRY; CLINICAL TRIAL; HALOGENATION; METABOLISM; METHODOLOGY; RADIATION DOSE; RADIOMETRY;

ADULT; BONE AND BONES; BONE MARROW; FEMALE; FLUORINE RADIOISOTOPES; HALOGENATION; HUMANS; LIGANDS; MALE; NITRILES; POSITRON-EMISSION TOMOGRAPHY; RADIATION DOSAGE; RADIOMETRY; RECEPTORS, METABOTROPIC GLUTAMATE; THIAZOLES;

EID: 79851483881     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-010-1447-8     Document Type: Article

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