-
1
-
-
33846207546
-
Deregulated Ras signaling in developmental disorders: new tricks for an old dog
-
Schubbert S., Bollag G., and Shannon K. Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Curr. Opin. Genet. Dev. 17 (2007) 15-22
-
(2007)
Curr. Opin. Genet. Dev.
, vol.17
, pp. 15-22
-
-
Schubbert, S.1
Bollag, G.2
Shannon, K.3
-
2
-
-
0035136213
-
Targeted genomic disruption of H-Ras and N-Ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development
-
Esteban L.M., Vicario-Abejon C., Fernandez-Salguero P., Fernandez-Medarde A., Swaminathan N., Yienger K., Lopez E., Malumbres M., McKay R., Ward J.M., Pellicer A., and Santos E. Targeted genomic disruption of H-Ras and N-Ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development. Mol. Cell. Biol. 21 (2001) 1444-1452
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1444-1452
-
-
Esteban, L.M.1
Vicario-Abejon, C.2
Fernandez-Salguero, P.3
Fernandez-Medarde, A.4
Swaminathan, N.5
Yienger, K.6
Lopez, E.7
Malumbres, M.8
McKay, R.9
Ward, J.M.10
Pellicer, A.11
Santos, E.12
-
3
-
-
0034880335
-
Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues
-
Stephens E., Thureen P.J., Goalstone M.L., Anderson M.S., Leitner J.W., Hay W.W., and Draznin B. Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues. Am. J. Physiol. Endocrinol. Metab. 281 (2001) E217-E223
-
(2001)
Am. J. Physiol. Endocrinol. Metab.
, vol.281
-
-
Stephens, E.1
Thureen, P.J.2
Goalstone, M.L.3
Anderson, M.S.4
Leitner, J.W.5
Hay, W.W.6
Draznin, B.7
-
4
-
-
1442276545
-
Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats
-
Kowluru R.A., Kowluru A., Chakrabarti S., and Khan Z. Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats. Diabetes 53 (2004) 775-783
-
(2004)
Diabetes
, vol.53
, pp. 775-783
-
-
Kowluru, R.A.1
Kowluru, A.2
Chakrabarti, S.3
Khan, Z.4
-
5
-
-
34447508212
-
Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes
-
Kowluru R.A., Kowluru A., and Kanwar M. Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes. Mol. Cell Biochem. 296 (2007) 69-76
-
(2007)
Mol. Cell Biochem.
, vol.296
, pp. 69-76
-
-
Kowluru, R.A.1
Kowluru, A.2
Kanwar, M.3
-
6
-
-
0347065356
-
Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation
-
Goetz C.A., O'Neil J.J., and Farrar M.A. Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation. J. Biol. Chem. 278 (2003) 51184-51189
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 51184-51189
-
-
Goetz, C.A.1
O'Neil, J.J.2
Farrar, M.A.3
-
7
-
-
61349129180
-
Role of phosphatidic acid in the coupling of the ERK cascade
-
Kraft C.A., Garrido J.L., Fluharty E., Leiva-Vega L., and Romero G. Role of phosphatidic acid in the coupling of the ERK cascade. J. Biol. Chem. 283 (2008) 36636-36645
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 36636-36645
-
-
Kraft, C.A.1
Garrido, J.L.2
Fluharty, E.3
Leiva-Vega, L.4
Romero, G.5
-
8
-
-
0037109099
-
Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation
-
Indolfi C., Lorenzo E.D., Perrino C., Stingone A.M., Curcio A., Torella D., Cittadini A., Cardone L., Coppola C., Cavuto L., Arcucci O., Sacca L., Avvedimento E.V., and Chiariello M. Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation. Circulation 106 (2002) 2118-2124
-
(2002)
Circulation
, vol.106
, pp. 2118-2124
-
-
Indolfi, C.1
Lorenzo, E.D.2
Perrino, C.3
Stingone, A.M.4
Curcio, A.5
Torella, D.6
Cittadini, A.7
Cardone, L.8
Coppola, C.9
Cavuto, L.10
Arcucci, O.11
Sacca, L.12
Avvedimento, E.V.13
Chiariello, M.14
-
9
-
-
63249102297
-
Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy
-
Kanwar M., and Kowluru R.A. Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. Diabetes 58 (2009) 227-234
-
(2009)
Diabetes
, vol.58
, pp. 227-234
-
-
Kanwar, M.1
Kowluru, R.A.2
-
10
-
-
34247542013
-
Effect of curcumin on retinal oxidative stress and inflammation in diabetes
-
Kowluru R.A., and Kanwar M. Effect of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr. Metab. (Lond.) 4 (2007) 1-8
-
(2007)
Nutr. Metab. (Lond.)
, vol.4
, pp. 1-8
-
-
Kowluru, R.A.1
Kanwar, M.2
-
11
-
-
4744347272
-
Role of interleukin-1beta in the pathogenesis of diabetic retinopathy
-
Kowluru R.A., and Odenbach S. Role of interleukin-1beta in the pathogenesis of diabetic retinopathy. Br. J. Ophthalmol. 88 (2004) 1343-1347
-
(2004)
Br. J. Ophthalmol.
, vol.88
, pp. 1343-1347
-
-
Kowluru, R.A.1
Odenbach, S.2
-
12
-
-
0142221070
-
Diabetes-induced mitochondrial dysfunction in the retina
-
Kowluru R.A., and Abbas S.N. Diabetes-induced mitochondrial dysfunction in the retina. Invest. Ophthalmol. Vis. Sci. 44 (2003) 5327-5334
-
(2003)
Invest. Ophthalmol. Vis. Sci.
, vol.44
, pp. 5327-5334
-
-
Kowluru, R.A.1
Abbas, S.N.2
-
13
-
-
0036023314
-
Diabetes-induced activation of caspase-3 in retina: effect of antioxidant therapy
-
Kowluru R.A., and Koppolu P. Diabetes-induced activation of caspase-3 in retina: effect of antioxidant therapy. Free Radic. Res. 36 (2002) 993-999
-
(2002)
Free Radic. Res.
, vol.36
, pp. 993-999
-
-
Kowluru, R.A.1
Koppolu, P.2
-
14
-
-
9444224415
-
Effect of long-term administration of alpha lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats
-
Kowluru R.A., and Odenbach S. Effect of long-term administration of alpha lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes 53 (2004) 3233-3238
-
(2004)
Diabetes
, vol.53
, pp. 3233-3238
-
-
Kowluru, R.A.1
Odenbach, S.2
-
15
-
-
34247403051
-
Increased oxidative stress in diabetes regulates activation of a small molecular weight G-protein, H-Ras, in the retina
-
Kowluru V., and Kowluru R.A. Increased oxidative stress in diabetes regulates activation of a small molecular weight G-protein, H-Ras, in the retina. Mol. Vis. 13 (2007) 602-610
-
(2007)
Mol. Vis.
, vol.13
, pp. 602-610
-
-
Kowluru, V.1
Kowluru, R.A.2
-
16
-
-
34648825492
-
Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase
-
Kanwar M., Chan P.S., Kern T.S., and Kowluru R.A. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest. Ophthalmol. Vis. Sci. 48 (2007) 3805-3811
-
(2007)
Invest. Ophthalmol. Vis. Sci.
, vol.48
, pp. 3805-3811
-
-
Kanwar, M.1
Chan, P.S.2
Kern, T.S.3
Kowluru, R.A.4
-
17
-
-
53649090339
-
Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: Implication in the development of retinopathy
-
Kanwar M., and Kowluru R.A. Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: Implication in the development of retinopathy. Microvasc. Res. 76 (2008) 189-193
-
(2008)
Microvasc. Res.
, vol.76
, pp. 189-193
-
-
Kanwar, M.1
Kowluru, R.A.2
-
18
-
-
0142180047
-
Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants
-
Kowluru R.A., Koppolu P., Chakrabarti S., and Chen S. Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants. Free Radic. Res. 37 (2003) 1169-1180
-
(2003)
Free Radic. Res.
, vol.37
, pp. 1169-1180
-
-
Kowluru, R.A.1
Koppolu, P.2
Chakrabarti, S.3
Chen, S.4
-
19
-
-
0037342855
-
Effect of re-institution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats
-
Kowluru R.A. Effect of re-institution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes 52 (2003) 818-823
-
(2003)
Diabetes
, vol.52
, pp. 818-823
-
-
Kowluru, R.A.1
-
20
-
-
0029973474
-
Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy
-
Mizutani M., Kern T.S., and Lorenzi M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J. Clin. Invest. 97 (1996) 2883-2890
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 2883-2890
-
-
Mizutani, M.1
Kern, T.S.2
Lorenzi, M.3
-
21
-
-
0033753702
-
Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia
-
Kern T.S., Tang J., Mizutani M., Kowluru R., Nagaraj R., and Lorenzi M. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3972-3978
-
(2000)
Invest. Ophthalmol. Vis. Sci.
, vol.41
, pp. 3972-3978
-
-
Kern, T.S.1
Tang, J.2
Mizutani, M.3
Kowluru, R.4
Nagaraj, R.5
Lorenzi, M.6
-
22
-
-
57049102872
-
Transmembrane signaling pathway mediates oxidized low-density lipoprotein-induced expression of plasminogen activator inhibitor-1 in vascular endothelial cells
-
Sangle G.V., Zhao R., and Shen G.X. Transmembrane signaling pathway mediates oxidized low-density lipoprotein-induced expression of plasminogen activator inhibitor-1 in vascular endothelial cells. Am. J. Physiol. Endocrinol. Metab. 295 (2008) E1243-E1254
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.295
-
-
Sangle, G.V.1
Zhao, R.2
Shen, G.X.3
-
23
-
-
55749098939
-
Pigment epithelium-derived factor (PEDF) mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized-LDL
-
Zhang S., Wang J., Dashti A., Wilson K., Zou M.H., Szweda L., Ma J.X., and Lyons T.J. Pigment epithelium-derived factor (PEDF) mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized-LDL. J. Mol. Endocrinol. 41 (2008) 135-143
-
(2008)
J. Mol. Endocrinol.
, vol.41
, pp. 135-143
-
-
Zhang, S.1
Wang, J.2
Dashti, A.3
Wilson, K.4
Zou, M.H.5
Szweda, L.6
Ma, J.X.7
Lyons, T.J.8
-
24
-
-
48249088030
-
Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy
-
Al-Shabrawey M., Bartoli M., El-Remessy A.B., Ma G., Matragoon S., Lemtalsi T., Caldwell R.W., and Caldwell R.A. Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 49 (2008) 3231-3238
-
(2008)
Invest. Ophthalmol. Vis. Sci.
, vol.49
, pp. 3231-3238
-
-
Al-Shabrawey, M.1
Bartoli, M.2
El-Remessy, A.B.3
Ma, G.4
Matragoon, S.5
Lemtalsi, T.6
Caldwell, R.W.7
Caldwell, R.A.8
-
25
-
-
50249141649
-
The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies
-
Medina R.J., O'Neill C.L., Devine A.B., Gardiner T.A., and Stitt A.W. The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies. PLoS ONE 3 (2008) e2584
-
(2008)
PLoS ONE
, vol.3
-
-
Medina, R.J.1
O'Neill, C.L.2
Devine, A.B.3
Gardiner, T.A.4
Stitt, A.W.5
-
26
-
-
2942709705
-
Protein farnesyl transferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis
-
Takada Y., Khuri F.R., and Aggarwal B.B. Protein farnesyl transferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis. J. Biol. Chem. 279 (2004) 26287-26299
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 26287-26299
-
-
Takada, Y.1
Khuri, F.R.2
Aggarwal, B.B.3
-
27
-
-
0034761030
-
In vivo retinal gene expression in early diabetes
-
Joussen A.M., Huang S., Poulaki V., Camphausen K., Beecken W.D., Kirchhof B., and Adamis A.P. In vivo retinal gene expression in early diabetes. Invest. Ophthalmol. Vis. Sci. 42 (2001) 3047-3057
-
(2001)
Invest. Ophthalmol. Vis. Sci.
, vol.42
, pp. 3047-3057
-
-
Joussen, A.M.1
Huang, S.2
Poulaki, V.3
Camphausen, K.4
Beecken, W.D.5
Kirchhof, B.6
Adamis, A.P.7
-
28
-
-
0037233913
-
HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells
-
Dichtl W., Dulak J., Frick M., Alber H.F., Schwarzacher S.P., Ares M.P., Nilsson J., Pachinger O., and Weidinger F. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 58-63
-
(2003)
Arterioscler. Thromb. Vasc. Biol.
, vol.23
, pp. 58-63
-
-
Dichtl, W.1
Dulak, J.2
Frick, M.3
Alber, H.F.4
Schwarzacher, S.P.5
Ares, M.P.6
Nilsson, J.7
Pachinger, O.8
Weidinger, F.9
|