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Volumn 32, Issue 3, 2013, Pages 130-135

Role of autophagy in acute myeloid leukemia therapy

Author keywords

Acute myeloid leukemia; Autophagy; Fusion oncoprotein

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; BECLIN 1; CALCITRIOL; CARBOPLATIN; CARNOSIC ACID; COLECALCIFEROL; DAPORINAD; DEXAMETHASONE; DOCETAXEL; EUPALININ A; FARNOQUINONE; HYBRID PROTEIN; MORPHINONE; ONCOPROTEIN; PACLITAXEL; PLATONIN; PML RAR PROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; SEOCALCITOL; SESQUITERPENE LACTONE; UNCLASSIFIED DRUG;

EID: 84874873315     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.012.10073     Document Type: Review
Times cited : (27)

References (64)
  • 1
    • 34249279169 scopus 로고    scopus 로고
    • GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation
    • Colell A, Ricci JE, Tait S, et al. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell, 2007,129:983-997.
    • (2007) Cell , vol.129 , pp. 983-997
    • Colell, A.1    Ricci, J.E.2    Tait, S.3
  • 2
    • 33645221489 scopus 로고    scopus 로고
    • Excess peroxisomes are degraded by autophagic machinery in mammals
    • Iwata J, Ezaki J, Komatsu M, et al. Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem, 2006,281:4035-4041.
    • (2006) J Biol Chem , vol.281 , pp. 4035-4041
    • Iwata, J.1    Ezaki, J.2    Komatsu, M.3
  • 3
    • 34249863298 scopus 로고    scopus 로고
    • Autophagy suppresses tumor progression by limiting chromosomal instability
    • Mathew R, Kongara S, Beaudoin B, et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev, 2007,21:1367-1381.
    • (2007) Genes Dev , vol.21 , pp. 1367-1381
    • Mathew, R.1    Kongara, S.2    Beaudoin, B.3
  • 4
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R, Karp CM, Beaudoin B, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell,2009,137:1062-1075.
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3
  • 5
    • 34548259958 scopus 로고    scopus 로고
    • p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv S, Clausen TH, Lamark T, et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem, 2007,282:24131-24145.
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3
  • 7
    • 64149090441 scopus 로고    scopus 로고
    • Autophagy provides nutrients but can lead to chop-dependent induction of Bim to sensitize growth factor deprived cells to apoptosis
    • Altman BJ, Wofford JA, Zhao Y, et al. Autophagy provides nutrients but can lead to chop-dependent induction of Bim to sensitize growth factor deprived cells to apoptosis. Mol Biol Cell, 2009,20:1180-1191.
    • (2009) Mol Biol Cell , vol.20 , pp. 1180-1191
    • Altman, B.J.1    Wofford, J.A.2    Zhao, Y.3
  • 8
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh R, Kaushik S, Wang Y, et al. Autophagy regulates lipid metabolism. Nature, 2009,458:1131-1135.
    • (2009) Nature , vol.458 , pp. 1131-1135
    • Singh, R.1    Kaushik, S.2    Wang, Y.3
  • 9
    • 0034012322 scopus 로고    scopus 로고
    • Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments
    • Bursch W, Hochegger K, Torok L, et al. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci, 2000,113:1189-1198.
    • (2000) J Cell Sci , vol.113 , pp. 1189-1198
    • Bursch, W.1    Hochegger, K.2    Torok, L.3
  • 10
    • 0037193474 scopus 로고    scopus 로고
    • DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death
    • Inbal B, Bialik S, Sabanay I, et al. DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol, 2002,157:455-468.
    • (2002) J Cell Biol , vol.157 , pp. 455-468
    • Inbal, B.1    Bialik, S.2    Sabanay, I.3
  • 11
    • 0035863399 scopus 로고    scopus 로고
    • A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
    • Paglin S, Hollister T, Delohery T, et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res, 2001,61:439-444.
    • (2001) Cancer Res , vol.61 , pp. 439-444
    • Paglin, S.1    Hollister, T.2    Delohery, T.3
  • 12
    • 27144503701 scopus 로고    scopus 로고
    • Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin1-mediated autophagic cell death
    • Hoyer-H ansen M, Bastholm L, Mathiasen S, et al. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin1-mediated autophagic cell death. Cell Death Differ, 2005,12:1297-1309.
    • (2005) Cell Death Differ , vol.12 , pp. 1297-1309
    • Hoyer-Hansen, M.1    Bastholm, L.2    Mathiasen, S.3
  • 13
    • 54449093435 scopus 로고    scopus 로고
    • Vitamin D3 induces autophagy of human myeloid leukemia cells
    • Wang J, Lian H, Zhao Y, et al. Vitamin D3 induces autophagy of human myeloid leukemia cells. J Biol Chem, 2008,283:25596-25605.
    • (2008) J Biol Chem , vol.283 , pp. 25596-25605
    • Wang, J.1    Lian, H.2    Zhao, Y.3
  • 14
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature, 1999,402:672-676.
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3
  • 15
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA, 2003,100:15077-15082.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3
  • 16
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K, Mathew R, Beaudoin B, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell, 2006,10:51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3
  • 17
    • 33846244269 scopus 로고    scopus 로고
    • Role of autophagy in cancer: Management of metabolic stress
    • Jin S, White E. Role of autophagy in cancer: management of metabolic stress. Autophagy, 2007,3:28-31.
    • (2007) Autophagy , vol.3 , pp. 28-31
    • Jin, S.1    White, E.2
  • 18
    • 34347404887 scopus 로고    scopus 로고
    • Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    • Karantza-Wadsworth V, Patel S, Kravchuk O, et al. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev, 2007,21:1621-1635.
    • (2007) Genes Dev , vol.21 , pp. 1621-1635
    • Karantza-Wadsworth, V.1    Patel, S.2    Kravchuk, O.3
  • 19
    • 0037315894 scopus 로고    scopus 로고
    • Disruption of differentiation in human cancer
    • Tenen DG. Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer, 2003,3:89-101.
    • (2003) AML Shows the Way. Nat Rev Cancer , vol.3 , pp. 89-101
    • Tenen, D.G.1
  • 20
    • 6044234531 scopus 로고    scopus 로고
    • Mechanisms controlling pathogenesis and survival of leukemic stem cells
    • Jordan CT, Guzman ML. Mechanisms controlling pathogenesis and survival of leukemic stem cells. Oncogene, 2004,23:7178-7187.
    • (2004) Oncogene , vol.23 , pp. 7178-7187
    • Jordan, C.T.1    Guzman, M.L.2
  • 21
    • 34247599900 scopus 로고    scopus 로고
    • Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARa-positive stem cells
    • Zheng X, Seshire A, Ruster B, et al. Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARa-positive stem cells. Heamatologica, 2007,92:323-331.
    • (2007) Heamatologica , vol.92 , pp. 323-331
    • Zheng, X.1    Seshire, A.2    Ruster, B.3
  • 22
    • 0023752982 scopus 로고
    • Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
    • Huang ME, Ye YC, Chen SR, et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood, 1988,72:567-572.
    • (1988) Blood , vol.72 , pp. 567-572
    • Huang, M.E.1    Ye, Y.C.2    Chen, S.R.3
  • 23
    • 0033561797 scopus 로고    scopus 로고
    • Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia
    • Melnick A, Licht JD. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood, 1999,93:3167-3215.
    • (1999) Blood , vol.93 , pp. 3167-3215
    • Melnick, A.1    Licht, J.D.2
  • 24
    • 0010740572 scopus 로고    scopus 로고
    • 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-R AR alpha/PML proteins
    • Chen GQ, Zhu J, Shi XG, et al. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As 2O 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-R AR alpha/PML proteins. Blood, 1996,88: 1052-1061.
    • (1996) Blood , vol.88 , pp. 1052-1061
    • Chen, G.Q.1    Zhu, J.2    Shi, X.G.3
  • 25
    • 0030610686 scopus 로고    scopus 로고
    • 3 exerts dose-dependent dual effects on APL cells
    • Chen GQ, Shi XG, Tang W, et al. Use of arsenic trioxide (As 2O 3) in the treatment of acute promyelocytic leukemia (APL):I. As 2O 3 exerts dose-dependent dual effects on APL cells. Blood, 1997,89:3345-3353.
    • (1997) Blood , vol.89 , pp. 3345-3353
    • Chen, G.Q.1    Shi, X.G.2    Tang, W.3
  • 26
    • 0030610687 scopus 로고    scopus 로고
    • 3) in the treatment of acute promyelocytic leukemia (APL):II.clinical efficacy and pharmacokinetics in relapsed patients
    • Shen ZX, Chen GQ, Ni JH, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL):II.clinical efficacy and pharmacokinetics in relapsed patients. Blood, 1997,89:3354-3360.
    • (1997) Blood , vol.89 , pp. 3354-3360
    • Shen, Z.X.1    Chen, G.Q.2    Ni, J.H.3
  • 27
    • 43049096803 scopus 로고    scopus 로고
    • Arsenic degrades PML or PML-R ARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway
    • Lallemand-B reitenbach V, Jeanne M, Benhenda S, et al. Arsenic degrades PML or PML-R ARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol, 2008,10:547-555.
    • (2008) Nat Cell Biol , vol.10 , pp. 547-555
    • Lallemand-Breitenbach, V.1    Jeanne, M.2    Benhenda, S.3
  • 28
    • 43049093756 scopus 로고    scopus 로고
    • RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
    • Tatham MH, Geoffroy MC, Shen L, et al. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol, 2008,10:538-546.
    • (2008) Nat Cell Biol , vol.10 , pp. 538-546
    • Tatham, M.H.1    Geoffroy, M.C.2    Shen, L.3
  • 29
    • 77950826446 scopus 로고    scopus 로고
    • Arsenic trioxide controls the fate of the PML-R ARalpha oncoprotein by directly binding PML
    • Zhang XW, Yan XJ, Zhou ZR, et al. Arsenic trioxide controls the fate of the PML-R ARalpha oncoprotein by directly binding PML. Science, 2010,328:240-243.
    • (2010) Science , vol.328 , pp. 240-243
    • Zhang, X.W.1    Yan, X.J.2    Zhou, Z.R.3
  • 30
    • 11144355810 scopus 로고    scopus 로고
    • 3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia
    • Shen ZX, Shi ZZ, Fang J, et al. All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA, 2004,101:5328-5335.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 5328-5335
    • Shen, Z.X.1    Shi, Z.Z.2    Fang, J.3
  • 31
    • 62549083523 scopus 로고    scopus 로고
    • Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia
    • Hu J, Liu YF, Wu CF, et al. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA, 2009,106:3342-3347.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3342-3347
    • Hu, J.1    Liu, Y.F.2    Wu, C.F.3
  • 32
    • 33750447586 scopus 로고    scopus 로고
    • The mechanisms of PML-nuclear body formation
    • Shen TH, Lin HK, Scaglioni PP, et al. The mechanisms of PML-nuclear body formation. Mol Cell, 2006,24:331-339.
    • (2006) Mol Cell , vol.24 , pp. 331-339
    • Shen, T.H.1    Lin, H.K.2    Scaglioni, P.P.3
  • 33
    • 36448975490 scopus 로고    scopus 로고
    • Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
    • Bernardi R, Pandolfi PP. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol,2007,8:1006-1016.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 1006-1016
    • Bernardi, R.1    Pandolfi, P.P.2
  • 34
    • 67650517556 scopus 로고    scopus 로고
    • NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
    • Lamark T, Kirkin V, Dikic I, et al. NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle, 2009,8:1986-1990.
    • (2009) Cell Cycle , vol.8 , pp. 1986-1990
    • Lamark, T.1    Kirkin, V.2    Dikic, I.3
  • 35
    • 77957716030 scopus 로고    scopus 로고
    • Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein
    • Isakson P, Bjoras M, Boe SO, et al. Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood, 2010,116:2324-2331.
    • (2010) Blood , vol.116 , pp. 2324-2331
    • Isakson, P.1    Bjoras, M.2    Boe, S.O.3
  • 36
    • 73449102143 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells
    • Song J, Qu Z, Guo X, et al. Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. Autophagy, 2009,5:1131-1144.
    • (2009) Autophagy , vol.5 , pp. 1131-1144
    • Song, J.1    Qu, Z.2    Guo, X.3
  • 37
    • 33846077612 scopus 로고    scopus 로고
    • Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin1
    • Qian W, Liu J, Jin J, et al. Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin1. Leuk Res, 2007,31:329-339.
    • (2007) Leuk Res , vol.31 , pp. 329-339
    • Qian, W.1    Liu, J.2    Jin, J.3
  • 38
    • 77956898610 scopus 로고    scopus 로고
    • Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide
    • Goussetis DJ, Altman JK, Glaser H, et al. Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide. J Biol Chem, 2010,285:29989-29997.
    • (2010) J Biol Chem , vol.285 , pp. 29989-29997
    • Goussetis, D.J.1    Altman, J.K.2    Glaser, H.3
  • 39
    • 56449094841 scopus 로고    scopus 로고
    • Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection
    • Nedelsky NB, Todd PK, Taylor JP. Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochim Biophys Acta, 2008,1782:691-699.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 691-699
    • Nedelsky, N.B.1    Todd, P.K.2    Taylor, J.P.3
  • 40
    • 79953666792 scopus 로고    scopus 로고
    • Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARa oncoprotein
    • Wang Z, Cao L, Kang R, et al. Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARa oncoprotein. Autophagy, 2011,7:404-411.
    • (2011) Autophagy , vol.7 , pp. 404-411
    • Wang, Z.1    Cao, L.2    Kang, R.3
  • 41
    • 80053407220 scopus 로고    scopus 로고
    • PML-RARa enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway
    • Huang Y, Hou JK, Chen TT, et al. PML-RARa enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy, 2011,7:1132-1144.
    • (2011) Autophagy , vol.7 , pp. 1132-1144
    • Huang, Y.1    Hou, J.K.2    Chen, T.T.3
  • 42
    • 0027411688 scopus 로고
    • Fusion between a novel Kruppel-lik e zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t (11;17) translocation associated with acute promyelocytic leukaemia
    • Chen Z, Brand NJ, Chen A, et al. Fusion between a novel Kruppel-lik e zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t (11;17) translocation associated with acute promyelocytic leukaemia. EMBO J, 1993,12:1161-1167.
    • (1993) EMBO J , vol.12 , pp. 1161-1167
    • Chen, Z.1    Brand, N.J.2    Chen, A.3
  • 43
    • 0028899552 scopus 로고
    • Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)
    • Licht JD, Chomienne C, Goy A, et al. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17). Blood, 1995,85:1083-1094.
    • (1995) Blood , vol.85 , pp. 1083-1094
    • Licht, J.D.1    Chomienne, C.2    Goy, A.3
  • 44
    • 0030789181 scopus 로고    scopus 로고
    • Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RARalpha) and PLZF-R ARalpha fusion proteins on retinoic acid signaling
    • Ruthardt M, Testa U, Nervi C, et al. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RARalpha) and PLZF-R ARalpha fusion proteins on retinoic acid signaling. Mol Cell Biol, 1997,17:4859-4869.
    • (1997) Mol Cell Biol , vol.17 , pp. 4859-4869
    • Ruthardt, M.1    Testa, U.2    Nervi, C.3
  • 45
    • 0033611572 scopus 로고    scopus 로고
    • Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t (11;17) (q23;q21) APL patient
    • Koken MH, Daniel MT, Gianni M, et al. Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t (11;17) (q23;q21) APL patient. Oncogene, 1999,18:1113-1118.
    • (1999) Oncogene , vol.18 , pp. 1113-1118
    • Koken, M.H.1    Daniel, M.T.2    Gianni, M.3
  • 46
    • 0033037274 scopus 로고    scopus 로고
    • PIC-1/ SUMO-1-modified PML retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia
    • Sternsdorf T, Puccetti E, Jensen K, et al. PIC-1/ SUMO-1-modified PML retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Mol Cell Biol, 1999,19:5170-5178.
    • (1999) Mol Cell Biol , vol.19 , pp. 5170-5178
    • Sternsdorf, T.1    Puccetti, E.2    Jensen, K.3
  • 47
    • 0036796916 scopus 로고    scopus 로고
    • The role of retinoids and retinoic acid receptors in normal hematopoiesis
    • Collins SJ. The role of retinoids and retinoic acid receptors in normal hematopoiesis. Leukemia, 2002,16:1896-1905.
    • (2002) Leukemia , vol.16 , pp. 1896-1905
    • Collins, S.J.1
  • 48
    • 20144388533 scopus 로고    scopus 로고
    • Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells
    • Bug G, Gul H, Schwarz K, et al. Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Res, 2005,65:2537-2541.
    • (2005) Cancer Res , vol.65 , pp. 2537-2541
    • Bug, G.1    Gul, H.2    Schwarz, K.3
  • 49
    • 80053429512 scopus 로고    scopus 로고
    • ATRA-induced upregulation of Beclin1 prolongs the life span of differentiated acute promyelocytic leukemia cells
    • Trocoli A, Mathieu J, Priault M, et al. ATRA-induced upregulation of Beclin1 prolongs the life span of differentiated acute promyelocytic leukemia cells. Autophagy, 2011,7:1108-1114.
    • (2011) Autophagy , vol.7 , pp. 1108-1114
    • Trocoli, A.1    Mathieu, J.2    Priault, M.3
  • 50
    • 84855180031 scopus 로고    scopus 로고
    • S100A8-targeting siRNA enhances arsenic trioxide-induced myeloid leukemia cell death by down-regulating autophagy
    • Yang L, Yang M, Zhang H, et al. S100A8-targeting siRNA enhances arsenic trioxide-induced myeloid leukemia cell death by down-regulating autophagy. Int J Mol Med, 2012,29:65-72.
    • (2012) Int J Mol Med , vol.29 , pp. 65-72
    • Yang, L.1    Yang, M.2    Zhang, H.3
  • 51
    • 34548559114 scopus 로고    scopus 로고
    • Targeting MER1/2 blocks osteoclast differentiation function and cytokine secretion in multiple myeloma
    • Breitkreutz I, Raab MS, Vallet S, et al. Targeting MER1/2 blocks osteoclast differentiation function and cytokine secretion in multiple myeloma. Br J Haematol, 2007,139:55-63.
    • (2007) Br J Haematol , vol.139 , pp. 55-63
    • Breitkreutz, I.1    Raab, M.S.2    Vallet, S.3
  • 52
    • 16544373001 scopus 로고    scopus 로고
    • Inhibition of serum-stimulated mitogen activated protein kinase by 1alpha,25(OH)-vitamin D3 in MCF-7 breast cancer cells
    • Capiati D A, Rossi AM, Picotto G, et al. Inhibition of serum-stimulated mitogen activated protein kinase by 1alpha,25(OH)-vitamin D3 in MCF-7 breast cancer cells. J Cell Biochem, 2004,93:384-397.
    • (2004) J Cell Biochem , vol.93 , pp. 384-397
    • Capiati, D.A.1    Rossi, A.M.2    Picotto, G.3
  • 53
    • 57649096939 scopus 로고    scopus 로고
    • Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling
    • Wang J, Zhao Y, Kauss MA, et al. Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling. Eur J Cell Biol, 2009,88:103-115.
    • (2009) Eur J Cell Biol , vol.88 , pp. 103-115
    • Wang, J.1    Zhao, Y.2    Kauss, M.A.3
  • 54
    • 0038107401 scopus 로고    scopus 로고
    • The vitamin D3 analog EB1089 induces apoptosis via p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro
    • Pepper C, Thomas A, Hoy T, et al. The vitamin D3 analog EB1089 induces apoptosis via p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro. Blood, 2003,101:2454-2460.
    • (2003) Blood , vol.101 , pp. 2454-2460
    • Pepper, C.1    Thomas, A.2    Hoy, T.3
  • 55
    • 0037208558 scopus 로고    scopus 로고
    • Weekly high-dose calcitriol and docetaxel in metastatic androgen-independent prostate cancer
    • Beer TM, Eilers KM, Garzotto M, et al. Weekly high-dose calcitriol and docetaxel in metastatic androgen-independent prostate cancer. J Clin Oncol, 2003,21:128-138.
    • (2003) J Clin Oncol , vol.21 , pp. 128-138
    • Beer, T.M.1    Eilers, K.M.2    Garzotto, M.3
  • 56
    • 33947610197 scopus 로고    scopus 로고
    • Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: A report from the ASCENT investigators
    • Beer TM, Ryan CW, Venner PM. Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT investigators. J Clin Oncol, 2007,25:669-674.
    • (2007) J Clin Oncol , vol.25 , pp. 669-674
    • Beer, T.M.1    Ryan, C.W.2    Venner, P.M.3
  • 57
    • 0035881060 scopus 로고    scopus 로고
    • Carnosic acid and promotion of monocytic differentiation of HL-60 cells initiated by other agents
    • Danilenko M, Wang X, Studzinski GP. Carnosic acid and promotion of monocytic differentiation of HL-60 cells initiated by other agents. J Natl Cancer Inst, 2001,93:1224-1233.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1224-1233
    • Danilenko, M.1    Wang, X.2    Studzinski, G.P.3
  • 58
    • 48249148726 scopus 로고    scopus 로고
    • Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells
    • Yokoyama T, Miyazama K, Naito M, et al. Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells. Autophagy, 2008,4:629-640.
    • (2008) Autophagy , vol.4 , pp. 629-640
    • Yokoyama, T.1    Miyazama, K.2    Naito, M.3
  • 59
    • 64949200261 scopus 로고    scopus 로고
    • Intracellular glutathione regulates sequiterpene lactone-in duced conversion of autophagy to apoptosis in human leumia HL-60 cells
    • Itoh T, Ohguchi K, Nozawa Y, et al. Intracellular glutathione regulates sequiterpene lactone-in duced conversion of autophagy to apoptosis in human leumia HL-60 cells. Anticancer Res, 2009,29:1449-1457.
    • (2009) Anticancer Res , vol.29 , pp. 1449-1457
    • Itoh, T.1    Ohguchi, K.2    Nozawa, Y.3
  • 60
    • 34250333058 scopus 로고    scopus 로고
    • NF-B inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia
    • Fabre C, Carvalho G, Tasdemir E, et al. NF-B inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene, 2007,26:4071-4083.
    • (2007) Oncogene , vol.26 , pp. 4071-4083
    • Fabre, C.1    Carvalho, G.2    Tasdemir, E.3
  • 61
    • 33750697911 scopus 로고    scopus 로고
    • Induction of non-apoptotic cell death by morphinone in human promyclocytic leukemia HL-60 cells
    • Takeuchi R, Hoshijima H, Nagasaka H, et al. Induction of non-apoptotic cell death by morphinone in human promyclocytic leukemia HL-60 cells. Anticancer Res, 2006,26:3343-3348.
    • (2006) Anticancer Res , vol.26 , pp. 3343-3348
    • Takeuchi, R.1    Hoshijima, H.2    Nagasaka, H.3
  • 62
    • 65149084441 scopus 로고    scopus 로고
    • The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies
    • Nahimana A, Attingger A, Aubry D, et al. The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies. Blood, 2009,113:3276-3286.
    • (2009) Blood , vol.113 , pp. 3276-3286
    • Nahimana, A.1    Attingger, A.2    Aubry, D.3
  • 63
    • 61649107137 scopus 로고    scopus 로고
    • Platonin induces autophagy-associated cell death in human leukemia cells
    • Chen YJ, Huang WP, Yang YC, et al. Platonin induces autophagy-associated cell death in human leukemia cells. Autophagy, 2009,5:173-183.
    • (2009) Autophagy , vol.5 , pp. 173-183
    • Chen, Y.J.1    Huang, W.P.2    Yang, Y.C.3
  • 64
    • 80052382925 scopus 로고    scopus 로고
    • Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation
    • Mortensen M, Watson AS, Simon AK. Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation. Autophagy, 2011,7:1069-1070.
    • (2011) Autophagy , vol.7 , pp. 1069-1070
    • Mortensen, M.1    Watson, A.S.2    Simon, A.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.