Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARα fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)q23;q21) APL patient

Oncogene

Volumn 18, Issue 4, 1999, Pages 1113-1118

  Koken, Marcel H M ^a   Daniel, Marie Thérèse ^a   Gianni, Maurizio ^a   Zelent, Arthur ^d   Licht, Jonathan ^e   Buzyn, Agnes ^b   Minard, Patricia ^c   Degos, Laurent ^a   Varet, Bruno ^b   De Thé, Hugues ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c Hôpital de Moulins   (France)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^e MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Degradation; Leukaemia; Nuclear dot; PML; t(15; 17); Translocation

Indexed keywords

ARSENIC TRIOXIDE; HYBRID PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR;

ACUTE MYELOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL NUCLEUS INCLUSION BODY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; MONOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 17; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; ONCOGENE PROTEINS, FUSION; OXIDES; RECEPTORS, RETINOIC ACID; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0033611572     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202414     Document Type: Article

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