Controlling the proliferation and differentiation stages to initiate periodontal regeneration

Connective Tissue Research

Volumn 54, Issue 2, 2013, Pages 101-107

  Chong, Li Yen ^a   Chien, Li Ying ^a   Chung, Min Chun ^a   Liang, Kaicheng ^b   Lim, Jason Chu Shern ^b   Fu, Jia Hui ^a   Wang, Chi Hwa ^c   Chang, Po Chun ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cell proliferation; Drug delivery; Periodontal regeneration; Platelet derived growth factor; Simvastatin

Indexed keywords

BOVINE SERUM ALBUMIN; MICROSPHERE; PLATELET DERIVED GROWTH FACTOR; POLYGLACTIN; POLYLACTIDE; SIMVASTATIN;

ALVEOLAR BONE LOSS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MASS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DRUG RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MAXILLA; MICRO-COMPUTED TOMOGRAPHY; MICROENCAPSULATION; MITOGENESIS; NONHUMAN; OSSIFICATION; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; PERIODONTIUM; RAT; TISSUE REGENERATION; UPREGULATION;

ANIMALS; BONE AND BONES; CATTLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; MALE; MICROSPHERES; ORGAN SIZE; OSTEOGENESIS; PERIODONTIUM; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; X-RAY MICROTOMOGRAPHY;

EID: 84874866661     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2012.751985     Document Type: Article

References (45)

1. Williams, R.C. (1990). Periodontal disease. N. Engl. J. Med. 322(6): 373-382. (Pubitemid 20042743)
2. Polimeni, G., Xiropaidis, A.V., and Wikesjo, U.M. (2006). Biology and principles of periodontal wound healing/regeneration. Periodontol. 2000. 41:30-47. (Pubitemid 43941203)
3. Takahashi, Y., Yamamoto, M., Yamada, K., Kawakami, O., and Tabata, Y. (2007). Skull bone regeneration in nonhuman primates by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel. Tissue Eng. 13(2):293-300.
4. Tatakis, D.N., Wikesjo, U.M., Razi, S.S., Sigurdsson, T.J., Lee, M.B., Nguyen, T., Ongpipattanakul, B., and Hardwick, R. (2000). Periodontal repair in dogs: Effect of transforming growth factor-beta 1 on alveolar bone and cementum regeneration. J. Clin. Periodontol. 27 (9):698-704.
5. Jin, Q., Anusaksathien, O., Webb, S.A., Printz, M.A., and Giannobile, W.V. (2004). Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors. Mol. Ther. 9(4):519-526. (Pubitemid 38578802)
6. Chen, F.M., Zhao, Y.M., Wu, H., Deng, Z.H., Wang, Q.T., Zhou, W., Liu, Q., Dong, G.Y., Li, K., Wu, Z.F., and Jin, Y. (2006). Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran-co-gelatin microspheres. J. Control Release. 114(2):209-222. (Pubitemid 44291841)
7. Stein, D., Lee, Y., Schmid,M.J., Killpack, B., Genrich, M.A., Narayana,N., Marx, D.B., Cullen, D.M., and Reinhardt, R.A. (2005). Local simvastatin effects on mandibular bone growth and inflammation. J. Periodontol. 76(11): 1861-1870. (Pubitemid 41748975)
8. Chen, F.M., Zhang, M., and Wu, Z.F. (2010). Toward delivery ofmultiple growth factors in tissue engineering. Biomaterials. 31(24):6279-6308.
9. Taba, M., Jr., Jin, Q., Sugai, J.V., and Giannobile, W.V. (2005). Current concepts in periodontal bioengineering. Orthod. Craniofac. Res. 8(4):292-302.
10. Lynch, S.E., de Castilla, G.R., Williams, R.C., Kiritsy, C.P., Howell, T.H., Reddy, M.S., and Antoniades, H.N. (1991). The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing. J. Periodontol. 62(7): 458-467.
11. Howell, T.H., Fiorellini, J.P., Paquette, D.W., Offenbacher, S., Giannobile, W.V., and Lynch, S.E. (1997). A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. J. Periodontol. 68(12): 1186-1193. (Pubitemid 28041649)
12. Chen, F.M., Chen, R., Wang, X.J., Sun, H.H., and Wu, Z.F. (2009). In vitro cellular responses to scaffolds containing two microencapulated growth factors. Biomaterials. 30(28):5215-5224.
13. Yeh, L.C., Adamo, M.L., Olson, M.S., and Lee, J.C. (1997). Osteogenic protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell differentiation and proliferation. Endocrinology. 138 (10): 4181-4190. (Pubitemid 27408459)
14. Yeh, L.C., Zavala, M.C., and Lee, J.C. (2002). Osteogenic protein-1 and interleukin-6 with its soluble receptor synergistically stimulate rat osteoblastic cell differentiation. J. Cell Physiol. 190(3):322-331. (Pubitemid 34111973)
15. Marden, L.J., Fan, R.S., Pierce, G.F., Reddi, A.H., and Hollinger, J.O. (1993). Platelet-derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects. J. Clin. Invest. 92(6):2897-2905. (Pubitemid 24006560)
16. Vonau, R.L., Bostrom, M.P., Aspenberg, P., and Sams, A.E. (2001). Combination of growth factors inhibits bone ingrowth in the bone harvest chamber. Clin. Orthop. Relat. Res. 386:243-251. (Pubitemid 32391301)
17. Ripamonti, U., Crooks, J., Petit, J.C., and Rueger, D.C. (2001). Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein-1 and bone morphogenetic protein-2. A pilot study in Chacma baboons (Papio ursinus). Eur. J. Oral. Sci. 109(4):241-248. (Pubitemid 33774026)
18. Raiche, A.T., and Puleo, D.A. (2004). In vitro effects of combined and sequential delivery of two bone growth factors. Biomaterials. 25(4): 677-685. (Pubitemid 37357281)
19. Ostman, A., and Heldin, C.H. (2001). Involvement of platelet-derived growth factor in disease: Development of specific antagonists. Adv. Cancer Res. 80:1-38. (Pubitemid 33717320)
20. Fiedler, J., Etzel, N., and Brenner, R.E. (2004). To go or not to go: Migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF. J. Cell Biochem. 93(5):990-998. (Pubitemid 44264152)
21. Oates, T.W., Rouse, C.A., and Cochran, D.L. (1993). Mitogenic effects of growth factors on human periodontal ligament cells in vitro. J. Periodontol. 64(2):142-148.
22. Haase, H.R., Clarkson, R.W., Waters, M.J., and Bartold, P.M. (1998). Growth factor modulation of mitogenic responses and proteoglycan synthesis by human periodontal fibroblasts. J. Cell Physiol. 174 (3):353-361. (Pubitemid 28068712)
23. Chang, P.C., Cirelli, J.A., Jin, Q., Seol, Y.J., Sugai, J.V., D'Silva, N.J., Danciu, T.E., Chandler, L.A., Sosnowski, B.A., and Giannobile, W.V. (2009). Adenovirus encoding human platelet-derived growth factor-B delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use. Hum. Gene. Ther. 20(5):486-496.
24. Nevins, M., Giannobile, W.V., McGuire, M.K., Kao, R.T., Mellonig, J.T., Hinrichs, J.E., McAllister, B.S., Murphy, K.S., McClain, P.K., Nevins, M.L., Paquette, D.W., Han, T.J., Reddy, M. S., Lavin, P.T., Genco, R.J., and Lynch, S.E. (2005). Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: Results of a large multicenter randomized controlled trial. J. Periodontol. 76(12):2205-2215. (Pubitemid 43116085)
25. Mundy, G., Garrett, R., Harris, S., Chan, J., Chen, D., Rossini, G., Boyce, B., Zhao, M., and Gutierrez, G. (1999). Stimulation of bone formation in vitro and in rodents by statins. Science. 286(5446): 1946-1949. (Pubitemid 129515901)
26. Yoshikawa, M., Nakamura, K., Nagase, S., Sakuragi, S., Kusano, K.F., Matsubara, H., and Ohe, T. (2009). Effects of combined treatment with angiotensin II type 1 receptor blocker and statin on stent restenosis. J. Cardiovasc. Pharmacol. 53(2):179-186.
27. Chen, P.Y., Sun, J.S., Tsuang, Y.H., Chen, M.H., Weng, P.W., and Lin, F.H. (2010). Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway. Nutr. Res. 30(3):191-199.
28. Pradeep, A.R., and Thorat, M.S. (2010). Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: A randomized clinical trial. J. Periodontol. 81(2): 214-222.
29. Chang, P.C., Chung, M.C., Lei, C., Chong, L.Y., and Wang, C.H. (2012). Biocompatibility of PDGF-simvastatin double-walled PLGA (PDLLA) microspheres for dentoalveolar regeneration: A preliminary study. J. Biomed. Mater. Res. A. 100(11):2970-2978.
30. Nie, H., Dong, Z., Arifin, D.Y., Hu, Y., and Wang, C.H. (2010). Core/ shell microspheres via coaxial electrohydrodynamic atomization for sequential and parallel release of drugs. J. Biomed. Mater. Res. A. 95 (3):709-716.
31. Naraharisetti, P.K., Guan Lee, H.C., Fu, Y.C., Lee, D.J., and Wang, C.H. (2006). In vitro and in vivo release of gentamicin from biodegradable discs. J. Biomed. Mater. Res. B Appl. Biomater. 77(2):329-337. (Pubitemid 43667456)
32. Chang, P.C., Chung, M.C., Wang, Y.P., Chien, L.Y., Lim, J.C., Liang, K., Chong, L.Y., Kuo, Y.P., Chen, C.H., and Chiang, H.C. (2011). Patterns of diabetic periodontal wound repair: A study using micro-computed tomography and immunohistochemistry. J. Periodontol. 83(5):644-652.
33. Clarke, B. (2008). Normal bone anatomy and physiology. Clin. J. Am. Soc. Nephrol. 3(Suppl. 3):S131-S139.
34. Burghardt, A.J., Kazakia, G.J., and Majumdar, S. (2007). A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Ann. Biomed. Eng. 35(10):1678-1686. (Pubitemid 47444139)
35. Biondi, M., Ungaro, F., Quaglia, F., and Netti, P.A. (2008). Controlled drug delivery in tissue engineering. Adv. Drug Deliv. Rev. 60 (2):229-242. (Pubitemid 350236401)
36. Miller, R.A., Brady, J.M., and Cutright, D.E. (1977). Degradation rates of oral resorbable implants (polylactates and polyglycolates): Rate modification with changes in PLA/PGA copolymer ratios. J. Biomed. Mater. Res. 11(5):711-719. (Pubitemid 8159588)
37. Gurtner, G.C., Werner, S., Barrandon, Y., and Longaker, M.T. (2008). Wound repair and regeneration. Nature. 453(7193):314-321. (Pubitemid 351693137)
38. Kumar, A., Salimath, B.P., Stark, G.B., and Finkenzeller, G. (2010). Platelet-derived growth factor receptor signaling is not involved in osteogenic differentiation of human mesenchymal stem cells. Tissue Eng. Part A. 16(3):983-993.
39. Giannobile, W.V., Lee, C.S., Tomala, M.P., Tejeda, K.M., and Zhu, Z. (2001). Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering. J. Periodontol. 72(6):815-823. (Pubitemid 33606564)
40. Williams, D.F. (2008). On the mechanisms of biocompatibility. Biomaterials. 29(20):2941-2953.
41. Anusaksathien, O., Jin, Q., Zhao, M., Somerman, M.J., and Giannobile, W.V. (2004). Effect of sustained gene delivery of platelet-derived growth factor or its antagonist (PDGF-1308) on tissue-engineered cementum. J. Periodontol. 75(3):429-440. (Pubitemid 38461126)
42. Tokunaga, A., Oya, T., Ishii, Y., Motomura, H., Nakamura, C., Ishizawa, S., Fujimori, T., Nabeshima, Y., Umezawa, A., Kanamori, M., Kimura, T., and Sasahara, M. (2008). PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J. Bone Miner. Res. 23(9):1519- 1528.
43. Sun, H.H., Qu, T.J., Zhang, X.H., Yu, Q., and Chen, F.M. (2012). Designing biomaterials for in situ periodontal tissue regeneration. Biotechnol. Prog. 28(1):3-20.
44. Chen, F.M., An, Y., Zhang, R., and Zhang, M. (2011). New insights into and novel applications of release technology for periodontal reconstructive therapies. J. Control. Release. 149(2):92-110.
45. Zhang, Y., Shi, B., Li, C., Wang, Y., Chen, Y., Zhang, W., Luo, T., and Cheng, X. (2009). The synergetic bone-forming effects of combinations of growth factors expressed by adenovirus vectors on chitosan/collagen scaffolds. J. Control Release. 136(3):172-178.