PDGF receptor β is a potent regulator of mesenchymal stromal cell function

Journal of Bone and Mineral Research

Volumn 23, Issue 9, 2008, Pages 1519-1528

  Tokunaga, Ayano ^a   Oya, Takeshi ^a   Ishii, Yoko ^a   Motomura, Hiraku ^a   Nakamura, Chieko ^a   Ishizawa, Shin ^a   Fujimori, Toshihiko ^b   Nabeshima, Yo Ichi ^b   Umezawa, Akihiro ^c   Kanamori, Masahiko ^a   Kimura, Tomoatsu ^a   Sasahara, Masakiyo ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

Bone marrow; Cre loxP; Osteogenesis; Platelet derived growth factor receptor; Stromal cell

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; MESSENGER RNA; OSTEOCALCIN; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR C; PLATELET DERIVED GROWTH FACTOR D; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE REMODELING; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FRACTURE; GENE DELETION; MESENCHYME; MITOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STROMA CELL;

ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; FRACTURES, BONE; GENE DELETION; GENE EXPRESSION REGULATION; MESODERM; MICE; OSTEOCALCIN; OSTEOGENESIS; PLATELET-DERIVED GROWTH FACTOR; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STROMAL CELLS; TRANSCRIPTION FACTORS; WOUND HEALING;

EID: 50249133086     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.080409     Document Type: Article

References (35)

1. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR 1999 Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147.
2. Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, Muul L, Hofmann T 2002 Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth children with osteogenesis imperfecta: Implications for cell therapy of bone. Proc Natl Acad Sci USA 99:8932-8937.
3. Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, Lavroukov A, Kon E, Marcacci M 2001 Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 344:385-386.
4. Kawate K, Yajima H, Ohgushi H, Kotobuki N, Sugimoto K, Ohmura T, Kobata Y, Shigematsu K, Kawamura K, Tamai K, Takakura Y 2006 Tissue-engineered approach for the treatment of steroid-induced osteonecrosis of the femoral head: Transplantation of autologous mesenchymal stem cells cultured with beta-tricalcium phosphate ceramics and free vascularized fibula. Artif Organs 30:960-962.
5. Fiedler J, Roderer G, Gunther KP, Brenner RE 2002 BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells. J Cell Biochem 87:305-312.
6. Ryoo HM, Lee MH, Kim YJ 2006 Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells. Gene 366:51-57.
7. Minguell JJ, Erices A, Conget P 2001 Mesenchymal stem cells. Exp Biol Med 226:507-520.
8. Heldin CH, Westermark B 1999 Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79:1283-1316.
9. Kratchmarova I, Blagoev B, Haack-Sorensen M, Kassem M, Mann M 2005 Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science 308:1472-1477.
10. Fierro F, Illmer T, Jing D, Schleyer E, Ehninger G, Boxberger S, Bornhauser M 2007 Inhibition of platelet-derived growth factor receptorbeta by imatinib mesylate suppresses proliferation and alters differentiation of human mesenchymal stem cells in vitro. Cell Prolif 40:355-366.
11. Tamama K, Fan VH, Griffith LG, Blair HC, Wells A 2006 Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. Stem Cells 24:686-695.
12. Fujii H, Kitazawa R, Maeda S, Mizuno K, Kitazawa S 1999 Expression of platelet-derived growth factor proteins and their receptor alpha and beta mRNAs during fracture healing in the normal mouse. Histochem Cell Biol 112:131-138.
13. Rasubala L, Yoshikawa H, Nagata K, Iijima T, Ohishi M 2003 Platelet-derived growth factor and bone morphogenetic protein in the healing of mandibular fractures in rats. Br J Oral Maxillofac Surg 41:173-178.
14. Yu X, Hsieh SC, Bao W, Graves DT 1997 Temporal expression of PDGF receptors and PDGF regulatory effects on osteoblastic cells in mineralizing cultures. Am J Physiol 272:C1709-C1716.
15. Kono SJ, Oshima Y, Hoshi K, Bonewald LF, Oda H, Nakamura K, Kawaguchi H, Tanaka S 2007 Erk pathways negatively regulate matrix mineralization. Bone 40:68-74.
16. Chaudhary LR, Hofmeister AM, Hruska KA 2004 Differential growth factor control of bone formation through osteoprogenitor differentiation. Bone 34:402-411.
17. O'Sullivan S, Naot D, Callon K, Porteous F, Horne A, Wattie D, Watson M, Cornish J, Browett P, Grey A 2007 Imatinib Promotes Osteoblast Differentiation by Inhibiting PDGFR Signaling and Inhibits Osteoclastogenesis by Both Direct and Stromal Cell-Dependent Mechanisms. J Bone Miner Res 22:1679-1689.
18. Mitlak BH, Finkelman RD, Hill EL, Li J, Martin B, Smith T, D'Andrea M, Antoniades HN, Lynch SE 1996 The effect of systemically administered PDGF-BB on the rodent skeleton. J Bone Miner Res 11:238-247.
19. Nash TJ, Howlett CR, Martin C, Steele J, Johnson KA, Hicklin DJ 1994 Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 15:203-208.
20. Vikjaer D, Blom S, Hjørting-Hansen E, Pinholt EM 1997 Effect of platelet-derived growth factor-BB on bone formation in calvarial defects: An experimental study in rabbits. Eur J Oral Sci 105:59-66.
21. Ranly DM, McMillan J, Keller T, Lohmann CH, Meunch T, Cochran DL, Schwartz Z, Boyan BD 2005 Platelet-derived growth factor inhibits demineralized bone matrix-induced intramuscular cartilage and bone formation. A study of immunocompromised mice. J Bone Joint Surg Am 87:2052-2064.
22. Gilbertson DG, Duff ME, West JW, Kelly JD, Sheppard PO, Hofstrand PD, Gao Z, Shoemaker K, Bukowski TR, Moore M, Feldhaus AL, Humes JM, Palmer TE, Hart CE 2001 Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. J Biol Chem 276:27406-27414.
23. Tallquist M, Kazlauskas A 2004 PDGF signaling in cells and mice. Cytokine Growth Factor Rev 15:205-213.
24. Gao Z, Sasaoka T, Fujimori T, Oya T, Ishii Y, Sabit H, Kawaguchi M, Kurotaki Y, Naito M, Wada T, Ishizawa S, Kobayashi M, Nabeshima Y, Sasahara M 2005 Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing. J Biol Chem 280:9375-9389.
25. Fiedler J, Etzel N, Brenner RE 2004 To go or not to go: Migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF. J Cell Biochem 93:990-998.
26. Ishii Y, Oya T, Zheng L, Gao Z, Kawaguchi M, Sabit H, Matsushima T, Tokunaga A, Ishizawa S, Hori E, Nabeshima Y, Sasaoka T, Fujimori T, Mori H, Sasahara M 2006 Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury. J Neurochem 98:588-600.
27. Hayashi S, McMahon AP 2002 Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: A tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 244:305-318.
28. Watanabe H, Shionyu M, Kimura T, Kimata K, Watanabe H 2007 Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation. J Biol Chem 282:20728-20738.
29. Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU 1998 In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 238:265-272.
30. Kang YJ, Jeon ES, Song HY, Woo JS, Jung JS, Kim YK, Kim JH 2005 Role of c-Jun N-terminal kinase in the PDGF-induced proliferation and migration of human adipose tissue-derived mesenchymal stem cells. J Cell Biochem 95:1135-1145.
31. Mehrotra M, Krane SM, Walters K, Pilbeam C 2004 Differential regulation of platelet-derived growth factor stimulated migration and proliferation in osteoblastic cells. J Cell Biochem 93:741-752.
32. Jikko A, Harris SE, Chen D, Mendrick DL, Damsky CH 1999 Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2. J Bone Miner Res 14:1075-1083.
33. Heldin CH, Miyazono K, ten Dijke P 1997 TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390:465-471.
34. Kretzschmar M, Doody J, Massague J 1997 Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smadl. Nature 389:618-622.
35. Takahashi T, Abe H, Arai H, Matsubara T, Nagai K, Matsuura M, Iehara N, Yokode M, Nishikawa S, Kita T, Dot T 2005 Activation of STAT3/Smadl is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis. J Biol Chem 280:7100-7106.