Chemopreventive effects of 4-methylthio-3-butenyl isothiocyanate (raphasatin) but not curcumin against pancreatic carcinogenesis in hamsters

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 9, 2013, Pages 2103-2108

  Okamura, Toshiya ^a   Umemura, Takashi ^a   Inoue, Tomoki ^a   Tasaki, Masako ^a   Ishii, Yuji ^a   Nakamura, Yasushi ^b   Park, Eun Young ^b   Sato, Kenji ^b   Matsuo, Tomoaki ^c   Okamoto, Shigehisa ^c   Nishikawa, Akiyoshi ^a   Ogawa, Kumiko ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

chemoprevention; daikon; isothiocyanate; pancreatic cancer

Indexed keywords

CHEMOPREVENTION; CHEMOPREVENTIVE EFFECTS; DAIKON; ISOTHIOCYANATES; MODIFYING EFFECTS; NATURALLY OCCURRING; PANCREATIC CANCERS; PANCREATIC LESIONS;

PATHOLOGY;

NUTRITION;

4 (METHYLTHIO) 3 BUTENYL ISOTHIOCYANATE; 4-(METHYLTHIO)-3-BUTENYL ISOTHIOCYANATE; ANTINEOPLASTIC AGENT; BIS(2 OXOPROPYL)NITROSAMINE; CARCINOGEN; CURCUMIN; ISOTHIOCYANIC ACID DERIVATIVE; NITROSAMINE; NITROSOBIS(2-OXOPROPYL)AMINE;

ADENOCARCINOMA; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DIET; HAMSTER; HYPERPLASIA; MALE; MESOCRICETUS; PANCREAS; PANCREAS TUMOR; PATHOLOGY;

ADENOCARCINOMA; ANIMALS; ANTICARCINOGENIC AGENTS; CARCINOGENS; CRICETINAE; CURCUMIN; DIET; HYPERPLASIA; ISOTHIOCYANATES; MALE; MESOCRICETUS; NITROSAMINES; PANCREAS; PANCREATIC NEOPLASMS;

EID: 84874860911     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf3003174     Document Type: Article

References (24)

1. Saif, M. W. Pancreatic neoplasm in 2011: an update J. Pancreas 2011, 12, 316-321
2. Chua, T. C.; Saxena, A. Preoperative chemoradiation followed by surgical resection for resectable pancreatic cancer: A review of current results Surg. Oncol. 2011, 20, e161-e168
3. Yamamoto, M.; Ohashi, O.; Saitoh, Y. Japan pancreatic cancer registry: current status Pancreas 1998, 16, 238-242
4. Broese, M.; Hoy, L.; Jaehne, J. Surgical therapy of exocrine pancreatic carcinoma -results at an academic teaching hospital and evaluation of prognostic factors Hepatogastroenterology 2011, 58, 593-598
5. Nishikawa, A.; Furukawa, F.; Lee, I. S.; Tanaka, T.; Hirose, M. Potent chemopreventive agents against pancreatic cancer Curr. Cancer Drug Targets 2004, 4, 373-384
6. Nakamura, Y.; Nakamura, K.; Asai, Y.; Wada, T.; Tanaka, K.; Matsuo, T.; Okamoto, S.; Meijer, J.; Kitamura, Y.; Nishikawa, A.; Park, E. Y.; Sato, K.; Ohtsuki, K. Comparison of the glucosinolate-myrosinase systems among daikon (Raphanus sativus, Japanese white radish) varieties J. Agric. Food Chem. 2008, 56, 2702-2707
7. Nakamura, Y.; Iwahashi, T.; Tanaka, A.; Koutani, J.; Matsuo, T.; Okamoto, S.; Sato, K.; Ohtsuki, K. 4-(Methylthio)-3-butenyl isothiocyanate, a principal antimutagen in daikon (Raphanus sativus; Japanese white radish) J. Agric. Food Chem. 2001, 49, 5755-5760
8. Shehzad, A.; Wahid, F.; Lee, Y. S. Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials Arch. Pharm. (Weinheim) 2010, 343, 489-499
9. Aggarwal, B. B.; Kumar, A.; Bharti, A. C. Anticancer potential of curcumin: preclinical and clinical studies Anticancer Res. 2003, 23, 363-398
10. Pour, P.; Althoff, J.; Krüger, F. W.; Mohr, U. A potent pancreatic carcinogen in Syrian hamsters: N -nitrosobis(2-oxopropyl)amine J. Natl. Cancer Inst. 1977, 58, 1449-1453
11. Nishikawa, A.; Furukawa, F.; Uneyama, C.; Ikezaki, S.; Tanakamaru, Z.; Chung, F. L.; Takahashi, M.; Hayashi, Y. Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in N -nitrosobis(2- oxopropyl)amine-treated hamsters Carcinogenesis 1996, 17, 1381-1384
12. Son, H. Y.; Nishikawa, A.; Furukawa, F.; Lee, I. S.; Ikeda, T.; Miyauchi, M.; Nakamura, H.; Hirose, M. Modifying effects of 4-phenylbutyl isothiocyanate on N -nitrosobis(2-oxopropyl)amine-induced tumorigenesis in hamsters Cancer Lett. 2000, 160, 141-147
13. Hecht, S. S.; Trushin, N.; Rigotty, J.; Carmella, S. G.; Borukhova, A.; Akerkar, S.; Rivenson, A. Complete inhibition of 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone-induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate Cancer Epidemiol. Biomarkers Prev. 1996, 5, 645-652
14. Ben Salah-Abbès, J.; Abbès, S.; Ouanes, Z.; Abdel-Wahhab, M. A.; Bacha, H.; Oueslati, R. Isothiocyanate from the Tunisian radish (Raphanus sativus) prevents genotoxicity of zearalenone in vivo and in vitro Mutat. Res. 2009, 677, 59-65
15. Tokiwa, H.; Hasegawa, T.; Yamada, K.; Shigemori, H.; Hasegawa, K. A major factor in gravitropism in radish hypocotyls is the suppression of growth on the upper side of hypocotyls J. Plant Physiol. 2006, 163, 1267-1272
16. Yamasaki, M.; Omi, Y.; Fujii, N.; Ozaki, A.; Nakama, A.; Sakakibara, Y.; Suiko, M.; Nishiyama, K. Mustard oil in "Shibori Daikon" a variety of Japanese radish, selectively inhibits the proliferation of H-ras-transformed 3Y1 cells Biosci., Biotechnol., Biochem. 2009, 73, 2217-2221
17. Salah-Abbès, J. B.; Abbès, S.; Abdel-Wahhab, M. A.; Oueslati, R. In-vitro free radical scavenging, antiproliferative and anti-zearalenone cytotoxic effects of 4-(methylthio)-3-butenyl isothiocyanate from Tunisian Raphanus sativus J. Pharm. Pharmacol. 2010, 62, 231-239
18. Papi, A.; Orlandi, M.; Bartolini, G.; Barillari, J.; Iori, R.; Paolini, M.; Ferroni, F.; Grazia, F. M.; Pedulli, G. F.; Valgimigli, L. Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts J. Agric. Food Chem. 2008, 56, 875-883
19. Barillari, J.; Iori, R.; Papi, A.; Orlandi, M.; Bartolini, G.; Gabbanini, S.; Pedulli, G. F.; Valgimigli, L. Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent J. Agric. Food Chem. 2008, 56, 7823-7830
20. Scholl, C.; Eshelman, B. D.; Barnes, D. M.; Hanlon, P. R. Raphasatin is a more potent inducer of the detoxification enzymes than its degradation products J. Food Sci. 2011, 76, C504-511
21. Nakamura, Y.; Matsuo, T.; Okamoto, S.; Nishikawa, A.; Imai, T.; Park, E. Y.; Sato, K. Antimutagenic and anticarcinogenic properties of Kyo-yasai, heirloom vegetables in Kyoto Genes Environ. 2008, 30, 41-47
22. Beevi, S. S.; Mangamoori, L. N.; Dhand, V.; Ramakrishna, D. S. Isothiocyanate profile and selective antibacterial activity of root, stem, and leaf extracts derived from Raphanus sativus L Foodborne Pathog. Dis. 2009, 6, 129-136
23. Abdull Razis, A. F.; De Nicola, G. R.; Pagnotta, E.; Iori, R.; Ioannides, C. 4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent Arch. Toxicol. 2012, 86, 183-194
24. Furukawa, F.; Nishikawa, A.; Lee, I. S.; Kanki, K.; Umemura, T.; Okazaki, K.; Kawamori, T.; Wakabayashi, K.; Hirose, M. A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N -nitrosobis(2-oxopropyl)amine- induced pancreatic carcinogenesis in hamsters Int. J. Cancer 2003, 104, 269-273