Modifying effects of 4-phenylbutyl isothiocyanate on N-nitrosobis(2-oxopropyl)amine-induced tumorigenesis in hamsters

Cancer Letters

Volumn 160, Issue 2, 2000, Pages 141-147

  Son, Hwa Young ^a   Nishikawa, Akiyoshi ^a   Furukawa, Fumio ^a   Lee, In Seon ^b   Ikeda, Takako ^c   Miyauchi, Makoto ^a   Nakamura, Hideaki ^a   Hirose, Masao ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Keimyung University   (South Korea)

^c SHOWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

4 Phenylbutyl isothiocyanate; Carcinogene sis; Hamster; N nitrosobis(2 oxopropyl)amine

Indexed keywords

3 PHENYLPROPYL ISOTHIOCYANATE; 4 PHENYLBUTYL ISOTHIOCYANATE; ANTINEOPLASTIC AGENT; BIS(2 OXOPROPYL)NITROSAMINE; CORN OIL; ISOTHIOCYANIC ACID DERIVATIVE; PHENETHYL ISOTHIOCYANATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT CARCINOMA; CANCER INHIBITION; CANCER PREVENTION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG STRUCTURE; FEMALE; HISTOPATHOLOGY; LIVER CELL CARCINOMA; LUNG ADENOCARCINOMA; LUNG ADENOMA; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SYRIAN HAMSTER;

ADENOCARCINOMA; ANIMAL; ANTICARCINOGENIC AGENTS; BODY WEIGHT; CARCINOGENS; CARCINOMA, PANCREATIC DUCTAL; COMPARATIVE STUDY; DRUG INTERACTIONS; FEMALE; HAMSTERS; ISOTHIOCYANATES; KIDNEY NEOPLASMS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LUNG NEOPLASMS; MESOCRICETUS; NEOPLASMS, EXPERIMENTAL; NITROSAMINES; ORGAN WEIGHT; PANCREATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS; ZEA MAYS;

EID: 0034727785     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00570-X     Document Type: Article

References (28)

1. Glucosinolates
2. Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates
3. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice
4. Structure-activity relationships of isothiocyanates as mechanism-based inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice
5. Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in N-nitrosobis(2-oxopropyl)amine-treated hamsters
6. Dose-related inhibition by dietary phenethyl isothiocyanate of esophageal tumorigenesis and DNA methylation induced by N-nitrosomethylbenzylamine in rats
7. Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate
8. Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds
9. Effect of alkyl chain length on inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis and DNA methylation by isothiocyanates
10. A potent pancreatic carcinogen in Syrian hamsters; N-nitrosobis(2-oxopropyl)amine
11. Model studies in tobacco carcinogenesis with the Syrian golden hamster
12. Chemopreventive effects of 3-phenylpropyl isothiocyanate on hamster lung tumorigenesis initiated with N-nitrosobis(2-oxopropyl)amine
13. Effects of various prostaglandin synthesis inhibitors on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine
14. Metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone as measured by DNA alkylation in vitro and its inhibition by isothiocyanates
15. Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in mouse by dietary phenethyl isothiocyanate
16. Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechanisms
17. Induction of rat pancreatic glutathione S-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts
18. A comparison of the individual and collective effects of four glucosinolate breakdown products from Brussels sprouts on induction of detoxification enzymes
19. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity
20. Enhancement of esophageal carcinogenesis in male F344 rats by dietary phenylhexyl isothiocyanate
21. Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate
22. Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer
23. Mechanism of enhancement of esophageal tumorigenesis by 6-phenylhexyl isothiocyanate
24. Mechanistic insights into chemopreventive effects of phenethyl isothiocyanate in N-nitrosobis(2-oxopropyl)amine-treated hamsters
25. Carcinogenesis bioassay of allyl isothiocyanate
26. Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats
27. Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8-10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model
28. Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initiation phase