Single-nucleotide polymorphisms in the Toll-like receptor pathway increase susceptibility to infections in severely injured trauma patients

Journal of Trauma and Acute Care Surgery

Volumn 74, Issue 3, 2013, Pages 862-870

  Bronkhorst, Maarten W G A ^a   Boyé, Nicole D A ^a   Lomax, Miranda A Z ^a   Vossen, Rolf H A M ^b   Bakker, Jan ^a   Patka, Peter ^a   Van Lieshout, Esther M M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CD14; Infection; Single nucleotide polymorphism (SNP); Toll like receptor (TLR); Trauma

Indexed keywords

CD14 ANTIGEN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

ADULT; AGED; ALLELE; ARTICLE; BLOOD ANALYSIS; COHORT ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENOTYPE; GRAM NEGATIVE INFECTION; GRAM POSITIVE INFECTION; HUMAN; INFECTION RISK; INFECTION SENSITIVITY; INJURY; INJURY SCALE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NUCLEOTIDE SEQUENCE; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SEPTIC SHOCK; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SPUTUM ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; URINALYSIS; WOUND;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD14; DNA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IMMUNITY, INNATE; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; SEPSIS; TOLL-LIKE RECEPTORS; WOUND INFECTION; WOUNDS, PENETRATING; YOUNG ADULT;

EID: 84874859584     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31827e1534     Document Type: Article

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