Functional significance of CD14 promoter polymorphisms and their clinical relevance in a Chinese Han population

Critical Care Medicine

Volumn 36, Issue 8, 2008, Pages 2274-2280

  Gu, Wei ^a   Dong, Hong ^a   Jiang, Dong Po ^a   Zhou, Jian ^a   Du, Ding Yuan ^b   Gao, Jin Mou ^b   Yao, Yuan Zhang ^a   Zhang, Lian Yang ^a   Wen, Ai Qing ^a   Liu, Qing ^a   Wang, Zheng Guo ^a   Jiang, Jian Xin ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHONGQING EMERGENCY MEDICAL CENTER   (China)

Author keywords

CD14; Functional study; Gene polymorphisms; Multiple organ dysfunction; Sepsis; Trauma

Indexed keywords

BIOLOGICAL MARKER; CD14 ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; DNA;

ADULT; AGED; ARTICLE; BIOINFORMATICS; CHINESE; CLINICAL FEATURE; CONTROLLED STUDY; DONOR; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; LABORATORY; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; POPULATION; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SEPSIS; SINGLE NUCLEOTIDE POLYMORPHISM; UNIVERSITY HOSPITAL; ADOLESCENT; BIOLOGY; BLOOD; CHINA; CLINICAL TRIAL; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; INJURY; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; ANTIGENS, CD14; CHINA; COMPUTATIONAL BIOLOGY; DNA; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; WOUNDS AND INJURIES;

EID: 49949086033     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318180b1ed     Document Type: Article

References (65)

1. Triantafilou M, Traintafilou K: Lipopolysac-charide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol 2002; 23:301-304
2. Jiang JX, Zhu PF, Wang ZG: Receptor-signal transduction - Mechanisms of endotoxin actions. Crit Care Shock 2000; 3:35-48
3. Dziarski R, Gupta D: Peptidoglycan recognition in innate immunity. J Endotoxin Res 2005; 11:304-310
4. Triantafilou M, Triantafilou K: The dynamics of LPS recognition: Complex orchestration of multiple receptors. J Endotoxin Res 2005; 11:5-11
5. Ulevitch RJ: Toll gates for pathogen selection. Nature 1999; 401:755-756
6. Henneke P, Golenbock DT: Innate immune recognition of lipopolysaccharide by endothelial cells. Crit Care Med 2002; 30 (Suppl): S207-S213
7. Jiang JX, Chen YH, Xie GQ, et al: Intra-pulmonary expression of scavenger receptor and CD14 and their relationship with local inflammatory responses in endotoxemia in mice. World J Surg 2003; 27:1-9
8. Sladek Z, Rysanek D: The role of CD14 during resolution of experimentally induced Staphylococcus aureus and Streptococcus uberis mastitis. Comp Immunol Microbiol Infect Dis 2006; 29:243-262
9. Reinhart K, Gluck T, Ligtenberg J, et al: CD14 receptor occupancy in severe sepsis: Results of a phase I clinical trial with a re-combinant chimeric CD14 monoclonal antibody (IC14). Crit Care Med 2004; 32: 1100-1108
10. Burgmann H, Winkler S, Locker GJ, et al: Increased serum concentration of soluble CD14 is a prognostic marker in grampositive sepsis. Clin Immunol Immunopathol 1996; 80:307-310
11. Haziot A, Ferrero E, Kontgen F, et al: Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 1996; 4:407-414
12. Arcaroli J, Fessler MB, Abraham E: Genetic polymorphisms and sepsis. Shock 2005; 24: 300-312
13. Lin MT, Albertson TE: Genomic polymorphisms in sepsis. Crit Care Med 2004; 32: 569-579
14. Sadee W, Dai Z: Pharmacogenetics/genomics and personalized medicine. Hum Mol Genet 2005; 15:R207-R214
15. Mehta NM, Arnold JH: Genetic polymorphisms in acute respiratory distress syndrome: New approach to an old problem. Crit Care Med 2005; 33:2443-2445
16. Baldini M, Lohman IC, Halonen M, et al: A polymorphism in the 5′flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999; 20:976-983
17. Hubacek JA, Rothe G, Pit'ha J, et al: C( - 260)→T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction. Circulation 1999; 99:3218-3220
18. Gibot S, Cariou A, Drouet L, et al: Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate. Crit Care Med 2002; 30:969-973
19. Sutherland AM, Walley KR, Russell JA: Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med 2005; 33: 638-644
20. Koenig W, Khuseyinova N, Hoffmann MM, et al: CD14 C( - 260)→T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease. J Am Coll Cardiol 2002; 40:34-42
21. Hohda S, Kimura A, Sasaoka T, et al: Association study of CD14 polymorphism with myocardial infarction in a Japanese population. Jpn Heart J 2003; 44:613-622
22. Leung TF, Tang NL, Sung YM, et al: The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children. Pediatr Allergy Immunol 2003; 14:255-260
23. Leynaert B, Guilloud-Bataille M, Soussan D, et al: Association between farm exposure and atopy, according to the CD14 C-159T polymorphism. J Allergy Clin Immunol 2006; 118:658-665
24. Leung TF, Tang NL, Wong GW, et al: CD14 and toll-like receptors: Potential contribution of genetic factors and mechanisms to inflammation and allergy. Curr Drug Targets Inflamm Allergy 2005; 4:169-175
25. Obana N, Takahashi S, Kinouchi Y, et al: Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccharide receptor gene, CD14. Scand J Gastroenterol 2002; 37:699-704
26. Klein W, Tromm A, Griga T, et al: A poly- morphism in the CD14 gene is associated with Crohn disease. Scand J Gastroenterol 2002; 37:189-191
27. Klein W, Tromm A, Griga T, et al: Interaction of polymorphisms in the CARD15 and CD14 genes in patients with Crohn disease. Scand J Gastroenterol 2003; 38:834-836
28. Rahman SH, Salter G, Holmfield J, et al: Soluble CD14 receptor expression and monocyte heterogeneity but not the C-260T CD14 genotype are associated with severe acute pancreatitis. Crit Care Med 2004; 32: 2457-2463
29. Sengler C, Haider A, Sommerfeld C, et al: Evaluation of the CD14 C-159T polymorphism in the German multicenter allergy study cohort. Clin Exp Allergy 2003; 33: 166-169
30. Heinzmann A, Dietrich H, Jerkic SP, et al: Promoter polymorphisms of the CD14 gene are not associated with bronchial asthma in Caucasian children. Eur J Immunogenet 2003; 30:345-348
31. Koch W, Kastrati A, Mehilli J, et al: CD14 gene - 159C/T polymorphism is not associated with coronary artery disease and myocardial infarction. Am Heart J 2002; 143: 971-976
32. Hubacek JA, Stuber F, Frohlich D, et al: The common functional C( - 159)T polymorphism within the promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality. Genes Immun 2000; 1:405-407
33. Liang XH, Cheung W, Heng CK, et al: CD14 promoter polymorphisms have no functional significance and are not associated with atopic phenotypes. Pharmacogenet Genom 2006; 16:229-236
34. LeVan TD, Essen SV, Romberger DJ, et al: Polymorphisms in the CD14 gene associated with pulmonary function in farmers. Am J Respir Crit Care Med 2005; 171:773-779
35. Vercelli D, Baldini M, Stern D, et al: CD14: A bridge between innate immunity and adaptive IgE responses. J Endotoxin Res 2001; 7:45-48
36. Vercelli D, Baldini M, Martinez F: The monocyte/IgE connection: May polymorphisms in the CD14 gene teach us about IgE regulation? Int Arch Allergy Immunol 2001; 124: 20-24
37. Chao YC, Chu HC, Chang WK, et al: CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis. World J Gastroenterol 2005; 11:6043-6048
38. Guo QS, Xia B, Jiang Y, et al: Polymorphisms of CD14 gene and TLR4 gene are not associated with ulcerative colitis in Chinese patients. Postgrad Med J 2005; 81:526-529
39. Guo Q, Zhu J, Xia B: Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients. J Gastroenterol Hepatol 2006; 21: 92-97
40. Wang Z, Jiang J: An overview of research advances in road traffic trauma in China. Traffic Injury Prev 2003; 4:9-16
41. Wang ZG: Advances in basically scientific research on trauma. Chin J Traumatol 2005; 21:6-10
42. Heinzelmann M, Mercer-Jones M, Cheadle WG, et al: CD14 expression in injured patients correlates with outcome. Ann Surg 1996; 224:91-96
43. Kruger C, Schutt C, Obertacke U, et al: Serum CD14 levels in polytraumatized and severely burned patients. Clin Exp Immunol 1991; 85:297-301
44. Endo S, Inada K, Kasai T, et al: Soluble CD14 (sCD14) levels in patients with multiple organ failure (MOF). Res Commun Chem Pathol Pharmacol 1994; 84:17-25
45. Eisenmenger SJ, Wichmann MW, Angele P, et al: Differences in the expression of LPS-receptors are not responsible for the sex-specific immune response after trauma and hemorrhagic shock. Cell Immunol 2004; 230:17-22
46. Jiang JX, Diao YF, Tian KL, et al: Effect of hemorrhagic shock on endotoxin-induced TNF production and its molecular mechanism. Shock 1997; 7:206-210
47. Cho K, Adamson LK, Jeong J, et al: CD14-dependent alterations in c-Jun expression in the liver after burn injury. J Surg Res 2004; 122:36-42
48. Phan HH, Cho K, Sainz-Lyon KS, et al: CD14-dependent modulation of NF-kappaB alternative splicing in the lung after burn injury. Gene 2006; 371:121-129
49. The Abbreviated Injury Scale: 1998 revision (AIS-98). Association for the Advancement of Automotive Medicine, Barrington. Illinois; 1998
50. Zhang DE, Hetherington CJ, Tans S, et al: Spl is a critical factor for the monocytic specific expression of human CD14. J Biol Chem 1994; 269:11425-11434
51. Marshall JC, Cook DJ, Christou NV, et al: Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome. Crit Care Med 1995; 23:1638-1652
52. Armour JA: Tandemly repeated DNA: why should anyone care? Mutat Res 2006; 598:6-14
53. LeVan TD, Bloom JW, Bailey TJ, et al: A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol 2001; 167:5838-5844
54. Tan CY, Chen YL, Wu LS, et al: Association of CD14 promoter polymorphisms and soluble CD14 levels in mite allergen sensitization of children in Taiwan. J Hum Genet 2006; 51: 59-67
55. Yoon HJ, Shin JH, Yang SH, et al: Association of the CD14 gene - 159C polymorphism with progression of IgA nephropathy. J Med Genet 2003; 40:104-108
56. LeVan TD, Guerra S, Klimecki W, et al: The impact of CD14 polymorphisms on the development of soluble CD14 levels during infancy. Genes Immun 2006; 7:77-80
57. Karhukorpi J, Yan Y, Niemela S, et al: Effect of CD14 promoter polymorphism and H. pylori infection and its clinical outcomes on circulating CD14. Clin Exp Immun 2002; 128:326-332
58. Carrillo EH, Gordon L, Goode E, et al: Early elevation of soluble CD14 may help identify trauma patients at high risk for infection. J Trauma 2001; 50:810-816
59. Hadjigeorgiou GM, Paterakis K, Dardiotis E, et al: IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury. Neurology 2005; 65: 1077-1082
60. Majetschak M, Krehmeier U, Ostroverkh L, et al: Alterations in leukocyte function following surgical trauma: Differentiation of distinct reaction types and association with tumor necrosis factor gene polymorphisms. Clin Diagn Lab Immunol 2005; 12:296-303
61. Schroder O, Laun RA, Held B, et al: Association of interleukin-10 promoter polymorphism with the incidence of multiple organ dysfunction following major trauma: Results of a prospective pilot study. Shock 2004; 21: 306-310
62. Schroder O, Schulter KM, Ostermann P, et al: Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. Crit Care Med 2003; 31:73-79
63. Stassen NA, Leslie-Norfleet LA, Robertson AM, et al: Interferon-gamma gene polymorphisms and the development of sepsis in patients with trauma. Surgery 2002; 132: 289-292
64. Stassen NA, Breit CM, Norfleet LA, et al: IL-18 promoter polymorphisms correlate with the development of post-injury sepsis. Surgery 2003; 134:351-356
65. Heesen M, Bloemeke B, Schade U, et al: The -260 C→T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients. Intensive Care Med 2002; 28:1161-1163