메뉴 건너뛰기




Volumn 91, Issue 1, 2013, Pages 14-21

Biological embedding in mental health: An epigenomic perspective

Author keywords

Animal models; DNA methylation; Early life adversity; Epigenetics; Psychiatric disorders

Indexed keywords

ANIMAL MODEL; DNA METHYLATION; EARLY LIFE; EPIGENETICS; PSYCHIATRIC DISORDERS;

EID: 84874856388     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/bcb-2012-0070     Document Type: Review
Times cited : (31)

References (94)
  • 1
    • 0010377117 scopus 로고    scopus 로고
    • From genomics to epigenomics: A loftier view of life
    • 10.1038/70651. 10585673.
    • Beck S. Olek A. Walter J. 1999. From genomics to epigenomics: a loftier view of life. Nat. Biotechnol. 17: 1144. 10.1038/70651. 10585673.
    • (1999) Nat. Biotechnol. , vol.17 , pp. 1144
    • Beck, S.1    Olek, A.2    Walter, J.3
  • 2
    • 33646675330 scopus 로고    scopus 로고
    • Do the effects of early severe deprivation on cognition persist into early adolescence? Findings from the English and Romanian adoptees study
    • 10.1111/j.1467-8624.2006.00898.x. 16686796.
    • Beckett C. Maughan B. Rutter M. Castle J. Colvert E. Groothues C. et al. 2006. Do the effects of early severe deprivation on cognition persist into early adolescence? Findings from the English and Romanian adoptees study. Child Dev. 77: 696-711. 10.1111/j.1467-8624.2006.00898.x. 16686796.
    • (2006) Child Dev. , vol.77 , pp. 696-711
    • Beckett, C.1    Maughan, B.2    Rutter, M.3    Castle, J.4    Colvert, E.5    Groothues, C.6
  • 3
    • 0642306491 scopus 로고    scopus 로고
    • HIDden targets of microRNAs for growth control
    • 10.1016/S0968-0004(03)00175-0. 13678953.
    • Bergmann A. Lane M.E. 2003. HIDden targets of microRNAs for growth control. Trends Biochem. Sci. 28: 461-463. 10.1016/S0968-0004(03)00175-0. 13678953.
    • (2003) Trends Biochem. Sci. , vol.28 , pp. 461-463
    • Bergmann, A.1    Lane, M.E.2
  • 4
    • 84858657971 scopus 로고    scopus 로고
    • Associations with early-life socio-economic position in adult DNA methylation
    • 10.1093/ije/dyr147. 22422449.
    • Borghol N. Suderman M. McArdle W. Racine A. Hallett M. Pembrey M. et al. 2011. Associations with early-life socio-economic position in adult DNA methylation. Int. J. Epidemiol. 41: 62-74. 10.1093/ije/dyr147. 22422449.
    • (2011) Int. J. Epidemiol. , vol.41 , pp. 62-74
    • Borghol, N.1    Suderman, M.2    McArdle, W.3    Racine, A.4    Hallett, M.5    Pembrey, M.6
  • 5
    • 33846231861 scopus 로고    scopus 로고
    • Spectrum of effectiveness of valproate in neuropsychiatry
    • 10.1586/14737175.7.1.9. 17187491.
    • Bowden C.L. 2007. Spectrum of effectiveness of valproate in neuropsychiatry. Expert Rev. Neurother. 7: 9-16. 10.1586/14737175.7.1.9. 17187491.
    • (2007) Expert Rev. Neurother. , vol.7 , pp. 9-16
    • Bowden, C.L.1
  • 6
    • 28444439242 scopus 로고    scopus 로고
    • A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
    • 10.1101/gad.1364105. 16287714.
    • Bultman S.J. Gebuhr T.C. Magnuson T. 2005. A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 19: 2849-2861. 10.1101/gad.1364105. 16287714.
    • (2005) Genes Dev. , vol.19 , pp. 2849-2861
    • Bultman, S.J.1    Gebuhr, T.C.2    Magnuson, T.3
  • 7
    • 45849105557 scopus 로고    scopus 로고
    • MeCP2, a key contributor to neurological disease, activates and represses transcription
    • 10.1126/science.1153252. 18511691.
    • Chahrour M. Jung S.Y. Shaw C. Zhou X. Wong S.T. Qin J. Zoghbi H.Y. 2008. MeCP2, a key contributor to neurological disease, activates and represses transcription. Science, 320: 1224-1229. 10.1126/science.1153252. 18511691.
    • (2008) Science , vol.320 , pp. 1224-1229
    • Chahrour, M.1    Jung, S.Y.2    Shaw, C.3    Zhou, X.4    Wong, S.T.5    Qin, J.6    Zoghbi, H.Y.7
  • 8
    • 84855213297 scopus 로고    scopus 로고
    • The Neurological Ecology of Fear: Insights Neuroscientists and Ecologists Have to Offer one Another
    • 10.3389/fnbeh.2011.00021. 21629856.
    • Clinchy M. Schulkin J. Zanette L.Y. Sheriff M.J. McGowan P.O. Boonstra R. 2010. The Neurological Ecology of Fear: Insights Neuroscientists and Ecologists Have to Offer one Another. Front. Behav. Neurosci. 4: 21. 10.3389/fnbeh.2011. 00021. 21629856.
    • (2010) Front. Behav. Neurosci. , vol.4 , pp. 21
    • Clinchy, M.1    Schulkin, J.2    Zanette, L.Y.3    Sheriff, M.J.4    McGowan, P.O.5    Boonstra, R.6
  • 9
    • 84860315722 scopus 로고    scopus 로고
    • Social influences on neuroplasticity: Stress and interventions to promote well-being
    • 10.1038/nn.3093. 22534579.
    • Davidson R.J. McEwen B.S. 2012. Social influences on neuroplasticity: stress and interventions to promote well-being. Nat. Neurosci. 15: 689-695. 10.1038/nn.3093. 22534579.
    • (2012) Nat. Neurosci. , vol.15 , pp. 689-695
    • Davidson, R.J.1    McEwen, B.S.2
  • 10
    • 58849091288 scopus 로고    scopus 로고
    • Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults
    • 10.1016/j.yhbeh.2008.11.006. 19084531.
    • Entringer S. Kumsta R. Hellhammer D.H. Wadhwa P.D. Wust S. 2009. Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults. Horm. Behav. 55: 292-298. 10.1016/j.yhbeh.2008.11.006. 19084531.
    • (2009) Horm. Behav. , vol.55 , pp. 292-298
    • Entringer, S.1    Kumsta, R.2    Hellhammer, D.H.3    Wadhwa, P.D.4    Wust, S.5
  • 11
    • 79957554838 scopus 로고    scopus 로고
    • Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta
    • 10.4161/epi.6.5.15236. 21521940.
    • Filiberto A.C. Maccani M.A. Koestler D. Wilhelm-Benartzi C. Avissar-Whiting M. Banister C.E. et al. 2011. Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta. Epigenetics, 6: 566-572. 10.4161/epi.6.5.15236. 21521940.
    • (2011) Epigenetics , vol.6 , pp. 566-572
    • Filiberto, A.C.1    MacCani, M.A.2    Koestler, D.3    Wilhelm-Benartzi, C.4    Avissar-Whiting, M.5    Banister, C.E.6
  • 13
    • 63149135457 scopus 로고    scopus 로고
    • Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients
    • 10.1093/hmg/ddp033. 19153073.
    • Flanagan J.M. Munoz-Alegre M. Henderson S. Tang T. Sun P. Johnson N. et al. 2009. Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. Hum. Mol. Genet. 18: 1332-1342. 10.1093/hmg/ddp033. 19153073.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1332-1342
    • Flanagan, J.M.1    Munoz-Alegre, M.2    Henderson, S.3    Tang, T.4    Sun, P.5    Johnson, N.6
  • 14
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • 10.1073/pnas.0500398102. 16009939.
    • Fraga M.F. Ballestar E. Paz M.F. Ropero S. Setien F. Ballestar M.L. et al. 2005. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. U.S.A. 102: 10604-10609. 10.1073/pnas.0500398102. 16009939.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 10604-10609
    • Fraga, M.F.1    Ballestar, E.2    Paz, M.F.3    Ropero, S.4    Setien, F.5    Ballestar, M.L.6
  • 15
    • 0033527727 scopus 로고    scopus 로고
    • Nongenomic transmission across generations of maternal behavior and stress responses in the rat
    • 10.1126/science.286.5442.1155. 10550053.
    • Francis D. Diorio J. Liu D. Meaney M.J. 1999. Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science, 286: 1155-1158. 10.1126/science.286.5442.1155. 10550053.
    • (1999) Science , vol.286 , pp. 1155-1158
    • Francis, D.1    Diorio, J.2    Liu, D.3    Meaney, M.J.4
  • 16
    • 53149124034 scopus 로고    scopus 로고
    • Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory
    • 10.1111/j.1460-9568.2008.06428.x. 18973563.
    • Fukuda E. Hamada S. Hasegawa S. Katori S. Sanbo M. Miyakawa T. et al. 2008. Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory. Eur. J. Neurosci. 28: 1362-1376. 10.1111/j.1460-9568.2008.06428.x. 18973563.
    • (2008) Eur. J. Neurosci. , vol.28 , pp. 1362-1376
    • Fukuda, E.1    Hamada, S.2    Hasegawa, S.3    Katori, S.4    Sanbo, M.5    Miyakawa, T.6
  • 17
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • 10.1016/j.cell.2011.03.022. 21496894.
    • Guo J.U. Su Y. Zhong C. Ming G.L. Song H. 2011. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell, 145: 423-434. 10.1016/j.cell.2011.03.022. 21496894.
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 18
    • 77955951477 scopus 로고    scopus 로고
    • Socioeconomic status and the brain: Mechanistic insights from human and animal research
    • 10.1038/nrn2897. 20725096.
    • Hackman D.A. Farah M.J. Meaney M.J. 2010. Socioeconomic status and the brain: mechanistic insights from human and animal research. Nat. Rev. Neurosci. 11: 651-659. 10.1038/nrn2897. 20725096.
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 651-659
    • Hackman, D.A.1    Farah, M.J.2    Meaney, M.J.3
  • 19
    • 79957990635 scopus 로고    scopus 로고
    • Developmental plasticity and developmental origins of non-communicable disease: Theoretical considerations and epigenetic mechanisms
    • 10.1016/j.pbiomolbio.2010.12.008. 21219925.
    • Hanson M. Godfrey K.M. Lillycrop K.A. Burdge G.C. Gluckman P.D. 2010. Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms. Prog. Biophys. Mol. Biol. 106: 272-280. 10.1016/j.pbiomolbio.2010.12.008. 21219925.
    • (2010) Prog. Biophys. Mol. Biol. , vol.106 , pp. 272-280
    • Hanson, M.1    Godfrey, K.M.2    Lillycrop, K.A.3    Burdge, G.C.4    Gluckman, P.D.5
  • 20
    • 23044460521 scopus 로고    scopus 로고
    • Epigenetics, histone H3 variants, and the inheritance of chromatin states
    • 10.1101/sqb.2004.69.235. 16117654.
    • Henikoff S. McKittrick E. Ahmad K. 2004. Epigenetics, histone H3 variants, and the inheritance of chromatin states. Cold Spring Harb. Symp. Quant. Biol. 69: 235-243. 10.1101/sqb.2004.69.235. 16117654.
    • (2004) Cold Spring Harb. Symp. Quant. Biol. , vol.69 , pp. 235-243
    • Henikoff, S.1    McKittrick, E.2    Ahmad, K.3
  • 21
    • 9744251005 scopus 로고    scopus 로고
    • Biochemistry and biology of mammalian DNA methyltransferases
    • 10.1007/s00018-004-4201-1. 15526163.
    • Hermann A. Gowher H. Jeltsch A. 2004. Biochemistry and biology of mammalian DNA methyltransferases. Cell. Mol. Life Sci. 61: 2571-2587. 10.1007/s00018-004-4201-1. 15526163.
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 2571-2587
    • Hermann, A.1    Gowher, H.2    Jeltsch, A.3
  • 22
    • 77952735964 scopus 로고    scopus 로고
    • How experience gets under the skin to create gradients in developmental health
    • 10.1146/annurev.publhealth.012809.103538. 20070189.
    • Hertzman C. Boyce T. 2010. How experience gets under the skin to create gradients in developmental health. Annu. Rev. Public Health, 31: 329-347. 10.1146/annurev.publhealth.012809.103538. 20070189.
    • (2010) Annu. Rev. Public Health , vol.31 , pp. 329-347
    • Hertzman, C.1    Boyce, T.2
  • 23
    • 20044389866 scopus 로고    scopus 로고
    • DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia
    • 10.1523/JNEUROSCI.0766-05.2005. 15930386.
    • Iwamoto K. Bundo M. Yamada K. Takao H. Iwayama-Shigeno Y. Yoshikawa T. Kato T. 2005. DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. J. Neurosci. 25: 5376-5381. 10.1523/JNEUROSCI.0766-05.2005. 15930386.
    • (2005) J. Neurosci. , vol.25 , pp. 5376-5381
    • Iwamoto, K.1    Bundo, M.2    Yamada, K.3    Takao, H.4    Iwayama-Shigeno, Y.5    Yoshikawa, T.6    Kato, T.7
  • 24
    • 79955557706 scopus 로고    scopus 로고
    • Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons
    • 10.1101/gr.112755.110. 21467265.
    • Iwamoto K. Bundo M. Ueda J. Oldham M.C. Ukai W. Hashimoto E. et al. 2011. Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Res. 21: 688-696. 10.1101/gr.112755.110. 21467265.
    • (2011) Genome Res. , vol.21 , pp. 688-696
    • Iwamoto, K.1    Bundo, M.2    Ueda, J.3    Oldham, M.C.4    Ukai, W.5    Hashimoto, E.6
  • 25
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • 10.1126/science.1063127. 11498575.
    • Jenuwein T. Allis C.D. 2001. Translating the histone code. Science, 293: 1074-1080. 10.1126/science.1063127. 11498575.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 26
    • 59249107052 scopus 로고    scopus 로고
    • DNA methylation profiles in monozygotic and dizygotic twins
    • 10.1038/ng.286. 19151718.
    • Kaminsky Z.A. Tang T. Wang S.C. Ptak C. Oh G.H. Wong A.H. et al. 2009. DNA methylation profiles in monozygotic and dizygotic twins. Nat. Genet. 41: 240-245. 10.1038/ng.286. 19151718.
    • (2009) Nat. Genet. , vol.41 , pp. 240-245
    • Kaminsky, Z.A.1    Tang, T.2    Wang, S.C.3    Ptak, C.4    Oh, G.H.5    Wong, A.H.6
  • 27
    • 0028352678 scopus 로고
    • Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy
    • 10.1016/0165-0327(94)90116-3. 8071475.
    • Kato T. Takahashi S. Shioiri T. Murashita J. Hamakawa H. Inubushi T. 1994. Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. J. Affect. Disord. 31: 125-133. 10.1016/0165-0327(94)90116-3. 8071475.
    • (1994) J. Affect. Disord. , vol.31 , pp. 125-133
    • Kato, T.1    Takahashi, S.2    Shioiri, T.3    Murashita, J.4    Hamakawa, H.5    Inubushi, T.6
  • 28
    • 67651176011 scopus 로고    scopus 로고
    • Protocadherin-alpha family is required for serotonergic projections to appropriately innervate target brain areas
    • 10.1523/JNEUROSCI.5478-08.2009. 19625505.
    • Katori S. Hamada S. Noguchi Y. Fukuda E. Yamamoto T. Yamamoto H. et al. 2009. Protocadherin-alpha family is required for serotonergic projections to appropriately innervate target brain areas. J. Neurosci. 29: 9137-9147. 10.1523/JNEUROSCI.5478-08.2009. 19625505.
    • (2009) J. Neurosci. , vol.29 , pp. 9137-9147
    • Katori, S.1    Hamada, S.2    Noguchi, Y.3    Fukuda, E.4    Yamamoto, T.5    Yamamoto, H.6
  • 30
    • 68149178554 scopus 로고    scopus 로고
    • Linking genetically defined neurons to behavior through a broadly applicable silencing allele
    • 10.1016/j.neuron.2009.07.010. 19679071.
    • Kim J.C. Cook M.N. Carey M.R. Shen C. Regehr W.G. Dymecki S.M. 2009. Linking genetically defined neurons to behavior through a broadly applicable silencing allele. Neuron, 63: 305-315. 10.1016/j.neuron.2009.07.010. 19679071.
    • (2009) Neuron , vol.63 , pp. 305-315
    • Kim, J.C.1    Cook, M.N.2    Carey, M.R.3    Shen, C.4    Regehr, W.G.5    Dymecki, S.M.6
  • 31
    • 77955917732 scopus 로고    scopus 로고
    • The expression of non-clustered protocadherins in adult rat hippocampal formation and the connecting brain regions
    • 10.1016/j.neuroscience.2010.05.027. 20541594.
    • Kim S.Y. Mo J.W. Han S. Choi S.Y. Han S.B. Moon B.H. et al. 2010. The expression of non-clustered protocadherins in adult rat hippocampal formation and the connecting brain regions. Neuroscience, 170: 189-199. 10.1016/j.neuroscience.2010.05.027. 20541594.
    • (2010) Neuroscience , vol.170 , pp. 189-199
    • Kim, S.Y.1    Mo, J.W.2    Han, S.3    Choi, S.Y.4    Han, S.B.5    Moon, B.H.6
  • 32
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • 10.1126/science.1169786. 19372393.
    • Kriaucionis S. Heintz N. 2009. The nuclear DNA base 5- hydroxymethylcytosine is present in Purkinje neurons and the brain. Science, 324: 929-930. 10.1126/science.1169786. 19372393.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 33
    • 0032142918 scopus 로고    scopus 로고
    • Roles of histone acetyltransferases and deacetylases in gene regulation
    • 10.1002/(SICI)1521-1878(199808)20:8<615: AID-BIES4>3.0.CO;2-H. 9780836.
    • Kuo M.H. Allis C.D. 1998. Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays, 20: 615-626. 10.1002/(SICI)1521- 1878(199808)20:8<615::AID-BIES4>3.0.CO;2-H. 9780836.
    • (1998) Bioessays , vol.20 , pp. 615-626
    • Kuo, M.H.1    Allis, C.D.2
  • 34
    • 84862027231 scopus 로고    scopus 로고
    • Differential Glucocorticoid Receptor Exon 1(B), 1(C), and 1(H) Expression and Methylation in Suicide Completers with a History of Childhood Abuse
    • 10.1016/j.biopsych.2012.01.034. 22444201.
    • Labonte B. Yerko V. Gross J. Mechawar N. Meaney M.J. Szyf M. Turecki G. 2012. Differential Glucocorticoid Receptor Exon 1(B), 1(C), and 1(H) Expression and Methylation in Suicide Completers with a History of Childhood Abuse. Biol. Psychiatry, 72: 41-48. 10.1016/j.biopsych.2012.01.034. 22444201.
    • (2012) Biol. Psychiatry , vol.72 , pp. 41-48
    • Labonte, B.1    Yerko, V.2    Gross, J.3    Mechawar, N.4    Meaney, M.J.5    Szyf, M.6    Turecki, G.7
  • 35
    • 0035282573 scopus 로고    scopus 로고
    • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • 10.1038/35065132. 11242053.
    • Lachner M. O'Carroll D. Rea S. Mechtler K. Jenuwein T. 2001. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature, 410: 116-120. 10.1038/35065132. 11242053.
    • (2001) Nature , vol.410 , pp. 116-120
    • Lachner, M.1    O'Carroll, D.2    Rea, S.3    Mechtler, K.4    Jenuwein, T.5
  • 36
    • 0027465862 scopus 로고
    • A positive role for histone acetylation in transcription factor access to nucleosomal DNA
    • 10.1016/0092-8674(93)90051-Q. 8422685.
    • Lee D.Y. Hayes J.J. Pruss D. Wolffe A.P. 1993. A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell, 72: 73-84. 10.1016/0092-8674(93)90051-Q. 8422685.
    • (1993) Cell , vol.72 , pp. 73-84
    • Lee, D.Y.1    Hayes, J.J.2    Pruss, D.3    Wolffe, A.P.4
  • 37
    • 36448960912 scopus 로고    scopus 로고
    • Placental sharing, birthweight discordance, and vascular anastomoses in monochorionic diamniotic twin placentas
    • 10.1016/j.ajog.2007.05.009. 18060944. e581-e588
    • Lewi L. Cannie M. Blickstein I. Jani J. Huber A. Hecher K. et al. 2007. Placental sharing, birthweight discordance, and vascular anastomoses in monochorionic diamniotic twin placentas. Am. J. Obstet. Gynecol. 197: 587 e581-e588. 10.1016/j.ajog.2007.05.009. 18060944.
    • (2007) Am. J. Obstet. Gynecol. , vol.197 , pp. 587
    • Lewi, L.1    Cannie, M.2    Blickstein, I.3    Jani, J.4    Huber, A.5    Hecher, K.6
  • 38
    • 0035831505 scopus 로고    scopus 로고
    • The dynamics of myogenin site-specific demethylation is strongly correlated with its expression and with muscle differentiation
    • 10.1074/jbc.M008234200. 11096088.
    • Lucarelli M. Fuso A. Strom R. Scarpa S. 2001. The dynamics of myogenin site-specific demethylation is strongly correlated with its expression and with muscle differentiation. J. Biol. Chem. 276: 7500-7506. 10.1074/jbc.M008234200. 11096088.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7500-7506
    • Lucarelli, M.1    Fuso, A.2    Strom, R.3    Scarpa, S.4
  • 39
    • 77953959186 scopus 로고    scopus 로고
    • Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression
    • 10.1016/j.eurpsy.2010.01.009. 20451357.
    • Mann J.J. Currier D.M. 2010. Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression. Eur. Psychiatry, 25: 268-271. 10.1016/j.eurpsy.2010.01.009. 20451357.
    • (2010) Eur. Psychiatry , vol.25 , pp. 268-271
    • Mann, J.J.1    Currier, D.M.2
  • 40
    • 18144434396 scopus 로고    scopus 로고
    • Appraisal of genetic and epigenetic congruity of a monozygotic twin pair discordant for schizophrenia
    • 10.1136/jmg.40.2.e16. 12566534.
    • McDonald P. Lewis M. Murphy B. O'Reilly R. Singh S.M. 2003. Appraisal of genetic and epigenetic congruity of a monozygotic twin pair discordant for schizophrenia. J. Med. Genet. 40: E16. 10.1136/jmg.40.2.e16. 12566534.
    • (2003) J. Med. Genet. , vol.40 , pp. 16
    • McDonald, P.1    Lewis, M.2    Murphy, B.3    O'Reilly, R.4    Singh, S.M.5
  • 41
    • 0141745017 scopus 로고    scopus 로고
    • Early life influences on life-long patterns of behavior and health
    • 10.1002/mrdd.10074. 12953293.
    • McEwen B.S. 2003. Early life influences on life-long patterns of behavior and health. Ment. Retard. Dev. Disabil. Res. Rev. 9: 149-154. 10.1002/mrdd.10074. 12953293.
    • (2003) Ment. Retard. Dev. Disabil. Res. Rev. , vol.9 , pp. 149-154
    • McEwen, B.S.1
  • 42
    • 84862007416 scopus 로고    scopus 로고
    • Epigenetic clues to the biological embedding of early life adversity
    • 10.1016/j.biopsych.2012.04.017. 22682394.
    • McGowan P.O. 2012. Epigenetic clues to the biological embedding of early life adversity. Biol. Psychiatry, 72: 4-5. 10.1016/j.biopsych.2012.04.017. 22682394.
    • (2012) Biol. Psychiatry , vol.72 , pp. 4-5
    • McGowan, P.O.1
  • 43
    • 42049120953 scopus 로고    scopus 로고
    • Epigenetics in mood disorders
    • 10.1007/s12199-007-0002-0. 19568875.
    • McGowan P.O. Kato T. 2008. Epigenetics in mood disorders. Environ. Health Prev. Med. 13: 16-24. 10.1007/s12199-007-0002-0. 19568875.
    • (2008) Environ. Health Prev. Med. , vol.13 , pp. 16-24
    • McGowan, P.O.1    Kato, T.2
  • 44
    • 77952887606 scopus 로고    scopus 로고
    • The epigenetics of social adversity in early life: Implications for mental health outcomes
    • a. 10.1016/j.nbd.2009.12.026. 20053376.
    • McGowan P.O. Szyf M. 2010 a. The epigenetics of social adversity in early life: implications for mental health outcomes. Neurobiol. Dis. 39: 66-72. 10.1016/j.nbd.2009.12.026. 20053376.
    • (2010) Neurobiol. Dis. , vol.39 , pp. 66-72
    • McGowan, P.O.1    Szyf, M.2
  • 45
    • 79952114038 scopus 로고    scopus 로고
    • Environmental epigenomics: Understanding the effects of parental care on the epigenome
    • b. 10.1042/bse0480275. 20822499.
    • McGowan P.O. Szyf M. 2010 b. Environmental epigenomics: understanding the effects of parental care on the epigenome. Essays Biochem. 48: 275-287. 10.1042/bse0480275. 20822499.
    • (2010) Essays Biochem. , vol.48 , pp. 275-287
    • McGowan, P.O.1    Szyf, M.2
  • 46
    • 53349103842 scopus 로고    scopus 로고
    • Diet and the epigenetic (re)programming of phenotypic differences in behavior
    • a. 10.1016/j.brainres.2008.07.074. 18694740.
    • McGowan P.O. Meaney M.J. Szyf M. 2008 a. Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res. 1237: 12-24. 10.1016/j.brainres.2008.07.074. 18694740.
    • (2008) Brain Res. , vol.1237 , pp. 12-24
    • McGowan, P.O.1    Meaney, M.J.2    Szyf, M.3
  • 47
    • 47749133462 scopus 로고    scopus 로고
    • Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain
    • b. 10.1371/journal.pone.0002085. 18461137.
    • McGowan P.O. Sasaki A. Huang T.C. Unterberger A. Suderman M. Ernst C. et al. 2008 b. Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS One, 3: e2085. 10.1371/journal.pone.0002085. 18461137.
    • (2008) PLoS One , vol.3 , pp. 2085
    • McGowan, P.O.1    Sasaki, A.2    Huang, T.C.3    Unterberger, A.4    Suderman, M.5    Ernst, C.6
  • 48
    • 60749105468 scopus 로고    scopus 로고
    • Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
    • 10.1038/nn.2270. 19234457.
    • McGowan P.O. Sasaki A., D' Alessio A.C. Dymov S. Labonte B. Szyf M. et al. 2009. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 12: 342-348. 10.1038/nn.2270. 19234457.
    • (2009) Nat. Neurosci. , vol.12 , pp. 342-348
    • McGowan, P.O.1    Sasaki, A.D.2    Alessio, A.C.3    Dymov, S.4    Labonte, B.5    Szyf, M.6
  • 49
    • 79952212084 scopus 로고    scopus 로고
    • Broad epigenetic signature of maternal care in the brain of adult rats
    • 10.1371/journal.pone.0014739. 21386994.
    • McGowan P.O. Suderman M. Sasaki A. Huang T.C. Hallett M. Meaney M.J. Szyf M. 2011. Broad epigenetic signature of maternal care in the brain of adult rats. PLoS One, 6: e14739. 10.1371/journal.pone.0014739. 21386994.
    • (2011) PLoS One , vol.6 , pp. 14739
    • McGowan, P.O.1    Suderman, M.2    Sasaki, A.3    Huang, T.C.4    Hallett, M.5    Meaney, M.J.6    Szyf, M.7
  • 50
    • 64749112939 scopus 로고    scopus 로고
    • Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs
    • 10.1056/NEJMoa0803531. 19369666.
    • Meador K.J. Baker G.A. Browning N. Clayton-Smith J. Combs-Cantrell D.T. Cohen M et al. 2009. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. N. Engl. J. Med. 360: 1597-1605. 10.1056/NEJMoa0803531. 19369666.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1597-1605
    • Meador, K.J.1    Baker, G.A.2    Browning, N.3    Clayton-Smith, J.4    Combs-Cantrell, D.T.5    Cohen, M.6
  • 51
    • 0034928759 scopus 로고    scopus 로고
    • Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
    • 10.1146/annurev.neuro.24.1.1161. 11520931.
    • Meaney M.J. 2001. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu. Rev. Neurosci. 24: 1161-1192. 10.1146/annurev.neuro.24.1.1161. 11520931.
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 1161-1192
    • Meaney, M.J.1
  • 52
    • 33747706117 scopus 로고    scopus 로고
    • Non-coding RNAs in the nervous system
    • 10.1113/jphysiol.2006.113191. 16809366.
    • Mehler M.F. Mattick J.S. 2006. Non-coding RNAs in the nervous system. J. Physiol. 575: 333-341. 10.1113/jphysiol.2006.113191. 16809366.
    • (2006) J. Physiol. , vol.575 , pp. 333-341
    • Mehler, M.F.1    Mattick, J.S.2
  • 53
    • 34249724360 scopus 로고    scopus 로고
    • Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease
    • 10.1152/physrev.00036.2006. 17615389.
    • Mehler M.F. Mattick J.S. 2007. Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease. Physiol. Rev. 87: 799-823. 10.1152/physrev.00036.2006. 17615389.
    • (2007) Physiol. Rev. , vol.87 , pp. 799-823
    • Mehler, M.F.1    Mattick, J.S.2
  • 54
    • 47249088331 scopus 로고    scopus 로고
    • Identifying autism loci and genes by tracing recent shared ancestry
    • 10.1126/science.1157657. 18621663.
    • Morrow E.M. Yoo S.-Y. Flavell S.W. Kim T.-K. Lin Y. Hill R.S. et al. 2008. Identifying autism loci and genes by tracing recent shared ancestry. Science, 321: 218-223. 10.1126/science.1157657. 18621663.
    • (2008) Science , vol.321 , pp. 218-223
    • Morrow, E.M.1    Yoo, S.-Y.2    Flavell, S.W.3    Kim, T.-K.4    Lin, Y.5    Hill, R.S.6
  • 55
    • 54049086269 scopus 로고    scopus 로고
    • Sex-specific programming of offspring emotionality after stress early in pregnancy
    • 10.1523/JNEUROSCI.1424-08.2008. 18768700.
    • Mueller B.R. Bale T.L. 2008. Sex-specific programming of offspring emotionality after stress early in pregnancy. J. Neurosci. 28: 9055-9065. 10.1523/JNEUROSCI.1424-08.2008. 18768700.
    • (2008) J. Neurosci. , vol.28 , pp. 9055-9065
    • Mueller, B.R.1    Bale, T.L.2
  • 56
    • 70549104872 scopus 로고    scopus 로고
    • Dynamic DNA methylation programs persistent adverse effects of early-life stress
    • 10.1038/nn.2436. 19898468.
    • Murgatroyd C. Patchev A.V. Wu Y. Micale V. Bockmuhl Y. Fischer D. et al. 2009. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat. Neurosci. 12: 1559-1566. 10.1038/nn.2436. 19898468.
    • (2009) Nat. Neurosci. , vol.12 , pp. 1559-1566
    • Murgatroyd, C.1    Patchev, A.V.2    Wu, Y.3    Micale, V.4    Bockmuhl, Y.5    Fischer, D.6
  • 57
    • 0342437491 scopus 로고    scopus 로고
    • MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
    • 10.1016/S0092-8674(00)81887-5. 9038338.
    • Nan X. Campoy F.J. Bird A. 1997. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell, 88: 471-481. 10.1016/S0092-8674(00)81887-5. 9038338.
    • (1997) Cell , vol.88 , pp. 471-481
    • Nan, X.1    Campoy, F.J.2    Bird, A.3
  • 58
    • 47149100122 scopus 로고    scopus 로고
    • Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
    • 10.4161/epi.3.2.6034. 18536531.
    • Oberlander T.F. Weinberg J. Papsdorf M. Grunau R. Misri S. Devlin A.M. 2008. Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics, 3: 97-106. 10.4161/epi.3.2.6034. 18536531.
    • (2008) Epigenetics , vol.3 , pp. 97-106
    • Oberlander, T.F.1    Weinberg, J.2    Papsdorf, M.3    Grunau, R.4    Misri, S.5    Devlin, A.M.6
  • 59
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    • 10.1038/890. 9662389.
    • Okano M. Xie S. Li E. 1998. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat. Genet. 19: 219-220. 10.1038/890. 9662389.
    • (1998) Nat. Genet. , vol.19 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 60
    • 77957859197 scopus 로고    scopus 로고
    • DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome
    • 10.1093/hmg/ddq336. 20699328.
    • Ollikainen M. Smith K.R. Joo E.J. Ng H.K. Andronikos R. Novakovic B. et al. 2010. DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome. Hum. Mol. Genet. 19: 4176-4188. 10.1093/hmg/ddq336. 20699328.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 4176-4188
    • Ollikainen, M.1    Smith, K.R.2    Joo, E.J.3    Ng, H.K.4    Andronikos, R.5    Novakovic, B.6
  • 61
    • 45449114804 scopus 로고    scopus 로고
    • The colorful history of active DNA demethylation
    • 10.1016/j.cell.2008.06.009. 18585349.
    • Ooi S.K. Bestor T.H. 2008. The colorful history of active DNA demethylation. Cell, 133: 1145-1148. 10.1016/j.cell.2008.06.009. 18585349.
    • (2008) Cell , vol.133 , pp. 1145-1148
    • Ooi, S.K.1    Bestor, T.H.2
  • 62
    • 0015298215 scopus 로고
    • The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid
    • 4538516.
    • Penn N.W. Suwalski R. O'Riley C. Bojanowski K. Yura R. 1972. The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem. J. 126: 781-790. 4538516.
    • (1972) Biochem. J. , vol.126 , pp. 781-790
    • Penn, N.W.1    Suwalski, R.2    O'Riley, C.3    Bojanowski, K.4    Yura, R.5
  • 63
    • 0020479282 scopus 로고
    • Histone acetylation increases the solubility of chromatin and occurs sequentially over most of the chromatin
    • 7085629.
    • Perry M. Chalkley R. 1982. Histone acetylation increases the solubility of chromatin and occurs sequentially over most of the chromatin. A novel model for the biological role of histone acetylation. J. Biol. Chem. 257: 7336-7347. 7085629.
    • (1982) A Novel Model for the Biological Role of Histone Acetylation. J. Biol. Chem. , vol.257 , pp. 7336-7347
    • Perry, M.1    Chalkley, R.2
  • 64
    • 33745752370 scopus 로고    scopus 로고
    • Epigenetics and twins: Three variations on the theme
    • 10.1016/j.tig.2006.04.010. 16697072.
    • Petronis A. 2006. Epigenetics and twins: three variations on the theme. Trends Genet. 22: 347-350. 10.1016/j.tig.2006.04.010. 16697072.
    • (2006) Trends Genet. , vol.22 , pp. 347-350
    • Petronis, A.1
  • 65
    • 77953469917 scopus 로고    scopus 로고
    • Epigenetics as a unifying principle in the aetiology of complex traits and diseases
    • 10.1038/nature09230. 20535201.
    • Petronis A. 2010. Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature, 465: 721-727. 10.1038/nature09230. 20535201.
    • (2010) Nature , vol.465 , pp. 721-727
    • Petronis, A.1
  • 66
    • 0038825296 scopus 로고    scopus 로고
    • Monozygotic twins exhibit numerous epigenetic differences: Clues to twin discordance? Schizophr
    • 10.1093/oxfordjournals.schbul.a006988. 12908672.
    • Petronis A. Gottesman, I.I. Kan P. Kennedy J.L. Basile V.S. Paterson A.D. Popendikyte V. 2003. Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance? Schizophr. Bull. 29: 169-178. 10.1093/ oxfordjournals.schbul.a006988. 12908672.
    • (2003) Bull. , vol.29 , pp. 169-178
    • Petronis, A.1    Gottesman, I.I.2    Kan, P.3    Kennedy, J.L.4    Basile, V.S.5    Paterson, A.D.6    Popendikyte, V.7
  • 67
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • 10.1074/jbc.M101287200. 11473107.
    • Phiel C.J. Zhang F. Huang E.Y. Guenther M.G. Lazar M.A. Klein P.S. 2001. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J. Biol. Chem. 276: 36734-36741. 10.1074/jbc.M101287200. 11473107.
    • (2001) J. Biol. Chem. , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 68
    • 70350126990 scopus 로고    scopus 로고
    • Regulation of non-coding RNA networks in the nervous system-what's the REST of the story? Neurosci
    • 10.1016/j.neulet.2009.07.093. 19679163.
    • Qureshi I.A. Mehler M.F. 2009. Regulation of non-coding RNA networks in the nervous system-what's the REST of the story? Neurosci. Lett. 466: 73-80. 10.1016/j.neulet.2009.07.093. 19679163.
    • (2009) Lett. , vol.466 , pp. 73-80
    • Qureshi, I.A.1    Mehler, M.F.2
  • 69
    • 79960649740 scopus 로고    scopus 로고
    • Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor
    • 10.1038/tp.2011.21. 2283253.
    • Radtke K.M. Ruf M. Gunter M. Dohrmann K. Schauer M. Meyer A. Elbert T. 2011. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Transl. Psychiatry, 1. 10.1038/tp.2011.21. 2283253.
    • (2011) Transl. Psychiatry , vol.1
    • Radtke, K.M.1    Ruf, M.2    Gunter, M.3    Dohrmann, K.4    Schauer, M.5    Meyer, A.6    Elbert, T.7
  • 70
    • 0032168678 scopus 로고    scopus 로고
    • CpG methylation, chromatin structure and gene silencing-A three-way connection
    • 10.1093/emboj/17.17.4905. 9724627.
    • Razin A. 1998. CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J. 17: 4905-4908. 10.1093/emboj/17.17.4905. 9724627.
    • (1998) EMBO J. , vol.17 , pp. 4905-4908
    • Razin, A.1
  • 71
    • 0011923583 scopus 로고
    • Distribution of 5-methylcytosine in chromatin
    • 10.1073/pnas.74.7.2725. 268622.
    • Razin A. Cedar H. 1977. Distribution of 5-methylcytosine in chromatin. Proc. Natl. Acad. Sci. U.S.A. 74: 2725-2728. 10.1073/pnas.74.7.2725. 268622.
    • (1977) Proc. Natl. Acad. Sci. U.S.A. , vol.74 , pp. 2725-2728
    • Razin, A.1    Cedar, H.2
  • 72
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • 10.1126/science.1063443. 11498579.
    • Reik W. Dean W. Walter J. 2001. Epigenetic reprogramming in mammalian development. Science, 293: 1089-1093. 10.1126/science.1063443. 11498579.
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 73
    • 68649088591 scopus 로고    scopus 로고
    • Regulation of chromatin structure in memory formation
    • 10.1016/j.conb.2009.05.011. 19539459.
    • Roth T.L. Sweatt J.D. 2009. Regulation of chromatin structure in memory formation. Curr. Opin. Neurobiol. 19: 336-342. 10.1016/j.conb.2009.05.011. 19539459.
    • (2009) Curr. Opin. Neurobiol. , vol.19 , pp. 336-342
    • Roth, T.L.1    Sweatt, J.D.2
  • 74
    • 63449085750 scopus 로고    scopus 로고
    • Lasting epigenetic influence of early-life adversity on the BDNF gene
    • 10.1016/j.biopsych.2008.11.028. 19150054.
    • Roth T.L. Lubin F.D. Funk A.J. Sweatt J.D. 2009. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol. Psychiatry, 65: 760-769. 10.1016/j.biopsych.2008.11.028. 19150054.
    • (2009) Biol. Psychiatry , vol.65 , pp. 760-769
    • Roth, T.L.1    Lubin, F.D.2    Funk, A.J.3    Sweatt, J.D.4
  • 75
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • 10.1016/j.cell.2004.12.012. 15620353.
    • Shi Y. Lan F. Matson C. Mulligan P. Whetstine J.R. Cole P.A. et al. 2004. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell, 119: 941-953. 10.1016/j.cell.2004.12.012. 15620353.
    • (2004) Cell , vol.119 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3    Mulligan, P.4    Whetstine, J.R.5    Cole, P.A.6
  • 76
    • 84872236734 scopus 로고    scopus 로고
    • Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus
    • 10.1073/pnas.1121260109. 23045659
    • Suderman M. McGowan P.O. Sasaki A. Huang T.C. Hallett M.T. Meaney M.J. Turecki G. Szyf M. 2012. Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus. Proc Natl Acad Sci USA. Suppl., 2: 17266-17272. 10.1073/pnas.1121260109. 23045659.
    • (2012) Proc Natl Acad Sci USA. , vol.2 , Issue.SUPPL. , pp. 17266-17272
    • Suderman, M.1    McGowan, P.O.2    Sasaki, A.3    Huang, T.C.4    Hallett, M.T.5    Meaney, M.J.6    Turecki, G.7    Szyf, M.8
  • 77
    • 33845727992 scopus 로고    scopus 로고
    • The cadherin superfamily in neuronal connections and interactions
    • 10.1038/nrn2043. 17133224.
    • Takeichi M. 2007. The cadherin superfamily in neuronal connections and interactions. Nat. Rev. Neurosci. 8: 11-20. 10.1038/nrn2043. 17133224.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 11-20
    • Takeichi, M.1
  • 78
    • 38949150121 scopus 로고    scopus 로고
    • Methylation Status of the Reelin Promoter Region in the Brain of Schizophrenic Patients
    • doi:10.1016/j.biopsych.2007.07.003. PMID:17870056
    • Tochigi, M., Iwamoto, K., Bundo, M., Komori, A., Sasaki, T., Kato, N., and Kato, T. 2007. Methylation Status of the Reelin Promoter Region in the Brain of Schizophrenic Patients. Biol. Psychiatry. doi:10.1016/j.biopsych.2007.07. 003. PMID:17870056.
    • (2007) Biol. Psychiatry.
    • Tochigi, M.1    Iwamoto, K.2    Bundo, M.3    Komori, A.4    Sasaki, T.5    Kato, N.6    Kato, T.7
  • 79
    • 34247509796 scopus 로고    scopus 로고
    • Epigenetic regulation in psychiatric disorders
    • 10.1038/nrm2162, 10.1038/nrn2132. 17453016.
    • Tsankova N. Renthal W. Kumar A. Nestler E.J. 2007. Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 8: 355-367. 10.1038/nrm2162, 10.1038/nrn2132. 17453016.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 355-367
    • Tsankova, N.1    Renthal, W.2    Kumar, A.3    Nestler, E.J.4
  • 81
    • 32844454603 scopus 로고    scopus 로고
    • Histone demethylation by a family of JmjC domain-containing proteins
    • 10.1038/nature04433. 16362057.
    • Tsukada Y. Fang J. Erdjument-Bromage H. Warren M.E. Borchers C.H. Tempst P. Zhang Y. 2006. Histone demethylation by a family of JmjC domain-containing proteins. Nature, 439: 811-816. 10.1038/nature04433. 16362057.
    • (2006) Nature , vol.439 , pp. 811-816
    • Tsukada, Y.1    Fang, J.2    Erdjument-Bromage, H.3    Warren, M.E.4    Borchers, C.H.5    Tempst, P.6    Zhang, Y.7
  • 82
    • 84855313124 scopus 로고    scopus 로고
    • The neurodevelopmental origins of suicidal behavior
    • 10.1016/j.tins.2011.11.008. 22177979.
    • Turecki G. Ernst C. Jollant F. Labonte B. Mechawar N. 2012. The neurodevelopmental origins of suicidal behavior. Trends Neurosci. 35: 14-23. 10.1016/j.tins.2011.11.008. 22177979.
    • (2012) Trends Neurosci. , vol.35 , pp. 14-23
    • Turecki, G.1    Ernst, C.2    Jollant, F.3    Labonte, B.4    Mechawar, N.5
  • 83
    • 78149479362 scopus 로고    scopus 로고
    • Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents
    • 10.1523/JNEUROSCI.1436-10.2010. 21068306.
    • Uchida S. Hara K. Kobayashi A. Funato H. Hobara T. Otsuki K. et al. 2010. Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. J. Neurosci. 30: 15007-15018. 10.1523/JNEUROSCI.1436-10.2010. 21068306.
    • (2010) J. Neurosci. , vol.30 , pp. 15007-15018
    • Uchida, S.1    Hara, K.2    Kobayashi, A.3    Funato, H.4    Hobara, T.5    Otsuki, K.6
  • 84
    • 28044439909 scopus 로고    scopus 로고
    • A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
    • 10.1073/pnas.0508448102. 16260724.
    • Vo N. Klein M.E. Varlamova O. Keller D.M. Yamamoto T. Goodman R.H. Impey S. 2005. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 102: 16426-16431. 10.1073/pnas.0508448102. 16260724.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 16426-16431
    • Vo, N.1    Klein, M.E.2    Varlamova, O.3    Keller, D.M.4    Yamamoto, T.5    Goodman, R.H.6    Impey, S.7
  • 86
    • 28044436691 scopus 로고    scopus 로고
    • Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: Altering epigenetic marking later in life
    • 10.1523/JNEUROSCI.3652-05.2005. 16306417.
    • Weaver I.C. Champagne F.A. Brown S.E. Dymov S. Sharma S. Meaney M.J. Szyf M. 2005. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J. Neurosci. 25: 11045-11054. 10.1523/JNEUROSCI.3652-05.2005. 16306417.
    • (2005) J. Neurosci. , vol.25 , pp. 11045-11054
    • Weaver, I.C.1    Champagne, F.A.2    Brown, S.E.3    Dymov, S.4    Sharma, S.5    Meaney, M.J.6    Szyf, M.7
  • 87
    • 77956095231 scopus 로고    scopus 로고
    • Active DNA demethylation: Many roads lead to Rome
    • 10.1038/nrm2950. 20683471.
    • Wu S.C. Zhang Y. 2010. Active DNA demethylation: many roads lead to Rome. Nat. Rev. Mol. Cell Biol. 11: 607-620. 10.1038/nrm2950. 20683471.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 607-620
    • Wu, S.C.1    Zhang, Y.2
  • 88
    • 84864079345 scopus 로고    scopus 로고
    • Molecular codes for neuronal individuality and cell assembly in the brain
    • 10.3389/fnmol.2012.00045. 22518100.
    • Yagi T. 2012. Molecular codes for neuronal individuality and cell assembly in the brain. Front. Mol. Neurosci. 5: 45. 10.3389/fnmol.2012.00045. 22518100.
    • (2012) Front. Mol. Neurosci. , vol.5 , pp. 45
    • Yagi, T.1
  • 89
    • 74549164152 scopus 로고    scopus 로고
    • The relevance of epigenetics to PTSD: Implications for the DSM-V
    • 10.1002/jts.20448. 19813242.
    • Yehuda R. Bierer L.M. 2009. The relevance of epigenetics to PTSD: implications for the DSM-V. J. Trauma Stress, 22: 427-434. 10.1002/jts.20448. 19813242.
    • (2009) J. Trauma Stress , vol.22 , pp. 427-434
    • Yehuda, R.1    Bierer, L.M.2
  • 90
    • 34147116701 scopus 로고    scopus 로고
    • Valproic acid improves psychotic agitation without influencing plasma risperidone levels in schizophrenic patients
    • 10.1055/s-2007-958521. 17327954.
    • Yoshimura R. Shinkai K. Ueda N. Nakamura J. 2007. Valproic acid improves psychotic agitation without influencing plasma risperidone levels in schizophrenic patients. Pharmacopsychiatry, 40: 9-13. 10.1055/s-2007-958521. 17327954.
    • (2007) Pharmacopsychiatry , vol.40 , pp. 9-13
    • Yoshimura, R.1    Shinkai, K.2    Ueda, N.3    Nakamura, J.4
  • 91
    • 52949112243 scopus 로고    scopus 로고
    • Transgenerational epigenetic effects
    • 10.1146/annurev.genom.9.081307.164445. 18767965.
    • Youngson N.A. Whitelaw E. 2008. Transgenerational epigenetic effects. Annu. Rev. Genomics Hum. Genet. 9: 233-257. 10.1146/annurev.genom.9.081307. 164445. 18767965.
    • (2008) Annu. Rev. Genomics Hum. Genet. , vol.9 , pp. 233-257
    • Youngson, N.A.1    Whitelaw, E.2
  • 92
    • 84858327532 scopus 로고    scopus 로고
    • Linking epigenetics to human disease and Rett syndrome: The emerging novel and challenging concepts in MeCP2 research
    • 10.1155/2012/415825. 22474603.
    • Zachariah R.M. Rastegar M. 2012. Linking epigenetics to human disease and Rett syndrome: the emerging novel and challenging concepts in MeCP2 research. Neural. Plast. 2012: 415825. 10.1155/2012/415825. 22474603.
    • (2012) Neural. Plast. , vol.2012 , pp. 415825
    • Zachariah, R.M.1    Rastegar, M.2
  • 93
    • 77956689355 scopus 로고    scopus 로고
    • Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus
    • 10.1523/JNEUROSCI.1039-10.2010. 20881131.
    • Zhang T.Y. Hellstrom I.C. Bagot R.C. Wen X. Diorio J. Meaney M.J. 2010. Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus. J. Neurosci. 30: 13130-13137. 10.1523/JNEUROSCI.1039-10.2010. 20881131.
    • (2010) J. Neurosci. , vol.30 , pp. 13130-13137
    • Zhang, T.Y.1    Hellstrom, I.C.2    Bagot, R.C.3    Wen, X.4    Diorio, J.5    Meaney, M.J.6
  • 94
    • 33845212678 scopus 로고    scopus 로고
    • Sequence analysis and expression mapping of the rat clustered protocadherin gene repertoires
    • 10.1016/j.neuroscience.2006.10.011. 17110050.
    • Zou C. Huang W. Ying G. Wu Q. 2007. Sequence analysis and expression mapping of the rat clustered protocadherin gene repertoires. Neuroscience, 144: 579-603. 10.1016/j.neuroscience.2006.10.011. 17110050.
    • (2007) Neuroscience , vol.144 , pp. 579-603
    • Zou, C.1    Huang, W.2    Ying, G.3    Wu, Q.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.