Environmental epigenomics: Understanding the effects of parental care on the epigenome

Essays in Biochemistry

Volumn 48, Issue , 2010, Pages 275-287

  McGowan, Patrick O ^a,b   Szyf, Moshe ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION REGULATION; GENOMICS; HUMAN; PARENT; REVIEW;

ANIMALS; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION REGULATION; GENOMICS; HUMANS; PARENTS;

EID: 79952114038     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSE0480275     Document Type: Article

References (37)

1. McGowan, P.O. and Szyf, M. (2010) The epigenetics of social adversity in early life: Implications for mental health outcomes. Neurobiol. Dis. 39, 66-72
2. Szyf, M. (2009) The early life environment and the epigenome. Biochim. Biophys. Acta 1790, 878-885
3. Meaney, M.J. (2010) Epigenetics and the biological definition of gene x environment interactions. Child Dev. 81, 41-79
4. Henikoff, S., McKittrick, E. and Ahmad, K. (2004) Epigenetics, histone H3 variants, and the inheritance of chromatin states. Cold Spring Harb. Symp. Quant. Biol. 69, 235-243
5. Jenuwein, T. and Allis, C.D. (2001) Translating the histone code. Science 293, 1074-1080
6. Beck, S., Olek, A. and Walter, J. (1999) From genomics to epigenomics: a loftier view of life. Nat. Biotechnol. 17, 1144
7. Weaver, I.C., Cervoni, N., Champagne, F.A., D'Alessio, A.C., Sharma, S., Seckl, J.R., Dymov, S., Szyf, M. and Meaney, M.J. (2004) Epigenetic programming by maternal behavior. Nat. Neurosci. 7, 847-854
8. Suzuki, M.M. and Bird, A. (2008) DNA methylation landscapes: provocative insights from epigenomics. Nat. Rev. Genet. 9, 465-476
9. Irizarry, R.A., Ladd-Acosta, C., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M. et al. (2009) The human colon cancer methylome shows similar hypoand hypermethylation at conserved tissue-specific CpG island shores. Nat. Genet. 41, 178-186
10. Doi, A., Park, I.H., Wen, B., Murakami, P., Aryee, M.J., Irizarry, R., Herb, B., Ladd-Acosta, C., Rho, J., Loewer, S. et al. (2009) Differential methylation of tissue-and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat. Genet. 41, 1350-1353
11. Jost, J.P. (1993) Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine. Proc. Natl. Acad. Sci. U.S.A. 90, 4684 -4688
12. Miller, C.A. and Sweatt, J.D. (2007) Covalent modification of DNA regulates memory formation. Neuron 53, 857-869
13. Bhattacharya, S.K., Ramchandani, S., Cervoni, N. and Szyf, M. (1999) A mammalian protein with specific demethylase activity for mCpG DNA. Nature 397, 579-583
14. Ng, H.H., Zhang, Y., Hendrich, B., Johnson, C.A., Turner, B.M., Erdjument-Bromage, H., Tempst, P., Reinberg, D. and Bird, A. (1999) MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat. Genet. 23, 58-61
15. Barreto, G., Schafer, A., Marhold, J., Stach, D., Swaminathan, S.K., Handa, V., Döderlein, G., Maltry, N., Wu, W., Lyko, F. and Niehrs, C. (2007) Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 445, 671-675
16. Jin, S.G., Guo, C. and Pfeifer, G.P. (2008) GADD45A does not promote DNA demethylation. PLoS Genet. 4, e1000013
17. Kangaspeska, S., Stride, B., Metivier, R., Polycarpou-Schwarz, M., Ibberson, D., Carmouche, R.P., Benes, V., Gannon, F. and Reid, G. (2008) Transient cyclical methylation of promoter DNA. Nature 452, 112-115
18. Ramchandani, S., Bhattacharya, S.K., Cervoni, N. and Szyf, M. (1999) DNA methylation is a reversible biological signal. Proc. Natl. Acad. Sci. U.S.A. 96, 6107-6112
19. Lucarelli, M., Fuso, A., Strom, R. and Scarpa, S. (2001) The dynamics of myogenin site-specific demethylation is strongly correlated with its expression and with muscle differentiation. J. Biol. Chem. 276, 7500-7506
20. Kersh, E.N., Fitzpatrick, D.R., Murali-Krishna, K., Shires, J., Speck, S.H., Boss, J.M. and Ahmed, R. (2006) Rapid demethylation of the IFN-gene occurs in memory but not naive CD8 T cells. J. Immunol. 176, 4083-4093
21. Francis, D., Diorio, J., Liu, D. and Meaney, M.J. (1999) Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286, 1155-1158
22. Murgatroyd, C., Patchev, A.V., Wu, Y., Micale, V., Bockmuhl, Y., Fischer, D., Holsboer, F., Wotjak, C.T., Almeida, O.F. and Spengler, D. (2009) Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat. Neurosci. 12, 1559-1566
23. Tsankova, N., Renthal, W., Kumar, A. and Nestler, E.J. (2007) Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 8, 355-367
24. Grayson, D.R., Jia, X., Chen, Y., Sharma, R.P., Mitchell, C.P., Guidotti, A. and Costa, E. (2005) Reelin promoter hypermethylation in schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 102, 9341-9346
25. Veldic, M., Kadriu, B., Maloku, E., Agis-Balboa, R.C., Guidotti, A., Davis, J.M. and Costa, E. (2007) Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder. Schizophr. Res. 91, 51-61
26. McGowan, P.O., Sasaki, A., Huang, T.C., Unterberger, A., Suderman, M., Ernst, C., Meaney, M.J., Turecki, G. and Szyf, M. (2008) Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS ONE 3, e2085
27. McGowan, P.O., Sasaki, A., D'Alessio, A.C., Dymov, S., Labonté, B., Szyf, M., Turecki, G. and Meaney, M.J. (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 12, 342-348
28. Kaminsky, Z.A., Tang, T., Wang, S.C., Ptak, C., Oh, G.H., Wong, A.H., Feldcamp, L.A., Virtanen, C., Halfvarson, J., Tysk, C. et al. (2009) DNA methylation profiles in monozygotic and dizygotic twins. Nat. Genet. 41, 240-245
29. Fraga, M.F., Ballestar, E., Paz, M.F., Ropero, S., Setien, F., Ballestar, M.L., Heine-Suñer, D., Cigudosa, J.C., Urioste, M., Benitez, J. et al. (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. U.S.A. 102, 10604-10609
30. Weaver, I.C., Champagne, F.A., Brown, S.E., Dymov, S., Sharma, S., Meaney, M.J. and Szyf, M. (2005) Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J. Neurosci. 25, 11045-11054
31. Phiel, C.J., Zhang, F., Huang, E.Y., Guenther, M.G., Lazar, M.A. and Klein, P.S. (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J. Biol. Chem. 276, 36734-36741
32. Yoshimura, R., Shinkai, K., Ueda, N. and Nakamura, J. (2007) Valproic acid improves psychotic agitation without influencing plasma risperidone levels in schizophrenic patients. Pharmacopsychiatry 40, 9-13
33. McGowan, P.O. and Kato, T. (2008) Epigenetics in mood disorders. Environ. Health Prev. Med. 13, 16-24
34. Kato, T., Takahashi, S., Shioiri, T., Murashita, J., Hamakawa, H. and Inubushi, T. (1994) Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. J. Affect. Disord. 31, 125-133
35. Roth, T.L., Lubin, F.D., Funk, A.J. and Sweatt, J.D. (2009) Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol. Psychiatry 65, 760-769
36. Murgatroyd, C., Wu, Y., Bockmuhl, Y. and Spengler, D. (2010) Genes learn from stress: How infantile trauma programs us for depression. Epigenetics 5, 194-199
37. Dolinoy, D.C., Huang, D. and Jirtle, R.L. (2007) Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc. Natl. Acad. Sci. U.S.A. 104, 13056-13061