Mitochondrial Biogenesis Drives a Vicious Cycle of Metabolic Insufficiency and Mitochondrial DNA Deletion Mutation Accumulation in Aged Rat Skeletal Muscle Fibers

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Herbst, Allen ^a   Johnson, Chad J ^b   Hynes, Kayla ^a   McKenzie, Debbie ^a   Aiken, Judd M ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANIDINOPROPIONIC ACID; MITOCHONDRIAL DNA;

AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CELL EXPANSION; CONTROLLED STUDY; COPY NUMBER VARIATION; DISEASE ACTIVITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA REPLICATION; ELECTRON TRANSPORT; GENE DELETION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; IMMUNOHISTOCHEMISTRY; METABOLIC DISORDER; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MUSCLE INJURY; MUSCLE METABOLISM; NONHUMAN; POSITIVE FEEDBACK; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; UPREGULATION;

ANIMALS; DNA, MITOCHONDRIAL; GENE EXPRESSION PROFILING; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; MALE; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL TURNOVER; MUSCLE, SKELETAL; POLYMERASE CHAIN REACTION; RATS; SEQUENCE DELETION;

EID: 84874839604     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059006     Document Type: Article

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