메뉴 건너뛰기




Volumn 112, Issue 5, 2013, Pages 834-848

Three-dimensional impulse propagation in myocardium: Arrhythmogenic mechanisms at the tissue level

Author keywords

electric anisotropy; electrophysiology; fibrosis; infarct border zone; myocardial architecture; normal activation; reentrant arrhythmia

Indexed keywords

CALCIUM CHANNEL; CONNEXIN 40; CONNEXIN 43; CONNEXIN 45; SODIUM CHANNEL;

EID: 84874788232     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.300157     Document Type: Review
Times cited : (48)

References (107)
  • 1
    • 78751681578 scopus 로고    scopus 로고
    • Pathophysiological mechanisms of atrial fibrillation: A translational appraisal
    • Schotten U, Verheule S, Kirchhof P, Goette A. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiol Rev. 2011;91:265-325.
    • (2011) Physiol Rev , vol.91 , pp. 265-325
    • Schotten, U.1    Verheule, S.2    Kirchhof, P.3    Goette, A.4
  • 2
    • 34248595219 scopus 로고    scopus 로고
    • Arrhythmogenic ion-channel remodeling in the heart: Heart failure, myocardial infarction, and atrial fibrillation
    • Nattel S, Maguy A, Le Bouter S, Yeh YH. Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev. 2007;87:425-456.
    • (2007) Physiol Rev , vol.87 , pp. 425-456
    • Nattel, S.1    Maguy, A.2    Le Bouter, S.3    Yeh, Y.H.4
  • 3
    • 51749110724 scopus 로고    scopus 로고
    • Remodelling of gap junctions and connexin expression in diseased myocardium
    • Severs NJ, Bruce AF, Dupont E, Rothery S. Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res. 2008;80:9-19.
    • (2008) Cardiovasc Res , vol.80 , pp. 9-19
    • Severs, N.J.1    Bruce, A.F.2    Dupont, E.3    Rothery, S.4
  • 4
    • 84862262717 scopus 로고    scopus 로고
    • Arrhythmogenic implications of fibroblast-myocyte interactions
    • Rohr S. Arrhythmogenic implications of fibroblast-myocyte interactions. Circ Arrhythm Electrophysiol. 2012;5:442-452.
    • (2012) Circ Arrhythm Electrophysiol , vol.5 , pp. 442-452
    • Rohr, S.1
  • 5
    • 26844581525 scopus 로고    scopus 로고
    • Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure
    • Helm PA, Tseng HJ, Younes L, McVeigh ER, Winslow RL. Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure. Magn Reson Med. 2005;54:850-859.
    • (2005) Magn Reson Med , vol.54 , pp. 850-859
    • Helm, P.A.1    Tseng, H.J.2    Younes, L.3    McVeigh, E.R.4    Winslow, R.L.5
  • 8
    • 0028233422 scopus 로고
    • A dynamic model of the cardiac ventricular action potential I. Simulations of ionic currents and concentration changes
    • Luo CH, Rudy Y. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res. 1994;74:1071-1096.
    • (1994) Circ Res , vol.74 , pp. 1071-1096
    • Luo, C.H.1    Rudy, Y.2
  • 9
    • 79251636579 scopus 로고    scopus 로고
    • Whole-heart modeling: Applications to cardiac electrophysiology and electromechanics
    • Trayanova NA. Whole-heart modeling: applications to cardiac electrophysiology and electromechanics. Circ Res. 2011;108:113-128.
    • (2011) Circ Res , vol.108 , pp. 113-128
    • Trayanova, N.A.1
  • 13
    • 73349125098 scopus 로고    scopus 로고
    • Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure
    • Burstein B, Comtois P, Michael G, Nishida K, Villeneuve L, Yeh YH, Nattel S. Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure. Circ Res. 2009;105:1213-1222.
    • (2009) Circ Res , vol.105 , pp. 1213-1222
    • Burstein, B.1    Comtois, P.2    Michael, G.3    Nishida, K.4    Villeneuve, L.5    Yeh, Y.H.6    Nattel, S.7
  • 14
    • 79251647651 scopus 로고    scopus 로고
    • Alternans and arrhythmias: From cell to heart
    • Weiss JN, Nivala M, Garfinkel A, Qu Z. Alternans and arrhythmias: from cell to heart. Circ Res. 2011;108:98-112.
    • (2011) Circ Res , vol.108 , pp. 98-112
    • Weiss, J.N.1    Nivala, M.2    Garfinkel, A.3    Qu, Z.4
  • 15
    • 84864266812 scopus 로고    scopus 로고
    • Highresolution 3-dimensional reconstruction of the infarct border zone: Impact of structural remodeling on electrical activation
    • Rutherford SL, Trew ML, Sands GB, LeGrice IJ, Smaill BH. Highresolution 3-dimensional reconstruction of the infarct border zone: impact of structural remodeling on electrical activation. Circ Res. 2012;111:301-311.
    • (2012) Circ Res , vol.111 , pp. 301-311
    • Rutherford, S.L.1    Trew, M.L.2    Sands, G.B.3    Legrice, I.J.4    Smaill, B.H.5
  • 16
    • 0001376159 scopus 로고
    • The electrical constants of purkinje fibres
    • Weidman S. The electrical constants of Purkinje fibres. J Physiol. 1952;118:348-360
    • (1952) J Physiol , vol.118 , pp. 348-360
    • Weidman, S.1
  • 17
    • 0019365075 scopus 로고
    • The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents
    • Spach MS, Miller WT III, Geselowitz DB, Barr RC, Kootsey JM, Johnson EA. The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents. Circ Res. 1981;48:39-54.
    • (1981) Circ Res , vol.48 , pp. 39-54
    • Spach, M.S.1    Miller III, W.T.2    Geselowitz, D.B.3    Barr, R.C.4    Kootsey, J.M.5    Johnson, E.A.6
  • 18
    • 1942438935 scopus 로고    scopus 로고
    • Biophysical properties of homomeric and heteromultimeric channels formed by cardiac connexins
    • Moreno AP. Biophysical properties of homomeric and heteromultimeric channels formed by cardiac connexins. Cardiovasc Res. 2004;62:276-286.
    • (2004) Cardiovasc Res , vol.62 , pp. 276-286
    • Moreno, A.P.1
  • 19
    • 0023502646 scopus 로고
    • A model study of the effects of the discrete cellular structure on electrical propagation in cardiac tissue
    • Rudy Y, Quan WL. A model study of the effects of the discrete cellular structure on electrical propagation in cardiac tissue. Circ Res. 1987;61:815-823.
    • (1987) Circ Res , vol.61 , pp. 815-823
    • Rudy, Y.1    Quan, W.L.2
  • 20
    • 0030665763 scopus 로고    scopus 로고
    • Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-Type calcium currents during reduced excitability and decreased gap junction coupling
    • Shaw RM, Rudy Y. Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-Type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res. 1997;81:727-741.
    • (1997) Circ Res , vol.81 , pp. 727-741
    • Shaw, R.M.1    Rudy, Y.2
  • 21
    • 0029061766 scopus 로고
    • Cardiac tissue geometry as a determinant of unidirectional conduction block: Assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model
    • Fast VG, Kléber AG. Cardiac tissue geometry as a determinant of unidirectional conduction block: assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model. Cardiovasc Res. 1995;29:697-707.
    • (1995) Cardiovasc Res , vol.29 , pp. 697-707
    • Fast, V.G.1    Kléber, A.G.2
  • 22
    • 0032547804 scopus 로고    scopus 로고
    • Slow conduction in cardiac tissue, I: Effects of a reduction of excitability versus a reduction of electrical coupling on microconduction
    • Rohr S, Kucera JP, Kléber AG. Slow conduction in cardiac tissue, I: effects of a reduction of excitability versus a reduction of electrical coupling on microconduction. Circ Res. 1998;83:781-794.
    • (1998) Circ Res , vol.83 , pp. 781-794
    • Rohr, S.1    Kucera, J.P.2    Kléber, A.G.3
  • 24
    • 0035110241 scopus 로고    scopus 로고
    • Transient outward current modulates discontinuous conduction in rabbit ventricular cell pairs
    • Huelsing DJ, Pollard AE, Spitzer KW. Transient outward current modulates discontinuous conduction in rabbit ventricular cell pairs. Cardiovasc Res. 2001;49:779-789.
    • (2001) Cardiovasc Res , vol.49 , pp. 779-789
    • Huelsing, D.J.1    Pollard, A.E.2    Spitzer, K.W.3
  • 25
    • 1442359119 scopus 로고    scopus 로고
    • Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43
    • van Rijen HV, Eckardt D, Degen J, Theis M, Ott T, Willecke K, Jongsma HJ, Opthof T, de Bakker JM. Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43. Circulation. 2004;109: 1048-1055.
    • (2004) Circulation , vol.109 , pp. 1048-1055
    • Van Rijen, H.V.1    Eckardt, D.2    Degen, J.3    Theis, M.4    Ott, T.5    Willecke, K.6    Jongsma, H.J.7    Opthof, T.8    De Bakker, J.M.9
  • 27
    • 79957835117 scopus 로고    scopus 로고
    • A 50% reduction of excitability but not of intercellular coupling affects conduction velocity restitution and activation delay in the mouse heart
    • Stein M, van Veen TA, Hauer RN, de Bakker JM, van Rijen HV. A 50% reduction of excitability but not of intercellular coupling affects conduction velocity restitution and activation delay in the mouse heart. PLoS ONE. 2011;6:e20310.
    • (2011) PLoS ONE , vol.6
    • Stein, M.1    Van Veen, T.A.2    Hauer, R.N.3    De Bakker, J.M.4    Van Rijen, H.V.5
  • 28
    • 0030466763 scopus 로고    scopus 로고
    • Immunocytochemical localization of rH1 sodium channel in adult rat heart atria and ventricle. Presence in terminal intercalated disks
    • Cohen SA. Immunocytochemical localization of rH1 sodium channel in adult rat heart atria and ventricle. Presence in terminal intercalated disks. Circulation. 1996;94:3083-3086.
    • (1996) Circulation , vol.94 , pp. 3083-3086
    • Cohen, S.A.1
  • 30
    • 0034705469 scopus 로고    scopus 로고
    • Gap junctions in cardiovascular disease
    • Jongsma HJ, Wilders R. Gap junctions in cardiovascular disease. Circ Res. 2000;86:1193-1197.
    • (2000) Circ Res , vol.86 , pp. 1193-1197
    • Jongsma, H.J.1    Wilders, R.2
  • 31
    • 0036201740 scopus 로고    scopus 로고
    • Electric field interactions between closely abutting excitable cells
    • Sperelakis N, McConnell K. Electric field interactions between closely abutting excitable cells. IEEE Eng Med Biol Mag. 2002;21:77-89.
    • (2002) IEEE Eng Med Biol Mag , vol.21 , pp. 77-89
    • Sperelakis, N.1    McConnell, K.2
  • 32
    • 0036945719 scopus 로고    scopus 로고
    • Localization of sodium channels in intercalated disks modulates cardiac conduction
    • Kucera JP, Rohr S, Rudy Y. Localization of sodium channels in intercalated disks modulates cardiac conduction. Circ Res. 2002;91:1176-1182.
    • (2002) Circ Res , vol.91 , pp. 1176-1182
    • Kucera, J.P.1    Rohr, S.2    Rudy, Y.3
  • 33
    • 78650448740 scopus 로고    scopus 로고
    • Modeling electrical activity of myocardial cells incorporating the effects of ephaptic coupling
    • Lin J, Keener JP. Modeling electrical activity of myocardial cells incorporating the effects of ephaptic coupling. Proc Natl Acad Sci USA. 2010;107:20935-20940.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 20935-20940
    • Lin, J.1    Keener, J.P.2
  • 34
    • 84856009897 scopus 로고    scopus 로고
    • Structural remodeling and mechanical function in heart failure
    • Leonard BL, Smaill BH, LeGrice IJ. Structural remodeling and mechanical function in heart failure. Microsc Microanal. 2012;18:50-67.
    • (2012) Microsc Microanal , vol.18 , pp. 50-67
    • Leonard, B.L.1    Smaill, B.H.2    Legrice, I.J.3
  • 35
    • 79951938038 scopus 로고    scopus 로고
    • Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation
    • Yue L, Xie J, Nattel S. Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res. 2011;89:744-753.
    • (2011) Cardiovasc Res , vol.89 , pp. 744-753
    • Yue, L.1    Xie, J.2    Nattel, S.3
  • 36
    • 1842507518 scopus 로고    scopus 로고
    • Fibroblast network in rabbit sinoatrial node: Structural and functional identification of homogeneous and heterogeneous cell coupling
    • Camelliti P, Green CR, LeGrice I, Kohl P. Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling. Circ Res. 2004;94:828-835.
    • (2004) Circ Res , vol.94 , pp. 828-835
    • Camelliti, P.1    Green, C.R.2    Legrice, I.3    Kohl, P.4
  • 37
    • 33645743440 scopus 로고    scopus 로고
    • Electrotonic modulation of cardiac impulse conduction by myofibroblasts
    • Miragoli M, Gaudesius G, Rohr S. Electrotonic modulation of cardiac impulse conduction by myofibroblasts. Circ Res. 2006;98:801-810.
    • (2006) Circ Res , vol.98 , pp. 801-810
    • Miragoli, M.1    Gaudesius, G.2    Rohr, S.3
  • 38
    • 34547852342 scopus 로고    scopus 로고
    • Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts
    • Chilton L, Giles WR, Smith GL. Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. J Physiol (Lond). 2007;583:225-236.
    • (2007) J Physiol (Lond) , vol.583 , pp. 225-236
    • Chilton, L.1    Giles, W.R.2    Smith, G.L.3
  • 40
    • 33846508259 scopus 로고    scopus 로고
    • A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts
    • MacCannell KA, Bazzazi H, Chilton L, Shibukawa Y, Clark RB, Giles WR. A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts. Biophys J. 2007;92:4121-4132.
    • (2007) Biophys J , vol.92 , pp. 4121-4132
    • MacCannell, K.A.1    Bazzazi, H.2    Chilton, L.3    Shibukawa, Y.4    Clark, R.B.5    Giles, W.R.6
  • 41
    • 70449109710 scopus 로고    scopus 로고
    • Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization
    • Maleckar MM, Greenstein JL, Giles WR, Trayanova NA. Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization. Biophys J. 2009;97:2179-2190.
    • (2009) Biophys J , vol.97 , pp. 2179-2190
    • Maleckar, M.M.1    Greenstein, J.L.2    Giles, W.R.3    Trayanova, N.A.4
  • 42
    • 80053110376 scopus 로고    scopus 로고
    • Susceptibility to arrhythmia in the infarcted heart depends on myofibroblast density
    • McDowell KS, Arevalo HJ, Maleckar MM, Trayanova NA. Susceptibility to arrhythmia in the infarcted heart depends on myofibroblast density. Biophys J. 2011;101:1307-1315.
    • (2011) Biophys J , vol.101 , pp. 1307-1315
    • McDowell, K.S.1    Arevalo, H.J.2    Maleckar, M.M.3    Trayanova, N.A.4
  • 44
    • 0028284599 scopus 로고
    • Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium
    • Saffitz JE, Kanter HL, Green KG, Tolley TK, Beyer EC. Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ Res. 1994;74:1065-1070.
    • (1994) Circ Res , vol.74 , pp. 1065-1070
    • Saffitz, J.E.1    Kanter, H.L.2    Green, K.G.3    Tolley, T.K.4    Beyer, E.C.5
  • 45
    • 0029151575 scopus 로고
    • Laminar structure of the heart: Ventricular myocyte arrangement and connective tissue architecture in the dog
    • LeGrice IJ, Smaill BH, Chai LZ, Edgar SG, Gavin JB, Hunter PJ. Laminar structure of the heart: ventricular myocyte arrangement and connective tissue architecture in the dog. Am J Physiol. 1995;269:H571-H582.
    • (1995) Am J Physiol , vol.269
    • Legrice, I.J.1    Smaill, B.H.2    Chai, L.Z.3    Edgar, S.G.4    Gavin, J.B.5    Hunter, P.J.6
  • 46
    • 79955393914 scopus 로고    scopus 로고
    • Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayers
    • Auerbach DS, Grzda KR, Furspan PB, Sato PY, Mironov S, Jalife J. Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayers. J Physiol (Lond). 2011;589:2363-2381.
    • (2011) J Physiol (Lond) , vol.589 , pp. 2363-2381
    • Auerbach, D.S.1    Grzda, K.R.2    Furspan, P.B.3    Sato, P.Y.4    Mironov, S.5    Jalife, J.6
  • 47
    • 0028061307 scopus 로고
    • Wave-front curvature as a cause of slow conduction and block in isolated cardiac muscle
    • Cabo C, Pertsov AM, Baxter WT, Davidenko JM, Gray RA, Jalife J. Wave-front curvature as a cause of slow conduction and block in isolated cardiac muscle. Circ Res. 1994;75:1014-1028.
    • (1994) Circ Res , vol.75 , pp. 1014-1028
    • Cabo, C.1    Pertsov, A.M.2    Baxter, W.T.3    Davidenko, J.M.4    Gray, R.A.5    Jalife, J.6
  • 48
    • 0034051941 scopus 로고    scopus 로고
    • Action potential propagation in inhomogeneous cardiac tissue: Safety factor considerations and ionic mechanism
    • Wang Y, Rudy Y. Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism. Am J Physiol Heart Circ Physiol. 2000;278:H1019-H1029.
    • (2000) Am J Physiol Heart Circ Physiol , vol.278
    • Wang, Y.1    Rudy, Y.2
  • 49
    • 0344431276 scopus 로고    scopus 로고
    • Slow conduction in cardiac tissue ii: Effects of branching tissue geometry
    • Kucera JP, Kléber AG, Rohr S. Slow conduction in cardiac tissue, II: effects of branching tissue geometry. Circ Res. 1998;83:795-805.
    • (1998) Circ Res , vol.83 , pp. 795-805
    • Kucera, J.P.1    Kléber, A.G.2    Rohr, S.3
  • 50
    • 0035955759 scopus 로고    scopus 로고
    • Mechanistic insights into very slow conduction in branching cardiac tissue: A model study
    • Kucera JP, Rudy Y. Mechanistic insights into very slow conduction in branching cardiac tissue: a model study. Circ Res. 2001;89:799-806.
    • (2001) Circ Res , vol.89 , pp. 799-806
    • Kucera, J.P.1    Rudy, Y.2
  • 51
    • 74949089885 scopus 로고    scopus 로고
    • Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function
    • Bishop MJ, Plank G, Burton RA, Schneider JE, Gavaghan DJ, Grau V, Kohl P. Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function. Am J Physiol Heart Circ Physiol. 2010;298:H699-H718.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Bishop, M.J.1    Plank, G.2    Burton, R.A.3    Schneider, J.E.4    Gavaghan, D.J.5    Grau, V.6    Kohl, P.7
  • 54
    • 70349288385 scopus 로고    scopus 로고
    • Three distinct directions of intramural activation reveal nonuniform side-To-side electrical coupling of ventricular myocytes
    • Caldwell BJ, Trew ML, Sands GB, Hooks DA, LeGrice IJ, Smaill BH. Three distinct directions of intramural activation reveal nonuniform side-To-side electrical coupling of ventricular myocytes. Circ Arrhythm Electrophysiol. 2009;2:433-440.
    • (2009) Circ Arrhythm Electrophysiol , vol.2 , pp. 433-440
    • Caldwell, B.J.1    Trew, M.L.2    Sands, G.B.3    Hooks, D.A.4    Legrice, I.J.5    Smaill, B.H.6
  • 55
    • 0034730304 scopus 로고    scopus 로고
    • A computer model of normal conduction in the human atria
    • Harrild D, Henriquez C. A computer model of normal conduction in the human atria. Circ Res. 2000;87:E25-E36.
    • (2000) Circ Res , vol.87
    • Harrild, D.1    Henriquez, C.2
  • 59
    • 84871952356 scopus 로고    scopus 로고
    • Imagebased model of atrial anatomy and electrical activation: A computational platform for investigating atrial arrhythmia
    • Zhao J, Butters TD, Zhang H, Legrice IJ, Sands GB, Smaill BH. Imagebased model of atrial anatomy and electrical activation: a computational platform for investigating atrial arrhythmia. IEEE Trans Med Imaging. 2013;32:18-27.
    • (2013) IEEE Trans Med Imaging , vol.32 , pp. 18-27
    • Zhao, J.1    Butters, T.D.2    Zhang, H.3    Legrice, I.J.4    Sands, G.B.5    Smaill, B.H.6
  • 60
    • 20044378836 scopus 로고    scopus 로고
    • Computer three-dimensional reconstruction of the sinoatrial node
    • Dobrzynski H, Li J, Tellez J, et al. Computer three-dimensional reconstruction of the sinoatrial node. Circulation. 2005;111:846-854.
    • (2005) Circulation , vol.111 , pp. 846-854
    • Dobrzynski, H.1    Li, J.2    Tellez, J.3
  • 62
    • 77956585767 scopus 로고    scopus 로고
    • So little source, so much sink: Requirements for afterdepolarizations to propagate in tissue
    • Xie Y, Sato D, Garfinkel A, Qu Z, Weiss JN. So little source, so much sink: requirements for afterdepolarizations to propagate in tissue. Biophys J. 2010;99:1408-1415.
    • (2010) Biophys J , vol.99 , pp. 1408-1415
    • Xie, Y.1    Sato, D.2    Garfinkel, A.3    Qu, Z.4    Weiss, J.N.5
  • 65
    • 33846829659 scopus 로고    scopus 로고
    • Action potential duration dispersion and alternans in simulated heterogeneous cardiac tissue with a structural barrier
    • Krogh-Madsen T, Christini DJ. Action potential duration dispersion and alternans in simulated heterogeneous cardiac tissue with a structural barrier. Biophys J. 2007;92:1138-1149.
    • (2007) Biophys J , vol.92 , pp. 1138-1149
    • Krogh-Madsen, T.1    Christini, D.J.2
  • 66
    • 77951933461 scopus 로고    scopus 로고
    • Structural heterogeneity alone is a sufficient substrate for dynamic instability and altered restitution
    • Engelman ZJ, Trew ML, Smaill BH. Structural heterogeneity alone is a sufficient substrate for dynamic instability and altered restitution. Circ Arrhythm Electrophysiol. 2010;3:195-203.
    • (2010) Circ Arrhythm Electrophysiol , vol.3 , pp. 195-203
    • Engelman, Z.J.1    Trew, M.L.2    Smaill, B.H.3
  • 67
    • 84865581574 scopus 로고    scopus 로고
    • Transient outward K+ current reduction prolongs action potentials and promotes afterdepolarisations: A dynamic-clamp study in human and rabbit cardiac atrial myocytes
    • Workman AJ, Marshall GE, Rankin AC, Smith GL, Dempster J. Transient outward K+ current reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. J Physiol (Lond). 2012;590:4289-4305.
    • (2012) J Physiol (Lond) , vol.590 , pp. 4289-4305
    • Workman, A.J.1    Marshall, G.E.2    Rankin, A.C.3    Smith, G.L.4    Dempster, J.5
  • 68
    • 58049185304 scopus 로고    scopus 로고
    • Atrial septopulmonary bundle of the posterior left atrium provides a substrate for atrial fibrillation initiation in a model of vagally mediated pulmonary vein tachycardia of the structurally normal heart
    • Klos M, Calvo D, Yamazaki M, Zlochiver S, Mironov S, Cabrera JA, Sanchez-Quintana D, Jalife J, Berenfeld O, Kalifa J. Atrial septopulmonary bundle of the posterior left atrium provides a substrate for atrial fibrillation initiation in a model of vagally mediated pulmonary vein tachycardia of the structurally normal heart. Circ Arrhythm Electrophysiol. 2008;1:175-183.
    • (2008) Circ Arrhythm Electrophysiol , vol.1 , pp. 175-183
    • Klos, M.1    Calvo, D.2    Yamazaki, M.3    Zlochiver, S.4    Mironov, S.5    Cabrera, J.A.6    Sanchez-Quintana, D.7    Jalife, J.8    Berenfeld, O.9    Kalifa, J.10
  • 69
    • 84860837931 scopus 로고    scopus 로고
    • Clinical mapping approach to diagnose electrical rotors and focal impulse sources for human atrial fibrillation
    • Narayan SM, Krummen DE, Rappel WJ. Clinical mapping approach to diagnose electrical rotors and focal impulse sources for human atrial fibrillation. J Cardiovasc Electrophysiol. 2012;23:447-454.
    • (2012) J Cardiovasc Electrophysiol , vol.23 , pp. 447-454
    • Narayan, S.M.1    Krummen, D.E.2    Rappel, W.J.3
  • 71
    • 0037076797 scopus 로고    scopus 로고
    • Frequencydependent breakdown of wave propagation into fibrillatory conduction across the pectinate muscle network in the isolated sheep right atrium
    • Berenfeld O, Zaitsev AV, Mironov SF, Pertsov AM, Jalife J. Frequencydependent breakdown of wave propagation into fibrillatory conduction across the pectinate muscle network in the isolated sheep right atrium. Circ Res. 2002;90:1173-1180.
    • (2002) Circ Res , vol.90 , pp. 1173-1180
    • Berenfeld, O.1    Zaitsev, A.V.2    Mironov, S.F.3    Pertsov, A.M.4    Jalife, J.5
  • 73
    • 84867767699 scopus 로고    scopus 로고
    • Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation
    • Harada M, Luo X, Qi XY, et al. Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation. 2012;126:2051-2064.
    • (2012) Circulation , vol.126 , pp. 2051-2064
    • Harada, M.1    Luo, X.2    Qi, X.Y.3
  • 74
    • 84856030636 scopus 로고    scopus 로고
    • The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: Implications for electrogram-based catheter ablation
    • Ashihara T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Nakazawa Y, Ozawa T, Ito M, Horie M, Trayanova NA. The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: implications for electrogram-based catheter ablation. Circ Res. 2012;110:275-284.
    • (2012) Circ Res , vol.110 , pp. 275-284
    • Ashihara, T.1    Haraguchi, R.2    Nakazawa, K.3    Namba, T.4    Ikeda, T.5    Nakazawa, Y.6    Ozawa, T.7    Ito, M.8    Horie, M.9    Trayanova, N.A.10
  • 75
    • 79959960476 scopus 로고    scopus 로고
    • Repolarization alternans reveals vulnerability to human atrial fibrillation
    • Narayan SM, Franz MR, Clopton P, Pruvot EJ, Krummen DE. Repolarization alternans reveals vulnerability to human atrial fibrillation. Circulation. 2011;123:2922-2930.
    • (2011) Circulation , vol.123 , pp. 2922-2930
    • Narayan, S.M.1    Franz, M.R.2    Clopton, P.3    Pruvot, E.J.4    Krummen, D.E.5
  • 76
    • 84873870254 scopus 로고    scopus 로고
    • Mechanisms of human atrial fibrillation initiation: Clinical and computational studies of repolarization restitution and activation latency
    • Krummen DE, Bayer JD, Ho J, Ho G, Smetak MR, Clopton P, Trayanova NA, Narayan SM. Mechanisms of human atrial fibrillation initiation: clinical and computational studies of repolarization restitution and activation latency. Circ Arrhythm Electrophysiol. 2012;5:1149-1159.
    • (2012) Circ Arrhythm Electrophysiol , vol.5 , pp. 1149-1159
    • Krummen, D.E.1    Bayer, J.D.2    Ho, J.3    Ho, G.4    Smetak, M.R.5    Clopton, P.6    Trayanova, N.A.7    Narayan, S.M.8
  • 78
    • 67549109080 scopus 로고    scopus 로고
    • Role of the His-Purkinje system in the genesis of cardiac arrhythmia
    • Scheinman MM. Role of the His-Purkinje system in the genesis of cardiac arrhythmia. Heart Rhythm. 2009;6:1050-1058.
    • (2009) Heart Rhythm , vol.6 , pp. 1050-1058
    • Scheinman, M.M.1
  • 80
    • 79954594124 scopus 로고    scopus 로고
    • Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis
    • Priori SG, Chen SR. Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis. Circ Res. 2011;108:871-883.
    • (2011) Circ Res , vol.108 , pp. 871-883
    • Priori, S.G.1    Chen, S.R.2
  • 81
    • 26844449563 scopus 로고    scopus 로고
    • Contributions of Purkinje-myocardial coupling to suppression and facilitation of early afterdepolarization-induced triggered activity
    • Schafferhofer-Steltzer I, Hofer E, Huelsing DJ, Bishop SP, Pollard AE. Contributions of Purkinje-myocardial coupling to suppression and facilitation of early afterdepolarization-induced triggered activity. IEEE Trans Biomed Eng. 2005;52:1522-1531.
    • (2005) IEEE Trans Biomed Eng , vol.52 , pp. 1522-1531
    • Schafferhofer-Steltzer, I.1    Hofer, E.2    Huelsing, D.J.3    Bishop, S.P.4    Pollard, A.E.5
  • 82
    • 79959984154 scopus 로고    scopus 로고
    • A model of canine purkinje cell electrophysiology and Ca2+ cycling: Rate dependence, triggered activity, and comparison to ventricular myocytes
    • Li P, Rudy Y. A model of canine purkinje cell electrophysiology and Ca2+ cycling: rate dependence, triggered activity, and comparison to ventricular myocytes. Circ Res. 2011;109:71-79.
    • (2011) Circ Res , vol.109 , pp. 71-79
    • Li, P.1    Rudy, Y.2
  • 83
    • 0032104217 scopus 로고    scopus 로고
    • Purkinje-muscle reentry as a mechanism of polymorphic ventricular arrhythmias in a 3-dimensional model of the ventricles
    • Berenfeld O, Jalife J. Purkinje-muscle reentry as a mechanism of polymorphic ventricular arrhythmias in a 3-dimensional model of the ventricles. Circ Res. 1998;82:1063-1077.
    • (1998) Circ Res , vol.82 , pp. 1063-1077
    • Berenfeld, O.1    Jalife, J.2
  • 87
    • 0037423877 scopus 로고    scopus 로고
    • Cx43 and dual-pathway electrophysiology of the atrioventricular node and atrioventricular nodal reentry
    • Nikolski VP, Jones SA, Lancaster MK, Boyett MR, Efimov IR. Cx43 and dual-pathway electrophysiology of the atrioventricular node and atrioventricular nodal reentry. Circ Res. 2003;92:469-475.
    • (2003) Circ Res , vol.92 , pp. 469-475
    • Nikolski, V.P.1    Jones, S.A.2    Lancaster, M.K.3    Boyett, M.R.4    Efimov, I.R.5
  • 88
    • 0037423821 scopus 로고    scopus 로고
    • Remodeling of gap junctional channel function in epicardial border zone of healing canine infarcts
    • Yao JA, Hussain W, Patel P, Peters NS, Boyden PA, Wit AL. Remodeling of gap junctional channel function in epicardial border zone of healing canine infarcts. Circ Res. 2003;92:437-443.
    • (2003) Circ Res , vol.92 , pp. 437-443
    • Yao, J.A.1    Hussain, W.2    Patel, P.3    Peters, N.S.4    Boyden, P.A.5    Wit, A.L.6
  • 90
    • 0025905587 scopus 로고
    • Remodeling of ventricular conduction pathways in healed canine infarct border zones
    • Luke RA, Saffitz JE. Remodeling of ventricular conduction pathways in healed canine infarct border zones. J Clin Invest. 1991;87:1594-1602.
    • (1991) J Clin Invest , vol.87 , pp. 1594-1602
    • Luke, R.A.1    Saffitz, J.E.2
  • 91
    • 0021914173 scopus 로고
    • Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing
    • Ursell PC, Gardner PI, Albala A, Fenoglio JJ Jr, Wit AL. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ Res. 1985;56:436-451.
    • (1985) Circ Res , vol.56 , pp. 436-451
    • Ursell, P.C.1    Gardner, P.I.2    Albala, A.3    Fenoglio Jr., J.J.4    Wit, A.L.5
  • 92
    • 0030969591 scopus 로고    scopus 로고
    • Alterations of Na+ currents in myocytes from epicardial border zone of the infarcted heart. A possible ionic mechanism for reduced excitability and postrepolarization refractoriness
    • Pu J, Boyden PA. Alterations of Na+ currents in myocytes from epicardial border zone of the infarcted heart. A possible ionic mechanism for reduced excitability and postrepolarization refractoriness. Circ Res. 1997;81:110-119.
    • (1997) Circ Res , vol.81 , pp. 110-119
    • Pu, J.1    Boyden, P.A.2
  • 93
    • 4143124380 scopus 로고    scopus 로고
    • Dynamic remodeling of K+ and Ca2+ currents in cells that survived in the epicardial border zone of canine healed infarcted heart
    • Dun W, Baba S, Yagi T, Boyden PA. Dynamic remodeling of K+ and Ca2+ currents in cells that survived in the epicardial border zone of canine healed infarcted heart. Am J Physiol Heart Circ Physiol. 2004;287:H1046-H1054.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Dun, W.1    Baba, S.2    Yagi, T.3    Boyden, P.A.4
  • 97
    • 33748319556 scopus 로고    scopus 로고
    • Effect of changes in action potential spike configuration, junctional sarcoplasmic reticulum micro-architecture and altered t-Tubule structure in human heart failure
    • Cannell MB, Crossman DJ, Soeller C. Effect of changes in action potential spike configuration, junctional sarcoplasmic reticulum micro-architecture and altered t-Tubule structure in human heart failure. J Muscle Res Cell Motil. 2006;27:297-306.
    • (2006) J Muscle Res Cell Motil , vol.27 , pp. 297-306
    • Cannell, M.B.1    Crossman, D.J.2    Soeller, C.3
  • 98
    • 0023907606 scopus 로고
    • Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart
    • Coronel R, Fiolet JW, Wilms-Schopman FJ, Schaapherder AF, Johnson TA, Gettes LS, Janse MJ. Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart. Circulation. 1988;77:1125-1138.
    • (1988) Circulation , vol.77 , pp. 1125-1138
    • Coronel, R.1    Fiolet, J.W.2    Wilms-Schopman, F.J.3    Schaapherder, A.F.4    Johnson, T.A.5    Gettes, L.S.6    Janse, M.J.7
  • 100
    • 0031868917 scopus 로고    scopus 로고
    • Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans
    • Rossi MA. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens. 1998;16:1031-1041.
    • (1998) J Hypertens , vol.16 , pp. 1031-1041
    • Rossi, M.A.1
  • 105
    • 55949136438 scopus 로고    scopus 로고
    • Action potential dynamics explain arrhythmic vulnerability in human heart failure: A clinical and modeling study implicating abnormal calcium handling
    • Narayan SM, Bayer JD, Lalani G, Trayanova NA. Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handling. J Am Coll Cardiol. 2008;52:1782-1792.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1782-1792
    • Narayan, S.M.1    Bayer, J.D.2    Lalani, G.3    Trayanova, N.A.4
  • 106
    • 0037306333 scopus 로고    scopus 로고
    • Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model
    • Ten Tusscher KH, Panfilov AV. Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model. Am J Physiol Heart Circ Physiol. 2003;284:H542-H548.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284
    • Ten Tusscher, K.H.1    Panfilov, A.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.