Transient outward K+ current reduction prolongs action potentials and promotes afterdepolarisations: A dynamic-clamp study in human and rabbit cardiac atrial myocytes

Journal of Physiology

Volumn 590, Issue 17, 2012, Pages 4289-4305

  Workman, A J ^a   Marshall, G E ^a   Rankin, A C ^a   Smith, G L ^a   Dempster, J ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL MEMBRANE DEPOLARIZATION; CELL STIMULATION; CONTROLLED STUDY; HEART ATRIUM FIBRILLATION; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HUMAN; HUMAN CELL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT;

ACTION POTENTIALS; ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ADRENERGIC BETA-AGONISTS; ANIMALS; ARRHYTHMIAS, CARDIAC; ATENOLOL; ELECTRIC STIMULATION; ELECTROPHYSIOLOGICAL PHENOMENA; HEART ATRIA; HUMANS; ION TRANSPORT; ISOPROTERENOL; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS; RABBITS;

EID: 84865581574     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.235986     Document Type: Article

References (47)

1. 2+ exchange to action potential of human atrial myocytes. Am J Physiol Heart Circ Physiol 271, H1151-H1161.
2. Cha TJ, Ehrlich JR, Chartier D, Qi XY, Xiao L & Nattel S (2006). Kir3-based inward rectifier potassium current: potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmias. Circulation 113, 1730-1737.
3. K, ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation. Br J Pharmacol 154, 1619-1630.
4. Courtemanche M, Ramirez RJ & Nattel S (1998). Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol Heart Circ Physiol 275, H301-H321.
5. de Abreu LRP, de Castro SAC & Pedrazzoli J Jr (2003). Atenolol quantification in human plasma by high-performance liquid chromatography: application to bioequivalence study. AAPS PharmSci 5, 1-7.
6. Dobrev D, Carlsson L & Nattel S (2012). Novel molecular targets for atrial fibrillation therapy. Nat Rev Drug Discov 11, 275-291.
7. K, ACh is constitutively active in patients with chronic atrial fibrillation. Circulation 112, 3697-3706.
8. to on guinea pig and canine ventricular action potential morphology. Am J Physiol Heart Circ Physiol 291, H631-H637.
9. Dong M, Yan S, Chen Y, Niklewski PJ, Sun X, Chenault K & Wang HS (2010). Role of the transient outward current in regulating mechanical properties of canine ventricular myocytes. J Cardiovasc Electrophysiol 21, 697-703.
10. Drummond GB (2009). Reporting ethical matters in The Journal of Physiology: standards and advice. J Physiol 587, 713-719.
11. + current in canine atrial myocytes. Circ Res 93, 744-751.
12. Fermini B, Wang Z, Duan D & Nattel S (1992). Differences in rate dependence of transient outward current in rabbit and human atrium. Am J Physiol Heart Circ Physiol 263, H1747-H1754.
13. Giles WR & Imaizumi Y (1988). Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol 405, 123-145.
14. 2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res 109, 1055-1066.
15. Gross GJ & Castle NA (1998). Propafenone inhibition of human atrial myocyte repolarizing currents. J Mol Cell Cardiol 30, 783-793.
16. Johnson N, Danilo P Jr, Wit AL & Rosen MR (1986). Characteristics of initiation and termination of catecholamine-induced triggered activity in atrial fibers of the coronary sinus. Circulation 74, 1168-1179.
17. Le Grand B, Hatem S, Deroubaix E, Couetil JP & Coraboeuf E (1994). Depressed transient outward and calcium currents in dilated human atria. Cardiovasc Res 28, 548-556.
18. Lindblad DS, Murphey CR, Clark JW & Giles WR (1996). A model of the action potential and underlying membrane currents in a rabbit atrial cell. Am J Physiol Heart Circ Physiol 271, H1666-H1696.
19. 2+ conductance to suppress early afterdepolarizations in cardiac myocytes. J Physiol 589, 6081-6092.
20. + currents but not ion channel expression by chronic β-blockade. Pflugers Arch 463, 537-548.
21. Nattel S, Maguy A, Le Bouter S & Yeh YH (2007). Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev 87, 425-456.
22. + currents in repolarization. Circ Res 82, 63-81.
23. Pandit SV, Berenfeld O, Anumonwo JMB, Zaritski RM, Kneller J, Nattel S & Jalife J (2005). Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation. Biophys J 88, 3806-3821.
24. Redpath CJ, Rankin AC, Kane KA & Workman AJ (2006). Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic. J Mol Cell Cardiol 40, 717-724.
25. v4.2N transgenic mice. Circulation 105, 1850-1856.
26. to). J Physiol 546, 5-18.
27. 2+-exchange. Cardiovasc Res 73, 37-47.
28. Schotten U, Verheule S, Kirchhof P & Goette A (2011). Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiol Rev 91, 265-325.
29. to) in shaping canine ventricular action potential - a dynamic clamp study. J Physiol 564, 411-419.
30. + current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ Res 80, 772-781.
31. Varro A, Virag L & Papp JG (1996). Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes. Br J Pharmacol 117, 1181-1186.
32. 2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation 125, 2059-2070.
33. Wagner MB, Kumar R, Joyner RW & Wang Y (2004). Induced automaticity in isolated rat atrial cells by incorporation of a stretch-activated conductance. Pflugers Arch 447, 819-829.
34. + current in rabbit and human atrial myocytes. Circ Res 84, 551-561.
35. + current similar to Kv1.5 cloned channel currents. Circ Res 73, 1061-1076.
36. Wang Z, Fermini B & Nattel S (1995). Effects of flecainide, quinidine, and 4-aminopyridine on transient outward and ultrarapid delayed rectifier currents in human atrial myocytes. J Pharmacol Exp Thera 272, 184-196.
37. Kur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation. Circulation 110, 2299-2306.
38. Wilders R (2006). Dynamic clamp: a powerful tool in cardiac electrophysiology. J Physiol 576, 349-359.
39. Workman AJ (2010). Cardiac adrenergic control and atrial fibrillation. Naunyn Schmiedebergs Arch Pharmacol 381, 235-249.
40. Workman AJ, Kane KA & Rankin AC (2001). The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovasc Res 52, 226-235.
41. Workman AJ, Kane KA & Rankin AC (2008). Cellular bases for human atrial fibrillation. Heart Rhythm 5, S1-S6.
42. Workman AJ, Kane KA, Russell JA, Norrie J & Rankin AC (2003). Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling. Cardiovasc Res 58, 518-525.
43. Workman AJ, Kane KA & Rankin AC (2000). Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium. J Mol Cell Cardiol 32, 1525-1537.
44. Workman AJ, Pau D, Redpath CJ, Marshall GE, Russell JA, Norrie J, Kane KA & Rankin AC (2009). Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF. Heart Rhythm 6, 445-451.
45. Workman AJ, Smith GL & Rankin AC (2011). Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacol Ther 131, 221-241.
46. Xu H, Li H & Nerbonne JM (1999). Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 α subunit. J Physiol 519, 11-21.
47. K1 in action potential shortening associated with atrial fibrillation in humans. Cardiovasc Res 66, 493-502.