Action potential propagation in inhomogeneous cardiac tissue: Safety factor considerations and ionic mechanism

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 278, Issue 4 47-4, 2000, Pages

  Wang, Yan ^a   Rudy, Yoram ^a,b  

^a Case Western Reserve University ^*  (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Calcium current; Inhomogeneities; Sodium current

Indexed keywords

ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; GAP JUNCTION; GUINEA PIG; HEART MUSCLE EXCITABILITY; HEART MUSCLE POTENTIAL; HYPERKALEMIA; NONHUMAN; PRIORITY JOURNAL; SAFETY; SODIUM CURRENT;

EID: 0034051941     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.278.4.h1019     Document Type: Article

References (41)

1. 2+ currents in myocytes surviving in the epicardial border zone of the 5-day infarcted canine heart. Circ Res 77: 1180-1191, 1995.
2. Beeler GW and Reuter H. Reconstruction of the action potential of ventricular myocardial fibres. J Physiol (Lond) 268: 177-210, 1977.
3. Cabo C, Pertsov AM, Baxter WT, Davidenko JM, Gray RA, and Jalife J. Wave-front curvature as a cause of slow conduction and block in isolated cardiac muscle. Circ Res 75: 1014-1028, 1994.
4. De Bakker JM, van Capelle FJ, Janse MJ, Tasseron S, Vermeulen JT, de Jonge N, and Lahpor JR. Slow conduction in the infarcted human heart. "Zigzag" course of activation. Circulation 88: 915-926, 1993.
5. Dillon SM, Allessie MA, Ursell PC, and Wit AL. Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts. Circ Res 63: 182-206, 1988.
6. Fareh S, Villemaire C, and Nattel S. Importance of refractoriness heterogeneity in the enhanced vulnerability to atrial fibrillation induction caused by tachycardia-induced atrial electrical remodeling. Circulation 98: 2202-2209, 1998.
7. Fast VG and Kleber AG. Block of impulse propagation at an abrupt tissue expansion: evaluation of the critical strand diameter in 2-and 3-dimensional computer models. Cardiovasc Res 30: 449-459, 1995.
8. Fast VG and Kleber AG. Cardiac tissue geometry as a determinant of unidirectional conduction block: assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model. Cardiovasc Res 29: 697-707, 1995.
9. FitzHugh RA. Impulses and physiological states in theoretical models of nerve membrane. Biophys J 1: 445-466, 1961.
10. + current in a chronic dog model of atrial fibrillation. Circ Res 81: 1045-1052, 1997.
11. Goldstein SS and Rall W. Changes of action potential shape and velocity for changing core conductor geometry. Biophys J 14: 731-757, 1974.
12. Huang XD, Sandusky GE, and Zipes DP. Heterogeneous loss of connexin43 protein in ischemic dog hearts. J Cardiovasc Electrophysiol 10: 79-91, 1999.
13. Joyner RW. Mechanisms of unidirectional block in cardiac tissues. Biophys J 35: 113-125, 1981.
14. Joyner RW, Kumar R, Wilders R, Jongsma HJ, Verheijck EE, Golod DA, Van Ginneken AC, Wagner MB, and Goolsby WN. Modulating L-type calcium current affects discontinuous cardiac action potential conduction. Biophys J 71: 237-245, 1996.
15. Joyner RW, Picone J, Veenstra R, and Rawling D. Propagation through electrically coupled cells. Effects of regional changes in membrane properties. Circ Res 53: 526-534, 1983.
16. Joyner RW, Veenstra R, Rawling D, and Chorro A. Propagation through electrically coupled cells. Effects of a resistive barrier. Biophys J 45: 1017-1025, 1984.
17. Kagiyama Y, Hill JL, and Gettes LS. Interaction of acidosis and increased extracellular potassium on action potential characteristics and conduction in guinea pig ventricular muscle. Circ Res 51: 614-623, 1982.
18. Kucera JP, Kleber AG, and Rohr S. Slow conduction in cardiac tissue. II. Effects of branching tissue geometry. Circ Res 83: 795-805, 1998.
19. Kumar R and Joyner RW. Calcium currents of ventricular cell pairs during action potential conduction. Am J Physiol Heart Circ Physiol 268: H2476-H2486, 1995.
20. Leon LJ and Roberge FA. Directional characteristics of action potential propagation in cardiac muscle. A model study. Circ Res 69: 378-395, 1991.
21. Luo CH and Rudy Y. A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circ Res 68: 1501-1526, 1991.
22. Luo CH and Rudy Y. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res 74: 1071-1096, 1994.
23. Nagumo J, Arimoto S, and Yoshizawa S. An active pulse transmission line simulating nerve axon. Proc IRE 50: 2061-2070, 1962.
24. Peters NS, Coromilas J, Severs NJ, and Wit AL. Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation 95: 988-996, 1997.
25. + currents in myocytes from epicardial border zone of the infarcted heart. A possible ionic mechanism for reduced excitability and postrepolarization refractoriness. Circ Res 81: 110-119, 1997.
26. Rohr S and Kucera JP. Involvement of the calcium inward current in cardiac impulse propagation: induction of unidirectional conduction block by nifedipine and reversal by Bay K 8644. Biophys J 72: 754-766, 1997.
27. Rohr S, Kucera JP, Fast VG, and Kleber AG. Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling. Science 275: 841-844, 1997.
28. Rohr S, Kucera JP, and Kleber AG. Slow conduction in cardiac tissue. I. Effects of a reduction of excitability versus a reduction of electrical coupling on microconduction. Circ Res 83: 781-794, 1998.
29. Rudy Y and Quan W. Propagation delays across gap junctions and their reflection in extracellular potentials: a simulation study. J Cardiovasc Electrophysiol 2: 299-315, 1991.
30. Rudy Y and Quan WL. A model study of the effects of the discrete cellular structure on electrical propagation in cardiac tissue. Circ Res 61: 815-823, 1987.
31. Sahakian AV, Myers GA, and Maglaveras N. Unidirectional block in cardiac fibers: effects of discontinuities in coupling resistance and spatial changes in resting membrane potential in a computer simulation study. IEEE Trans Biomed Eng 39: 510-522, 1992.
32. Shaw RM and Rudy Y. Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure. Circ Res 80: 124-138, 1997.
33. Shaw RM and Rudy Y. Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovasc Res 35: 256-272, 1997.
34. Shaw RM and Rudy Y. Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res 81: 727-741, 1997.
35. Spach MS and Dolber PC. Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age. Circ Res 58: 356-371, 1986.
36. Spach MS and Heidlage JF. The stochastic nature of cardiac propagation at a microscopic level. Electrical description of myocardial architecture and its application to conduction. Circ Res 76: 366-380, 1995.
37. Ursell PC, Gardner PI, Albala A, Fenoglio JJ Jr, and Wit AL. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ Res 56: 436-451, 1985.
38. Ks heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation 99: 2466-2474, 1999.
39. Wang Y and Rudy Y. Effects of structural and membrane inhomogeneities on action potential propagation in cardiac tissue: conduction safety and ionic mechanisms (Abstract). Biophys J 76: A88, 1999.
40. Yue L, Feng J, Gaspo R, Li GR, Wang Z, and Nattel S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res 81: 512-525, 1997.
41. + current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circ Res 77: 140-152, 1995.