Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes

Journal of Endocrinology

Volumn 216, Issue 2, 2013, Pages 111-123

  Bogdani, Marika ^a   Henschel, Angela M ^b   Kansra, Sanjay ^b   Fuller, Jessica M ^c   Geoffrey, Rhonda ^b   Jia, Shuang ^b   Kaldunski, Mary L ^b   Pavletich, Scott ^b   Prosser, Simon ^b   Chen, Yi Guang ^b   Lernmark, Åke ^d   Hessner, Martin J ^b  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^b Children's Hospital of Wisconsin   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

5 OXOPROLINASE; ACETYLCYSTEINE; ANTIOXIDANT; APOLIPOPROTEIN E; EXTRACELLULAR SUPEROXIDE DISMUTASE; GAMMA INTERFERON; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M2; GLUTATHIONE TRANSFERASE M7; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; HYDROGEN PEROXIDE; INTERLEUKIN 1BETA; MANGANESE SUPEROXIDE DISMUTASE; ORNITHINE DECARBOXYLASE; PEROXIDASE; PEROXIREDOXIN 4; PEROXIREDOXIN 5; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; REACTIVE OXYGEN METABOLITE; SPERMIDINE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYSTEINE; OXIDOREDUCTASE; PEROXIREDOXIN; SUPEROXIDE REDUCTASE;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOBREEDING RAT; DETOXIFICATION; DIABETOGENESIS; DISEASE COURSE; DISEASE SEVERITY; EOSINOPHIL; EXOCRINE SECRETION; FISCHER 344 RAT; FOLLOW UP; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUTATHIONE METABOLISM; IMMUNOMODULATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; IPEX SYNDROME; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; PANCREATITIS; PHENOTYPE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SURVIVAL FACTOR; THERAPY DELAY; ANIMAL; BLOOD; DRUG EFFECT; FLOW CYTOMETRY; GENETICS; METABOLISM; PANCREAS ISLET; PANCREAS ISLET BETA CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC ANIMAL; TUMOR CELL LINE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIOXIDANTS; CELL LINE, TUMOR; CYSTEINE; DIABETES MELLITUS, TYPE 1; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GLUTATHIONE TRANSFERASE; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; OXIDOREDUCTASES; PEROXIDASES; PEROXIREDOXINS; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

MLCS; MLOWN;

EID: 84874778734     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-12-0385     Document Type: Article

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