Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene

Physiological Genomics

Volumn 38, Issue 1, 2009, Pages 89-97

  Fuller, J M ^a,b   Bogdani, M ^c   Tupling, T D ^b   Jensen, R A ^b   Pefley, R ^b   Manavi, S ^b   Cort, L ^d   Blankenhorn, E P ^d   Mordes, J P ^e   Lernmark, A ^a,b   Kwitek, A E ^f  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF WASHINGTON   (United States)

^c PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^d DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF IOWA   (United States)

Author keywords

Autoimmune; BB rat; T cell receptor; Type 1 diabetes

Indexed keywords

DNA; DNA FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CHROMOSOME 4; CONTROLLED STUDY; DISSECTION; GENE; GENE LOCUS; GENE SEQUENCE; GENETICS; GENOTYPE; GIMAP5 GENE; HEREDITY; HISTOLOGY; INBRED STRAIN; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTOPENIA; MONONUCLEAR CELL; NONHUMAN; PANCREAS; PANCREAS DUCT; PANCREAS ISLET CELL; PHENOTYPE; PRIORITY JOURNAL; RAT; SEQUENCE ANALYSIS;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GTP-BINDING PROTEINS; LYMPHOPENIA; RATS;

RATTUS;

EID: 67649506344     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00015.2009     Document Type: Article

References (47)

1. Backdahl L, Ribbhammar U, Lorentzen JC. Mapping and functional characterization of rat chromosome 4 regions that regulate arthritis models and phenotypes in congenic strains. Arthritis Rheum 48: 551-559, 2003. (Pubitemid 36278025)
2. Bartsocas CS, Gerasimidi-Vazeou A. Genetics of type 1 diabetes mellitus. Pediatr Endocrinol Rev 3, Suppl 3: 508-513, 2006.
3. Bieg S, Koike G, Jiang J, Klaff L, Pettersson A, MacMurray AJ, Jacob HJ, Lander ES, Lernmark A. Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Mamm Genome 9: 324-326, 1998. (Pubitemid 28181035)
4. Bieg S, Koike G, Jiang J, Klaff L, Pettersson A, MacMurray AJ, Jacob HJ, Lander ES, Lernmark A° . Genetic isolation of the Lyp region on chromosome 4 in the diabetes prone BioBreeding (BB) rat. Mamm Genome 9: 324-326, 1998. (Pubitemid 28181035)
5. Blankenhorn EP, Descipio C, Rodemich L, Cort L, Leif JH, Greiner DL, Mordes JP. Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene. Ann NY Acad Sci 1103: 128-131, 2007. (Pubitemid 46791120)
6. Blankenhorn EP, Rodemich L, Martin-Fernandez C, Leif J, Greiner DL, Mordes JP. The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Diabetes 54: 1233-1237, 2005. (Pubitemid 40446342)
7. Cerna M. Genetics of autoimmune diabetes mellitus. Wien Med Wochenschr 158: 2-12, 2008. (Pubitemid 351268496)
8. Ellerman KE, Like AA. Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats. Diabetologia 43: 890-898, 2000. (Pubitemid 30463169)
9. Ettinger RA, Moustakas AK, Lobaton SD. Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles. Immunogenetics 56: 585-596, 2004. (Pubitemid 40012760)
10. Farber CR, Medrano JF. Dissection of a genetically complex cluster of growth and obesity QTLs on mouse chromosome 2 using subcongenic intercrosses. Mamm Genome 18: 635-645, 2007. (Pubitemid 47556512)
11. Fuller JM, Kwitek AE, Hawkins TJ, Moralejo DH, Lu W, Tupling TD, Macmurray AJ, Borchardt G, Hasinoff M, Lernmark A. Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB rats. Diabetes 55: 3351-3357, 2006. (Pubitemid 44923592)
12. Gold DP, Shaikewitz ST, Mueller D, Redd JR, Sellins KS, Pettersson A, Lernmark A, Bellgrau D. T cells from BB-DP rats show a unique cytokine mRNA profile associated with the IDDM1 susceptibility gene, Lyp. Autoimmunity 22: 149-161, 1995. (Pubitemid 26159675)
13. Hawkins T, Fuller J, Olson K, Speros S, Lernmark ADR. lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats. J Autoimmun 25: 251-257, 2005. (Pubitemid 41642970)
14. Hornum L, Romer J, Markholst H. The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Diabetes 51: 1972-1979, 2002. (Pubitemid 34564313)
15. Jackerott M, Hornum L, Andreasen BE, Markholst H. Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats. J Autoimmun 10: 35-41, 1997. (Pubitemid 27110306)
16. Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark A, Lander ES. Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet 2: 56-60, 1992.
17. Klaff LS, Koike G, Jiang J, Wang Y, Bieg S, Pettersson A, Lander E, Jacob H, Lernmark A. BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Mamm Genome 10: 883-887, 1999. (Pubitemid 29445377)
18. Kloting I, Schmidt S, Kovacs P. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Biochem Biophys Res Commun 245: 483-486, 1998. (Pubitemid 28418529)
19. Kloting I, Van Den Brandt J, Kovacs P. Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat. Int J Mol Med 2: 597-601, 1998.
20. Kloting I, van den Brandt J, Kuttler B. Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains. Biochem Biophys Res Commun 283: 399-405, 2001. (Pubitemid 32924705)
21. Kloting I, Vogt L, Serikawa T. Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Diabet Metab 21: 338-344, 1995. (Pubitemid 26022286)
22. Kloting N, Wilke B, Kloting I. Triplet repeat in the Repin1 3′-untranslated region on rat chromosome 4 correlates with facets of the metabolic syndrome. Diabetes Metab Res Rev 23: 406-410, 2007. (Pubitemid 47091245)
23. Landin-Olsson M, Borgstrom A, Blom L, Sundkvist G, Lernmark A. Immunoreactive trypsin(ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls. The Swedish Childhood Diabetes Group. Pancreas 5: 241-247, 1990. (Pubitemid 20149056)
24. Lenzen S, Tiedge M, Elsner M, Lortz S, Weiss H, Jorns A, Kloppel G, Wedekind D, Prokop CM, Hedrich HJ. The LEW1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus. Diabetologia 44: 1189-1196, 2001. (Pubitemid 32835513)
25. Liang J, Song W, Tromp G, Kolattukudy PE, Fu M. Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. PLoS ONE 3: e2880, 2008.
26. Mackay DJ, Callaway JL, Marks SM, White HE, Acerini CL, Boonen SE, Dayanikli P, Firth HV, Goodship JA, Haemers AP, Hahnemann JM, Kordonouri O, Masoud AF, Oestergaard E, Storr J, Ellard S, Hattersley AT, Robinson DO, Temple IK. Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57. Nat Genet 40: 949-951, 2008.
27. MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES, Lernmark A. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res 12: 1029-1039, 2002. (Pubitemid 34785195)
28. Markholst H, Eastman S, Wilson D, Andreasen BE, Lernmark A. Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes. J Exp Med 174: 297-300, 1991.
29. Martin AM, Maxson MN, Leif J, Mordes JP, Greiner DL, Blankenhorn EP. Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4. Diabetes 48: 2138-2144, 1999.
30. Moore JK, Gold DP, Dreskin SC, Lernmark A, Bellgrau D. A diabetogenic gene prevents T cells from receiving costimulatory signals. Cell Immunol 194: 90-97, 1999. (Pubitemid 29283980)
31. Moralejo DH, Park HA, Speros SJ, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. J Autoimmun 21: 315-324, 2003. (Pubitemid 37414928)
32. Mordes JP, Bortell R, Blankenhorn EP, Rossini AA, Greiner DL. Rat models of type 1 diabetes: genetics, environment, and autoimmunity. ILAR J 45: 278-291, 2004.
33. Mordes JP, Cort L, Norowski E, Leif J, Fuller JM, Lernmark A, Greiner DL, Blankenhorn EP. Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus. Mamm Genome 20: 162-169, 2009.
34. Mordes JP, Poussier P, Rossini AA, Blankenhorn EP, Greiner DL. Rat models of type 1 diabetes: genetics, environment, and autoimmunity. In: Animal Models of Diabetes: Frontiers in Research, edited by Shafrir E. Boca Raton, FL: CRC, 2007, p. 1-39.
35. Moreno C, Kaldunski ML, Wang T, Roman RJ, Greene AS, Lazar J, Jacob HJ, Cowley AW Jr. Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat. Physiol Genomics 31: 228-235, 2007. (Pubitemid 350014400)
36. Moreno C, Kennedy K, Andrae JW, Jacob HJ. Genome-wide scanning with SSLPs in the rat. Meth Mol Med 108: 131-138, 2005.
37. Moroy T, Zeng H, Jin J, Schmid KW, Carpinteiro A, Gulbins E. The zinc finger protein and transcriptional repressor Gfi1 as a regulator of the innate immune response. Immunobiology 213: 341-352, 2008.
38. Ruf C, Carosone-Link P, Springett J, Bennett B. Confirmation and genetic dissection of a major quantitative trait locus for alcohol preference drinking. Alcohol Clin Exp Res 28: 1613-1621, 2004. (Pubitemid 39551820)
39. Saad Y, Yerga-Woolwine S, Saikumar J, Farms P, Manickavasagam E, Toland EJ, Joe B. Congenic interval mapping of RNO10 reveals a complex cluster of closely-linked genetic determinants of blood pressure. Hypertension 50: 891-898, 2007. (Pubitemid 350287531)
40. Saijou E, Itoh T, Kim KW, Iemura S, Natsume T, Miyajima A. Nucleocytoplasmic shuttling of the zinc finger protein EZI is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. J Biol Chem 282: 32327-32337, 2007. (Pubitemid 350106445)
41. Samuelson DJ, Hesselson SE, Aperavich BA, Zan Y, Haag JD, Trentham-Dietz A, Hampton JM, Mau B, Chen KS, Baynes C, Khaw KT, Luben R, Perkins B, Shah M, Pharoah PD, Dunning AM, Easton DF, Ponder BA, Gould MN. Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Proc Natl Acad Sci USA 104: 6299-6304, 2007. (Pubitemid 47186089)
42. Shin JH, Janer M, McNeney B, Blay S, Deutsch K, Sanjeevi CB, Kockum I, Lernmark A, Graham J, Arnqvist H, Bjorck E, Eriksson J, Nystrom L, Ohlson LO, Schersten B, Ostman J, Aili M, Baath LE, Carlsson E, Edenwall H, Forsander G, Granstrom BW, Gustavsson I, Hanas R, Hellenberg L, Hellgren H, Holmberg E, Hornell H, Ivarsson SA, Johansson C, Jonsell G, Kockum K, Lindblad B, Lindh A, Ludvigsson J, Myrdal U, Neiderud J, Segnestam K, Sjoblad S, Skogsberg L, Stromberg L, Stahle U, Thalme B, Tullus K, Tuvemo T, Wallensteen M, Westphal O, Aman J. IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5. Genes Immun 8: 503-512, 2007. (Pubitemid 47370844)
43. Simmonds S, Mason D. Induction of autoimmune disease by depletion of regulatory T cells. Curr Protoc Immunol 15: Unit 15.12, 2001.
44. Smith LR, Kono DH, Theofilopoulos AN. Complexity and sequence identification of 24 rat V beta genes. J Immunol 147: 375-379, 1991.
45. Stienekemeier M, Hofmann K, Gold R, Herrmann T. A polymorphism of the rat T-cell receptor beta-chain variable gene 13 (BV13S1) correlates with the frequency of BV13S1-positive CD4 cells. Immunogenetics 51: 296-305, 2000. (Pubitemid 30198884)
46. Wallis RH, Wang K, Dabrowski D, Marandi L, Ning T, Hsieh E, Paterson AD, Mordes JP, Blankenhorn EP, Poussier P. A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes. Diabetes 56: 1731-1736, 2007. (Pubitemid 46842622)
47. Yokoi N. Identification of a major gene responsible for type 1 diabetes in the Komeda diabetes-prone rat. Exp Anim 54: 111-115, 2005. (Pubitemid 41349854)