Catalytic intermediates of inducible nitric-oxide synthase stabilized by the W188H mutation

Journal of Biological Chemistry

Volumn 288, Issue 9, 2013, Pages 6095-6106

  Sabat, Joseph ^a   Egawa, Tsuyoshi ^a   Lu, Changyuan ^a   Stuehr, Dennis J ^b   Gerfen, Gary J ^a   Rousseau, Denis L ^a   Yeh, Syun Ru ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOPHYSICAL STUDIES; CATALYTIC INTERMEDIATES; CATALYTIC MECHANISMS; CATION-RADICALS; CITRULLINE; COFACTORS; CRYSTALLOGRAPHIC DATA; CURRENT DATA; HYDROXYLATION REACTIONS; L-ARGININE; MACROCYCLES; NITRIC-OXIDE SYNTHASE; OUT-OF-PLANE DISTORTIONS; OXYGEN CHEMISTRY; SPECTROSCOPIC DATA; STOPPED FLOW; TETRAHYDROBIOPTERIN; THIOLATE LIGANDS; TRYPTOPHAN RESIDUES; TWO-STEP PROCESS;

AMINO ACIDS; HYDROXYLATION; NITRIC OXIDE; PORPHYRINS; POSITIVE IONS; SYNTHESIS (CHEMICAL);

REACTION INTERMEDIATES;

CATION; FERRIC HEME SPECIES; HEME; HISTIDINE; HYDROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; OXYGEN; RADICAL; TETRAHYDROBIOPTERIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME STABILITY; MUTATION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SPECTROSCOPY; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; HEME; IRON; MICE; MUTATION, MISSENSE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II;

EID: 84874777557     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.403238     Document Type: Article

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