Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site

Journal of Inorganic Biochemistry

Volumn 81, Issue 3, 2000, Pages 141-151

  Yoshioka, Shiro ^a   Takahashi, Satoshi ^a   Ishimori, Koichiro ^a   Morishima, Isao ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Cytochrome P450; Iron hydroperoxo intermediate; NH S hydrogen bonds; Push effect; Thiolate

Indexed keywords

AMIDE; CAMPHOR; CAMPHOR 5 MONOOXYGENASE; CUMENE HYDROPEROXIDE; CYSTEINE; CYTOCHROME P450; HEME; IRON; MUTANT PROTEIN; NITROGEN 15; OXYGEN; PROTON; SULFUR; THIOL DERIVATIVE; THIOLATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; ELECTRICITY; ELECTRON; ENZYME SUBSTRATE; HYDROGEN BOND; HYDROXYLATION; NUCLEAR MAGNETIC RESONANCE; OXIDATION REDUCTION POTENTIAL; OXYGENATION; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; RAMAN SPECTROMETRY; REACTION ANALYSIS; REDUCTION; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY;

BINDING SITES; CAMPHOR; CAMPHOR 5-MONOOXYGENASE; CYSTEINE; ELECTRONS; ESCHERICHIA COLI; FERRICYANIDES; FERROUS COMPOUNDS; HEME; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXYGEN; PLASMIDS; PROTEIN CONFORMATION; PROTONS; SPECTROPHOTOMETRY; SULFUR;

EID: 0034739018     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-0134(00)00097-0     Document Type: Article

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