Antioxidant Supplements Improve Profiles of Hepatic Oxysterols and Plasma Lipids in Butter-fed Hamsters

Nutrition and Metabolic Insights

Volumn 3, Issue , 2010, Pages

  Poirier, Johanne ^a   Cockell, Kevin A ^a,b,c   Ratnayake, W M Nimal ^b   Scoggan, Kylie A ^b,c   Hidiroglou, Nick ^b   Gagnon, Claude ^b   Rocheleau, Hélène ^b   Gruber, Heidi ^b   Griffin, Philip ^b   Madère, René ^b   Trick, Keith ^b   Kubow, Stan ^a  

^a MCGILL UNIVERSITY   (Canada)

^b Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

glutathione; lipid hydroperoxide; selenium; sterol 27 hydroxylase mRNA; thiobarbituric acid reading substances; tocopherols

Indexed keywords

EID: 84874757075     PISSN: None     EISSN: 11786388     Source Type: Journal    
DOI: 10.4137/NMI.S3911     Document Type: Article

References (73)

1. Swagell C.D., Henly D.C., Morris C.P. Expression analysis of a human hepatic cell line in response to palmitate. Biochem Biophys Res Comm. 2005; 328(2): 432–41.
2. Aviram M., Cogan U., Mokady S. Excessive dietary tryptophan enhances plasma lipid peroxidation in rats. Atherosclerosis. 1991; 88(1): 29–34.
3. Lu Y.F., Chiang C.F. Effect of dietary cholesterol and fat levels on lipid peroxidation and activities of antioxidant enzymes in rats. Int J Vitam Nutr Res. 2001; 71(6): 339–46.
4. Khosla P., Sundram K. Effects of dietary fatty acid composition on plasma cholesterol. Prog Lipid Res. 1996; 35(2): 93–132.
5. Toescu V., Nuttall S.L., Martin U. et al. Changes in plasma lipids and markers of oxidative stress in normal pregnancy and pregnancies complicated by diabetes. Clin Science. 2004; 106(1): 93–8.
6. Chidambaram N., Baradarajan A. Effect of selenium on lipids and some lipid metabolizing enzymes in DMBA induced mammary tumor rats. Cancer Biochem Biophys. 1995; 15(11): 41–7.
7. Crespo A.M., Lanca M.J., Vasconcelos S. et al. Effect of selenium supplementation on some blood biochemical parameters in male rats. Biol Trace Elem Res. 1995; 47(3): 343–7.
8. Vinson J.A., Stella J.M., Flanagan T.J. Selenium yeast is an effective in vitro and in vivo antioxidant and hypolipidemic agent in normal hamsters. Nutr Res. 1998; 18(4): 735–42.
9. Kang B.P.S., Bansal M.P., Mehta U. Hyperlipidemia and type I 5‘-monodeiodinase activity. Biol Trace Elem Res. 2000; 77(3): 231–9.
10. Poirier J., Cockell K., Hidiroglou N., Madere R., Trick K., Kubow S. The effects of vitamin E and selenium intake on oxidative stress and plasma lipids in hamsters fed fish oil. Lipids. 2002; 37(12): 1125–33.
11. Wojcicki J., Rozewicka L., Barcew-Wiszniewska B. et al. Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits. Atherosclerosis. 1991; 87(1): 9–16.
12. Mehta U., Kang B.P.S., Kukreja R.S., Bansal M.P. Ultrastructural examination of rabbit aortic wall following high-fat diet feeding and selenium supplementation: a transmission electron microscopy study. J Appl Toxicol. 2002; 22(6): 405–13.
13. Kang B.P.S., Bansal M.P., Mehta U. Se supplementation and diet induced hypercholesterolemia in the rat: changes in lipid levels, malonyldialdehyde production and the nitric oxide synthase activity. Gen Physiol Biophys. 1998; 17(1): 71–8.
14. Kang B.P.S., Mehta U., Bansal M.P. Effect of diet induced hypercholesterolemia and selenium supplementation on nitric oxide synthase activity. Arch Physiol Biochem. 1997; 105: 603–7.
15. Dhingra S., Bansal M.P. Hypercholesterolemia and apolipoprotein B expression: regulation by selenium status. Lipids Health Dis. 2005; 4: 28.
16. Dhingra S., Bansal M.P. Modulation of hypercholesterolemia-induced alterations in apolipoprotein B and Hmg-Coa Reductase expression by selenium supplementation. Chem-Biol Interac. 2006; 161(1): 49–56.
17. Dhingra S., Bansal M.P. Hypercholesterolemia and LDL-C receptor mRNA expression: modulation by selenium supplementation. Bio Metals. 2006; 19(5): 493–501.
18. Dhingra S., Bansal M.P. Hypercholesterolemia and tissue-specific differential mRNA expression of type-1 5‘-iodothyronine deiodinase under different selenium status in rats. Biol Res. 2006; 39(2): 307–19.
19. Dhingra S., Bansal M.P. Attenuation of LDL-C receptor gene expression by selenium deficiency during hypercholesterolemia. Mol Cell Biochem. 2006; 282(1): 75–82.
20. Iizuka Y., Sakurai E., Tanaka Y. Effect of selenium on serum, hepatic and lipoprotein lipids concentration in rats fed a high-cholesterol diet. Yakugaku Zasshi. 2001; 121: 93–6.
21. Djujic I.S., Jozanov-Stankov O.N., Milovac M., Jankovic V., Djermanovic V. Bioavailability and possible benefits of wheat intake naturally enriched with selenium and its products. Biol Trace Elem Res. 2000; 77(3): 273–85.
22. Kauf E., Dawczynski H., Jahreis G., Janitzky E., Winnefeld K. Sodium selenite therapy and thyroid-hormone status in cystic fibrosis and congenital hypothyroidism. Biol Trace Elem Res. 1994; 40(3): 247–53.
23. Luoma P.V., Sotaniemi E.A., Korpela H., Kumpulainen J. Serum selenium, glutathione peroxidase activity and high-density lipoprotein cholesterol—effect of selenium supplementation. Res Comm Chem Pathol Pharmacol. 1984; 3(3): 469–72.
24. Karita K., Yamanouchi Y., Takano T. et al. Associations of blood selenium and serum lipid levels in Japanese premenopausal and postmenopausal women. Menopause. 2008; 15(1): 119–24.
25. Westrope K.L., Miller R.A., Wilson R.B. Vitamin E in a rabbit model of endogenous hypercholesterolemia and atherosclerosis. Nutr Rep Int. 1982; 25: 83–8.
26. Wilson R.B., Middleton C.C., Sun G.Y. Vitamin E, antioxidants and lipid per-oxidation in experimental atherosclerosis of rabbits. J Nutr. 1978; 108(11): 1858–67.
27. Prasad K., Kalra J. Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E. Am Heart J. 1993; 125(4): 958–73.
28. Brattsand R. Actions of vitamins A and E and some nicotinic acid derivatives on plasma lipids and on lipid infiltration of aorta in cholesterolfed rabbits. Atherosclerosis. 1975; 22(1): 47–61.
29. Stein O., Dabach Y., Hollander G. et al. Relative resistance of the hamster to aortic atherosclerosis in spite of prolonged vitamin E deficiency and dietary hypercholesterolemia. Putative effect of increased HDL? Biochim Biophys Acta. 1996; 1299(2): 216–22.
30. Kubow S., Goyette N., Kermasha S., Stewart-Phillip J., Koski K.G. Vitamin E inhibits fish oil-induced hyperlipidemia and tissue lipid peroxidation in hamsters. Lipids. 1996; 31(8): 839–47.
31. Jain S.K., McVie R., Jaramilla J.J. et al. The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients. Lipids. 1996; 31: S-87–90.
32. Pal S., Thomson A.M., Bottema C.D., Roach P.D. Alpha-tocopherol modulates the low density lipoprotein receptor of human HepG2 cells. Nutr J. 2003; 2: 3.
33. Phonpanichrasamee C., Komaratat P., Wilairat P. Hypocholesterolemic effect of vitamin E on cholesterol-fed rabbit. Internat J Vit Nutr Res. 1990; 60(3): 240–4.
34. Peet D.J., Turley S.D., Ma W. et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell. 1998; 93(5): 693–704.
35. Forman B.M., Ruan B., Chen J., Schroepfer G.J. Jr, Evans R.M. The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism. Proc Natl Acad Sci USA. 1997; 94(20): 10588–93.
36. Janowski B.A., Grogan M.J., Jones S.A. et al. Structural requirements of ligands for the oxysterol liver X receptors LXRa and LXRβ. Proc Natl Acad Sci USA. 1999; 96(1): 266–71.
37. Lehmann J.M., Kliewer S.A., Moore L.B. et al. Activation of the nuclear receptor LXRα by oxysterols defines a new hormone response pathway. J Biol Chem. 1997; 272(6): 3137–40.
38. Chen W., Chen G., Head D.L., Mangelsdorf D.J., Russell D.W. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metabol. 2007; 5(1): 73–9.
39. Pikuleva I.A. Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006; 34(4): 513–20.
40. Pascoe G.A., Correia M.A. Structural and functional assembly of rat intestinal cytochrome P-450 isozymes. Effects of dietary iron and selenium. Biochem Biopharmacol. 1985; 34(5): 599–608.
41. Lund E., Breuer O., Bjorkhem I. Evidence that 24- and 27-hydroxylation are not involved in the cholesterol-induced down-regulation of hydroxy-methylglutaryl-coa reductase in mouse liver. J Biol Chem. 1992; 267(35): 25092–7.
42. Saucier S.E., Kandutsch A.A., Gayen A.K., Swahn D.K., Spencer T.A. Oxysterol regulators of 3-hydroxy-3-methylglutaryl-coa reductase in liver. J Biol Chem. 1989; 264(12): 6863–9.
43. Zhang Z., Li D., Blanchard D.E., Lear S.R., Erickson S.K., Spencer T.A. Key regulatory oxysterols in liver: analysis as δ4-3-ketone derivatives by HPLC and response to physiological perturbations. J Lipid Res. 2001; 42(4): 649–58.
44. Yuan Y.V., Kitts D.D., Godin D.V. Interactive effects of increased intake of saturated fat and cholesterol on atherosclerosis in the Japanese quail (Coturnix japonica). Br J Nutr. 1998; 80(1): 89–100.
45. Zhu Y., Liao H., Xie X. et al. Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovasc Res. 2005; 68(3): 425–32.
46. Björkhem I. Do oxysterols control cholesterol homeostasis? J Clin Invest. 2002; 110(6): 725–730.
47. Menendez-Carreno M., Ansorena D., Milagro F.I., Campion J., Martinez J.A., Astiasaran I. Inhibition of serum cholesterol oxidation by dietary vitamin C and selenium intake in high fat fed rats. Lipids. 2008; 43(3): 383–90.
48. Spady D.K., Dietschy J.M. Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster and rat. J Lipid Research. 1983; 24(3): 303–15.
49. Willhite C.C., Ferm V.H., Zeise L. Route-dependent pharmacokinetics, distribution, and placental permeability of organic and inorganic selenium in hamsters. Teratology. 1990; 42(4): 359–71.
50. Birt D.F., Julius A.D., Runice C.E., Sayed S. Tolerance of diets deficient or excessive in selenium by Syrian hamsters. Ann Nutr Metab. 1983; 27(2): 81–93.
51. Beems R.B., van Beek L. Short-Term (6-week) oral toxicity study of selenium in Syrian hamsters. Fd Chem Toxic. 1985; 23(10): 945–7.
52. Julius A.D., Davies M.H., Birt D.F. Toxic effects of dietary selenium in the Syrian hamster. Ann Nutr Metab. 1983; 27(4): 296–305.
53. National Research Council. Nutrient requirements of the hamster. In: Nutrient Requirements of Laboratory Animals, 4th ed. Washington, DC: National Academy Press; 1995.
54. Canadian Council on Animal Care. Guide to the care and use of experimental animals, vols. I and II. Ottawa, ON: National Library of Canada; 1984.
55. Asakawa T., Matsushita S. Thiobarbituric acid test for detecting lipid peroxides. Lipids. 1980; 14(4): 401–6.
56. Wong S.H.Y., Knight J.A., Hopfer S.M., Zaharia O., Leach C.N. Jr, Sunderman F.W. Jr Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem. 1987; 33(2): 214–20.
57. L'Abbé M.R., Trick K.D., Beare-Rogers J.L. Dietary (n-3) fatty acids affect rat heart, liver and aorta protective enzyme activities and lipid peroxidation. J Nutr. 1991; 121(9): 1331–40.
58. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967; 70(1): 158–69.
59. Cockell K.A., Wotherspoon A.T.L., Belonje B. et al. Limited effects of combined dietary copper deficiency: iron overload on oxidative stress parameters in rat liver and plasma. J Nutr Biochem. 2005; 16(12): 750–6.
60. National Center for Biotechnology Information. Basic local alignment search tool. Available at: http://www.ncbi.nlm.nih.gov/blast/Blast.cgi. Accessed March 18, 2006.
61. Yu H., Pandit B., Klett E. et al. The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats. BMC Cardiovasc Disord. 2003; 3: 4–19.
62. SAS. USA release 9.1. Cary, NC: SAS Institute Inc; 1989-96.
63. Fu X., Menke J.G., Chen Y. et al. 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem. 2001; 276(42): 38378–87.
64. Bansal G., Singh U., Bansal M.P. Influence of 7-βeta-hydroxycholesterol on glutathione status and nitric oxide production in macrophages: in vitro studies. Indian J Biochem Biophys. 2001; 38(3): 176–9.
65. Lu Y.F., Chiang C.F. Effect of dietary cholesterol and fat levels on lipid per-oxidation and activities of antioxidant enzymes in rats. Int J Vitam Nutr Res. 2001; 71(6): 339–46.
66. Chung A.S., Maines M.D. Effect of selenium on glutathione metabolism. Induction of γ-glutamylcysteine synthetase and glutathione reductase in the rat liver. Biochem Pharmacol. 1981; 30(23): 3217–23.
67. Poirier J., Kubow S. The relationship between α-tocopherol, selenium and fish oil in the diet and effects on the heart and liver. In: Preedy V.R., Watson R.R., eds. The Encyclopaedia of Vitamin E. Wallingford: CABI; 2006: 273–84.
68. Comporti M. Glutathione depleting agents and lipid peroxidation. Chem Phys Lipids. 1987; 45(24): 143–69.
69. Stranges S., Laclaustra M., Ji C. et al. Higher selenium status is associated with adverse blood lipid profile in British adults. J Nutr. DOI: 10.3945/jn.109.111252. 2009.
70. Bjelakovic G., Nikolova D., Gluud L.L., Simonetti R.G., Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database of Systematic Reviews. 2008, Issue 2. Art. No.: CD007176. DOI: 10.1002/14651858.CD007176.
71. Lippman S.M., Goodman P.J., Klein E.A. et al. Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Natl Cancer Inst. 2005; 97(2): 94–102.
72. Marshall J.R., Sakr W., Wood D. et al. Design and progress of a trial of selenium to prevent prostate cancer among men with high-grade prostatic intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev. 2006; 15(8): 1479–84.
73. Violi F., Cangemi R. Statin treatment as a confounding factor in human trials with vitamin E. J Nutr. 2008; 138(6): 1179–81.