Effect of antioxidant supplementation on the total yield, oxidative stress levels, and multipotency of bone marrow-derived human mesenchymal stromal cells

Tissue Engineering - Part A

Volumn 19, Issue 7-8, 2013, Pages 928-937

  Alves, Hugo ^a   Mentink, Anouk ^a   Le, Bach ^a   Van Blitterswijk, Clemens A ^a   De Boer, Jan ^a  

^a UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS; BONE; FLOWCHARTING; PHOSPHATASES;

ALKALINE PHOSPHATASE; ANTI-OXIDANT ACTIVITIES; ANTIOXIDANT SUPPLEMENTATION; BONE MARROW; CELL TYPES; CELLULAR DAMAGE; CLINICAL EFFICACY; DNA DAMAGES; EX-VIVO; MESENCHYMAL STROMAL CELLS; MSC EXPANSIONS; MULTIPOTENT MESENCHYMAL STROMAL CELLS; OXIDATIVE DAMAGE; OXIDATIVE DNA DAMAGE; OXIDIZING AGENTS; REACTIVE OXYGEN SPECIES; TOTAL YIELD;

CELL CULTURE;

ANTIOXIDANT; REACTIVE OXYGEN METABOLITE; SCAVENGER; SELENIUM;

AGED; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; DNA DAMAGE; DRUG EFFECT; FEMALE; HUMAN; MALE; MESENCHYMAL STROMA CELL; METABOLISM; OXIDATIVE STRESS;

AGED; ANTIOXIDANTS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA DAMAGE; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; MALE; MESENCHYMAL STROMAL CELLS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SELENIUM;

EID: 84874739979     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2011.0700     Document Type: Article

References (46)

1. Kadiyala, S. Culture-expanded, bone marrow-derived mesenchymal stem cells can regenerate a critical-sized segmental bone defect. Tissue Eng 3, 173, 1997.
2. Bruder, S.P., et al. Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin Orthop Relat Res (355 Suppl), S247, 1998.
3. Almeida-Porada, G., et al. Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation. Blood 95, 3620, 2000.
4. Tse, W.T., et al. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 75, 389, 2003.
5. Ringden, O., et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 81, 1390, 2006.
6. Pittenger, M.F., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143, 1999.
7. Petite, H., et al. Tissue-engineered bone regeneration. Nat Biotechnol 18, 959, 2000.
8. Agata, H., et al. Characteristic change and loss of in vivo osteogenic abilities of human bone marrow stromal cells during passage. Tissue Eng Part A 16, 663, 2010.
9. Siddappa, R., et al. Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering. J Orthop Res 25, 1029, 2007.
10. Alves, H., et al. A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells. J Cell Mol Med 14, 2729, 2010.
11. Fagan, J.M., Sleczka, B.G., and Sohar, I. Quantitation of oxidative damage to tissue proteins. Int J Biochem Cell Biol 31, 751, 1999.
12. Kohen, R., and Nyska, A. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol 30, 620, 2002.
13. Dalle-Donne, I., et al. Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta 329, 23, 2003.
14. Niki, E., et al. Lipid peroxidation: mechanisms, inhibition, and biological effects. Biochem Biophys Res Commun 338, 668, 2005.
15. Cadet, J., et al. Hydroxyl radicals and DNA base damage. Mutat Res 424, 9, 1999.
16. Finkel, T., and Holbrook, N.J. Oxidants, oxidative stress and the biology of ageing. Nature 408, 239, 2000.
17. Valko, M., et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39, 44, 2007.
18. Dudas, S.P., and Arking, R. A coordinate upregulation of antioxidant gene activities is associated with the delayed onset of senescence in a long-lived strain of Drosophila. J Gerontol A Biol Sci Med Sci 50, B117, 1995.
19. Harshman, L.G., and Haberer, B.A. Oxidative stress resistance: a robust correlated response to selection in extended longevity lines of Drosophila melanogaster? J Gerontol A Biol Sci Med Sci 55, B415, 2000.
20. Balaban, R.S., Nemoto, S., and Finkel, T. Mitochondria, oxidants, and aging. Cell 120, 483, 2005.
21. Ku, H.H., Brunk, U.T., and Sohal, R.S. Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radic Biol Med 15, 621, 1993.
22. Maggio, D., et al. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab 88, 1523, 2003.
23. Basu, S., et al. Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 288, 275, 2001.
24. de Boer, J., et al. Premature aging in mice deficient in DNA repair and transcription. Science 296, 1276, 2002.
25. Tyner, S.D., et al. p53 mutant mice that display early ageingassociated phenotypes. Nature 415, 45, 2002.
26. Ito, K., et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431, 997, 2004.
27. Ebert, R., et al. Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro. Stem Cells 24, 1226, 2006.
28. Hockenbery, D.M., et al. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241, 1993.
29. Jakubowski, W., and Bartosz, G. 2,7-dichlorofluorescin oxidation and reactive oxygen species: what does it measure? Cell Biol Int 24, 757, 2000.
30. De Boer, J., Wang, H.J., and Van Blitterswijk, C. Effects of Wnt signaling on proliferation and differentiation of human mesenchymal stem cells. Tissue Eng 10, 393, 2004.
31. Bors, W., Saran, M., and Michel, C. Pulse-radiolytic investigations of catechols and catecholamines. II. Reactions of Tiron with oxygen radical species. Biochim Biophys Acta 582, 537, 1979.
32. Ching, T.L., Haenen, G.R., and Bast, A. Cimetidine and other H2 receptor antagonists as powerful hydroxyl radical scavengers. Chem Biol Interact 86, 119, 1993.
33. Valko, M., et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160, 1, 2006.
34. Joyeux, M., et al. tert-Butyl hydroperoxide-induced injury in isolated rat hepatocytes: a model for studying anti-hepatotoxic crude drugs. Planta Med 56, 171, 1990.
35. Fernandes, E.R., et al. Hepatoprotective activity of xanthones and xanthonolignoids against tert-butylhydroperoxideinduced toxicity in isolated rat hepatocytes -comparison with silybin. Pharm Res 12, 1756, 1995.
36. Tseng, T.H., et al. Protective effects of dried flower extracts of Hibiscus sabdariffa L. against oxidative stress in rat primary hepatocytes. Food Chem Toxicol 35, 1159, 1997.
37. Halliwell, B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging 18, 685, 2001.
38. Nordberg, J., and Arner, E.S. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Med 31, 1287, 2001.
39. Radi, R., et al. Unraveling peroxynitrite formation in biological systems. Free Radic Biol Med 30, 463, 2001.
40. Qi,W., et al. Chromium(III)-induced 8-hydroxydeoxyguanosine in DNA and its reduction by antioxidants: comparative effects of melatonin, ascorbate, and vitamin E. EnvironHealth Perspect 108, 399, 2000.
41. Lenton, K.J., et al. Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency. Am J Clin Nutr 77, 189, 2003.
42. Carr, A., and Frei, B. Does vitamin C act as a prooxidant under physiological conditions? FASEB J 13, 1007, 1999.
43. Yanes, O., et al. Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol 6, 411, 2010.
44. Ji, A.R., et al. Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage. Exp Mol Med 42, 175, 2010.
45. Higuchi, M., Dusting, G.J., Peshavariya, H., Jiang, F., Hsiao, S.T., Chan, E., and Liu, G.S. Differentiation of human adipose-derived stem cells into fat involves reactive oxygen species and forkhead box O1 mediated upregulation of antioxidant enzymes. Stem Cells Dev 2012 [Epub ahead of print]; DOI: 10.1089/scd.2012.0306.
46. Smith, J., et al. Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell. Proc Natl Acad Sci U S A 97, 10032, 2000.