메뉴 건너뛰기




Volumn 45, Issue 4-6, 2002, Pages 237-250

Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: Breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection

Author keywords

Drug antiviral therapy; Hepatitis B; Immunologic tolerance; In vivo animal models; Lymphocyte proliferation; Therapeutic vaccination; Woodchuck; Woodchuck hepatitis virus

Indexed keywords

CLEVUDINE; HEPATITIS ANTIBODY; HEPATITIS ANTIGEN; HEPATITIS B VACCINE; LIVER ENZYME; MEMBRANE ANTIGEN; VIRUS DNA;

EID: 0036983178     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000067914     Document Type: Conference Paper
Times cited : (38)

References (52)
  • 1
    • 0032417858 scopus 로고    scopus 로고
    • Status of hepatitis B immunization programmes in 1998
    • Kane MA: Status of hepatitis B immunization programmes in 1998. Vaccine 1998;16(suppl):S104-S108.
    • (1998) Vaccine , vol.16 , Issue.SUPPL.
    • Kane, M.A.1
  • 2
    • 0034167525 scopus 로고    scopus 로고
    • Rous-Whipple Award Lecture. Viruses, immunity, and cancer: Lessons from hepatitis B
    • Chisari FV: Rous-Whipple Award Lecture. Viruses, immunity, and cancer: Lessons from hepatitis B. Am J Pathol 2000;156:1117-1132.
    • (2000) Am J Pathol , vol.156 , pp. 1117-1132
    • Chisari, F.V.1
  • 3
    • 0032826033 scopus 로고    scopus 로고
    • Unraveling hepatitis B virus infection of mice and men (and woodchucks and ducks)
    • Menne S, Tennant BC: Unraveling hepatitis B virus infection of mice and men (and woodchucks and ducks). Nat Med 1999;10:1125-1126.
    • (1999) Nat Med , vol.10 , pp. 1125-1126
    • Menne, S.1    Tennant, B.C.2
  • 5
    • 0029067476 scopus 로고
    • Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection
    • Jung MC, Diepolder HM, Spengler U, Wierenga EA, Zachoval R, Hoffmann RM, Eichenlaub D, Froesner G, Will H, Pape GR: Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J Virol 1995;69:3358-3368.
    • (1995) J Virol , vol.69 , pp. 3358-3368
    • Jung, M.C.1    Diepolder, H.M.2    Spengler, U.3    Wierenga, E.A.4    Zachoval, R.5    Hoffmann, R.M.6    Eichenlaub, D.7    Froesner, G.8    Will, H.9    Pape, G.R.10
  • 6
    • 0029134818 scopus 로고
    • Proliferative response of CD4+ T-cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants
    • Löhr HF, Weber W, Schlaak J, Goergen B, Meyer zum Bueschenfelde KH, Gerken G: Proliferative response of CD4+ T-cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants. Hepatology 1995;22:61-68.
    • (1995) Hepatology , vol.22 , pp. 61-68
    • Löhr, H.F.1    Weber, W.2    Schlaak, J.3    Goergen, B.4    Meyer zum Bueschenfelde, K.H.5    Gerken, G.6
  • 9
    • 0032519919 scopus 로고    scopus 로고
    • The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: A mechanism for persistence
    • Milich DR, Chen MK, Hughes JL, Jones JE: The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: A mechanism for persistence. J Immunol 1998;160:2013-2021.
    • (1998) J Immunol , vol.160 , pp. 2013-2021
    • Milich, D.R.1    Chen, M.K.2    Hughes, J.L.3    Jones, J.E.4
  • 10
    • 0029147455 scopus 로고
    • Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: A major factor in activation of the host immune response to the hepatitis B virus
    • Marinos G, Torre F, Chokshi S, Hussain M, Clarke BE, Rowlands DJ, Eddleston AL, Naoumov NV, Williams R: Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: A major factor in activation of the host immune response to the hepatitis B virus. Hepatology 1995;22:1040-1049.
    • (1995) Hepatology , vol.22 , pp. 1040-1049
    • Marinos, G.1    Torre, F.2    Chokshi, S.3    Hussain, M.4    Clarke, B.E.5    Rowlands, D.J.6    Eddleston, A.L.7    Naoumov, N.V.8    Williams, R.9
  • 11
    • 0026527586 scopus 로고
    • Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion
    • Tsai SL, Chen PJ, Lai MY, Yang PM, Sung JL, Huang JH, Hwang LH, Chang TH, Chen DS: Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. J Clin Invest 1992;89:87-96.
    • (1992) J Clin Invest , vol.89 , pp. 87-96
    • Tsai, S.L.1    Chen, P.J.2    Lai, M.Y.3    Yang, P.M.4    Sung, J.L.5    Huang, J.H.6    Hwang, L.H.7    Chang, T.H.8    Chen, D.S.9
  • 14
    • 0031927053 scopus 로고    scopus 로고
    • Therapy of viral hepatitis
    • Hoofnagle JH: Therapy of viral hepatitis. Digestion 1998;59:563-578.
    • (1998) Digestion , vol.59 , pp. 563-578
    • Hoofnagle, J.H.1
  • 16
    • 0029957570 scopus 로고    scopus 로고
    • Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection
    • Marinos G, Naoumov NV, Williams R: Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection. Hepatology 1996;24:991-995.
    • (1996) Hepatology , vol.24 , pp. 991-995
    • Marinos, G.1    Naoumov, N.V.2    Williams, R.3
  • 18
    • 0031400611 scopus 로고    scopus 로고
    • Anti-HBV vaccination before therapy with interferon (IFN) in chronic B hepatitis
    • Fruttaldo L, Schettino G, Mongio F: Anti-HBV vaccination before therapy with interferon (IFN) in chronic B hepatitis. Eur Rev Med Pharmacol Sci 1997;1:197-201.
    • (1997) Eur Rev Med Pharmacol Sci , vol.1 , pp. 197-201
    • Fruttaldo, L.1    Schettino, G.2    Mongio, F.3
  • 20
    • 0023881623 scopus 로고
    • Recognition of hepatitis B surface antigen by human T lymphocytes. Proliferative and cytotoxic responses to a major antigenic determinant defined by synthetic peptides
    • Celis E, Ou D, Otvos L Jr: Recognition of hepatitis B surface antigen by human T lymphocytes. Proliferative and cytotoxic responses to a major antigenic determinant defined by synthetic peptides. J Immunol 1988;140:1808-1815.
    • (1988) J Immunol , vol.140 , pp. 1808-1815
    • Celis, E.1    Ou, D.2    Otvos L., Jr.3
  • 21
    • 0033050827 scopus 로고    scopus 로고
    • Specific vaccine therapy in chronic hepatitis B: Induction of T cell proliferative responses specific for envelope antigens
    • Couillin I, Pol S, Mancini M, Driss F, Brechot C, Tiollais P, Michel ML: Specific vaccine therapy in chronic hepatitis B: Induction of T cell proliferative responses specific for envelope antigens. J Infect Dis 1999;180:15-26.
    • (1999) J Infect Dis , vol.180 , pp. 15-26
    • Couillin, I.1    Pol, S.2    Mancini, M.3    Driss, F.4    Brechot, C.5    Tiollais, P.6    Michel, M.L.7
  • 25
    • 0029979729 scopus 로고    scopus 로고
    • Humoral and cellular immune responses to hepatitis B vaccination in hepatitis B surface antigen-carrier children who cleared serum-hepatitis B surface antigen
    • Hsu HY, Chang MH, Hsieh RP, Ni YH, Chi WK: Humoral and cellular immune responses to hepatitis B vaccination in hepatitis B surface antigen-carrier children who cleared serum-hepatitis B surface antigen. Hepatology 1996;24:1355-1360.
    • (1996) Hepatology , vol.24 , pp. 1355-1360
    • Hsu, H.Y.1    Chang, M.H.2    Hsieh, R.P.3    Ni, Y.H.4    Chi, W.K.5
  • 27
    • 0027495046 scopus 로고
    • Efficacy of immunotherapy with vaccination against hepatitis B virus on virus B multiplication
    • Pol S, Driss F, Carnot F, Michel ML, Berthelot P, Brechot C: Efficacy of immunotherapy with vaccination against hepatitis B virus on virus B multiplication (in French). C R Acad Sci III 1993;316:688-691.
    • (1993) C R Acad Sci III , vol.316 , pp. 688-691
    • Pol, S.1    Driss, F.2    Carnot, F.3    Michel, M.L.4    Berthelot, P.5    Brechot, C.6
  • 28
    • 0030001099 scopus 로고    scopus 로고
    • The woodchuck as a model of hepadnavirus infection, pathogenesis and therapy
    • Cote PJ, Gerin JL: The woodchuck as a model of hepadnavirus infection, pathogenesis and therapy. Forum Trends Exp Clin Med 1996;6:131-159.
    • (1996) Forum Trends Exp Clin Med , vol.6 , pp. 131-159
    • Cote, P.J.1    Gerin, J.L.2
  • 29
    • 0028809476 scopus 로고
    • The woodchuck: An animal model for hepatitis B virus infection in man
    • Roggendorf M, Tolle TK: The woodchuck: An animal model for hepatitis B virus infection in man. Intervirology 1995;38:100-112.
    • (1995) Intervirology , vol.38 , pp. 100-112
    • Roggendorf, M.1    Tolle, T.K.2
  • 30
    • 0035223703 scopus 로고    scopus 로고
    • The woodchuck model of hepatitis B virus infection
    • Tennant BC, Gerin JL: The woodchuck model of hepatitis B virus infection. ILAR J 2001;42:89-102.
    • (2001) ILAR J , vol.42 , pp. 89-102
    • Tennant, B.C.1    Gerin, J.L.2
  • 31
    • 0034011592 scopus 로고    scopus 로고
    • Treatment of chronic woodchuck hepatitis virus infection in the Eastern woodchuck (Marmota monax) with nucleoside analogues is predictive of therapy for chronic hepatitis B virus infection in humans
    • Korba BE, Cote PJ, Hornbuckle WE, Tennant BC, Gerin JL: Treatment of chronic woodchuck hepatitis virus infection in the Eastern woodchuck (Marmota monax) with nucleoside analogues is predictive of therapy for chronic hepatitis B virus infection in humans. Hepatology 2000;31:1165-1175.
    • (2000) Hepatology , vol.31 , pp. 1165-1175
    • Korba, B.E.1    Cote, P.J.2    Hornbuckle, W.E.3    Tennant, B.C.4    Gerin, J.L.5
  • 32
    • 0035196639 scopus 로고    scopus 로고
    • Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax)
    • Peek SF, Cote PJ, Jacob JR, Toshkov IA, Hornbuckle WE, Baldwin BH, Wells FV, Chu CK, Gerin JL, Tennant BC, Korba BE: Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax). Hepatology 2001;33:254-266.
    • (2001) Hepatology , vol.33 , pp. 254-266
    • Peek, S.F.1    Cote, P.J.2    Jacob, J.R.3    Toshkov, I.A.4    Hornbuckle, W.E.5    Baldwin, B.H.6    Wells, F.V.7    Chu, C.K.8    Gerin, J.L.9    Tennant, B.C.10    Korba, B.E.11
  • 33
    • 0038095430 scopus 로고
    • Immunopathogenesis and immunomodulation of woodchuck hepatitis virus infection
    • Hollinger FB, Lemon SM, Margolis HS (eds). Baltimore, Williams & Wilkins
    • Cote PJ, Korba BE, Tennant BC, Gerin JL: Immunopathogenesis and immunomodulation of woodchuck hepatitis virus infection; in Hollinger FB, Lemon SM, Margolis HS (eds): Viral Hepatitis and Liver Disease. Baltimore, Williams & Wilkins, 1991, pp 483-486.
    • (1991) Viral Hepatitis and Liver Disease , pp. 483-486
    • Cote, P.J.1    Korba, B.E.2    Tennant, B.C.3    Gerin, J.L.4
  • 36
    • 0034945574 scopus 로고    scopus 로고
    • T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine
    • Hervas-Stubbs S, Lasarte JJ, Sarobe P, Vivas I, Condreay L, Cullen JM, Prieto J, Borras-Cuesta F: T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine. J Hepatol 2001;35:105-111.
    • (2001) J Hepatol , vol.35 , pp. 105-111
    • Hervas-Stubbs, S.1    Lasarte, J.J.2    Sarobe, P.3    Vivas, I.4    Condreay, L.5    Cullen, J.M.6    Prieto, J.7    Borras-Cuesta, F.8
  • 37
    • 0032889271 scopus 로고    scopus 로고
    • Immunization of woodchucks with plasmids expressing woodchuck hepatitis virus (WHV) core antigen and surface antigen suppresses WHV infection
    • Lu M, Hilken G, Kruppenbacher J, Kemper T, Schirmbeck R, Reimann J, Roggendorf M: Immunization of woodchucks with plasmids expressing woodchuck hepatitis virus (WHV) core antigen and surface antigen suppresses WHV infection. J Virol 1999;73:281-289.
    • (1999) J Virol , vol.73 , pp. 281-289
    • Lu, M.1    Hilken, G.2    Kruppenbacher, J.3    Kemper, T.4    Schirmbeck, R.5    Reimann, J.6    Roggendorf, M.7
  • 38
    • 0027177152 scopus 로고
    • Immunization with recombinant woodchuck hepatitis virus nucleocapsid antigen or hepatitis B virus nucleocapsid antigen protects woodchucks from woodchuck hepatitis virus infection
    • Schodel F, Neckermann G, Peterson D, Fuchs K, Fuller S, Will H, Roggendorf M: Immunization with recombinant woodchuck hepatitis virus nucleocapsid antigen or hepatitis B virus nucleocapsid antigen protects woodchucks from woodchuck hepatitis virus infection. Vaccine 1993;11:624-628.
    • (1993) Vaccine , vol.11 , pp. 624-628
    • Schodel, F.1    Neckermann, G.2    Peterson, D.3    Fuchs, K.4    Fuller, S.5    Will, H.6    Roggendorf, M.7
  • 40
    • 0029112180 scopus 로고
    • In vitro activation of woodchuck lymphocytes measured by radiopurine incorporation and interleukin-2 production: Implications for modeling immunity and therapy in hepatitis B virus infection
    • Cote PJ, Gerin JL: In vitro activation of woodchuck lymphocytes measured by radiopurine incorporation and interleukin-2 production: Implications for modeling immunity and therapy in hepatitis B virus infection. Hepatology 1995;22:687-699.
    • (1995) Hepatology , vol.22 , pp. 687-699
    • Cote, P.J.1    Gerin, J.L.2
  • 42
    • 0033803194 scopus 로고    scopus 로고
    • Temporal pathogenesis of experimental neonatal woodchuck hepatitis virus infection: Increased initial viral load and decreased severity of acute hepatitis during the development of chronic viral infection
    • Cote PJ, Toshkov IA, Bellezza C, Ascenzi M, Roneker CA, Graham LA, Baldwin BH, Gaye K, Nakamura I, Korba BE, Tennant BC, Gerin JL: Temporal pathogenesis of experimental neonatal woodchuck hepatitis virus infection: Increased initial viral load and decreased severity of acute hepatitis during the development of chronic viral infection. Hepatology 2000;32:807-817.
    • (2000) Hepatology , vol.32 , pp. 807-817
    • Cote, P.J.1    Toshkov, I.A.2    Bellezza, C.3    Ascenzi, M.4    Roneker, C.A.5    Graham, L.A.6    Baldwin, B.H.7    Gaye, K.8    Nakamura, I.9    Korba, B.E.10    Tennant, B.C.11    Gerin, J.L.12
  • 44
    • 0031060105 scopus 로고    scopus 로고
    • Characterization of T-cell response to woodchuck hepatitis virus core protein and protection of woodchucks from infection by immunization with peptides containing a T-cell epitope
    • Menne S, Maschke J, Tolle TK, Lu M, Roggendorf M: Characterization of T-cell response to woodchuck hepatitis virus core protein and protection of woodchucks from infection by immunization with peptides containing a T-cell epitope. J Virol 1997;71:65-74.
    • (1997) J Virol , vol.71 , pp. 65-74
    • Menne, S.1    Maschke, J.2    Tolle, T.K.3    Lu, M.4    Roggendorf, M.5
  • 45
    • 0002544856 scopus 로고    scopus 로고
    • Cellular immune response of woodchucks to woodchuck hepatitis virus surface protein during acute WHV infection
    • Rizzetto M, Gerin JL, Verme G (eds). Turin, Minerva Medica
    • Menne S, Maschke J, Klaes R, Grosse-Wilde H, Roggendorf M: Cellular immune response of woodchucks to woodchuck hepatitis virus surface protein during acute WHV infection; in Rizzetto M, Gerin JL, Verme G (eds): Viral Hepatitis and Liver Disease. Turin, Minerva Medica, 1997, pp 453-457.
    • (1997) Viral Hepatitis and Liver Disease , pp. 453-457
    • Menne, S.1    Maschke, J.2    Klaes, R.3    Grosse-Wilde, H.4    Roggendorf, M.5
  • 46
    • 0031747582 scopus 로고    scopus 로고
    • T-cell response to woodchuck hepatitis virus (WHV) antigens during acute self-limited WHV infection and convalescence and after viral challenge
    • Menne S, Maschke J, Lu M, Grosse-Wilde H, Roggendorf M: T-cell response to woodchuck hepatitis virus (WHV) antigens during acute self-limited WHV infection and convalescence and after viral challenge. J Virol 1998;72:6083-6091.
    • (1998) J Virol , vol.72 , pp. 6083-6091
    • Menne, S.1    Maschke, J.2    Lu, M.3    Grosse-Wilde, H.4    Roggendorf, M.5
  • 47
    • 0036147894 scopus 로고    scopus 로고
    • Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation
    • Menne S, Roneker CA, Gerin JL, Cote PJ, Tennant BC: Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation. J Virol 2002;76:1769-1780.
    • (2002) J Virol , vol.76 , pp. 1769-1780
    • Menne, S.1    Roneker, C.A.2    Gerin, J.L.3    Cote, P.J.4    Tennant, B.C.5
  • 48
    • 0034762225 scopus 로고    scopus 로고
    • Augmented hepatic interferon gamma expression and T-cell influx characterize acute hepatitis progressing to recovery and residual lifelong virus persistence in experimental adult woodchuck hepatitis virus infection
    • Hodgson PD, Michalak TI: Augmented hepatic interferon gamma expression and T-cell influx characterize acute hepatitis progressing to recovery and residual lifelong virus persistence in experimental adult woodchuck hepatitis virus infection. Hepatology 2001;34:1049-1059.
    • (2001) Hepatology , vol.34 , pp. 1049-1059
    • Hodgson, P.D.1    Michalak, T.I.2
  • 49
    • 0035140877 scopus 로고    scopus 로고
    • Pathogenesis of experimental neonatal woodchuck hepatitis virus infection: Chronicity as an outcome of infection is associated with a diminished acute hepatitis that is temporally deficient for the expression of interferon-gamma and tumor necrosis factor-alpha messenger RNAs
    • Nakamura I, Nupp JT, Cowlen M, Hall WC, Tennant BC, Casey JL, Gerin JL, Cote PJ: Pathogenesis of experimental neonatal woodchuck hepatitis virus infection: Chronicity as an outcome of infection is associated with a diminished acute hepatitis that is temporally deficient for the expression of interferon-gamma and tumor necrosis factor-alpha messenger RNAs. Hepatology 2001;33:439-447.
    • (2001) Hepatology , vol.33 , pp. 439-447
    • Nakamura, I.1    Nupp, J.T.2    Cowlen, M.3    Hall, W.C.4    Tennant, B.C.5    Casey, J.L.6    Gerin, J.L.7    Cote, P.J.8
  • 50
    • 0016527473 scopus 로고
    • Biophysical characterization of the adr subtype of hepatitis B antigen and preparation of anti-d sera in rabbits
    • Gerin JL, Faust RM, Holland PV: Biophysical characterization of the adr subtype of hepatitis B antigen and preparation of anti-d sera in rabbits. J Immunol 1975;115:100-105.
    • (1975) J Immunol , vol.115 , pp. 100-105
    • Gerin, J.L.1    Faust, R.M.2    Holland, P.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.