PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Tzeng, Horng Tay ^a   Tsai, Hwei Fang ^b,c   Liao, Hsiu Jung ^a   Lin, Yi Jiun ^a   Chen, Lieping ^d   Chen, Pei Jer ^a   Hsu, Ping Ning ^a,e  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d YALE CANCER CENTER   (United States)

^e NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HEPATITIS B CORE ANTIGEN; INTERLEUKIN 7 RECEPTOR; MONOCLONAL ANTIBODY; PROGRAMMED DEATH 1 RECEPTOR; PROGRAMMED DEATH 1 RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEPATITIS B; HEPATITIS B VIRUS; IMMUNE DYSFUNCTION; IMMUNOPATHOLOGY; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PERSISTENT INFECTION; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; REPEATED DRUG DOSE; T LYMPHOCYTE; VIRAL CLEARANCE;

EID: 84983720423     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039179     Document Type: Article

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