Novel bifunctional alkylating agents, 5,10-dihydropyrrolo[1,2-b] isoquinoline derivatives, synthesis and biological activity

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 275-286

  Chaniyara, Ravi ^a,d   Kapuriya, Naval ^a   Dong, Huajin ^b   Lee, Pei Chih ^a   Suman, Sharda ^a   Marvania, Bhavin ^a,d   Chou, Ting Chao ^b   Lee, Te Chang ^a   Kakadiya, Rajesh ^a   Shah, Anamik ^d   Su, Tsann Long ^a,c  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d SAURASHTRA UNIVERSITY   (India)

Author keywords

Antitumor agents; Cell cycle; DNA interstrand cross linking; Pyrrolo 1,2 b isoquinoline; Structure activity relationships

Indexed keywords

1,2 BIS(HYDROXYMETHYL) 3 METHYL 5,10 DIHYDROPYRROLO[1,2 B]ISOQUINOLINE; [3 (4 METHOXYPHENYL) 5,10 DIHYDROPYRROLO[1,2 B]ISOQUINOLINE 1,2 DIYL]BIS(METHYLENE)BIS(ISOPROPYLCARBAMATE); [3 (4 METHOXYPHENYL) 5,10 DIHYDROPYRROLO[1,2 B]ISOQUINOLINE 1,2 DIYL]DIMETHANOL; [3 METHYL 5,10 DIHYDROPYRROLO[1,2 B]ISOQUINOLINE 1,2 DIYL]BIS(METHYLENE)BIS (ETHYLCARBAMATE); AGAROSE; ALKYLATING AGENT; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; TUMOR REGRESSION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL CYCLE; CELL LINE, TUMOR; HUMANS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, NUDE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; MUS MUSCULUS;

EID: 78650756956     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.030     Document Type: Article

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