Co-delivery of ccl19 gene enhances anti-caries DNA vaccine pCIA-P immunogenicity in mice by increasing dendritic cell migration to secondary lymphoid tissues

Acta Pharmacologica Sinica

Volumn 34, Issue 3, 2013, Pages 432-440

  Yan, Yan Hong ^a   Qi, Sheng Cai ^b   Su, Ling Kai ^a   Xu, Qing An ^a   Fan, Ming Wen ^a  

^a WUHAN UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

anti caries DNA vaccine; CCL19; chemokine; dendritic cell; DNA vaccination; IFN ; IL 4; splenocyte; stomatology

Indexed keywords

ANTICARIES AGENT; CCL19 GFP FUSION PROTEIN; DNA VACCINE; GAMMA INTERFERON; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; PLASMID DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DNA IMMUNIZATION; DNA SEQUENCE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPE; GENE DELIVERY SYSTEM; IMMUNE RESPONSE; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE; LYMPHOID TISSUE; MOUSE; NONHUMAN; PLASMID; PROTEIN EXPRESSION; SPLEEN CELL; STOMATOLOGY; TH1 CELL; TH2 CELL;

ANIMALS; ANTIBODIES, BACTERIAL; CERCOPITHECUS AETHIOPS; CHEMOKINE CCL19; CHEMOTAXIS; COS CELLS; CYTOKINES; DENDRITIC CELLS; DENTAL CARIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; INJECTIONS, INTRAMUSCULAR; LYMPH NODES; MICE; PLASMIDS; RECOMBINANT FUSION PROTEINS; SPLEEN; STREPTOCOCCUS MUTANS; TRANSFECTION; VACCINES, DNA;

EID: 84874628046     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.153     Document Type: Article

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