PXR/CYP3A4-humanized mice for studying drug-drug interactions involving intestinal P-glycoprotein

Molecular Pharmaceutics

Volumn 10, Issue 3, 2013, Pages 1056-1062

  Holmstock, Nico ^a   Gonzalez, Frank J ^b   Baes, Myriam ^c   Annaert, Pieter ^a   Augustijns, Patrick ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

darunavir; humanized mouse; in situ intestinal perfusion; P glycoprotein; PXR; rifampicin

Indexed keywords

1 AMINOBENZOTRIAZOLE; CYTOCHROME P450 3A4; DARUNAVIR; ELACRIDAR; MULTIDRUG RESISTANCE PROTEIN; PREGNANE X RECEPTOR; RIFAMPICIN; SULFORAPHANE; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFECT; DRUG TRANSPORT; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; INTESTINE PERFUSION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; WESTERN BLOTTING;

EID: 84874627895     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300512r     Document Type: Article

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