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Volumn 4, Issue 4, 2008, Pages 759-765

Combating HIV resistance - Focus on darunavir

Author keywords

Antiretroviral therapy; HIV 1; Protease inhibitor; Resistance

Indexed keywords

ANTIRETROVIRUS AGENT; CYTOCHROME P450 3A4; DARUNAVIR; DARUNAVIR PLUS RITONAVIR; ETRAVIRINE; LOPINAVIR PLUS RITONAVIR; PROTEINASE INHIBITOR; TIPRANAVIR; UNCLASSIFIED DRUG;

EID: 52949132229     PISSN: 11766336     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (27)

References (40)
  • 1
    • 20644450806 scopus 로고    scopus 로고
    • TMC114/ritonavir substitution for protease inhibitor(s) in a non-suppressive antiretroviral regimen: A 14-day proof-of-principle trial
    • Arasteh K, Clumeck N, Pozniak A, et al. 2005. TMC114/ritonavir substitution for protease inhibitor(s) in a non-suppressive antiretroviral regimen: a 14-day proof-of-principle trial. Aids, 19:943-7.
    • (2005) Aids , vol.19 , pp. 943-947
    • Arasteh, K.1    Clumeck, N.2    Pozniak, A.3
  • 2
    • 34547421880 scopus 로고    scopus 로고
    • Darunavir: A second-generation protease inhibitor
    • Busse KH, Penzak SR. 2007. Darunavir: A second-generation protease inhibitor. Am J Health Syst Pharm, 64:1593-602.
    • (2007) Am J Health Syst Pharm , vol.64 , pp. 1593-1602
    • Busse, K.H.1    Penzak, S.R.2
  • 3
    • 35048840600 scopus 로고    scopus 로고
    • Maraviroc
    • discussion 2289-90
    • Carter NJ, Keating GM. 2007. Maraviroc. Drugs, 67, 2277-88; discussion 2289-90.
    • (2007) Drugs , vol.67 , pp. 2277-2288
    • Carter, N.J.1    Keating, G.M.2
  • 4
    • 34047207229 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials
    • Clotet B, Bellos N, Molina JM, et al. 2007. Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials. Lancet, 369:1169-78.
    • (2007) Lancet , vol.369 , pp. 1169-1178
    • Clotet, B.1    Bellos, N.2    Molina, J.M.3
  • 5
    • 52749099829 scopus 로고    scopus 로고
    • ARTEMIS - Efficacy and Safety of Lopinavir (BID vs QD) and Darunavir (QD) in Antiretroviral-Naive Patients
    • Madrid, Spain
    • Clumeck N, Chiliade P, Clotet B, et al. 2007. ARTEMIS - Efficacy and Safety of Lopinavir (BID vs QD) and Darunavir (QD) in Antiretroviral-Naive Patients 11th European AIDS Conference. Madrid, Spain.
    • (2007) 11th European AIDS Conference
    • Clumeck, N.1    Chiliade, P.2    Clotet, B.3
  • 6
    • 19544386471 scopus 로고    scopus 로고
    • TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates
    • De Meyer S, Azijn H, Surleraux D, et al. 2005. TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother, 49:2314-21.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2314-2321
    • De Meyer, S.1    Azijn, H.2    Surleraux, D.3
  • 7
    • 33846903003 scopus 로고    scopus 로고
    • Phenotypic and genotypic determinants of resistance to TMC114: Pooled analysis of POWER 1
    • and, Sitges, Spain
    • De Meyer S, Lefebvre E, Azijn H, et al. 2006. Phenotypic and genotypic determinants of resistance to TMC114: pooled analysis of POWER 1, 2 and 3. 15th International HIV Drug Resistance Workshop. Sitges, Spain.
    • (2006) 15th International HIV Drug Resistance Workshop , pp. 2-3
    • De Meyer, S.1    Lefebvre, E.2    Azijn, H.3
  • 8
    • 52949089193 scopus 로고    scopus 로고
    • Effect of baseline and on-treatment mutations on the antiretroviral activity of darunavir/ritonavir (DRV/r) and lopinavir/ritonavir (LPV/r): Results of a randomised, controlled, phase III study (TITAN)
    • Sydney, Australia
    • De Meyer S, Vangeneugden T, van Baelen B, et al. 2007. Effect of baseline and on-treatment mutations on the antiretroviral activity of darunavir/ritonavir (DRV/r) and lopinavir/ritonavir (LPV/r): results of a randomised, controlled, phase III study (TITAN). 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention. Sydney, Australia.
    • (2007) 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
    • De Meyer, S.1    Vangeneugden, T.2    van Baelen, B.3
  • 9
    • 41449098109 scopus 로고    scopus 로고
    • Resistance profile of darunavir: Combined 24-week results from the POWER trials
    • De Meyer S, Vangeneugden T, Van Baelen B, et al. 2008. Resistance profile of darunavir: combined 24-week results from the POWER trials. AIDS Res Hum Retroviruses, 24:379-88.
    • (2008) AIDS Res Hum Retroviruses , vol.24 , pp. 379-388
    • De Meyer, S.1    Vangeneugden, T.2    Van Baelen, B.3
  • 10
    • 42049111688 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir/ ritonavir versus lopinavir/ritonavir in ARV treatment-naive HIV-1-infected patients at week 48: ARTEMIS
    • ICAAC, Chicago, Illinois
    • Dejesus E, Ortiz R, Khanlou H. 2007. Efficacy and safety of darunavir/ ritonavir versus lopinavir/ritonavir in ARV treatment-naive HIV-1-infected patients at week 48: ARTEMIS. 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Chicago, Illinois.
    • (2007) 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Dejesus, E.1    Ortiz, R.2    Khanlou, H.3
  • 11
    • 34248549145 scopus 로고    scopus 로고
    • Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients
    • Delaugerre C, Mathez D, Peytavin G, et al. 2007. Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients. Aids, 21:1210-3.
    • (2007) Aids , vol.21 , pp. 1210-1213
    • Delaugerre, C.1    Mathez, D.2    Peytavin, G.3
  • 12
    • 52949148752 scopus 로고    scopus 로고
    • US Department of Health and Human Services. 2008. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. In DHHS (Ed.).
    • [DHHS] US Department of Health and Human Services. 2008. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. In DHHS (Ed.).
  • 13
    • 0032580479 scopus 로고    scopus 로고
    • HIV-protease inhibitors
    • Flexner C. 1999. HIV-protease inhibitors. N Engl J Med, 338:1291-92.
    • (1999) N Engl J Med , vol.338 , pp. 1291-1292
    • Flexner, C.1
  • 14
    • 38949203748 scopus 로고    scopus 로고
    • Design of HIV protease inhibitors targeting protein backbone: An effective strategy for combating drug resistance
    • Ghosh AK, Chapsal BD, Weber IT, et al. 2007. Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance. Acc Chem Res, 41:78-86.
    • (2007) Acc Chem Res , vol.41 , pp. 78-86
    • Ghosh, A.K.1    Chapsal, B.D.2    Weber, I.T.3
  • 15
    • 33747479539 scopus 로고    scopus 로고
    • Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance
    • Ghosh A K, Sridhar PR, Leshchenko S, et al. 2006. Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance. J Med Chem, 49:5252-61.
    • (2006) J Med Chem , vol.49 , pp. 5252-5261
    • Ghosh, A.K.1    Sridhar, P.R.2    Leshchenko, S.3
  • 16
    • 34147136222 scopus 로고    scopus 로고
    • Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
    • Grinsztejn B, Nguyen BY, Katlama C, et al. 2007. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet, 369:1261-9.
    • (2007) Lancet , vol.369 , pp. 1261-1269
    • Grinsztejn, B.1    Nguyen, B.Y.2    Katlama, C.3
  • 17
  • 18
    • 52949147975 scopus 로고    scopus 로고
    • Genotypic relationships between tipranavir and darunavir resistance in protease inhibitor experienced patients
    • Barbados, West Indies
    • Hall DB, Schapiro J, Boucher CAB, et al. 2007. Genotypic relationships between tipranavir and darunavir resistance in protease inhibitor experienced patients. 6th Intl HIV Drug Resistance Workshop. Barbados, West Indies.
    • (2007) 6th Intl HIV Drug Resistance Workshop
    • Hall, D.B.1    Schapiro, J.2    Boucher, C.A.B.3
  • 19
    • 34247562010 scopus 로고    scopus 로고
    • Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society - USA panel
    • Hammer SM, Saag MS, Schechter M, et al. 2006. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society - USA panel. Top HIV Med, 14:827-43.
    • (2006) Top HIV Med , vol.14 , pp. 827-843
    • Hammer, S.M.1    Saag, M.S.2    Schechter, M.3
  • 20
    • 35748933494 scopus 로고    scopus 로고
    • Update of the drug resistance mutations in HIV-1: 2007
    • Johnson VA, Brun-Vezinet F, Clotet B, et al. 2007. Update of the drug resistance mutations in HIV-1: 2007. Top HIV Med, 15:119-25.
    • (2007) Top HIV Med , vol.15 , pp. 119-125
    • Johnson, V.A.1    Brun-Vezinet, F.2    Clotet, B.3
  • 21
    • 33847041109 scopus 로고    scopus 로고
    • Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-week results of POWER 1
    • Katlama C, Esposito R, Gatell JM, et al. 2007. Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-week results of POWER 1. Aids, 21:395-402.
    • (2007) Aids , vol.21 , pp. 395-402
    • Katlama, C.1    Esposito, R.2    Gatell, J.M.3
  • 22
    • 6344231715 scopus 로고    scopus 로고
    • Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor
    • King NM, Prabu-Jeyabalan M, Nalivaika EA, et al. 2004. Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor. J Virol, 78:12012-21.
    • (2004) J Virol , vol.78 , pp. 12012-12021
    • King, N.M.1    Prabu-Jeyabalan, M.2    Nalivaika, E.A.3
  • 23
    • 35348960903 scopus 로고    scopus 로고
    • Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization
    • Koh Y, Matsumi S, Das D, et al. 2007. Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. J Biol Chem, 39:28709-20.
    • (2007) J Biol Chem , vol.39 , pp. 28709-28720
    • Koh, Y.1    Matsumi, S.2    Das, D.3
  • 24
    • 10744226241 scopus 로고    scopus 로고
    • Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro
    • Koh Y, Nakata H, Maeda K, et al. 2003. Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother, 47:3123-9.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3123-3129
    • Koh, Y.1    Nakata, H.2    Maeda, K.3
  • 25
    • 33748955158 scopus 로고    scopus 로고
    • Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114
    • Kovalevsky AY, Liu F, Leshchenko S, et al. 2006a. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. J Mol Biol, 363:161-73.
    • (2006) J Mol Biol , vol.363 , pp. 161-173
    • Kovalevsky, A.Y.1    Liu, F.2    Leshchenko, S.3
  • 26
    • 33144466093 scopus 로고    scopus 로고
    • Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M
    • Kovalevsky AY, Tie Y, Liu F, et al. 2006b. Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. J Med Chem, 49:1379-87.
    • (2006) J Med Chem , vol.49 , pp. 1379-1387
    • Kovalevsky, A.Y.1    Tie, Y.2    Liu, F.3
  • 27
    • 39049146710 scopus 로고    scopus 로고
    • HIV resistance: Frequency, testing, mechanisms
    • Kuritzkes DR. 2007, HIV resistance: frequency, testing, mechanisms. Top HIV Med, 15:150-4.
    • (2007) Top HIV Med , vol.15 , pp. 150-154
    • Kuritzkes, D.R.1
  • 28
    • 34347354196 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial
    • Lazzarin A, Campbell T, Clotet B, et al. 2007. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 370:39-48.
    • (2007) Lancet , vol.370 , pp. 39-48
    • Lazzarin, A.1    Campbell, T.2    Clotet, B.3
  • 29
    • 34347329093 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomised controlled phase III trial
    • Madruga JV, Berger D, McMurchie M, et al. 2007a. Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: a randomised controlled phase III trial. Lancet, 370:49-58.
    • (2007) Lancet , vol.370 , pp. 49-58
    • Madruga, J.V.1    Berger, D.2    McMurchie, M.3
  • 30
    • 34347327010 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
    • Madruga JV, Cahn P, Grinsztejn B, et al. 2007b. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 370:29-38.
    • (2007) Lancet , vol.370 , pp. 29-38
    • Madruga, J.V.1    Cahn, P.2    Grinsztejn, B.3
  • 31
    • 33847363099 scopus 로고    scopus 로고
    • Key reports from the XV International HIV Drug Resistance Workshop 2006
    • Mascolini M, Boucher C, Larder B, et al. 2007. Key reports from the XV International HIV Drug Resistance Workshop 2006. Antivir Ther, 12:131-45.
    • (2007) Antivir Ther , vol.12 , pp. 131-145
    • Mascolini, M.1    Boucher, C.2    Larder, B.3
  • 32
    • 34548212545 scopus 로고    scopus 로고
    • Safety and efficacy of darunavir (TMC114) with low-dose ritonavir in treatment-experienced patients: 24-week results of POWER 3
    • Molina JM, Cohen C, Katlama C, et al. 2007. Safety and efficacy of darunavir (TMC114) with low-dose ritonavir in treatment-experienced patients: 24-week results of POWER 3. J Acquir Immune Defic Syndr, 46:24-31.
    • (2007) J Acquir Immune Defic Syndr , vol.46 , pp. 24-31
    • Molina, J.M.1    Cohen, C.2    Katlama, C.3
  • 33
    • 52949104576 scopus 로고    scopus 로고
    • Analyses of susceptibility and cross-resistance between TMC114 and other protease inhibitors among >56,000 routine samples, using linear regression model-based fold change predictions
    • Sitges, Spain
    • Picchio G. 2006. Analyses of susceptibility and cross-resistance between TMC114 and other protease inhibitors among >56,000 routine samples, using linear regression model-based fold change predictions. X-V International Drug Resistance Workshop. Sitges, Spain.
    • (2006) International Drug Resistance Workshop
    • Picchio, G.1
  • 34
    • 34548749164 scopus 로고    scopus 로고
    • Prevalence of darunavir resistance mutations in HIV-1-infected patients failing other protease inhibitors
    • Poveda E, de Mendoza C, Martin-Carbonero L, et al. 2007. Prevalence of darunavir resistance mutations in HIV-1-infected patients failing other protease inhibitors. J Antimicrob Chemother, 60:885-8.
    • (2007) J Antimicrob Chemother , vol.60 , pp. 885-888
    • Poveda, E.1    de Mendoza, C.2    Martin-Carbonero, L.3
  • 35
    • 34247132119 scopus 로고    scopus 로고
    • Researchers buoyed by novel HIV drugs: Will expand drug arsenal against resistant virus
    • Stephenson J 2007. Researchers buoyed by novel HIV drugs: will expand drug arsenal against resistant virus. JAMA, 297:1535-6.
    • (2007) JAMA , vol.297 , pp. 1535-1536
    • Stephenson, J.1
  • 36
    • 20144382495 scopus 로고    scopus 로고
    • Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor
    • Surleraux DL, Tahri A, Verschueren WG, et al. 2005. Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor. J Med Chem, 48:1813-22.
    • (2005) J Med Chem , vol.48 , pp. 1813-1822
    • Surleraux, D.L.1    Tahri, A.2    Verschueren, W.G.3
  • 37
    • 33847361008 scopus 로고    scopus 로고
    • Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir
    • Tie Y, Kovalevsky AY, Boross P, et al. 2007. Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir. Proteins, 67:232-42.
    • (2007) Proteins , vol.67 , pp. 232-242
    • Tie, Y.1    Kovalevsky, A.Y.2    Boross, P.3
  • 38
    • 36448931967 scopus 로고    scopus 로고
    • Integrase inhibitor gains FDA approval
    • Traynor K. 2007. Integrase inhibitor gains FDA approval. Am J Health Syst Pharm, 64:2310.
    • (2007) Am J Health Syst Pharm , vol.64 , pp. 2310
    • Traynor, K.1
  • 40
    • 34547841291 scopus 로고    scopus 로고
    • Prediction of HIV-1 drug susceptibility phenotype from the viral genotype using linear regression modeling
    • Vermeiren H, van Craenenbroeck E, Alen P, et al. 2007. Prediction of HIV-1 drug susceptibility phenotype from the viral genotype using linear regression modeling. J Virol Methods, 145:47-55.
    • (2007) J Virol Methods , vol.145 , pp. 47-55
    • Vermeiren, H.1    van Craenenbroeck, E.2    Alen, P.3


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