-
1
-
-
20644450806
-
TMC114/ritonavir substitution for protease inhibitor(s) in a non-suppressive antiretroviral regimen: A 14-day proof-of-principle trial
-
Arasteh K, Clumeck N, Pozniak A, et al. 2005. TMC114/ritonavir substitution for protease inhibitor(s) in a non-suppressive antiretroviral regimen: a 14-day proof-of-principle trial. Aids, 19:943-7.
-
(2005)
Aids
, vol.19
, pp. 943-947
-
-
Arasteh, K.1
Clumeck, N.2
Pozniak, A.3
-
2
-
-
34547421880
-
Darunavir: A second-generation protease inhibitor
-
Busse KH, Penzak SR. 2007. Darunavir: A second-generation protease inhibitor. Am J Health Syst Pharm, 64:1593-602.
-
(2007)
Am J Health Syst Pharm
, vol.64
, pp. 1593-1602
-
-
Busse, K.H.1
Penzak, S.R.2
-
3
-
-
35048840600
-
Maraviroc
-
discussion 2289-90
-
Carter NJ, Keating GM. 2007. Maraviroc. Drugs, 67, 2277-88; discussion 2289-90.
-
(2007)
Drugs
, vol.67
, pp. 2277-2288
-
-
Carter, N.J.1
Keating, G.M.2
-
4
-
-
34047207229
-
Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials
-
Clotet B, Bellos N, Molina JM, et al. 2007. Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials. Lancet, 369:1169-78.
-
(2007)
Lancet
, vol.369
, pp. 1169-1178
-
-
Clotet, B.1
Bellos, N.2
Molina, J.M.3
-
5
-
-
52749099829
-
ARTEMIS - Efficacy and Safety of Lopinavir (BID vs QD) and Darunavir (QD) in Antiretroviral-Naive Patients
-
Madrid, Spain
-
Clumeck N, Chiliade P, Clotet B, et al. 2007. ARTEMIS - Efficacy and Safety of Lopinavir (BID vs QD) and Darunavir (QD) in Antiretroviral-Naive Patients 11th European AIDS Conference. Madrid, Spain.
-
(2007)
11th European AIDS Conference
-
-
Clumeck, N.1
Chiliade, P.2
Clotet, B.3
-
6
-
-
19544386471
-
TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates
-
De Meyer S, Azijn H, Surleraux D, et al. 2005. TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother, 49:2314-21.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 2314-2321
-
-
De Meyer, S.1
Azijn, H.2
Surleraux, D.3
-
7
-
-
33846903003
-
Phenotypic and genotypic determinants of resistance to TMC114: Pooled analysis of POWER 1
-
and, Sitges, Spain
-
De Meyer S, Lefebvre E, Azijn H, et al. 2006. Phenotypic and genotypic determinants of resistance to TMC114: pooled analysis of POWER 1, 2 and 3. 15th International HIV Drug Resistance Workshop. Sitges, Spain.
-
(2006)
15th International HIV Drug Resistance Workshop
, pp. 2-3
-
-
De Meyer, S.1
Lefebvre, E.2
Azijn, H.3
-
8
-
-
52949089193
-
Effect of baseline and on-treatment mutations on the antiretroviral activity of darunavir/ritonavir (DRV/r) and lopinavir/ritonavir (LPV/r): Results of a randomised, controlled, phase III study (TITAN)
-
Sydney, Australia
-
De Meyer S, Vangeneugden T, van Baelen B, et al. 2007. Effect of baseline and on-treatment mutations on the antiretroviral activity of darunavir/ritonavir (DRV/r) and lopinavir/ritonavir (LPV/r): results of a randomised, controlled, phase III study (TITAN). 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention. Sydney, Australia.
-
(2007)
4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
-
-
De Meyer, S.1
Vangeneugden, T.2
van Baelen, B.3
-
9
-
-
41449098109
-
Resistance profile of darunavir: Combined 24-week results from the POWER trials
-
De Meyer S, Vangeneugden T, Van Baelen B, et al. 2008. Resistance profile of darunavir: combined 24-week results from the POWER trials. AIDS Res Hum Retroviruses, 24:379-88.
-
(2008)
AIDS Res Hum Retroviruses
, vol.24
, pp. 379-388
-
-
De Meyer, S.1
Vangeneugden, T.2
Van Baelen, B.3
-
10
-
-
42049111688
-
Efficacy and safety of darunavir/ ritonavir versus lopinavir/ritonavir in ARV treatment-naive HIV-1-infected patients at week 48: ARTEMIS
-
ICAAC, Chicago, Illinois
-
Dejesus E, Ortiz R, Khanlou H. 2007. Efficacy and safety of darunavir/ ritonavir versus lopinavir/ritonavir in ARV treatment-naive HIV-1-infected patients at week 48: ARTEMIS. 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Chicago, Illinois.
-
(2007)
47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Dejesus, E.1
Ortiz, R.2
Khanlou, H.3
-
11
-
-
34248549145
-
Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients
-
Delaugerre C, Mathez D, Peytavin G, et al. 2007. Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients. Aids, 21:1210-3.
-
(2007)
Aids
, vol.21
, pp. 1210-1213
-
-
Delaugerre, C.1
Mathez, D.2
Peytavin, G.3
-
12
-
-
52949148752
-
-
US Department of Health and Human Services. 2008. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. In DHHS (Ed.).
-
[DHHS] US Department of Health and Human Services. 2008. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. In DHHS (Ed.).
-
-
-
-
13
-
-
0032580479
-
HIV-protease inhibitors
-
Flexner C. 1999. HIV-protease inhibitors. N Engl J Med, 338:1291-92.
-
(1999)
N Engl J Med
, vol.338
, pp. 1291-1292
-
-
Flexner, C.1
-
14
-
-
38949203748
-
Design of HIV protease inhibitors targeting protein backbone: An effective strategy for combating drug resistance
-
Ghosh AK, Chapsal BD, Weber IT, et al. 2007. Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance. Acc Chem Res, 41:78-86.
-
(2007)
Acc Chem Res
, vol.41
, pp. 78-86
-
-
Ghosh, A.K.1
Chapsal, B.D.2
Weber, I.T.3
-
15
-
-
33747479539
-
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance
-
Ghosh A K, Sridhar PR, Leshchenko S, et al. 2006. Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance. J Med Chem, 49:5252-61.
-
(2006)
J Med Chem
, vol.49
, pp. 5252-5261
-
-
Ghosh, A.K.1
Sridhar, P.R.2
Leshchenko, S.3
-
16
-
-
34147136222
-
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
-
Grinsztejn B, Nguyen BY, Katlama C, et al. 2007. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet, 369:1261-9.
-
(2007)
Lancet
, vol.369
, pp. 1261-1269
-
-
Grinsztejn, B.1
Nguyen, B.Y.2
Katlama, C.3
-
17
-
-
34548801428
-
Novel HIV treatment approved
-
Groeschen HM. 2007. Novel HIV treatment approved. Am J Health Syst Pharm, 64:1886.
-
(2007)
Am J Health Syst Pharm
, vol.64
, pp. 1886
-
-
Groeschen, H.M.1
-
18
-
-
52949147975
-
Genotypic relationships between tipranavir and darunavir resistance in protease inhibitor experienced patients
-
Barbados, West Indies
-
Hall DB, Schapiro J, Boucher CAB, et al. 2007. Genotypic relationships between tipranavir and darunavir resistance in protease inhibitor experienced patients. 6th Intl HIV Drug Resistance Workshop. Barbados, West Indies.
-
(2007)
6th Intl HIV Drug Resistance Workshop
-
-
Hall, D.B.1
Schapiro, J.2
Boucher, C.A.B.3
-
19
-
-
34247562010
-
Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society - USA panel
-
Hammer SM, Saag MS, Schechter M, et al. 2006. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society - USA panel. Top HIV Med, 14:827-43.
-
(2006)
Top HIV Med
, vol.14
, pp. 827-843
-
-
Hammer, S.M.1
Saag, M.S.2
Schechter, M.3
-
20
-
-
35748933494
-
Update of the drug resistance mutations in HIV-1: 2007
-
Johnson VA, Brun-Vezinet F, Clotet B, et al. 2007. Update of the drug resistance mutations in HIV-1: 2007. Top HIV Med, 15:119-25.
-
(2007)
Top HIV Med
, vol.15
, pp. 119-125
-
-
Johnson, V.A.1
Brun-Vezinet, F.2
Clotet, B.3
-
21
-
-
33847041109
-
Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-week results of POWER 1
-
Katlama C, Esposito R, Gatell JM, et al. 2007. Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-week results of POWER 1. Aids, 21:395-402.
-
(2007)
Aids
, vol.21
, pp. 395-402
-
-
Katlama, C.1
Esposito, R.2
Gatell, J.M.3
-
22
-
-
6344231715
-
Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor
-
King NM, Prabu-Jeyabalan M, Nalivaika EA, et al. 2004. Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor. J Virol, 78:12012-21.
-
(2004)
J Virol
, vol.78
, pp. 12012-12021
-
-
King, N.M.1
Prabu-Jeyabalan, M.2
Nalivaika, E.A.3
-
23
-
-
35348960903
-
Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization
-
Koh Y, Matsumi S, Das D, et al. 2007. Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. J Biol Chem, 39:28709-20.
-
(2007)
J Biol Chem
, vol.39
, pp. 28709-28720
-
-
Koh, Y.1
Matsumi, S.2
Das, D.3
-
24
-
-
10744226241
-
Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro
-
Koh Y, Nakata H, Maeda K, et al. 2003. Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother, 47:3123-9.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 3123-3129
-
-
Koh, Y.1
Nakata, H.2
Maeda, K.3
-
25
-
-
33748955158
-
Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114
-
Kovalevsky AY, Liu F, Leshchenko S, et al. 2006a. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. J Mol Biol, 363:161-73.
-
(2006)
J Mol Biol
, vol.363
, pp. 161-173
-
-
Kovalevsky, A.Y.1
Liu, F.2
Leshchenko, S.3
-
26
-
-
33144466093
-
Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M
-
Kovalevsky AY, Tie Y, Liu F, et al. 2006b. Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. J Med Chem, 49:1379-87.
-
(2006)
J Med Chem
, vol.49
, pp. 1379-1387
-
-
Kovalevsky, A.Y.1
Tie, Y.2
Liu, F.3
-
27
-
-
39049146710
-
HIV resistance: Frequency, testing, mechanisms
-
Kuritzkes DR. 2007, HIV resistance: frequency, testing, mechanisms. Top HIV Med, 15:150-4.
-
(2007)
Top HIV Med
, vol.15
, pp. 150-154
-
-
Kuritzkes, D.R.1
-
28
-
-
34347354196
-
Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial
-
Lazzarin A, Campbell T, Clotet B, et al. 2007. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 370:39-48.
-
(2007)
Lancet
, vol.370
, pp. 39-48
-
-
Lazzarin, A.1
Campbell, T.2
Clotet, B.3
-
29
-
-
34347329093
-
Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomised controlled phase III trial
-
Madruga JV, Berger D, McMurchie M, et al. 2007a. Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: a randomised controlled phase III trial. Lancet, 370:49-58.
-
(2007)
Lancet
, vol.370
, pp. 49-58
-
-
Madruga, J.V.1
Berger, D.2
McMurchie, M.3
-
30
-
-
34347327010
-
Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
-
Madruga JV, Cahn P, Grinsztejn B, et al. 2007b. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 370:29-38.
-
(2007)
Lancet
, vol.370
, pp. 29-38
-
-
Madruga, J.V.1
Cahn, P.2
Grinsztejn, B.3
-
31
-
-
33847363099
-
Key reports from the XV International HIV Drug Resistance Workshop 2006
-
Mascolini M, Boucher C, Larder B, et al. 2007. Key reports from the XV International HIV Drug Resistance Workshop 2006. Antivir Ther, 12:131-45.
-
(2007)
Antivir Ther
, vol.12
, pp. 131-145
-
-
Mascolini, M.1
Boucher, C.2
Larder, B.3
-
32
-
-
34548212545
-
Safety and efficacy of darunavir (TMC114) with low-dose ritonavir in treatment-experienced patients: 24-week results of POWER 3
-
Molina JM, Cohen C, Katlama C, et al. 2007. Safety and efficacy of darunavir (TMC114) with low-dose ritonavir in treatment-experienced patients: 24-week results of POWER 3. J Acquir Immune Defic Syndr, 46:24-31.
-
(2007)
J Acquir Immune Defic Syndr
, vol.46
, pp. 24-31
-
-
Molina, J.M.1
Cohen, C.2
Katlama, C.3
-
33
-
-
52949104576
-
Analyses of susceptibility and cross-resistance between TMC114 and other protease inhibitors among >56,000 routine samples, using linear regression model-based fold change predictions
-
Sitges, Spain
-
Picchio G. 2006. Analyses of susceptibility and cross-resistance between TMC114 and other protease inhibitors among >56,000 routine samples, using linear regression model-based fold change predictions. X-V International Drug Resistance Workshop. Sitges, Spain.
-
(2006)
International Drug Resistance Workshop
-
-
Picchio, G.1
-
34
-
-
34548749164
-
Prevalence of darunavir resistance mutations in HIV-1-infected patients failing other protease inhibitors
-
Poveda E, de Mendoza C, Martin-Carbonero L, et al. 2007. Prevalence of darunavir resistance mutations in HIV-1-infected patients failing other protease inhibitors. J Antimicrob Chemother, 60:885-8.
-
(2007)
J Antimicrob Chemother
, vol.60
, pp. 885-888
-
-
Poveda, E.1
de Mendoza, C.2
Martin-Carbonero, L.3
-
35
-
-
34247132119
-
Researchers buoyed by novel HIV drugs: Will expand drug arsenal against resistant virus
-
Stephenson J 2007. Researchers buoyed by novel HIV drugs: will expand drug arsenal against resistant virus. JAMA, 297:1535-6.
-
(2007)
JAMA
, vol.297
, pp. 1535-1536
-
-
Stephenson, J.1
-
36
-
-
20144382495
-
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor
-
Surleraux DL, Tahri A, Verschueren WG, et al. 2005. Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor. J Med Chem, 48:1813-22.
-
(2005)
J Med Chem
, vol.48
, pp. 1813-1822
-
-
Surleraux, D.L.1
Tahri, A.2
Verschueren, W.G.3
-
37
-
-
33847361008
-
Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir
-
Tie Y, Kovalevsky AY, Boross P, et al. 2007. Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir. Proteins, 67:232-42.
-
(2007)
Proteins
, vol.67
, pp. 232-242
-
-
Tie, Y.1
Kovalevsky, A.Y.2
Boross, P.3
-
38
-
-
36448931967
-
Integrase inhibitor gains FDA approval
-
Traynor K. 2007. Integrase inhibitor gains FDA approval. Am J Health Syst Pharm, 64:2310.
-
(2007)
Am J Health Syst Pharm
, vol.64
, pp. 2310
-
-
Traynor, K.1
-
40
-
-
34547841291
-
Prediction of HIV-1 drug susceptibility phenotype from the viral genotype using linear regression modeling
-
Vermeiren H, van Craenenbroeck E, Alen P, et al. 2007. Prediction of HIV-1 drug susceptibility phenotype from the viral genotype using linear regression modeling. J Virol Methods, 145:47-55.
-
(2007)
J Virol Methods
, vol.145
, pp. 47-55
-
-
Vermeiren, H.1
van Craenenbroeck, E.2
Alen, P.3
|