Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

Journal of Medicinal Chemistry

Volumn 56, Issue 4, 2013, Pages 1614-1628

  Assaf, Zeinab ^b,c   Larsen, Anja P ^a   Venskutonytě, Raminta ^a   Han, Liwei ^a   Abrahamsen, Bjarke ^a   Nielsen, Birgitte ^a   Gajhede, Michael ^a   Kastrup, Jette S ^a   Jensen, Anders A ^a   Pickering, Darryl S ^a   Frydenvang, Karla ^a   Gefflaut, Thierry ^b,c   Bunch, Lennart ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c ICCF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 AMINOETHYL)GLUTAMIC ACID; 4 (2 BENZYLOXYCARBONYLAMINOETHYL)GLUTAMIC ACID; 4 (2 CYANOETHYL)GLUTAMIC ACID; 4 (3 AMINOPROPYL)GLUTAMIC ACID; 4 (3 BENZYLOXYAMINO 3 OXOPROPYL)GLUTAMIC ACID; 4 (3 DIETHYLAMINO 3 OXOPROPYL)GLUTAMIC ACID; 4 (3 DIMETHYLAMINO 3 OXOPROPYL)GLUTAMIC ACID; 4 (3 HYDROXYAMINO 3 OXOPROPYL)GLUTAMIC ACID; 4 (3 OXO 3 TERT BUTOXYAMINOPROPYL)GLUTAMIC ACID; 4 [(3 OXO 3 PHENYLAMINOPROPYL)GLUTAMIC ACID; 4 [3 HYDROXY(METHYL)AMINO 3 OXOPROPYL]GLUTAMIC ACID; 4 [3 OXO 3 (2 PHENYLHYDRAZINYL)PROPYL]GLUTAMIC ACID; 4 [3 OXO 3 (PIPERIDIN 1 YL)PROPYL]GLUTAMIC ACID; 4 [3 OXO 3 (PROP 2 YNYLAMINO)PROPYL]GLUTAMIC ACID; AZEPANE 2,4 DICARBOXYLIC ACID; CYCLOHEXANONE; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMIC ACID DERIVATIVE; IONOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; CURTIUS REARRANGEMENT; DEBENZYLATION; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEN BOND; HYDROGENATION; IC 50; LIGAND BINDING; MALE; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TRANSAMINATION; X RAY CRYSTALLOGRAPHY;

EID: 84874626300     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301433m     Document Type: Article

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