Stereoselective chemoenzymatic synthesis of the four stereoisomers of L-2-(2-carboxycyclobutyl)glycine and pharmacological characterization at human excitatory amino acid transporter subtypes 1, 2, and 3

Journal of Medicinal Chemistry

Volumn 49, Issue 22, 2006, Pages 6532-6538

  Faure, Sophie ^b   Jensen, Anders A ^a   Maurat, Vincent ^b   Gu, Xin ^b   Sagot, Emmanuelle ^b   Aitken, David J ^b   Bolte, Jean ^b   Gefflaut, Thierry ^b   Bunch, Lennart ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LASMEA Universite Blake Pascal   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CARBOXYCYCLOBUTYL)GLYCINE; 2 OXALYLCYCLOBUTANECARBOXYLIC ACID DERIVATIVE; ASPARTATE AMINOTRANSFERASE; EXCITATORY AMINO ACID TRANSPORTER; GLYCINE DERIVATIVE; LIGAND; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CIS TRANS ISOMERISM; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; EMBRYO; ENANTIOMER; ENZYME MECHANISM; ESCHERICHIA COLI; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; NONHUMAN; STEREOCHEMISTRY; STEREOISOMERISM;

CATALYSIS; CHEMISTRY, PHYSICAL; CYCLOBUTANES; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; GLUTAMATES; GLYCINE; HUMANS; INDICATORS AND REAGENTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750437268     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060822s     Document Type: Article

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