Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro

Acta Pharmacologica Sinica

Volumn 34, Issue 3, 2013, Pages 360-366

  Chang, Chi Hao ^a   Huang, Yuan Li ^b   Shyu, Ming Kwang ^c   Chen, Shee Uan ^c   Lin, Chih Hsin ^a   Ju, Tsai Kai ^a   Lu, Jenher ^d   Lee, Hsinyu ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

fibroblast growth factor receptor 1; fibroblast growth factor 1; GM6001; human umbilical vein endothelial cells; matrix metalloproteinase 2; RNA interference; sphingosine 1 phosphate; SU5402; transactivation; VEGF C

Indexed keywords

3 [4 METHYL 2 (2 OXO 3 INDOLINYLMETHYLIDENYL) 3 PYRROLYL]PROPIONIC ACID; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GELATINASE A; ILOMASTAT; MESSENGER RNA; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; VASCULOTROPIN C;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UMBILICAL VEIN ENDOTHELIAL CELL;

CELL CULTURE TECHNIQUES; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLAST GROWTH FACTOR 1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LYSOPHOSPHOLIPIDS; MATRIX METALLOPROTEINASE 2; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPHINGOSINE; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 84874600392     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.186     Document Type: Article

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