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Volumn 7, Issue 1, 2013, Pages 66-75

Grey matter damage in multiple sclerosis A pathology perspective

Author keywords

Clinical relevance; Gray matter pathology; Imaging; Multiple sclerosis; Topology

Indexed keywords

ANTIINFLAMMATORY AGENT;

EID: 84874593079     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.23499     Document Type: Conference Paper
Times cited : (88)

References (73)
  • 1
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey
    • National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis, PMID:8780061
    • Lublin FD, Reingold SC; National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996; 46:907-11; PMID:8780061; http://dx.doi.org/10.1212/WNL. 46.4.907.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 2
    • 33644974688 scopus 로고    scopus 로고
    • Secondary progressive multiple sclerosis: Current knowledge and future challenges
    • PMID:16545751
    • Rovaris M, Confavreux C, Furlan R, Kappos L, Comi G, Filippi M. Secondary progressive multiple sclerosis: current knowledge and future challenges. Lancet Neurol 2006; 5:343-54; PMID:16545751; http://dx.doi.org/10.1016/S1474-4422(06) 70410-0.
    • (2006) Lancet Neurol , vol.5 , pp. 343-354
    • Rovaris, M.1    Confavreux, C.2    Furlan, R.3    Kappos, L.4    Comi, G.5    Filippi, M.6
  • 3
    • 34548633861 scopus 로고    scopus 로고
    • Primary-progressive multiple sclerosis
    • PMID:17884680
    • Miller DH, Leary SM. Primary-progressive multiple sclerosis. Lancet Neurol 2007; 6:903-12; PMID:17884680; http://dx.doi.org/10.1016/S1474-4422(07) 70243-0.
    • (2007) Lancet Neurol , vol.6 , pp. 903-912
    • Miller, D.H.1    Leary, S.M.2
  • 4
    • 0032946328 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis: A geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis
    • PMID:10219776
    • Cottrell DA, Kremenchutzky M, Rice GP, Koopman WJ, Hader W, Baskerville J, et al. The natural history of multiple sclerosis: a geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis. Brain 1999; 122:625- 39; PMID:10219776; http://dx.doi.org/ 10.1093/brain/122.4.625.
    • (1999) Brain , vol.122 , pp. 625-639
    • Cottrell, D.A.1    Kremenchutzky, M.2    Rice, G.P.3    Koopman, W.J.4    Hader, W.5    Baskerville, J.6
  • 5
    • 33846093882 scopus 로고    scopus 로고
    • Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis
    • PMID:17210812
    • Bö L, Geurts JJG, van der Valk P, Polman C, Barkhof F. Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis. Arch Neurol 2007; 64:76-80; PMID:17210812; http://dx.doi.org/10.1001/archneur.64.1.76.
    • (2007) Arch Neurol , vol.64 , pp. 76-80
    • Bö, L.1    Geurts, J.J.G.2    Van Der Valk, P.3    Polman, C.4    Barkhof, F.5
  • 6
    • 0001362922 scopus 로고
    • The distribution of plaques in the cerebrum in multiple sclerosis
    • PMID:14016083
    • Brownell B, Hughes JT. The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatry 1962; 25:315-20; PMID:14016083; http://dx.doi.org/10.1136/jnnp.25.4.315.
    • (1962) J Neurol Neurosurg Psychiatry , vol.25 , pp. 315-320
    • Brownell, B.1    Hughes, J.T.2
  • 7
    • 0037828315 scopus 로고    scopus 로고
    • Subpial demyelination in the cerebral cortex of multiple sclerosis patients
    • PMID:12901699
    • Bø L, Vedeler CA, Nyland HI, Trapp BD, Mørk SJ. Subpial demyelination in the cerebral cortex of multiple sclerosis patients. J Neuropathol Exp Neurol 2003; 62:723-32; PMID:12901699.
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 723-732
    • Bø, L.1    Vedeler, C.A.2    Nyland, H.I.3    Trapp, B.D.4    Mørk, S.J.5
  • 8
    • 0042123685 scopus 로고    scopus 로고
    • Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration
    • PMID:12926836
    • Bø L, Vedeler CA, Nyland H, Trapp BD, Mørk SJ. Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. Mult Scler 2003; 9:323-31; PMID:12926836; http://dx.doi.org/10.1191/1352458503ms917oa.
    • (2003) Mult Scler , vol.9 , pp. 323-331
    • Bø, L.1    Vedeler, C.A.2    Nyland, H.3    Trapp, B.D.4    Mørk, S.J.5
  • 9
    • 27644552194 scopus 로고    scopus 로고
    • Cortical demyelination and diffuse white matter injury in multiple sclerosis
    • PMID:16230320
    • Kutzelnigg A, Lucchinetti CF, Stadelmann C, Brück W, Rauschka H, Bergmann M, et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 2005; 128:2705-12; PMID:16230320; http://dx.doi.org/ 10.1093/brain/awh641.
    • (2005) Brain , vol.128 , pp. 2705-2712
    • Kutzelnigg, A.1    Lucchinetti, C.F.2    Stadelmann, C.3    Brück, W.4    Rauschka, H.5    Bergmann, M.6
  • 10
    • 79953274047 scopus 로고    scopus 로고
    • Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients
    • PMID:21446020
    • Dutta R, Chang A, Doud MK, Kidd GJ, Ribaudo MV, Young EA, et al. Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients. Ann Neurol 2011; 69:445-54; PMID:21446020; http://dx.doi.org/10.1002/ ana.22337.
    • (2011) Ann Neurol , vol.69 , pp. 445-454
    • Dutta, R.1    Chang, A.2    Doud, M.K.3    Kidd, G.J.4    Ribaudo, M.V.5    Young, E.A.6
  • 12
    • 33746792723 scopus 로고    scopus 로고
    • Spinal cord gray matter demyelination in multiple sclerosis-A novel pattern of residual plaque morphology
    • PMID:16911477
    • Gilmore CP, Bö L, Owens T, Lowe J, Esiri MM, Evangelou N. Spinal cord gray matter demyelination in multiple sclerosis-a novel pattern of residual plaque morphology. Brain Pathol 2006; 16:202-8; PMID:16911477; http://dx.doi.org/10.1111/j.1750-3639.2006.00018.x.
    • (2006) Brain Pathol , vol.16 , pp. 202-208
    • Gilmore, C.P.1    Bö, L.2    Owens, T.3    Lowe, J.4    Esiri, M.M.5    Evangelou, N.6
  • 13
    • 60249099507 scopus 로고    scopus 로고
    • Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: A comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord
    • PMID:18829630
    • Gilmore CP, Donaldson I, Bö L, Owens T, Lowe J, Evangelou N. Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord. J Neurol Neurosurg Psychiatry 2009; 80:182- 7; PMID:18829630; http://dx.doi.org/10.1136/jnnp.2008.148767.
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , pp. 182-187
    • Gilmore, C.P.1    Donaldson, I.2    Bö, L.3    Owens, T.4    Lowe, J.5    Evangelou, N.6
  • 15
  • 16
    • 33847227721 scopus 로고    scopus 로고
    • Widespread demyelination in the cerebellar cortex in multiple sclerosis
    • PMID:17493036
    • Kutzelnigg A, Faber-Rod JC, Bauer J, Lucchinetti CF, Sorensen PS, Laursen H, et al. Widespread demyelination in the cerebellar cortex in multiple sclerosis. Brain Pathol 2007; 17:38-44; PMID:17493036; http://dx.doi.org/10. 1111/j.1750-3639.2006.00041.x.
    • (2007) Brain Pathol , vol.17 , pp. 38-44
    • Kutzelnigg, A.1    Faber-Rod, J.C.2    Bauer, J.3    Lucchinetti, C.F.4    Sorensen, P.S.5    Laursen, H.6
  • 17
    • 61649099869 scopus 로고    scopus 로고
    • Substantial archaeocortical atrophy and neuronal loss in multiple sclerosis
    • PMID:18492094
    • Papadopoulos D, Dukes S, Patel R, Nicholas R, Vora A, Reynolds R. Substantial archaeocortical atrophy and neuronal loss in multiple sclerosis. Brain Pathol 2009; 19:238-53; PMID:18492094; http://dx.doi.org/10.1111/j.1750- 3639.2008.00177.x.
    • (2009) Brain Pathol , vol.19 , pp. 238-253
    • Papadopoulos, D.1    Dukes, S.2    Patel, R.3    Nicholas, R.4    Vora, A.5    Reynolds, R.6
  • 18
    • 0034842126 scopus 로고    scopus 로고
    • Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    • PMID:11558796
    • Peterson JW, Bö L, Mörk S, Chang A, Trapp BD. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 2001; 50:389-400; PMID:11558796; http://dx.doi.org/10.1002/ana.1123.
    • (2001) Ann Neurol , vol.50 , pp. 389-400
    • Peterson, J.W.1    Bö, L.2    Mörk, S.3    Chang, A.4    Trapp, B.D.5
  • 20
    • 33748997359 scopus 로고    scopus 로고
    • Neocortical neuronal, synaptic, and glial loss in multiple sclerosis
    • PMID:17000961
    • Wegner C, Esiri MM, Chance SA, Palace J, Matthews PM. Neocortical neuronal, synaptic, and glial loss in multiple sclerosis. Neurology 2006; 67:960-7; PMID:17000961; http://dx.doi.org/10.1212/01.wnl.0000237551.26858.39.
    • (2006) Neurology , vol.67 , pp. 960-967
    • Wegner, C.1    Esiri, M.M.2    Chance, S.A.3    Palace, J.4    Matthews, P.M.5
  • 21
    • 70149124713 scopus 로고    scopus 로고
    • Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter
    • PMID:19525897
    • Vercellino M, Masera S, Lorenzatti M, Condello C, Merola A, Mattioda A, et al. Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter. J Neuropathol Exp Neurol 2009; 68:489- 502; PMID:19525897; http://dx.doi.org/10.1097/NEN.0b013e3181a19a5a.
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 489-502
    • Vercellino, M.1    Masera, S.2    Lorenzatti, M.3    Condello, C.4    Merola, A.5    Mattioda, A.6
  • 22
    • 3543030420 scopus 로고    scopus 로고
    • The medial temporal lobe
    • PMID:15217334
    • Squire LR, Stark CEL, Clark RE. The medial temporal lobe. Annu Rev Neurosci 2004; 27:279-306; PMID:15217334; http://dx.doi.org/10.1146/annurev. neuro.27.070203.144130.
    • (2004) Annu Rev Neurosci , vol.27 , pp. 279-306
    • Squire, L.R.1    Stark, C.E.L.2    Clark, R.E.3
  • 23
    • 33645807857 scopus 로고    scopus 로고
    • The cognitive neuroscience of remote episodic, semantic and spatial memory
    • PMID:16564688
    • Moscovitch M, Nadel L, Winocur G, Gilboa A, Rosenbaum RS. The cognitive neuroscience of remote episodic, semantic and spatial memory. Curr Opin Neurobiol 2006; 16:179-90; PMID:16564688; http://dx.doi.org/10.1016/j.conb.2006. 03.013.
    • (2006) Curr Opin Neurobiol , vol.16 , pp. 179-190
    • Moscovitch, M.1    Nadel, L.2    Winocur, G.3    Gilboa, A.4    Rosenbaum, R.S.5
  • 24
    • 0035004650 scopus 로고    scopus 로고
    • Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions
    • PMID:11346369
    • Bakshi R, Ariyaratana S, Benedict RH, Jacobs L. Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions. Arch Neurol 2001; 58:742-8; PMID:11346369; http://dx.doi.org/10.1001/archneur.58.5.742.
    • (2001) Arch Neurol , vol.58 , pp. 742-748
    • Bakshi, R.1    Ariyaratana, S.2    Benedict, R.H.3    Jacobs, L.4
  • 25
    • 80053588889 scopus 로고    scopus 로고
    • Imaging the tip of the iceberg: Visualization of cortical lesions in multiple sclerosis
    • PMID:21561955
    • Seewann A, Vrenken H, Kooi EJ, van der Valk P, Knol DL, Polman CH, et al. Imaging the tip of the iceberg: visualization of cortical lesions in multiple sclerosis. Mult Scler 2011; 17:1202-10; PMID:21561955; http://dx.doi.org/10. 1177/1352458511406575.
    • (2011) Mult Scler , vol.17 , pp. 1202-1210
    • Seewann, A.1    Vrenken, H.2    Kooi, E.J.3    Van Der Valk, P.4    Knol, D.L.5    Polman, C.H.6
  • 26
    • 20744442122 scopus 로고    scopus 로고
    • Intracortical lesions in multiple sclerosis: Improved detection with 3D double inversion-recovery MR imaging
    • PMID:15987979
    • Geurts JJG, Pouwels PJW, Uitdehaag BMJ, Polman CH, Barkhof F, Castelijns JA. Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging. Radiology 2005; 236:254-60; PMID:15987979; http://dx.doi.org/10.1148/radiol.2361040450.
    • (2005) Radiology , vol.236 , pp. 254-260
    • Geurts, J.J.G.1    Pouwels, P.J.W.2    Uitdehaag, B.M.J.3    Polman, C.H.4    Barkhof, F.5    Castelijns, J.A.6
  • 27
    • 84858042410 scopus 로고    scopus 로고
    • Postmortem verification of MS cortical lesion detection with 3D DIR
    • PMID:22218278
    • Seewann A, Kooi EJ, Roosendaal SD, Pouwels PJW, Wattjes MP, van der Valk P, et al. Postmortem verification of MS cortical lesion detection with 3D DIR. Neurology 2012; 78:302-8; PMID:22218278; http://dx.doi.org/10.1212/WNL. 0b013e31824528a0.
    • (2012) Neurology , vol.78 , pp. 302-308
    • Seewann, A.1    Kooi, E.J.2    Roosendaal, S.D.3    Pouwels, P.J.W.4    Wattjes, M.P.5    Van Der Valk, P.6
  • 28
    • 84864819509 scopus 로고    scopus 로고
    • Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI
    • PMID:22807559
    • Sethi V, Yousry TA, Muhlert N, Ron M, Golay X, Wheeler-Kingshott C, et al. Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI. J Neurol Neurosurg Psychiatry 2012; 83:877-82; PMID:22807559; http://dx.doi.org/10.1136/jnnp-2012-303023.
    • (2012) J Neurol Neurosurg Psychiatry , vol.83 , pp. 877-882
    • Sethi, V.1    Yousry, T.A.2    Muhlert, N.3    Ron, M.4    Golay, X.5    Wheeler-Kingshott, C.6
  • 29
    • 59249106853 scopus 로고    scopus 로고
    • 3D MPRAGE improves classification of cortical lesions in multiple sclerosis
    • PMID:18952832
    • Nelson F, Poonawalla A, Hou P, Wolinsky JS, Narayana PA. 3D MPRAGE improves classification of cortical lesions in multiple sclerosis. Mult Scler 2008; 14:1214-9; PMID:18952832; http://dx.doi.org/10.1177/1352458508094644.
    • (2008) Mult Scler , vol.14 , pp. 1214-1219
    • Nelson, F.1    Poonawalla, A.2    Hou, P.3    Wolinsky, J.S.4    Narayana, P.A.5
  • 30
    • 84857090211 scopus 로고    scopus 로고
    • Focal cortical lesion detection in multiple sclerosis: 3 Tesla DIR versus 7 Tesla FLASH-T2
    • PMID:22045554
    • Nielsen AS, Kinkel RP, Tinelli E, Benner T, Cohen- Adad J, Mainero C. Focal cortical lesion detection in multiple sclerosis: 3 Tesla DIR versus 7 Tesla FLASH-T2. J Magn Reson Imaging 2012; 35:537- 42; PMID:22045554; http://dx.doi.org/10.1002/jmri.22847.
    • (2012) J Magn Reson Imaging , vol.35 , pp. 537-542
    • Nielsen, A.S.1    Kinkel, R.P.2    Tinelli, E.3    Benner, T.4    Cohen-Adad, J.5    Mainero, C.6
  • 31
    • 84878566112 scopus 로고    scopus 로고
    • Clinical application of multi-contrast 7-T MR imaging in multiple sclerosis: Increased lesion detection compared to 3 T confined to grey matter
    • PMID:22898935
    • de Graaf WL, Kilsdonk ID, Lopez-Soriano A, Zwanenburg JJM, Visser F, Polman CH, et al. Clinical application of multi-contrast 7-T MR imaging in multiple sclerosis: increased lesion detection compared to 3 T confined to grey matter. Eur Radiol 2012; PMID:22898935.
    • (2012) Eur Radiol
    • De Graaf, W.L.1    Kilsdonk, I.D.2    Lopez-Soriano, A.3    Zwanenburg, J.J.M.4    Visser, F.5    Polman, C.H.6
  • 32
    • 77953694020 scopus 로고    scopus 로고
    • Atrophy mainly affects the limbic system and the deep grey matter at the first stage of multiple sclerosis
    • PMID:20392976
    • Audoin B, Zaaraoui W, Reuter F, Rico A, Malikova I, Confort-Gouny S, et al. Atrophy mainly affects the limbic system and the deep grey matter at the first stage of multiple sclerosis. J Neurol Neurosurg Psychiatry 2010; 81:690-5; PMID:20392976; http://dx.doi.org/10.1136/jnnp.2009.188748.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 690-695
    • Audoin, B.1    Zaaraoui, W.2    Reuter, F.3    Rico, A.4    Malikova, I.5    Confort-Gouny, S.6
  • 33
    • 84856702269 scopus 로고    scopus 로고
    • Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis
    • PMID:21720932
    • Batista S, Zivadinov R, Hoogs M, Bergsland N, Heininen-Brown M, Dwyer MG, et al. Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis. J Neurol 2012; 259:139-46; PMID:21720932; http://dx.doi.org/10.1007/s00415-011-6147-1.
    • (2012) J Neurol , vol.259 , pp. 139-146
    • Batista, S.1    Zivadinov, R.2    Hoogs, M.3    Bergsland, N.4    Heininen-Brown, M.5    Dwyer, M.G.6
  • 34
    • 80051544967 scopus 로고    scopus 로고
    • The predictive value of gray matter atrophy in clinically isolated syndromes
    • PMID:21613600
    • Calabrese M, Rinaldi F, Mattisi I, Bernardi V, Favaretto A, Perini P, et al. The predictive value of gray matter atrophy in clinically isolated syndromes. Neurology 2011; 77:257-63; PMID:21613600; http://dx.doi.org/10.1212/ WNL.0b013e318220abd4.
    • (2011) Neurology , vol.77 , pp. 257-263
    • Calabrese, M.1    Rinaldi, F.2    Mattisi, I.3    Bernardi, V.4    Favaretto, A.5    Perini, P.6
  • 35
    • 84860389100 scopus 로고    scopus 로고
    • Grey matter volume in a large cohort of MS patients: Relation to MRI parameters and disability
    • PMID:21586487
    • Roosendaal SD, Bendfeldt K, Vrenken H, Polman CH, Borgwardt S, Radue EW, et al. Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability. Mult Scler 2011; 17:1098-106; PMID:21586487; http://dx.doi.org/10.1177/1352458511404916.
    • (2011) Mult Scler , vol.17 , pp. 1098-1106
    • Roosendaal, S.D.1    Bendfeldt, K.2    Vrenken, H.3    Polman, C.H.4    Borgwardt, S.5    Radue, E.W.6
  • 36
    • 35348874326 scopus 로고    scopus 로고
    • Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis
    • PMID:17923625
    • Calabrese M, De Stefano N, Atzori M, Bernardi V, Mattisi I, Barachino L, et al. Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis. Arch Neurol 2007; 64:1416-22; PMID:17923625; http://dx.doi.org/10.1001/archneur.64.10.1416.
    • (2007) Arch Neurol , vol.64 , pp. 1416-1422
    • Calabrese, M.1    De Stefano, N.2    Atzori, M.3    Bernardi, V.4    Mattisi, I.5    Barachino, L.6
  • 37
    • 58149095079 scopus 로고    scopus 로고
    • Evidence for relative cortical sparing in benign multiple sclerosis: A longitudinal magnetic resonance imaging study
    • PMID:18755823
    • Calabrese M, Filippi M, Rovaris M, Bernardi V, Atzori M, Mattisi I, et al. Evidence for relative cortical sparing in benign multiple sclerosis: a longitudinal magnetic resonance imaging study. Mult Scler 2009; 15:36-41; PMID:18755823; http://dx.doi.org/10.1177/1352458508096686.
    • (2009) Mult Scler , vol.15 , pp. 36-41
    • Calabrese, M.1    Filippi, M.2    Rovaris, M.3    Bernardi, V.4    Atzori, M.5    Mattisi, I.6
  • 38
    • 69549126590 scopus 로고    scopus 로고
    • Magnetic resonance evidence of cortical onset of multiple sclerosis
    • PMID:19667021
    • Calabrese M, Gallo P. Magnetic resonance evidence of cortical onset of multiple sclerosis. Mult Scler 2009; 15:933-41; PMID:19667021; http://dx.doi.org/10.1177/1352458509106510.
    • (2009) Mult Scler , vol.15 , pp. 933-941
    • Calabrese, M.1    Gallo, P.2
  • 39
    • 77950534279 scopus 로고    scopus 로고
    • A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis
    • PMID:20373349
    • Calabrese M, Rocca MA, Atzori M, Mattisi I, Favaretto A, Perini P, et al. A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis. Ann Neurol 2010; 67:376-83; PMID:20373349.
    • (2010) Ann Neurol , vol.67 , pp. 376-383
    • Calabrese, M.1    Rocca, M.A.2    Atzori, M.3    Mattisi, I.4    Favaretto, A.5    Perini, P.6
  • 40
    • 79956213976 scopus 로고    scopus 로고
    • In vivo evidence of disseminated subpial T2* signal changes in multiple sclerosis at 7 T: A surface-based analysis
    • PMID:21511042
    • Cohen-Adad J, Benner T, Greve D, Kinkel RP, Radding A, Fischl B, et al. In vivo evidence of disseminated subpial T2* signal changes in multiple sclerosis at 7 T: a surface-based analysis. Neuroimage 2011; 57:55-62; PMID:21511042; http://dx.doi.org/10.1016/j.neuroimage.2011.04.009.
    • (2011) Neuroimage , vol.57 , pp. 55-62
    • Cohen-Adad, J.1    Benner, T.2    Greve, D.3    Kinkel, R.P.4    Radding, A.5    Fischl, B.6
  • 41
    • 70349084196 scopus 로고    scopus 로고
    • Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis
    • PMID:19752305
    • Calabrese M, Agosta F, Rinaldi F, Mattisi I, Grossi P, Favaretto A, et al. Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis. Arch Neurol 2009; 66:1144-50; PMID:19752305; http://dx.doi.org/10.1001/archneurol.2009.174.
    • (2009) Arch Neurol , vol.66 , pp. 1144-1150
    • Calabrese, M.1    Agosta, F.2    Rinaldi, F.3    Mattisi, I.4    Grossi, P.5    Favaretto, A.6
  • 42
    • 66149183024 scopus 로고    scopus 로고
    • Accumulation of cortical lesions in MS: Relation with cognitive impairment
    • PMID:19435749
    • Roosendaal SD, Moraal B, Pouwels PJ, Vrenken H, Castelijns JA, Barkhof F, et al. Accumulation of cortical lesions in MS: relation with cognitive impairment. Mult Scler 2009; 15:708-14; PMID:19435749; http://dx.doi.org/10. 1177/1352458509102907.
    • (2009) Mult Scler , vol.15 , pp. 708-714
    • Roosendaal, S.D.1    Moraal, B.2    Pouwels, P.J.3    Vrenken, H.4    Castelijns, J.A.5    Barkhof, F.6
  • 45
    • 57649233372 scopus 로고    scopus 로고
    • Segmentation of brain magnetic resonance images for measurement of gray matter atrophy in multiple sclerosis patients
    • PMID:19007895
    • Nakamura K, Fisher E. Segmentation of brain magnetic resonance images for measurement of gray matter atrophy in multiple sclerosis patients. Neuroimage 2009; 44:769-76; PMID:19007895; http://dx.doi.org/10.1016/j.neuroimage.2008.09. 059.
    • (2009) Neuroimage , vol.44 , pp. 769-776
    • Nakamura, K.1    Fisher, E.2
  • 46
    • 54849431166 scopus 로고    scopus 로고
    • Gray matter atrophy in multiple sclerosis: A longitudinal study
    • PMID:18661561
    • Fisher E, Lee JC, Nakamura K, Rudick RA. Gray matter atrophy in multiple sclerosis: a longitudinal study. Ann Neurol 2008; 64:255-65; PMID:18661561; http://dx.doi.org/10.1002/ana.21436.
    • (2008) Ann Neurol , vol.64 , pp. 255-265
    • Fisher, E.1    Lee, J.C.2    Nakamura, K.3    Rudick, R.A.4
  • 47
    • 54849431592 scopus 로고    scopus 로고
    • Gray matter atrophy is related to long-term disability in multiple sclerosis
    • PMID:18570297
    • Fisniku LK, Chard DT, Jackson JS, Anderson VM, Altmann DR, Miszkiel KA, et al. Gray matter atrophy is related to long-term disability in multiple sclerosis. Ann Neurol 2008; 64:247-54; PMID:18570297; http://dx.doi.org/10.1002/ ana.21423.
    • (2008) Ann Neurol , vol.64 , pp. 247-254
    • Fisniku, L.K.1    Chard, D.T.2    Jackson, J.S.3    Anderson, V.M.4    Altmann, D.R.5    Miszkiel, K.A.6
  • 48
    • 14844293538 scopus 로고    scopus 로고
    • The pathology of multiple sclerosis is location-dependent: No significant complement activation is detected in purely cortical lesions
    • PMID:15751229
    • Brink BP, Veerhuis R, Breij ECW, van der Valk P, Dijkstra CD, Bö L. The pathology of multiple sclerosis is location-dependent: no significant complement activation is detected in purely cortical lesions. J Neuropathol Exp Neurol 2005; 64:147-55; PMID:15751229.
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 147-155
    • Brink, B.P.1    Veerhuis, R.2    Breij, E.C.W.3    Van Der Valk, P.4    Dijkstra, C.D.5    Bö, L.6
  • 49
    • 34147120603 scopus 로고    scopus 로고
    • The blood-brain barrier in cortical multiple sclerosis lesions
    • PMID:17413323
    • van Horssen J, Brink BP, de Vries HE, van der Valk P, Bø L. The blood-brain barrier in cortical multiple sclerosis lesions. J Neuropathol Exp Neurol 2007; 66:321- 8; PMID:17413323; http://dx.doi.org/10.1097/nen. 0b013e318040b2de.
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 321-328
    • Van Horssen, J.1    Brink, B.P.2    De Vries, H.E.3    Van Der Valk, P.4    Bø, L.5
  • 50
    • 83155173565 scopus 로고    scopus 로고
    • Inflammatory cortical demyelination in early multiple sclerosis
    • PMID:22150037
    • Lucchinetti CF, Popescu BFG, Bunyan RF, Moll NM, Roemer SF, Lassmann H, et al. Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med 2011; 365:2188-97; PMID:22150037; http://dx.doi.org/10.1056/NEJMoa1100648.
    • (2011) N Engl J Med , vol.365 , pp. 2188-2197
    • Lucchinetti, C.F.1    Popescu, B.F.G.2    Bunyan, R.F.3    Moll, N.M.4    Roemer, S.F.5    Lassmann, H.6
  • 51
    • 84867537711 scopus 로고    scopus 로고
    • Heterogeneity of cortical lesions in multiple sclerosis: Clinical and pathologic implications
    • PMID:22972651
    • Kooi EJ, Strijbis EM, van der Valk P, Geurts JJ. Heterogeneity of cortical lesions in multiple sclerosis: clinical and pathologic implications. Neurology 2012; 79:1369-76; PMID:22972651; http://dx.doi.org/10.1212/WNL. 0b013e31826c1b1c.
    • (2012) Neurology , vol.79 , pp. 1369-1376
    • Kooi, E.J.1    Strijbis, E.M.2    Van Der Valk, P.3    Geurts, J.J.4
  • 52
    • 84866117533 scopus 로고    scopus 로고
    • Increased PK11195 PET binding in the cortex of patients with MS correlates with disability
    • PMID:22764258
    • Politis M, Giannetti P, Su P, Turkheimer F, Keihaninejad S, Wu K, et al. Increased PK11195 PET binding in the cortex of patients with MS correlates with disability. Neurology 2012; 79:523-30; PMID:22764258; http://dx.doi.org/10.1212/ WNL.0b013e3182635645.
    • (2012) Neurology , vol.79 , pp. 523-530
    • Politis, M.1    Giannetti, P.2    Su, P.3    Turkheimer, F.4    Keihaninejad, S.5    Wu, K.6
  • 53
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • PMID:15831717
    • Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005; 308:1314- 8; PMID:15831717; http://dx.doi.org/10.1126/science.1110647.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 54
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • PMID:15895084
    • Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 2005; 8:752-8; PMID:15895084; http://dx.doi.org/10.1038/nn1472.
    • (2005) Nat Neurosci , vol.8 , pp. 752-758
    • Davalos, D.1    Grutzendler, J.2    Yang, G.3    Kim, J.V.4    Zuo, Y.5    Jung, S.6
  • 55
    • 0141616460 scopus 로고    scopus 로고
    • Chronic glial activation, neurodegeneration, and APP immunoreactive deposits following acute administration of double-stranded RNA
    • PMID:12951652
    • Melton LM, Keith AB, Davis S, Oakley AE, Edwardson JA, Morris CM. Chronic glial activation, neurodegeneration, and APP immunoreactive deposits following acute administration of double-stranded RNA. Glia 2003; 44:1-12; PMID:12951652; http://dx.doi.org/10.1002/glia.10276.
    • (2003) Glia , vol.44 , pp. 1-12
    • Melton, L.M.1    Keith, A.B.2    Davis, S.3    Oakley, A.E.4    Edwardson, J.A.5    Morris, C.M.6
  • 56
    • 0038348526 scopus 로고    scopus 로고
    • Microglial functions and proteases
    • PMID:12777686
    • Nakanishi H. Microglial functions and proteases. Mol Neurobiol 2003; 27:163-76; PMID:12777686; http://dx.doi.org/10.1385/MN:27:2:163.
    • (2003) Mol Neurobiol , vol.27 , pp. 163-176
    • Nakanishi, H.1
  • 57
    • 15244350494 scopus 로고    scopus 로고
    • Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor α-induced neurotoxicity in concert with microglial- derived Fas ligand
    • PMID:15772355
    • Taylor DL, Jones F, Kubota ESFCS, Pocock JM. Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor α-induced neurotoxicity in concert with microglial- derived Fas ligand. J Neurosci 2005; 25:2952- 64; PMID:15772355; http://dx.doi.org/10.1523/JNEUROSCI. 4456-04.2005.
    • (2005) J Neurosci , vol.25 , pp. 2952-2964
    • Taylor, D.L.1    Jones, F.2    Kubota, E.S.F.C.S.3    Pocock, J.M.4
  • 59
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • PMID:17438020
    • Magliozzi R, Howell O, Vora A, Serafini B, Nicholas R, Puopolo M, et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007; 130:1089-104; PMID:17438020; http://dx.doi.org/10.1093/brain/awm038.
    • (2007) Brain , vol.130 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3    Serafini, B.4    Nicholas, R.5    Puopolo, M.6
  • 60
    • 77953222826 scopus 로고    scopus 로고
    • Upregulation of immunoglobulin-related genes in cortical sections from multiple sclerosis patients
    • PMID:19919606
    • Torkildsen Ø, Stansberg C, Angelskår SM, Kooi EJ, Geurts JJG, van der Valk P, et al. Upregulation of immunoglobulin-related genes in cortical sections from multiple sclerosis patients. Brain Pathol 2010; 20:720- 9; PMID:19919606; http://dx.doi.org/10.1111/j.1750-3639.2009.00343.x.
    • (2010) Brain Pathol , vol.20 , pp. 720-729
    • Torkildsen, Ø.1    Stansberg, C.2    Angelskår, S.M.3    Kooi, E.J.4    Geurts, J.J.G.5    Van Der Valk, P.6
  • 61
    • 72649104099 scopus 로고    scopus 로고
    • Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain
    • PMID:19638446
    • Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, et al. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 2009; 132:3318-28; PMID:19638446; http://dx.doi.org/10. 1093/brain/awp200.
    • (2009) Brain , vol.132 , pp. 3318-3328
    • Willis, S.N.1    Stadelmann, C.2    Rodig, S.J.3    Caron, T.4    Gattenloehner, S.5    Mallozzi, S.S.6
  • 62
    • 78249280011 scopus 로고    scopus 로고
    • A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis
    • PMID:20976767
    • Magliozzi R, Howell OW, Reeves C, Roncaroli F, Nicholas R, Serafini B, et al. A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis. Ann Neurol 2010; 68:477-93; PMID:20976767; http://dx.doi.org/10.1002/ ana.22230.
    • (2010) Ann Neurol , vol.68 , pp. 477-493
    • Magliozzi, R.1    Howell, O.W.2    Reeves, C.3    Roncaroli, F.4    Nicholas, R.5    Serafini, B.6
  • 63
    • 70349577131 scopus 로고    scopus 로고
    • Meningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosis
    • PMID:19680141
    • Kooi EJ, Geurts JJG, van Horssen J, Bø L, van der Valk P. Meningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosis. J Neuropathol Exp Neurol 2009; 68:1021- 8; PMID:19680141; http://dx.doi.org/10.1097/NEN.0b013e3181b4bf8f.
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 1021-1028
    • Kooi, E.J.1    Geurts, J.J.G.2    Van Horssen, J.3    Bø, L.4    Van Der Valk, P.5
  • 64
    • 2542619146 scopus 로고    scopus 로고
    • Molecular changes in neurons in multiple sclerosis: Altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger
    • PMID:15148385
    • Craner MJ, Newcombe J, Black JA, Hartle C, Cuzner ML, Waxman SG. Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger. Proc Natl Acad Sci U S A 2004; 101:8168- 73; PMID:15148385; http://dx.doi.org/10.1073/pnas. 0402765101.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8168-8173
    • Craner, M.J.1    Newcombe, J.2    Black, J.A.3    Hartle, C.4    Cuzner, M.L.5    Waxman, S.G.6
  • 65
    • 33644817756 scopus 로고    scopus 로고
    • Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
    • PMID:16392116
    • Dutta R, McDonough J, Yin X, Peterson J, Chang A, Torres T, et al. Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol 2006; 59:478-89; PMID:16392116 http://dx.doi.org/10.1002/ana.20736.
    • (2006) Ann Neurol , vol.59 , pp. 478-489
    • Dutta, R.1    McDonough, J.2    Yin, X.3    Peterson, J.4    Chang, A.5    Torres, T.6
  • 66
    • 0034662806 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis
    • PMID:10980305
    • Lu F, Selak M, O'Connor J, Croul S, Lorenzana C, Butunoi C, et al. Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis. J Neurol Sci 2000; 177:95-103; PMID:10980305; http://dx.doi.org/10.1016/S0022-510X(00)00343-9.
    • (2000) J Neurol Sci , vol.177 , pp. 95-103
    • Lu, F.1    Selak, M.2    O'connor, J.3    Croul, S.4    Lorenzana, C.5    Butunoi, C.6
  • 67
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • PMID:17051205
    • Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443:787-95; PMID:17051205; http://dx.doi.org/10.1038/nature05292.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 68
    • 2142814324 scopus 로고    scopus 로고
    • Axonal degeneration in multiple sclerosis: Is it time for neuroprotective strategies?
    • PMID:15122698
    • Stys PK. Axonal degeneration in multiple sclerosis: is it time for neuroprotective strategies? Ann Neurol 2004; 55:601-3; PMID:15122698; http://dx.doi.org/10.1002/ana.20082.
    • (2004) Ann Neurol , vol.55 , pp. 601-603
    • Stys, P.K.1
  • 69
    • 59949106172 scopus 로고    scopus 로고
    • Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis
    • PMID:19233038
    • Trapp BD, Stys PK. Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. Lancet Neurol 2009; 8:280-91; PMID:19233038; http://dx.doi.org/10.1016/S1474-4422(09)70043-2.
    • (2009) Lancet Neurol , vol.8 , pp. 280-291
    • Trapp, B.D.1    Stys, P.K.2
  • 70
    • 0042266373 scopus 로고    scopus 로고
    • Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis
    • PMID:12805104
    • Geurts JJG, Wolswijk G, Bö L, van der Valk P, Polman CH, Troost D, et al. Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis. Brain 2003; 126:1755-66; PMID:12805104; http://dx.doi.org/10.1093/brain/awg179.
    • (2003) Brain , vol.126 , pp. 1755-1766
    • Geurts, J.J.G.1    Wolswijk, G.2    Bö, L.3    Van Der Valk, P.4    Polman, C.H.5    Troost, D.6
  • 71
    • 10344234219 scopus 로고    scopus 로고
    • Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions
    • PMID:15589052
    • Geurts JJG, Wolswijk G, Bö L, Redeker S, Ramkema M, Troost D, et al. Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions. J Neuroimmunol 2005; 158:182-90; PMID:15589052; http://dx.doi.org/10.1016/j.jneuroim.2004.08.012.
    • (2005) J Neuroimmunol , vol.158 , pp. 182-190
    • Geurts, J.J.G.1    Wolswijk, G.2    Bö, L.3    Redeker, S.4    Ramkema, M.5    Troost, D.6
  • 72
    • 38349145874 scopus 로고    scopus 로고
    • Glutamate receptor expression in multiple sclerosis lesions
    • PMID:17924980
    • Newcombe J, Uddin A, Dove R, Patel B, Turski L, Nishizawa Y, et al. Glutamate receptor expression in multiple sclerosis lesions. Brain Pathol 2008; 18:52-61; PMID:17924980; http://dx.doi.org/10.1111/j.1750-3639.2007.00101.x.
    • (2008) Brain Pathol , vol.18 , pp. 52-61
    • Newcombe, J.1    Uddin, A.2    Dove, R.3    Patel, B.4    Turski, L.5    Nishizawa, Y.6
  • 73
    • 77950237691 scopus 로고    scopus 로고
    • High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis
    • PMID:20123726
    • Schmierer K, Parkes HG, So PW, An SF, Brandner S, Ordidge RJ, et al. High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis. Brain 2010; 133:858-67; PMID:20123726; http://dx.doi.org/ 10.1093/brain/awp335.
    • (2010) Brain , vol.133 , pp. 858-867
    • Schmierer, K.1    Parkes, H.G.2    So, P.W.3    An, S.F.4    Brandner, S.5    Ordidge, R.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.