메뉴 건너뛰기




Volumn 15, Issue 3, 2013, Pages 565-574

Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation

Author keywords

Alveolar epithelial cells; Epithelial mesenchymal transition (EMT); Propolis; Transforming growth factor

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CAFFEIC ACID PHENETHYL ESTER; F ACTIN; NERVE CELL ADHESION MOLECULE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PINOCEMBRINE; PROPOLIS; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMAD2 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN;

EID: 84874590579     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.12.018     Document Type: Article
Times cited : (44)

References (43)
  • 1
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • R. Kalluri, and R.A. Weinberg The basics of epithelial-mesenchymal transition J Clin Invest 119 2009 1420 1428
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 2
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • J.P. Thiery, H. Acloque, R.Y.J. Huang, and M.A. Nieto Epithelial-mesenchymal transitions in development and disease Cell 139 2009 871 890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.J.3    Nieto, M.A.4
  • 3
    • 0036215753 scopus 로고    scopus 로고
    • The E-cadherin cell-cell adhesion complex and lung cancer invasion, metastasis, and prognosis
    • R.M. Bremnes, R. Veve, F.R. Hirsch, and W.A. Franklin The E-cadherin cell-cell adhesion complex and lung cancer invasion, metastasis, and prognosis Lung Cancer 36 2002 115 124
    • (2002) Lung Cancer , vol.36 , pp. 115-124
    • Bremnes, R.M.1    Veve, R.2    Hirsch, F.R.3    Franklin, W.A.4
  • 5
    • 22044450897 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology
    • S. Chakrabarti, and K.D. Patel Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology Exp Lung Res 31 2005 599 621
    • (2005) Exp Lung Res , vol.31 , pp. 599-621
    • Chakrabarti, S.1    Patel, K.D.2
  • 6
    • 39449111918 scopus 로고    scopus 로고
    • Matrix metalloproteinases-9/gelatinase B is a putative therapeutic target of chronic obstructive pulmonary disease and multiple sclerosis
    • H.R. Muroski, M.K. Roycid, R.G. Newcomer, P.E. Van den Steen, G. Opdenakker, and H.R. Monroe Matrix metalloproteinases-9/gelatinase B is a putative therapeutic target of chronic obstructive pulmonary disease and multiple sclerosis Curr Pharm Biotechnol 9 2008 34 46
    • (2008) Curr Pharm Biotechnol , vol.9 , pp. 34-46
    • Muroski, H.R.1    Roycid, M.K.2    Newcomer, R.G.3    Van Den Steen, P.E.4    Opdenakker, G.5    Monroe, H.R.6
  • 7
    • 33646590920 scopus 로고    scopus 로고
    • Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotype
    • V.G. Keshamouni, G. Michailidis, C.S. Grasso, S. Anthwal, J.R. Strahler, and A. Walker Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotype J Proteome Res 5 2006 1143 1154
    • (2006) J Proteome Res , vol.5 , pp. 1143-1154
    • Keshamouni, V.G.1    Michailidis, G.2    Grasso, C.S.3    Anthwal, S.4    Strahler, J.R.5    Walker, A.6
  • 8
    • 44949201593 scopus 로고    scopus 로고
    • Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis
    • H. Yu, M. Konigshoff, A. Jayachandran, D. Handley, W. Seeger, and N. Kaminski Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis FASEB J 22 2008 1778 1789
    • (2008) FASEB J , vol.22 , pp. 1778-1789
    • Yu, H.1    Konigshoff, M.2    Jayachandran, A.3    Handley, D.4    Seeger, W.5    Kaminski, N.6
  • 9
    • 69949124749 scopus 로고    scopus 로고
    • Direct contribution of epithelium to organ fibrosis: Epithelial- mesenchymal transition
    • M. Guarino, A. Tosoni, and M. Nebuloni Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition Hum Pathol 40 2009 1365 1376
    • (2009) Hum Pathol , vol.40 , pp. 1365-1376
    • Guarino, M.1    Tosoni, A.2    Nebuloni, M.3
  • 10
    • 75649088874 scopus 로고    scopus 로고
    • Mechanisms of the epithelial-mesenchymal transition by TGF-β
    • M.K. Wendt, T.M. Allington, and W.P. Schiemann Mechanisms of the epithelial-mesenchymal transition by TGF-β Future Oncol 5 2009 1145 1168
    • (2009) Future Oncol , vol.5 , pp. 1145-1168
    • Wendt, M.K.1    Allington, T.M.2    Schiemann, W.P.3
  • 11
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • H. Kasai, J.T. Allen, R.M. Mason, T. Kamimura, and Z. Zhang TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT) Respir Res 6 2005 56 71
    • (2005) Respir Res , vol.6 , pp. 56-71
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 12
    • 30744470159 scopus 로고    scopus 로고
    • The contribution of transforming growth factor-beta and epidermal growth factor signaling to airway remodeling in chronic asthma
    • C. Boxall, S.T. Holgate, and D.E. Davies The contribution of transforming growth factor-beta and epidermal growth factor signaling to airway remodeling in chronic asthma Eur Respir J 27 2006 208 229
    • (2006) Eur Respir J , vol.27 , pp. 208-229
    • Boxall, C.1    Holgate, S.T.2    Davies, D.E.3
  • 13
    • 1542435440 scopus 로고    scopus 로고
    • Mechanisms of airway epithelial damage: Epithelial-mesenchymal interactions in the pathogenesis of asthma
    • S.T. Holgate, D.E. Davies, S. Puddicombe, A. Richter, P. Lackie, and J. Lordan Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma Eur Respir J Suppl 44 2003 24s 29s
    • (2003) Eur Respir J Suppl , vol.44
    • Holgate, S.T.1    Davies, D.E.2    Puddicombe, S.3    Richter, A.4    Lackie, P.5    Lordan, J.6
  • 14
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: Potential role in idiopathic pulmonary fibrosis
    • B.C. Willis, J.M. Liebler, K. Luby-Phelps, A.G. Nicholson, E.D. Crandall, and R.M. du Bois Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis Am J Pathol 166 2005 1321 1332
    • (2005) Am J Pathol , vol.166 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3    Nicholson, A.G.4    Crandall, E.D.5    Du Bois, R.M.6
  • 15
    • 76649134077 scopus 로고    scopus 로고
    • Roles of epithelial- to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer
    • D.J. McConkey, W. Choi, L. Marquis, F. Martin, M.B. Williams, and J. Shah Roles of epithelial- to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer Cancer Metastasis Rev 28 2009 335 344
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 335-344
    • McConkey, D.J.1    Choi, W.2    Marquis, L.3    Martin, F.4    Williams, M.B.5    Shah, J.6
  • 16
    • 84856049288 scopus 로고    scopus 로고
    • Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β (1) signaling
    • G.M. Mutlu, G.R. Budinger, M. Wu, A.P. Lam, A. Zirk, and S. Rivera Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β (1) signaling Thorax 67 2012 139 146
    • (2012) Thorax , vol.67 , pp. 139-146
    • Mutlu, G.M.1    Budinger, G.R.2    Wu, M.3    Lam, A.P.4    Zirk, A.5    Rivera, S.6
  • 17
    • 0035746612 scopus 로고    scopus 로고
    • Propolis: Biological and pharmacological activities. Therapeutic uses of this bee-product
    • S.L. De Castro Propolis: biological and pharmacological activities. Therapeutic uses of this bee-product Ann Rev Biomed Sci 3 2001 49 83
    • (2001) Ann Rev Biomed Sci , vol.3 , pp. 49-83
    • De Castro, S.L.1
  • 18
    • 0026045838 scopus 로고
    • Antibacterial, antifungal, antiamoebic, antiinflammatory and antipyretic studies on propolis bee products
    • J.W. Dobrowolski, S.B. Vohora, K. Sharma, S.A. Shah, S.A.H. Naqvi, and P.C. Dandiya Antibacterial, antifungal, antiamoebic, antiinflammatory and antipyretic studies on propolis bee products J Ethnopharmacol 35 1991 77 82
    • (1991) J Ethnopharmacol , vol.35 , pp. 77-82
    • Dobrowolski, J.W.1    Vohora, S.B.2    Sharma, K.3    Shah, S.A.4    Naqvi, S.A.H.5    Dandiya, P.C.6
  • 19
    • 0032489791 scopus 로고    scopus 로고
    • Review of the biological properties and toxicity of bee propolis (propolis)
    • G.A. Burdock Review of the biological properties and toxicity of bee propolis (propolis) Food Chem Toxicol 36 1998 347 363
    • (1998) Food Chem Toxicol , vol.36 , pp. 347-363
    • Burdock, G.A.1
  • 20
    • 0028054897 scopus 로고
    • Scavenging action of propolis extract against oxygen radicals
    • C. Pascual, R. Gonzalez, and R.G. Torricella Scavenging action of propolis extract against oxygen radicals J Ethnopharmacol 41 1994 9 13
    • (1994) J Ethnopharmacol , vol.41 , pp. 9-13
    • Pascual, C.1    Gonzalez, R.2    Torricella, R.G.3
  • 21
    • 0033859612 scopus 로고    scopus 로고
    • Flavonoids as antioxidants
    • P.G. Pietta Flavonoids as antioxidants J Nat Prod 63 2000 1035 1042
    • (2000) J Nat Prod , vol.63 , pp. 1035-1042
    • Pietta, P.G.1
  • 22
    • 0025268637 scopus 로고
    • Antibacterial properties of propolis (bee glue)
    • J.M. Grange, and R.W. Davey Antibacterial properties of propolis (bee glue) J R Soc Med 83 1990 159 160
    • (1990) J R Soc Med , vol.83 , pp. 159-160
    • Grange, J.M.1    Davey, R.W.2
  • 23
    • 0027732287 scopus 로고
    • Mechanisms involved in the anti-inflammatory effect of propolis extract
    • M.T. Khayyal, M.A. el-Ghazaly, and A.S. el-Khatib Mechanisms involved in the anti-inflammatory effect of propolis extract Drugs Exp Clin Res 19 1993 197 203
    • (1993) Drugs Exp Clin Res , vol.19 , pp. 197-203
    • Khayyal, M.T.1    El-Ghazaly, M.A.2    El-Khatib, A.S.3
  • 24
    • 29844449645 scopus 로고    scopus 로고
    • Anti-inflammatory effects of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema
    • K. Tan-No, K.T. Nakajima, T. Shoii, O. Nakagawasai, F. Niijima, and M. Ishikawam Anti-inflammatory effects of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema Biol Pharm Bull 29 2006 96 99
    • (2006) Biol Pharm Bull , vol.29 , pp. 96-99
    • Tan-No, K.1    Nakajima, K.T.2    Shoii, T.3    Nakagawasai, O.4    Niijima, F.5    Ishikawam, M.6
  • 25
    • 0023838394 scopus 로고
    • Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis
    • D. Grunberger, R. Banerjee, K. Eisinger, E.M. Oltz, L. Efros, and M. Caldwell Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis Experientia 44 1988 230 232
    • (1988) Experientia , vol.44 , pp. 230-232
    • Grunberger, D.1    Banerjee, R.2    Eisinger, K.3    Oltz, E.M.4    Efros, L.5    Caldwell, M.6
  • 26
    • 22144470771 scopus 로고    scopus 로고
    • The protective effect of caffeic acid phenethyl ester against cyclosporine A-induced cardiotoxicity in rats
    • R. Rezzani, L. Giugno, B. Buffoli, F. Bonomini, and R. Bianchi The protective effect of caffeic acid phenethyl ester against cyclosporine A-induced cardiotoxicity in rats Toxicology 212 2005 155 164
    • (2005) Toxicology , vol.212 , pp. 155-164
    • Rezzani, R.1    Giugno, L.2    Buffoli, B.3    Bonomini, F.4    Bianchi, R.5
  • 27
    • 40649095837 scopus 로고    scopus 로고
    • NF-kappa B-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis
    • C.S. Chen, C.H. Wu, Y.C. Lai, W.S. Lee, H.M. Chen, and R.J. Chen NF-kappa B-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis Toxicology 246 2008 148 157
    • (2008) Toxicology , vol.246 , pp. 148-157
    • Chen, C.S.1    Wu, C.H.2    Lai, Y.C.3    Lee, W.S.4    Chen, H.M.5    Chen, R.J.6
  • 28
    • 59449090107 scopus 로고    scopus 로고
    • TGF-β-induced epithelial to mesenchymal transition
    • J. Xu, S. Lamouille, and R. Derynck TGF-β-induced epithelial to mesenchymal transition Cell Res 19 2009 156 172
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 29
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumor cells
    • E. Batlle, E. Sancho, C. Franci, D. Domínguez, M. Monfar, and J. Baulida The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumor cells Nat Cell Biol 2 2000 84 89
    • (2000) Nat Cell Biol , vol.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3    Domínguez, D.4    Monfar, M.5    Baulida, J.6
  • 30
    • 10744221529 scopus 로고    scopus 로고
    • Inhibitory effect of caffeic acid phenethyl ester on bleomycine-induced lung fibrosis in rats
    • H. Ozyurt, S. Söǧüt, Z. Yildirim, L. Kart, M. Iraz, and F. Armutçu Inhibitory effect of caffeic acid phenethyl ester on bleomycine-induced lung fibrosis in rats Clin Chim Acta 339 2004 65 75
    • (2004) Clin Chim Acta , vol.339 , pp. 65-75
    • Ozyurt, H.1    Söǧüt, S.2    Yildirim, Z.3    Kart, L.4    Iraz, M.5    Armutçu, F.6
  • 31
    • 79952376741 scopus 로고    scopus 로고
    • The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats
    • L.L. Shi, B.N. Chen, M. Gao, H.A. Zhang, Y.J. Li, and L. Wang The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats Life Sci 88 2011 521 528
    • (2011) Life Sci , vol.88 , pp. 521-528
    • Shi, L.L.1    Chen, B.N.2    Gao, M.3    Zhang, H.A.4    Li, Y.J.5    Wang, L.6
  • 32
    • 44649126021 scopus 로고    scopus 로고
    • Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro
    • R. Liu, M. Gao, Z.H. Yang, and G.H. Du Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro Brain Res 1216 2008 104 115
    • (2008) Brain Res , vol.1216 , pp. 104-115
    • Liu, R.1    Gao, M.2    Yang, Z.H.3    Du, G.H.4
  • 33
    • 77949580004 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ inhibits transformed growth of non-small cell lung cancer cells through selective suppression of snail
    • R. Choudhary, H. Li, R.A. Winn, A.L. Sorenson, M.C. Weiser-Evans, and R.A. Nemenoff Peroxisome proliferator-activated receptor-γ inhibits transformed growth of non-small cell lung cancer cells through selective suppression of snail Neoplasia 12 2010 224 234
    • (2010) Neoplasia , vol.12 , pp. 224-234
    • Choudhary, R.1    Li, H.2    Winn, R.A.3    Sorenson, A.L.4    Weiser-Evans, M.C.5    Nemenoff, R.A.6
  • 34
    • 78650450648 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition
    • A.K. Reka, H. Kurapati, V.R. Narala, G. Bommer, J. Chen, and T.J. Standiford Peroxisome proliferator-activated receptor-gamma activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition Mol Cancer Ther 9 2010 3221 3232
    • (2010) Mol Cancer Ther , vol.9 , pp. 3221-3232
    • Reka, A.K.1    Kurapati, H.2    Narala, V.R.3    Bommer, G.4    Chen, J.5    Standiford, T.J.6
  • 35
    • 77956613753 scopus 로고    scopus 로고
    • Ethanolic extracts of Brazilian red propolis promote adipocyte differentiation through PPARγ activation
    • A. Iio, K. Ohguchia, H. Inoueb, H. Maruyamac, Y. Arakic, and Y. Nozawa Ethanolic extracts of Brazilian red propolis promote adipocyte differentiation through PPARγ activation Phytomedicine 17 2010 974 979
    • (2010) Phytomedicine , vol.17 , pp. 974-979
    • Iio, A.1    Ohguchia, K.2    Inoueb, H.3    Maruyamac, H.4    Arakic, Y.5    Nozawa, Y.6
  • 36
    • 65849230894 scopus 로고    scopus 로고
    • The beneficial effect of propolis on fat accumulation and lipid metabolism in rats fed a high-fat diet
    • I. Ichi, H. Hori, Y. Takashima, N. Adachi, R. Kataoka, and K. Okihara The beneficial effect of propolis on fat accumulation and lipid metabolism in rats fed a high-fat diet J Food Sci 74 2009 H127 H131
    • (2009) J Food Sci , vol.74
    • Ichi, I.1    Hori, H.2    Takashima, Y.3    Adachi, N.4    Kataoka, R.5    Okihara, K.6
  • 37
    • 70349113042 scopus 로고    scopus 로고
    • Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components
    • H. Martin Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components Mutat Res 669 2009 1 7
    • (2009) Mutat Res , vol.669 , pp. 1-7
    • Martin, H.1
  • 39
    • 34548591700 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodeling in chronic lung disease
    • J.E. Ward, and X. Tan Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodeling in chronic lung disease PPAR Res 2007 14983 14995
    • (2007) PPAR Res , pp. 14983-14995
    • Ward, J.E.1    Tan, X.2
  • 40
    • 18844458812 scopus 로고    scopus 로고
    • PPAR gamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: Implications for therapy of lung fibrosis
    • H.A. Burgess, L.E. Daugherty, T.H. Thatcher, H.F. Lakatos, D.M. Ray, and M. Redonnet PPAR gamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis Am J Physiol Lung Cell Mol Physiol 288 2005 L1146 L1153
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288
    • Burgess, H.A.1    Daugherty, L.E.2    Thatcher, T.H.3    Lakatos, H.F.4    Ray, D.M.5    Redonnet, M.6
  • 42
    • 1842733168 scopus 로고    scopus 로고
    • Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma
    • A.K. Ghosh, S. Bhattacharyya, G. Lakos, S.J. Chen, Y. Mori, and J. Varga Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma Arthritis Rheum 50 2004 1305 1318
    • (2004) Arthritis Rheum , vol.50 , pp. 1305-1318
    • Ghosh, A.K.1    Bhattacharyya, S.2    Lakos, G.3    Chen, S.J.4    Mori, Y.5    Varga, J.6
  • 43
    • 35648968186 scopus 로고    scopus 로고
    • Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice
    • S.Y. Langenbach, B.J. Wheaton, D.J. Fernandes, C. Jones, T.E. Sutherland, and B.C. Wraith Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice Can J Physiol Pharmacol l85 2007 727 738
    • (2007) Can J Physiol Pharmacol , vol.185 , pp. 727-738
    • Langenbach, S.Y.1    Wheaton, B.J.2    Fernandes, D.J.3    Jones, C.4    Sutherland, T.E.5    Wraith, B.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.