Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice

Canadian Journal of Physiology and Pharmacology

Volumn 85, Issue 7, 2007, Pages 727-738

  Langenbach, Shenna Y ^a   Wheaton, Ben J ^a   Fernandes, Darren J ^a   Jones, Catherine ^a   Sutherland, Tara E ^a   Wraith, Bronwyn C ^a   Harris, Trudi ^a   Schuliga, Michael J ^a   McLean, Catriona ^b   Stewart, Alastair G ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ALFRED HOSPITAL   (Australia)

Author keywords

Bleomycin; Fibrosis; Hydroxyproline; Lung compliance; Methylprednisolone

Indexed keywords

2 METHOXYESTRADIOL; BLEOMYCIN; GLUCOCORTICOID; HYDROXYPROLINE; METHYLPREDNISOLONE;

ANIMAL MODEL; ANIMAL TISSUE; BODY MASS; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; EMPHYSEMA; GENE EXPRESSION; HISTOPATHOLOGY; LUNG COMPLIANCE; LUNG FIBROSIS; LUNG FUNCTION; LUNG LAVAGE; LUNG RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT;

AIRWAY RESISTANCE; ANIMALS; BLEOMYCIN; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; CELL ADHESION MOLECULES; CYTOKINES; DRUG RESISTANCE; ESTRADIOL; GENE EXPRESSION; GLUCOCORTICOIDS; HYDROXYPROLINE; LUNG; LUNG COMPLIANCE; MATRIX METALLOPROTEINASES; METHYLPREDNISOLONE; MICE; MICE, INBRED C57BL; ORGAN SIZE; PULMONARY ALVEOLI; PULMONARY EMPHYSEMA; PULMONARY FIBROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASES; TUBULIN MODULATORS;

EID: 35648968186     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y07-065     Document Type: Conference Paper

References (43)

1. Ashcroft, T., Simpson, J.M., and Timbrell, V. 1988. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J. Clin. Pathol. 41: 467-470. doi:10.1136/jcp.41.4.467.
2. Borzone, G., Moreno, R., Urrea, R., Meneses, M., Oyarzun, M., and Lisboa, C. 2001. Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 163: 1648-1653.
3. Chapman, H.A. 2004. Disorders of lung matrix remodeling. J. Clin. Invest. 113: 148-157. doi:10.1172/JCI200420729.
4. Collard, H.R., and King, T.E., Jr. 2003. Demystifying idiopathic interstitial pneumonia. Arch. Intern. Med. 163: 17-29. doi:10.1001/archinte.163.1.17.
5. Dik, W.A., McAnulty, R.J., Versnel, M.A., Naber, B.A., Zimmermann, L.J., Laurent, G.J., and Mutsaers, S.E. 2003a. Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats. Thorax, 58: 765-771. doi:10.1136/thorax.58.9.765.
6. Dik, W.A., Versnel, M.A., Naber, B.A., Janssen, D.J., van Kaam, A.H., and Zimmermann, L.J. 2003b. Dexamethasone treatment does not inhibit fibroproliferation in chronic lung disease of prematurity. Eur. Respir. J. 21: 842-847. doi:10.1183/09031936.03.00069002.
7. Dubey, R.K., Gillespie, D.G., Zacharia, L.C., Rosselli, M., Imthurn, B., and Jackson, E.K. 2002. Methoxyestradiols mediate the antimitogenic effects of locally applied estradiol on cardiac fibroblast growth. Hypertension, 39: 412-417. doi:10.1161/hy0202.102837.
8. Dunnill, M.S. 1962. Quantitative methods in the study of pulmonary pathology. Thorax, 17: 320-328.
9. Ebihara, T., Venkatesan, N., Tanaka, R., and Ludwig, M.S. 2000. Changes in extracellular matrix and tissue viscoelasticity in bleomycin-induced lung fibrosis. Temporal aspects. Am. J. Respir. Crit. Care Med. 162: 1569-1576.
10. Entzian, P., Zahringer, U., Schlaak, M., Gerlach, C., Galle, J., and Zabel, P. 1998. Comparative study on effects of pentoxifylline, prednisolone and colchicine in experimental alveolitis. Int. J. Immunopharmacol. 20: 723-735. doi:10.1016/S0192-0561(98)00056-3.
11. Fotsis, T., Zhang, Y., Pepper, M.S., Adlercreutz, H., Montesano, R., Nawroth, P.P., and Schweigerer, L. 1994. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature, 368: 237-239. doi:10.1038/368237a0.
12. Ginsberg, S.J., and Comis, R.L. 1982. The pulmonary toxicity of antineoplastic agents. Semin. Oncol. 9: 34-51.
13. Grunze, M.F., Parkinson, D., Sulavik, S.B., and Thrall, R.S. 1988. Effect of corticosteroids on lung volume-pressure curves in bleomycin-induced lung injury in the rat. Exp. Lung Res. 14: 183-195.
14. Gutala, R.V., and Reddy, P.H. 2004. The use of real-time PCR analysis in a gene expression study of Alzheimer's disease post mortem brains. J. Neurosci. Methods, 132: 101-107.
15. Hagimoto, N., Kuwano, K., Nomoto, Y., Kunitake, R., and Hara, N. 1997. Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am. J. Respir. Cell Mol. Biol. 16: 91-101.
16. Hay, J., Shahzeidi, S., and Laurent, G. 1991. Mechanisms of bleomycin-induced lung damage. Arch. Toxicol. 65: 81-94. doi:10.1007/BF02034932.
17. Hughes, R.A., Harris, T., Altmann, E., McAllister, D., Vlahos, R., Robertson, A., et al. 2002. 2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding. Mol. Pharmacol. 61: 1053-1069. doi:10.1124/mol.61.5. 1053.
18. Izbicki, G., Segel, M.J., Christensen, T.G., Conner, M.W., and Breuer, R. 2002. Time course of bleomycin-induced lung fibrosis. Int. J. Exp. Pathol. 83: 111-119. doi:10.1046/j.1365-2613.2002.00220.x.
19. Kehrer, J.P., Klein-Szanto, A.J., Sorensen, E.M., Pearlman, R., and Rosner, M.H. 1984. Enhanced acute lung damage following corticosteroid treatment. Am. Rev. Respir. Dis. 130: 256-261.
20. Klauber, N., Parangi, S., Flynn, E., Hamel, E., and D'Amato, R.J. 1997. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res. 57: 81-86.
21. Koshika, T., Hirayama, Y., Ohkubo, Y., Mutoh, S., and Ishizaka, A. 2005. Tacrolimus (FK506) has protective actions against murine bleomycin-induced acute lung injuries. Eur. J. Pharmacol. 515: 169-178. doi:10.1016/j.ejphar. 2005.03.042.
22. Lasky, J. 2004. Pirfenidone. IDrugs, 7: 166-172.
23. Li, H.P., Li, X., He, G.J., Yi, X.H., and Kaplan, A.P. 2004. The influence of dexamethasone on the proliferation and apoptosis of pulmonary inflammatory cells in bleomycin-induced pulmonary fibrosis in rats. Respirology, 9: 25-32. doi:10.1111/j.1440-1843.2003.00523.x.
24. Liu, Q.H., Li, D.G., Huang, X., Zong, C.H., Xu, Q.F., and Lu, H.M. 2004. Suppressive effects of 17beta-estradiol on hepatic fibrosis in CCl4-induced rat model. World J. Gastroenterol. 10: 1315-1320.
25. Miller, M., Cho, J.Y., Mcelwain, K., Mcelwain, S., Shim, J.Y., Manni, M., Baek, J.S., and Broide, D.H. 2006. Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L162-L169.
26. Mutsaers, S.E., Marshall, R.P., Goldsack, N.R., Laurent, G.J., and Mcanulty, R.J. 1998. Effect of endothelin receptor antagonists (BQ-485, Ro 47-0203) on collagen deposition during the development of bleomycin-induced pulmonary fibrosis in rats. Pulm. Pharmacol. Ther. 11: 221-225.
27. Mutsaers, S.E., McAnulty, R.J., Laurent, G.J., and Knight, D.A. 2004. Evaluation of experimental models of idiopathic pulmonary fibrosis. Drug Discov. Today, 1: 329-336.
28. Nettelbladt, O., Tengblad, A., and Hallgren, R. 1990. High-dose corticosteroids during bleomycin-induced alveolitis in the rat do not suppress the accumulation of hyaluronan (hyaluronic acid) in lung tissue. Eur. Respir. J. 3: 421-428.
29. Nishigaki, I., Sasaguri, Y., and Yagi, K. 1995. Anti-proliferative effect of 2-methoxyestradiol on cultured smooth muscle cells from rabbit aorta. Atherosclerosis, 113: 167-170. doi:10.1016/0021-9150(94)05442-L.
30. Okine, L.K., Lowe, M.C., Mimnaugh, E.G., Goochee, J.M., and Gram, T.E. 1986. Protection by methylprednisolone against butylated hydroxytoluene-induced pulmonary damage and impairment of microsomal monooxygenase activities in the mouse: lack of effect on fibrosis. Exp. Lung Res. 10: 1-22.
31. Park, S.H., Saleh, D., Giaid, A., and Michel, R.P. 1997. Increased endothelin-1 in bleomycin-induced pulmonary fibrosis and the effect of an endothelin receptor antagonist. Am. J. Respir. Crit. Care Med. 156: 600-608.
32. Phan, S.H., Thrall, R.S., and Williams, C. 1981. Bleomycin-induced pulmonary fibrosis. Effects of steroid on lung collagen metabolism. Am. Rev. Respir. Dis. 124: 428-434.
33. Raghu, G., and Chang, J. 2004b. Idiopathic pulmonary fibrosis: current trends in management. Clin. Chest Med. 25: 621-636. [v.] doi:10.1016/j.ccm.2004.08.002.
34. Raghu, G., Brown, K.K., Bradford, W.Z., Starko, K., Noble, P.W., Schwartz, D.A., and King, T.E., Jr. 2004a. A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis. N. Engl. J. Med. 350: 125-133. doi:10.1056/NEJMoa030511.
35. Rudd, R.M., Prescott, R.J., Chalmers, J.C., and Johnston, I.D. 2007. British Thoracic Society Study on cryptogenic fibrosing alveolitis: Response to treatment and survival. Thorax, 62: 62-66. doi:10.1136/thx.2005.045591.
36. Selman, M., Thannickal, V.J., Pardo, A., Zisman, D.A., Martinez, F.J., and Lynch, J.P., 3rd. 2004. Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches. Drugs, 64: 405-430. doi:10.2165/00003495- 200464040-00005.
37. Sterling, K.M., Jr., DiPetrillo, T., Cutroneo, K.R., and Prestayko, A. 1982. Inhibition of collagen accumulation by glucocorticoids in rat lung after intratracheal bleomycin instillation. Cancer Res. 42: 405-408.
38. Stewart, A.G., Vlahos, R., Fernandes, D.J., and Hughes, R.A. 2001. Oestradiol metabolites: effects on airway wall remodelling. Karger, Basel.
39. Sutherland, T.E., Schuliga, M., Harris, T., Eckhardt, B.L., Anderson, R.L., Quan, L., and Stewart, A.G. 2005. 2-methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer. Clin. Cancer Res. 11: 1722-1732. doi:10.1158/1078-0432.CCR-04- 1789.
40. Sweeney, C., Liu, G., Yiannoutsos, C., Kolesar, J., Horvath, D., Staab, M.J., et al. 2005. A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer. Clin. Cancer Res. 11: 6625-6633. doi:10.1158/1078-0432.CCR-05-0440.
41. Tamagawa, K., Taooka, Y., Maeda, A., Hiyama, K., Ishioka, S., and Yamakido, M. 2000. Inhibitory effects of a lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis in mice. Am. J. Respir. Crit. Care Med. 161: 1279-1284.
42. Thurlbeck, W.M. 1967. The internal surface area of nonemphysematous lungs. Am. Rev. Respir. Dis. 95: 765-773.
43. Ward, J.E., Fernandes, D.J., Taylor, C.C., Bonacci, J.V., Quan, L., and Stewart, A.G. 2006. The PPARgamma ligand, rosiglitazone, reduces airways hyperresponsiveness in a murine model of allergen-induced inflammation. Pulm. Pharmacol. Ther. 19: 39-46.