The beneficial effect of propolis on fat accumulation and lipid metabolism in rats fed a high-fat diet

Journal of Food Science

Volumn 74, Issue 5, 2009, Pages

  Ichi, I ^a   Hori, H ^a   Takashima, Y ^a   Adachi, N ^a   Kataoka, R ^a   Okihara, K ^b   Hashimoto, K ^b   Kojo, S ^a  

^a NARA WOMEN'S UNIVERSITY   (Japan)

^b Yamada Apiculture Center Inc   (Japan)

Author keywords

Adipocyte; Cholesterol; Lipid metabolism; PPAR; Triglyceride

Indexed keywords

ANTIINFECTIVE AGENT; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROPOLIS; PROTEIN; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BLOOD; DIET; DOSE RESPONSE; DRUG EFFECT; FAT INTAKE; LIPID METABOLISM; LIVER; MALE; METABOLISM; METHODOLOGY; RAT; WESTERN BLOTTING; WISTAR RAT;

ADIPOSE TISSUE; ANIMALS; ANTI-INFECTIVE AGENTS; BLOTTING, WESTERN; CHOLESTEROL; DIET; DIETARY FATS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIPID METABOLISM; LIVER; MALE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PROPOLIS; PROTEINS; RATS; RATS, WISTAR; TRIGLYCERIDES;

RATTUS; RATTUS NORVEGICUS;

EID: 65849230894     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2009.01147.x     Document Type: Article

References (38)

1. Aprikian O, Duclos V, Guyot S, Besson C, Manach C, Bernalier A, Morand C, Remesy C, Demigne C. 2003. Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats. J Nutr 133 : 1860 5. (Pubitemid 36666526)
2. Castro SL. 2001. Propolis: biological and pharmacological activities. Therapeutic uses of this bee-product. Ann Rev Biomed Sci 3 : 49 83.
3. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365 : 855 9. (Pubitemid 23341031)
4. Desvergne B, Wahli W. 1999. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20 : 649 88. (Pubitemid 30650602)
5. Fletcher MJ. 1968. A colorimetric method for estimation of serum triglycerides. Clin Chim Acta 22 : 393 7.
6. Fuliang HU, Hepburn HR, Xuan H, Chen M, Daya S, Radloff SE. 2005. Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus. Pharmacol Res 51 : 147 52. (Pubitemid 40040545)
7. Funatsu T, Kakuta H, Takasu T, Noguchi M, Suzuki M, Miyata K. 2003. Experimental model of postprandial hypertriglyceridemia in sucrose-fed rats and the effectiveness of atorvastatin in the model. Metabolism 52 : 609 15. (Pubitemid 36896288)
8. Ghisalberti EL. 1979. Propolis: a review. Bee World 60 : 59 84.
9. Gil G, Faust JR, Chin DJ, Goldstein JL, Brown MS. 1985. Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. Cell 41 : 249 58. (Pubitemid 15068442)
10. Golay A, Bobbioni E. 1997. The role of dietary fat in obesity. Int J Obes Relat Metab Disord 21 : 2 11. (Pubitemid 27271983)
11. Han KH, Sekikawa M, Shimada K, Sasaki K, Ohba K, Fukushima M. 2004. Resistant starch fraction prepared from kintoki bean affects gene expression of genes associated with cholesterol metabolism in rats. Exp Biol Med 229 : 787 92. (Pubitemid 39166483)
12. Han LK, Sumiyoshi M, Zhang J, Liu MX, Zhang XF, Zheng YN. 2003. Anti-obesity action of Salix matsudana leaves (Part 1). Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals. Phytother Res 17 : 1188 94. (Pubitemid 38057177)
13. Harmon AW, Harp JB. 2001. Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis. Am J Physiol Cell Physiol 280 : 807 13. (Pubitemid 32472320)
14. Huleihel M, Isanu V. 2002. Anti-herpes simplex virus effect of an aqueous extract of propolis. Isr Med Assoc J 4 : 923 7. (Pubitemid 35291272)
15. Ikeda I, Tanaka K, Sugano M, Vahouny GV, Gallo LL. 1988. Discrimination between cholesterol and sitosterol for absorption in rats. J Lipid Res 29 : 1583 91. (Pubitemid 19030526)
16. Istvan ES. 2002. Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Am Heart J 144 : 27 32. (Pubitemid 36026902)
17. Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K, Satoh S, Nakano R, Ishii C, Sugiyama T, Eto K, Tsubamoto Y, Okuno A, Murakami K, Sekihara H, Hasegawa G, Naito M, Toyoshima Y, Tanaka S, Shiota K, Kitamura T, Fujita T, Ezaki O, Aizawa S, Kadowaki T. 1999. PPAR mediates high-fat dietinduced adipocyte hypertrophy and insulin resistance. Mol Cell 4 : 597 609. (Pubitemid 29531139)
18. Lee SH, Park YB, Bae KH, Bok SH, Kwon YK, Lee ES. 1999. Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A: cholesterol acyltransferase in rats. Ann Nutr Metab 43 : 173 80. (Pubitemid 29494862)
19. Linden D, Alsterholm M, Wennbo H, Oscarsson J. 2001. PPARα deficiency increases secretion and serum levels of apolipoprotein B-containing lipoproteins. J Lipid Res 42 : 1831 40. (Pubitemid 33116714)
20. Linden D, Lindberg K, Oscarsson J, Claesson C, Asp L, Lu L. 2002. Influence of peroxisome proliferator-activated receptor α agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48. J Biol Chem 277 : 23044 53.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall J. 1951. Protein measurement with folin phenol reagent. J Biol Chem 19 : 265 75.
22. Marcucci MC, Ferreres F, Garcia-Viguera C, Bankova VS, De Castro SL, Dantas AP, Paulino N. 2001. Phenolic compounds from Brazilian propolis with pharmacological activities. J Ethnopharmacol 74 : 105 12. (Pubitemid 32141092)
23. Michael RP. 2006. Flavonoids attenuate cardiovascular disease, Inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver. Exp Biol Med 231 : 1287 99.
24. Moen CJ, Tholens AP, Voshol PJ, de Haan W, Havekes LM, Gargalovic P. 2007. The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides. J Lipid Res 48 : 2182 92. (Pubitemid 47529561)
25. Naaz A, Yellayi S, Zakroczymski MA, Bunick D, Doerge DR, Lubahn DB, Helferich WG, Cooke PS. 2003. The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology 144 : 3315 20. (Pubitemid 36904405)
26. Neve BP, Fruchart JC, Staels B. 2000. Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis. Biochem Pharmacol 60 : 1245 50.
27. Pai J, Guryev O, Brown MS, Goldstein JL. 1998. Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins. J Biol Chem 273 : 26138 48. (Pubitemid 28475850)
28. Philip GS, Forrest HN, George CF. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123 : 1939 51.
29. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. 2004. Sirt1 promotes fat mobilization in white adipocytes by repressing ppar-gamma. Nature 429 : 771 6. (Pubitemid 38833129)
30. Pickavance LC, Tadayyon M, Widdowson PS, Buckingham RE, Wilding JP. 1999. Therapeutic index for rosiglitazone in dietary obese rats: separation of efficacy and haemodilution. Br J Pharmacol 128 : 1570 6.
31. Pietta PG. 2000. Flavonoids as antioxidants. J Nat Prod 63 : 1035 42.
32. Rayalam S, Della-Fera MA, Yang JY, Park HJ, Ambati S, Baile CA. 2007. Resveratrol potentiates genistein's antiadipogenic and proapoptotic effects in 3T3-L1 adipocytes. J Nutr 137 : 2268 73. (Pubitemid 350255295)
33. Sheng Z, Otani H, Brown MS, Goldstein JL. 1995. Independent regulation of sterol regulatory element-binding protein 1 and 2 in hamster liver. Proc Natl Acad Sci USA 92 : 935 8.
34. Shimizu K, Ashida H, Matsuura Y, Kanazawa K. 2004. Antioxidative bioavailability of artepillin C in Brazilian propolis. Arch Biochem Biophys 424 : 181 8. (Pubitemid 38401951)
35. Sri Balasubashini M, Rukkumani R, Menon VP. 2003. Protective effects of ferulic acid on hyperlipidemic diabetic rats. Acta Diabetol 40 : 118 22. (Pubitemid 37288120)
36. Suzuki ST, Zhao B, Yang J. 2008. Enhanced muscle by myostatin propeptide increases adipose tissue adiponectin, PPAR-alpha, and PPAR-gamma expressions. Biochem Biophys Res Commun 369 : 767 73.
37. Takahashi Y, Ide T. 2008. Effects of soy protein and isoflavone on hepatic fatty acid synthesis and oxidation and mRNA expression of uncoupling proteins and peroxisome proliferator-activated receptor gamma in adipose tissues of rats. J Nutr Biochem 19 : 682 93.
38. Tan-No K, Nakajima KT, Shoii T, Nakagawasai O, Niijima F, Ishikawa M, Endo Y, Sato T, Satoh S, Tadano T. 2006. Anti-inflammatory effect of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema. Biol Pharm Bull 29 : 96 9. (Pubitemid 43036702)