Interaction of native bile acids with human apical sodium-dependent bile acid transporter (hASBT): Influence of steroidal hydroxylation pattern and C-24 conjugation

Pharmaceutical Research

Volumn 23, Issue 7, 2006, Pages 1451-1459

  Balakrishnan, Anand ^a   Wring, Stephen A ^b   Polli, James E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b Trimeris Inc   (United States)

Author keywords

ASBT; bile acid; Prodrug; QSAR; SLC10A2; Transporter

Indexed keywords

BILE ACID; CARBON 14; CHENODEOXYCHOLIC ACID; CHOLIC ACID; GLYCINE; GLYCOLITHOCHOLIC ACID; GLYCOURSODEOXYCHOLIC ACID; HUMAN APICAL SODIUM DEPENDENT BILE ACID TRANSPORTER; LITHOCHOLIC ACID; MANNITOL; PEPTIDE; TAURINE; TAUROCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; DRUG TARGETING; ILEUM; INTESTINE ABSORPTION; KIDNEY CELL; KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMINATION; ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CELL LINE; CHENODEOXYCHOLIC ACID; DOGS; GLYCINE; HYDROXYLATION; KINETICS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PERMEABILITY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS; TAURINE; TAUROCHOLIC ACID; TRANSFECTION; URSODEOXYCHOLIC ACID;

EID: 33745584351     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-0219-4     Document Type: Article

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