Genome-Wide ENU Mutagenesis in Combination with High Density SNP Analysis and Exome Sequencing Provides Rapid Identification of Novel Mouse Models of Developmental Disease

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Caruana, Georgina ^a   Farlie, Peter G ^a,b   Hart, Adam H ^a,f   Bagheri Fam, Stefan ^a,c   Wallace, Megan J ^a   Dobbie, Michael S ^d   Gordon, Christopher T ^b   Miller, Kerry A ^b   Whittle, Belinda ^d   Abud, Helen E ^a   Arkell, Ruth M ^e   Cole, Timothy J ^a   Harley, Vincent R ^a,c   Smyth, Ian M ^a   Bertram, John F ^a  

^a MONASH UNIVERSITY   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^e AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^f LA TROBE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA;

ALLELE; ANATOMICAL VARIATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CONTROLLED STUDY; CRANIOFACIAL MORPHOLOGY; DEVELOPMENTAL DISORDER; EMBRYO; EXOME; FRAS1 GENE; GENE; GENE ACTIVITY; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GONAD; HOMOZYGOSITY; IFT140 GENE; INTESTINE; KIDNEY; LIG1 GENE; LINKAGE ANALYSIS; LUNG; MALE; MOUSE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PHENOTYPE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN; URETER; VASCULARIZATION;

ALLELES; ANIMALS; CONGENITAL ABNORMALITIES; DISEASE MODELS, ANIMAL; DNA LIGASES; ETHYLNITROSOUREA; EXOME; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GERM-LINE MUTATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HOMOZYGOTE; LEFT-RIGHT DETERMINATION FACTORS; MALE; MICE; MICE, INBRED C57BL; MUTAGENESIS; MUTAGENS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84874574612     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055429     Document Type: Article

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