ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level

Blood Cells, Molecules, and Diseases

Volumn 50, Issue 2, 2013, Pages 86-92

  Brown, Fiona C ^a,b   Scott, Nicholas ^a   Rank, Gerhard ^a   Collinge, Janelle E ^c   Vadolas, Jim ^b   Vickaryous, Nicola ^d   Whitelaw, Nadia ^d,e   Whitelaw, Emma ^e   Kile, Benjamin T ^b,c   Jane, Stephen M ^a,f   Curtis, David J ^a,f  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f ALFRED HOSPITAL   (Australia)

Author keywords

Major globin; Thalassemia; ENU mutagenesis; Massively parallel sequencing

Indexed keywords

ETHYLNITROSOUREA; HEMOGLOBIN BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA MAJOR GLOBIN GENE; CODON; CONTROLLED STUDY; EMBRYO; ERYTHROCYTE LIFESPAN; ERYTHROCYTE VOLUME; ERYTHROPOIESIS; EXON; FEMALE; GENE; GENE LOCUS; GENE REPLICATION; GENETIC COMPLEMENTATION; GENETIC SCREENING; HETEROZYGOSITY; HETEROZYGOTE; IRON DEFICIENCY ANEMIA; MALE; MICROCYTIC ANEMIA; MOUSE; MOUSE MUTANT; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; NONSENSE MUTATION; POLYADENYLATION; PREGNANCY; PRIORITY JOURNAL; RETICULOCYTOSIS; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SPLENOMEGALY; THALASSEMIA MAJOR;

ANIMALS; BETA-GLOBINS; BETA-THALASSEMIA; CODON; CODON, NONSENSE; DISEASE MODELS, ANIMAL; ERYTHROCYTE INDICES; ETHYLNITROSOUREA; EXONS; FEMALE; FETAL DEATH; GENES, DOMINANT; GENES, LETHAL; GENETIC COMPLEMENTATION TEST; GENOTYPE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MUTAGENESIS; MUTAGENS; POLYADENYLATION; PREGNANCY; SPLEEN;

MUS;

EID: 84871964957     PISSN: 10799796     EISSN: 10960961     Source Type: Journal    
DOI: 10.1016/j.bcmd.2012.09.004     Document Type: Article

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