Acute blast injury reduces brain abeta in two rodent species

Frontiers in Neurology

Volumn 3 DEC, Issue , 2012, Pages

  De Gasperi, Rita ^a,b   Sosa, Miguel A Gama ^a,b   Kim, Soong Ho ^b   Steele, John W ^b,c   Shaughness, Michael C ^d   Maudlin Jeronimo, Eric ^d   Hall, Aaron A ^d   DeKosky, Steven T ^e   McCarron, Richard M ^d   Nambiar, Madhusoodana P ^f   Gandy, Sam ^a,b   Ahlers, Stephen T ^d   Elder, Gregory A ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d NAVAL MEDICAL RESEARCH CENTER   (United States)

^e UNIVERSITY OF VIRGINIA   (United States)

^f WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

siteapp cleaving enzyme 1; Abeta; Amyloid precursor protein; Blast; Mouse; Presenilin 1; Rat; Traumatic brain injury

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE 1; GAMMA SECRETASE; PRESENILIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLAST INJURY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL DESIGN; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PEPTIDE SYNTHESIS; RAT; RODENT; TRAUMATIC BRAIN INJURY;

EID: 84874558742     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2012.00177     Document Type: Article

References (47)

1. Abrahamson, E. E., Ikonomovic, M. D., Dixon, C. E., and Dekosky, S. T. (2009). Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels. Ann. Neurol. 66, 407-414.
2. Ahlers, S. T., Vasserman-Stokes, E., Shaughness, M. C., Hall, A. A., Shear, D. A., Chavko, M., et al. (2012). Assessment of the effects of acute and repeated exposure to blast overpressure in rodents: toward a greater understanding of blast and the potential ram-ifications for injury in humans exposed to blast. Front. Neurol. 3:32. doi:10.3389/fneur.2012.00032
3. Blasko, I., Beer, R., Bigl, M., Apelt, J., Franz, G., Rudzki, D., et al. (2004). Experimental traumatic brain injury in rats stimulates the expres-sion, production and activity of Alzheimer's disease beta-secretase (BACE-1). J. Neural Transm. 111, 523-536.
4. Cernak, I. (2010). The importance of systemic response in the pathobiology of blast-induced neurotrauma. Front. Neurol. 1:151. doi:10.3389/fneur.2010.00151
5. Cernak, I., and Noble-Haeusslein, L. J. (2010). Traumatic brain injury: an overview of pathobiology with emphasis on military populations. J. Cereb. Blood Flow Metab. 30, 255-266.
6. Chavko, M., Koller, W. A., Prusaczyk, W. K., and McCarron, R. M. (2007). Measurement of blast wave by a miniature fiber optic pressure trans-ducer in the rat brain. J. Neurosci. Methods 159, 277-281.
7. Chavko, M., Prusaczyk, W. K., and McCarron, R. M. (2006). Lung injury and recovery after exposure to blast overpressure. J. Trauma 61, 933-942.
8. Chen, X. H., Siman, R., Iwata, A., Meaney, D. F., Trojanowski, J. Q., and Smith, D. H. (2004). Long-term accumulation of amyloid-beta,beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma. Am. J. Pathol. 165, 357-371.
9. Ciallella, J. R., Ikonomovic, M. D., Paljug, W. R., Wilbur, Y. I., Dixon, C. E., Kochanek, P. M., et al. (2002). Changes in expression of amyloid precursor protein and interleukin-1beta after experimental traumatic brain injury in rats. J. Neurotrauma 19, 1555-1567.
10. DeKosky, S. T., Abrahamson, E. E., Cial-lella, J. R., Paljug, W. R., Wisniewski, S. R., Clark, R. S., et al. (2007). Asso-ciation of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans. Arch. Neurol. 64, 541-544.
11. DeKosky, S. T., Ikonomovic, M. D., and Gandy, S. (2010). Traumatic brain injury: football, warfare, and long-term effects. N. Engl. J. Med. 363, 1293-1296.
12. Elder, G. A., Dorr, N. P., De Gasperi, R., Gama Sosa, M. A., Shaughness, M. C., Maudlin-Jeronimo, E., et al. (2012). Blast exposure induces post-traumatic stress disorder-related traits in a rat model of mild trau-matic brain injury. J. Neurotrauma 29, 2564-2575.
13. Elder, G. A., Mitsis, E. M., Ahlers, S. T., and Cristian, A. (2010). Blast-induced mild traumatic brain injury. Psychiatr. Clin. North Am. 33, 757-781.
14. Gama Sosa, M. A., Gasperi, R. D., Rocher, A. B., Wang, A. C., Janssen, W. G., Flores, T., et al. (2010). Age-related vascular pathology in trans-genic mice expressing presenilin 1-associated familial Alzheimer's dis-ease mutations. Am. J. Pathol. 176, 353-368.
15. Gandy, S. (2005). The role of cerebral amyloid beta accumulation in com-mon forms of Alzheimer disease. J. Clin. Invest. 115, 1121-1129.
16. Garman, R. H., Jenkins, L. W., Switzer, R. C. III, Bauman, R. A., Tong, L. C., Swauger, P. V., et al. (2011). Blast exposure in rats with body shield-ing is characterized primarily by dif-fuse axonal injury. J. Neurotrauma 28, 947-959.
17. Gennarelli, T. A., and Grahm, D. I. (2005). "Neuropathology," in Text-book of Traumatic Brain Injury, eds J. M. Silver, T. W. McAllister, and S. C. Yudofsky (Arlington, VA: American Psychiatric Publishing, Inc.), 27-50.
18. Gentleman, S. M., Nash, M. J., Sweet-ing, C. J., Graham, D. I., and Roberts, G. W. (1993). Beta-amyloid precur-sor protein (beta APP) as a marker for axonal injury after head injury. Neurosci. Lett. 160, 139-144.
19. Ikonomovic, M. D., Uryu, K., Abra-hamson, E. E., Ciallella, J. R., Tro-janowski, J. Q., Lee, V. M., et al. (2004). Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury. Exp. Neurol. 190, 192-203.
20. Johnson, V. E., Stewart, W., and Smith, D. H. (2010). Traumatic brain injury and amyloid-beta pathology: a link to Alzheimer's disease? Nat. Rev. Neurosci. 11, 361-370.
21. Jones, E., Fear, N. T., and Wessely, S. (2007). Shell shock and mild traumatic brain injury: a histori-cal review. Am. J. Psychiatry 164, 1641-1645.
22. Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., and Younkin, S. G. (2001). Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neu-rosci. 21, 372-381.
23. Keilani, S., Lun, Y., Stevens, A. C., Williams, H. N., Sjoberg, E. R., Khanna, R., et al. (2012). Lyso-somal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-beta peptide. J. Neurosci. 32, 5223-5236.
24. Kuehn, R., Simard, P. F., Driscoll, I., Keledjian, K., Ivanova, S., Tosun, C., et al. (2011). Rodent model of direct cranial blast injury. J. Neurotrauma 28, 2155-2169.
25. Lewen, A., Li, G. L., Nilsson, P., Ols-son,Y.,and Hillered,L. (1995). Trau-matic brain injury in rat produces changes of beta-amyloid precursor protein immunoreactivity. Neurore-port 6, 357-360.
26. Loane, D. J., Pocivavsek, A., Moussa, C. E., Thompson, R., Matsuoka, Y., Faden, A. I., et al. (2009). Amyloid precursor protein secretases as ther-apeutic targets for traumatic brain injury. Nat. Med. 15, 377-379.
27. Loane, D. J., Washington, P. M., Var-danian, L., Pocivavsek, A., Hoe, H. S., Duff, K. E., et al. (2011). Mod-ulation of ABCA1 by an LXR ago-nist reduces beta-amyloid levels and improves outcome after traumatic brain injury. J. Neurotrauma 28, 225-236.
28. Mayeux, R., Ottman, R., Maestre, G., Ngai, C., Tang, M. X., Gins-berg, H., et al. (1995). Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology 45, 555-557.
29. Murakami, N., Yamaki, T., Iwamoto, Y., Sakakibara, T., Kobori, N., Fushiki, S., et al. (1998). Experimental brain injury induces expression of amy-loid precursor protein, which may be related to neuronal loss in the hippocampus. J. Neurotrauma 15, 993-1003.
30. Nadler, Y., Alexandrovich, A., Grigori-adis, N., Hartmann, T., Rao, K. S., Shohami, E., et al. (2008). Increased expression of the gamma-secretase components presenilin-1 and nicas-trin in activated astrocytes and microglia following traumatic brain injury. Glia 56, 552-567.
31. Pierce, J. E., Trojanowski, J. Q., Gra-ham, D. I., Smith, D. H., and McIn-tosh, T. K. (1996). Immunohisto-chemical characterization of alter-ations in the distribution of amy-loid precursor proteins and beta-amyloid peptide after experimental brain injury in the rat. J. Neurosci. 16, 1083-1090.
32. Pun, P. B., Kan, E. M., Salim, A., Li, Z., Ng, K. C., Moochhala, S. M., et al. (2011). Low level primary blast injury in rodent brain. Front. Neurol. 2:19. doi:10.3389/fneur.2011.00019
33. Risling, M., Plantman, S., Angeria, M., Rostami, E., Bellander, B. M., Kirkegaard, M., et al. (2011). Mecha-nisms of blast induced brain injuries, experimental studies in rats. Neu-roimage 54(Suppl. 1), S89-S97.
34. Schwetye, K. E., Cirrito, J. R., Esparza, T. J., Mac Donald, C. L., Holtz-man, D. M., and Brody, D. L. (2010). Traumatic brain injury reduces sol-uble extracellular amyloid-beta in mice:a methodologically novel com-bined microdialysis-controlled cor-tical impact study. Neurobiol. Dis. 40, 555-564.
35. Sherriff, F. E., Bridges, L. R., and Sival-oganathan, S. (1994). Early detec-tion of axonal injury after human head trauma using immunocyto-chemistry for beta-amyloid precur-sor protein. Acta Neuropathol. 87, 55-62.
36. Smith, D. H., Nakamura, M., McIntosh, T. K., Wang, J., Rodriguez, A., Chen, X. H., et al. (1998). c. Am. J. Pathol. 153, 1005-1010.
37. Steele, J. W., Kim, S. H., Cirrito, J. R., Verges, D. K., Restivo, J. L., West-away, D., et al. (2009). Acute dos-ing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, ele-vates extracellular amyloid-beta lev-els in vitro and in vivo. Mol. Neu-rodegener. 4, 51.
38. Stone, J. R., Singleton, R. H., and Povlishock, J. T. (2000). Antibod-ies to the C-terminus of the beta-amyloid precursor protein (APP): a site specific marker for the detection of traumatic axonal injury. Brain Res. 871, 288-302.
39. Tian, L., Guo, R., Yue, X., Lv, Q., Ye, X., Wang, Z., et al. (2012). Intranasal administration of nerve growth fac-tor ameliorate beta-amyloid deposi-tion after traumatic brain injury in rats. Brain Res. 1440, 47-55.
40. Tran, H. T., Laferla, F. M., Holtzman, D. M., and Brody, D. L. (2011). Controlled cortical impact trau-matic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-beta accumulation and indepen-dently accelerates the development of tau abnormalities. J. Neurosci. 31, 9513-9525.
41. Uryu, K., Chen, X. H., Martinez, D., Browne, K. D., Johnson, V. E., Gra-ham, D. I., et al. (2007). Multiple proteins implicated in neurodegen-erative diseases accumulate in axons after brain trauma in humans. Exp. Neurol. 208, 185-192.
42. Van Den Heuvel, C., Blumbergs, P., Finnie, J., Manavis, J., Lewis, S., Jones, N., et al. (2000). Upregula-tion of amyloid precursor protein and its mRNA in an experimental model of paediatric head injury. J. Clin. Neurosci. 7, 140-145.
43. Wang, Y., Wei, Y., Oguntayo, S., Wilkins, W., Arun, P., Valiyaveettil, M., et al. (2011). Tightly coupled repeti-tive blast-induced traumatic brain injury: development and character-ization in mice. J. Neurotrauma 28, 2171-2183.
44. Yu, F., Zhang, Y., and Chuang, D. M. (2012). Lithium reduces BACE1 overexpression,beta amyloid accumulation and spatial learning deficits in mice with traumatic brain injury. J. Neurotrauma 29, 362-374.
45. Zhang, Q. G., Laird, M. D., Han, D., Nguyen, K., Scott, E., Dong, Y., et al. (2012). Critical role of NADPH oxidase in neuronal oxidative damage and microglia activation following traumatic brain injury. PLoS ONE 7:e34504. doi:10.1371/journal.pone.0034504
46. Zhou, W., Xu, D., Peng, X., Zhang, Q., Jia, J., and Crutcher, K. A. (2008). Meta-analysis of APOE4 allele and outcome after traumatic brain injury. J. Neurotrauma 25, 279-290.
47. Zohar, O., Lavy, R., Zi, X., Nelson, T. J., Hongpaisan, J., Pick, C. G., et al. (2011). PKC activator therapeu-tic for mild traumatic brain injury in mice. Neurobiol. Dis. 41, 329-337.