The Thoc1 Encoded Ribonucleoprotein Is a Substrate for the NEDD4-1 E3 Ubiquitin Protein Ligase

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Song, Fei ^a   Fan, Chuandong ^a   Wang, Xinjiang ^a   Goodrich, David W ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEASOME; PROTEIN THOC1; RIBONUCLEOPROTEIN; UBIQUITIN PROTEIN LIGASE NEDD4; UBIQUITIN PROTEIN LIGASE NEDD4 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; GENE ACTIVITY; GENE FUNCTION; GENETIC CONSERVATION; GENETIC MANIPULATION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MAMMAL; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN SYNTHESIS REGULATION; THOC1 GENE; UBIQUITINATION; YEAST;

ANIMALS; CELL CYCLE PROTEINS; DICHLORORIBOFURANOSYLBENZIMIDAZOLE; DNA-BINDING PROTEINS; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; HELA CELLS; HUMANS; MICE; NUCLEAR PROTEINS; POLYUBIQUITIN; PROTEIN BINDING; PROTEIN STABILITY; RIBONUCLEOPROTEINS; RNA-BINDING PROTEINS; SUBSTRATE SPECIFICITY; TRANSCRIPTION ELONGATION, GENETIC; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84874547561     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057995     Document Type: Article

References (32)

1. Luna R, Gaillard H, Gonzalez-Aguilera C, Aguilera A, (2008) Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus. Chromosoma 117: 319-331.
2. Glisovic T, Bachorik JL, Yong J, Dreyfuss G, (2008) RNA-binding proteins and post-transcriptional gene regulation. FEBS Letters 582: 1977-1986.
3. Moore MJ, (2005) From Birth to Death: The Complex Lives of Eukaryotic mRNAs. Science 309: 1514-1518.
4. Keene JD, (2007) RNA regulons: coordination of post-transcriptional events. Nature Reviews Genetics 8: 533-543.
5. Cooper TA, Wan L, Dreyfuss G, (2009) RNA and disease. Cell 136: 777-793.
6. Li Y, Wang X, Zhang X, Goodrich DW, (2005) Human hHpr1/p84/Thoc1 Regulates Transcriptional Elongation and Physically Links RNA Polymerase II and RNA Processing Factors. Molecular & Cellular Biology 25: 4023-4033.
7. Chang M, French-Cornay D, Fan HY, Klein H, Denis CL, et al. (1999) A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Molecular & Cellular Biology 19: 1056-1067.
8. Cheng H, Dufu K, Lee C-S, Hsu JL, Dias A, et al. (2006) Human mRNA Export Machinery Recruited to the 5′ End of mRNA. Cell 127: 1389-1400.
9. Dufu K, Livingstone MJ, Seebacher J, Gygi SP, Wilson SA, et al. (2010) ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Genes & Development 24: 2043-2053.
10. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, et al. (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417: 304-308.
11. Zenklusen D, Vinciguerra P, Wyss JC, Stutz F, (2002) Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Molecular & Cellular Biology 22: 8241-8253.
12. Jimeno S, Rondon AG, Luna R, Aguilera A, (2002) The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO Journal 21: 3526-3535.
13. Huertas P, Aguilera A, (2003) Cotranscriptionally formed DNA: RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Molecular Cell 12: 711-721.
14. Wellinger RE, Prado F, Aguilera A, (2006) Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex. Molecular & Cellular Biology 26: 3327-3334.
15. Dominguez-Sanchez MS, Barroso S, Gomez-Gonzalez B, Luna R, Aguilera A, (2011) Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. PLoS Genetics 7: e1002386.
16. Voynov V, Verstrepen KJ, Jansen A, Runner VM, Buratowski S, et al. (2006) Genes with internal repeats require the THO complex for transcription. Proceedings of the National Academy of Sciences of the United States of America 103: 14423-14428.
17. Saguez C, Schmid M, Olesen JR, Ghazy MA, Qu X, et al. (2008) Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation. Molecular Cell 31: 91-103.
18. Schneiter R, Guerra CE, Lampl M, Gogg G, Kohlwein SD, et al. (1999) The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA. Molecular & Cellular Biology 19: 3415-3422.
19. Hornbeck PV, Kornhauser JM, Tkachev S, Zhang B, Skrzypek E, et al. (2012) PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res 40: D261-270.
20. Albuquerque CP, Smolka MB, Payne SH, Bafna V, Eng J, et al. (2008) A multidimensional chromatography technology for in-depth phosphoproteome analysis. Mol Cell Proteomics 7: 1389-1396.
21. Gwizdek C, Hobeika M, Kus B, Ossareh-Nazari B, Dargemont C, et al. (2005) The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation. Journal of Biological Chemistry 280: 13401-13405.
22. Huertas P, Garcia-Rubio ML, Wellinger RE, Luna R, Aguilera A, (2006) An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination. Molecular & Cellular Biology 26: 7451-7465.
23. Mancini A, Niemann-Seyde SC, Pankow R, El Bounkari O, Klebba-Farber S, et al. (2010) THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biology 8: 1.
24. Cao XR, Lill NL, Boase N, Shi PP, Croucher DR, et al. (2008) Nedd4 controls animal growth by regulating IGF-1 signaling. Science Signaling 1: ra5.
25. Wang X, Shi Y, Wang J, Huang G, Jiang X, (2008) Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation. Biochemical Journal 414: 221-229.
26. Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, et al. (2007) NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128: 129-139.
27. Li Y, Lin AW, Zhang X, Wang Y, Wang X, et al. (2007) Cancer cells and normal cells differ in their requirements for Thoc1. Cancer Research 67: 6657-6664.
28. Durfee T, Mancini MA, Jones D, Elledge SJ, Lee WH, (1994) The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. Journal of Cell Biology 127: 609-622.
29. Gasparri F, Sola F, Locatelli G, Muzio M, (2004) The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm. FEBS Letters 574: 13-19.
30. Kasanov J, Pirozzi G, Uveges AJ, Kay BK, (2001) Characterizing Class I WW domains defines key specificity determinants and generates mutant domains with novel specificities. Chemistry & Biology 8: 231-241.
31. Hicke L, Schubert HL, Hill CP, (2005) Ubiquitin-binding domains. Nature Reviews Molecular Cell Biology 6: 610-621.
32. Gwizdek C, Iglesias N, Rodriguez MS, Ossareh-Nazari B, Hobeika M, et al. (2006) Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription. Proceedings of the National Academy of Sciences of the United States of America 103: 16376-16381.