Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 6, 2013, Pages 1511-1515

  Tuccinardi, Tiziano ^a   Bertini, Simone ^a   Granchi, Carlotta ^a   Ortore, Gabriella ^a   Macchia, Marco ^a   Minutolo, Filippo ^a   Martinelli, Adriano ^a   Supuran, Claudiu T ^b  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic anhydrase; Docking; QM MM calculation; Salicylaldoxime; Zinc binding group

Indexed keywords

3,5 DIFLUOROPHENOL; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; ENZYME INHIBITOR; OXYGEN; SALICYLALDOXIME; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SULFONAMIDE; UNCLASSIFIED DRUG; ZINC ION;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG DISPOSITION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MATHEMATICAL COMPUTING; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; HYDROGEN BONDING; ISOENZYMES; KINETICS; MOLECULAR DOCKING SIMULATION; OXIMES; PROTEIN BINDING; QUANTUM THEORY; ZINC;

EID: 84874527057     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.057     Document Type: Article

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