-
1
-
-
84874549774
-
-
FDA, Food and Drug Administration, Center for Drug Evaluation and research (CDER), U, S. Department of Health and Human Services
-
FDA, Food and Drug Administration, Center for Drug Evaluation and research (CDER), U, S. Department of Health and Human Services (2008) Safety testing of drug metabolites, Guidance for Industry, http://www. fda. gov/OHRMS/DOCKETS/98fr/FDA-2008-D-0065-GDL. pdf.
-
(2008)
Safety testing of drug metabolites, Guidance for Industry
-
-
-
3
-
-
82955193812
-
Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?
-
Obach RS, Nedderman AN, Smith DA (2012) Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary? Xenobiotica 42: 45-56.
-
(2012)
Xenobiotica
, vol.42
, pp. 45-56
-
-
Obach, R.S.1
Nedderman, A.N.2
Smith, D.A.3
-
5
-
-
22744441263
-
Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring information-dependent acquisition on a QTrap instrument
-
Li AC, Alton D, Bryant MS, Shou WZ (2005) Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring information-dependent acquisition on a QTrap instrument. Rapid Commun Mass Spectrom 19: 1943-1950.
-
(2005)
Rapid Commun Mass Spectrom
, vol.19
, pp. 1943-1950
-
-
Li, A.C.1
Alton, D.2
Bryant, M.S.3
Shou, W.Z.4
-
6
-
-
27644585407
-
A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer
-
Shou WZ, Magis L, Li AC, Naidong W, Bryant MS (2005) A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer. J Mass Spectrom 40: 1347-1356.
-
(2005)
J Mass Spectrom
, vol.40
, pp. 1347-1356
-
-
Shou, W.Z.1
Magis, L.2
Li, A.C.3
Naidong, W.4
Bryant, M.S.5
-
7
-
-
34247542644
-
N-in-one' strategy for metabolite identification using a liquid chromatography/hybrid triple quadrupole linear ion trap instrument using multiple dependent product ion scans triggered with full mass scan
-
Li AC, Gohdes MA, Shou WZ (2007) 'N-in-one' strategy for metabolite identification using a liquid chromatography/hybrid triple quadrupole linear ion trap instrument using multiple dependent product ion scans triggered with full mass scan. Rapid Commun Mass Spectrom 21: 1421-1430.
-
(2007)
Rapid Commun Mass Spectrom
, vol.21
, pp. 1421-1430
-
-
Li, A.C.1
Gohdes, M.A.2
Shou, W.Z.3
-
8
-
-
30044451706
-
In vivo metabolite detection and identification in drug discovery via LC-MS/MS with data-dependent scanning and postacquisition data mining
-
Triolo A, Altamura M, Dimoulas T, Guidi A, Lecci A, Tramontana M (2005) In vivo metabolite detection and identification in drug discovery via LC-MS/MS with data-dependent scanning and postacquisition data mining. J Mass Spectrom 40: 1572-1582.
-
(2005)
J Mass Spectrom
, vol.40
, pp. 1572-1582
-
-
Triolo, A.1
Altamura, M.2
Dimoulas, T.3
Guidi, A.4
Lecci, A.5
Tramontana, M.6
-
9
-
-
33344464424
-
Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements
-
Peterman SM, Duczak N, Kalgutkar AS, Lame ME, Soglia JR (2006) Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements. J Am Soc Mass Spectrom 17: 363-375.
-
(2006)
J Am Soc Mass Spectrom
, vol.17
, pp. 363-375
-
-
Peterman, S.M.1
Duczak, N.2
Kalgutkar, A.S.3
Lame, M.E.4
Soglia, J.R.5
-
10
-
-
37649024925
-
Complete profiling and characterization of in vitro nefazodone metabolites using two different tandem mass spectrometric platforms
-
Li AC, Shou WZ, Mai TT, Jiang XY (2007) Complete profiling and characterization of in vitro nefazodone metabolites using two different tandem mass spectrometric platforms. Rapid Commun Mass Spectrom 21: 4001-4008.
-
(2007)
Rapid Commun Mass Spectrom
, vol.21
, pp. 4001-4008
-
-
Li, A.C.1
Shou, W.Z.2
Mai, T.T.3
Jiang, X.Y.4
-
11
-
-
66149181775
-
Proposal of buspirone collision-induced dissociation rearrangement by exact mass measurements
-
Li AC, Shou WZ, Jiang XY (2009) Proposal of buspirone collision-induced dissociation rearrangement by exact mass measurements. Rapid Commun Mass Spectrom 23: 1742-1745.
-
(2009)
Rapid Commun Mass Spectrom
, vol.23
, pp. 1742-1745
-
-
Li, A.C.1
Shou, W.Z.2
Jiang, X.Y.3
-
12
-
-
69849089067
-
Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification
-
Li AC, Ding J, Jiang X, Denissen J (2009) Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification. Rapid Commun Mass Spectrom 23: 3003-3012.
-
(2009)
Rapid Commun Mass Spectrom
, vol.23
, pp. 3003-3012
-
-
Li, A.C.1
Ding, J.2
Jiang, X.3
Denissen, J.4
-
13
-
-
34250707998
-
Metabolite identification by data-dependent accurate mass spectrometric analysis at resolving power of 60,000 in external calibration mode using an LTQ/Orbitrap
-
Lim H-K, Chen J, Sensenhauser C, Cook K, Subrahmanyam V (2007) Metabolite identification by data-dependent accurate mass spectrometric analysis at resolving power of 60, 000 in external calibration mode using an LTQ/Orbitrap. Rapid Commun Mass Spectrom 21: 1821-1832.
-
(2007)
Rapid Commun Mass Spectrom
, vol.21
, pp. 1821-1832
-
-
Lim, H.-K.1
Chen, J.2
Sensenhauser, C.3
Cook, K.4
Subrahmanyam, V.5
-
14
-
-
42649118458
-
A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry
-
Lim H-K, Chen J, Cook K, Sensenhauser C, Silva J, Evans DC (2008) A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry. Rapid Commun Mass Spectrom 22: 1295-1311.
-
(2008)
Rapid Commun Mass Spectrom
, vol.22
, pp. 1295-1311
-
-
Lim, H.-K.1
Chen, J.2
Cook, K.3
Sensenhauser, C.4
Silva, J.5
Evans, D.C.6
-
15
-
-
39749201504
-
An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection
-
Ruan Q, Peterman S, Szewc MA, Ma L, Cui D, Humphreys WG, Zhu M (2008) An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection. J Mass Spectrom 43: 251-261.
-
(2008)
J Mass Spectrom
, vol.43
, pp. 251-261
-
-
Ruan, Q.1
Peterman, S.2
Szewc, M.A.3
Ma, L.4
Cui, D.5
Humphreys, W.G.6
Zhu, M.7
-
16
-
-
35848937158
-
Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering
-
Zhu M, Ma L, Zhang H, Humphreys WG (2007) Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering. Anal Chem 79: 8333-8341.
-
(2007)
Anal Chem
, vol.79
, pp. 8333-8341
-
-
Zhu, M.1
Ma, L.2
Zhang, H.3
Humphreys, W.G.4
-
17
-
-
33748902567
-
Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data
-
Zhu M, Ma L, Zhang D, Ray K, Zhao W, Humphreys WG, Skiles G, Sanders M, Zhanh H (2006) Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data. Drug Metab Dispos 34: 1722-1733.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1722-1733
-
-
Zhu, M.1
Ma, L.2
Zhang, D.3
Ray, K.4
Zhao, W.5
Humphreys, W.G.6
Skiles, G.7
Sanders, M.8
Zhanh, H.9
-
18
-
-
15344344076
-
Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes
-
Zhu M, Zhao W, Jimenez H, Zhanh D, Yeola S, Dai R, Vachharajani N, Mitroka J (2005) Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos 33: 500-507.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 500-507
-
-
Zhu, M.1
Zhao, W.2
Jimenez, H.3
Zhanh, D.4
Yeola, S.5
Dai, R.6
Vachharajani, N.7
Mitroka, J.8
-
19
-
-
46849098946
-
Mass defect filtering on high resolution LC/MS data as a methodology for detecting metabolites with unpredictable structures: identification of oxazole-ring opened metabolites of muraglitazar
-
Zhang D, Cheng PT, Zhang H (2007) Mass defect filtering on high resolution LC/MS data as a methodology for detecting metabolites with unpredictable structures: identification of oxazole-ring opened metabolites of muraglitazar. Drug Metab Lett 1: 287-292.
-
(2007)
Drug Metab Lett
, vol.1
, pp. 287-292
-
-
Zhang, D.1
Cheng, P.T.2
Zhang, H.3
-
20
-
-
0242521617
-
A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses
-
Zhang H, Zhang D, Ray KL (2003) A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses. J Mass Spectrom 38: 1110-1112.
-
(2003)
J Mass Spectrom
, vol.38
, pp. 1110-1112
-
-
Zhang, H.1
Zhang, D.2
Ray, K.L.3
-
21
-
-
46849091191
-
Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection
-
Zhang H, Zhu M, Rey KL, Ma L, Zhang D (2008) Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection. Rapid Commun Mass Spectrom 22: 2082-2088.
-
(2008)
Rapid Commun Mass Spectrom
, vol.22
, pp. 2082-2088
-
-
Zhang, H.1
Zhu, M.2
Rey, K.L.3
Ma, L.4
Zhang, D.5
-
23
-
-
25144468977
-
All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching
-
Wrona M, Mauriala T, Bateman KP, Mortishire-Smith RJ, O'Conner D (2005) 'All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching. Rapid Commun Mass Spectrom 19: 2597-2602.
-
(2005)
Rapid Commun Mass Spectrom
, vol.19
, pp. 2597-2602
-
-
Wrona, M.1
Mauriala, T.2
Bateman, K.P.3
Mortishire-Smith, R.J.4
O'Conner, D.5
-
25
-
-
41549139685
-
High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies
-
Tiller PR, Yu S, Castro-Perez JM, Fillgrove KL, Baillie TA (2008) High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies. Rapid Commun Mass Spectrom 22: 1053-1061.
-
(2008)
Rapid Commun Mass Spectrom
, vol.22
, pp. 1053-1061
-
-
Tiller, P.R.1
Yu, S.2
Castro-Perez, J.M.3
Fillgrove, K.L.4
Baillie, T.A.5
-
26
-
-
80053232023
-
E with in silico data mining is an information-rich approach to reactive metabolite screening
-
E with in silico data mining is an information-rich approach to reactive metabolite screening. Rapid Commun Mass Spectrom 25: 3029-3040.
-
(2011)
Rapid Commun Mass Spectrom
, vol.25
, pp. 3029-3040
-
-
Barbara, J.E.1
Castro-Perez, J.M.2
-
27
-
-
36448958008
-
The rapid detection and identification of the impurities of simvastatin using high resolution sub 2 micron particle LC coupled to hybrid quadrupole time of flight MS operating with alternating high-low collision energy
-
Plumb RS, Jones MD, Rainville P, Castro-Perez JM (2007) The rapid detection and identification of the impurities of simvastatin using high resolution sub 2 micron particle LC coupled to hybrid quadrupole time of flight MS operating with alternating high-low collision energy. J Sep Sci 30(16): 2666-2675.
-
(2007)
J Sep Sci
, vol.30
, Issue.16
, pp. 2666-2675
-
-
Plumb, R.S.1
Jones, M.D.2
Rainville, P.3
Castro-Perez, J.M.4
-
28
-
-
80053361590
-
Rapid wide-scope screening of drugs of abuse, prescription drugs with potential for abuse and their metabolites in influent and effluent urban wastewater by ultrahigh pressure liquid chromatography-quadrupole-time-of-flight-mass spectrometry
-
Hernandez F, Bijlsma L, Sancho JV, Diaz R, Ibanez M (2011) Rapid wide-scope screening of drugs of abuse, prescription drugs with potential for abuse and their metabolites in influent and effluent urban wastewater by ultrahigh pressure liquid chromatography-quadrupole-time-of-flight-mass spectrometry. Anal Chim Acta 684: 96-106.
-
(2011)
Anal Chim Acta
, vol.684
, pp. 96-106
-
-
Hernandez, F.1
Bijlsma, L.2
Sancho, J.V.3
Diaz, R.4
Ibanez, M.5
-
29
-
-
80052818083
-
Fragmentation pathways of drugs of abuse and their metabolites based on QTOF MS/MS and MS(E) accurate-mass spectra
-
Bijlsma L, Sancho JV, Hernandez F, Niessen WMA (2011) Fragmentation pathways of drugs of abuse and their metabolites based on QTOF MS/MS and MS(E) accurate-mass spectra. J Mass Spectrom 46: 865-875.
-
(2011)
J Mass Spectrom
, vol.46
, pp. 865-875
-
-
Bijlsma, L.1
Sancho, J.V.2
Hernandez, F.3
Niessen, W.M.A.4
-
30
-
-
63049084861
-
The detection, correlation, and comparison of peptide precursor and product ions from data independent LC-MS with data dependant LC-MS/MS
-
Geromanos SJ, Vissers JPC, Silva JC, Dorschel CA, Li G-Z, Gorenstein MV, Bateman RH, Langridge JI (2009) The detection, correlation, and comparison of peptide precursor and product ions from data independent LC-MS with data dependant LC-MS/MS. Proteomics 9: 1683-1695.
-
(2009)
Proteomics
, vol.9
, pp. 1683-1695
-
-
Geromanos, S.J.1
Vissers, J.P.C.2
Silva, J.C.3
Dorschel, C.A.4
Li, G.-Z.5
Gorenstein, M.V.6
Bateman, R.H.7
Langridge, J.I.8
-
31
-
-
38749131205
-
The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
-
Blech S, Ebner T, Ludwig-Schwellinger E, Stangier J, Roth W (2008) The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. J Drug Metab Dispos 36: 386-399.
-
(2008)
J Drug Metab Dispos
, vol.36
, pp. 386-399
-
-
Blech, S.1
Ebner, T.2
Ludwig-Schwellinger, E.3
Stangier, J.4
Roth, W.5
-
32
-
-
77950197593
-
The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans
-
Blech S, Ludwig-Schwellinger E, Gräfe-Mody EU, Withopf B, Wagner K (2010) The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans. J Drug Metab Dispos 38: 667-678.
-
(2010)
J Drug Metab Dispos
, vol.38
, pp. 667-678
-
-
Blech, S.1
Ludwig-Schwellinger, E.2
Gräfe-Mody, E.U.3
Withopf, B.4
Wagner, K.5
-
33
-
-
39149137577
-
Ion mobility-mass spectrometry
-
and literature cited therein
-
Kanu AB, Dwivedi P, Tam M, Matz L, Hill HH (2008) Ion mobility-mass spectrometry. J Mass Spectrom 43(1), and literature cited therein.
-
(2008)
J Mass Spectrom
, vol.43
, Issue.1
-
-
Kanu, A.B.1
Dwivedi, P.2
Tam, M.3
Matz, L.4
Hill, H.H.5
-
34
-
-
80052669512
-
Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry
-
Castro-Perez J, Roddy TP, Nibbering NMM, Shah V, McLaren DG, Previs S, Attygalle AB, Herath K, Chen Z, Wang SP, Mitnaul L, Hubbard BK, Vreeken RJ, Johns DG, Hankemeier T (2011) Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry. J Am Mass Spectrom 22: 1552-1567.
-
(2011)
J Am Mass Spectrom
, vol.22
, pp. 1552-1567
-
-
Castro-Perez, J.1
Roddy, T.P.2
Nibbering, N.M.M.3
Shah, V.4
McLaren, D.G.5
Previs, S.6
Attygalle, A.B.7
Herath, K.8
Chen, Z.9
Wang, S.P.10
Mitnaul, L.11
Hubbard, B.K.12
Vreeken, R.J.13
Johns, D.G.14
Hankemeier, T.15
-
35
-
-
81555223066
-
Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites
-
Cuyckens F, Wassvik C, Mortishire-Smith RJ, Tresadern G, Campuzano I, Claereboudt J (2011) Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites. Rapid Commun Mass Spectrom 25: 3497-3503.
-
(2011)
Rapid Commun Mass Spectrom
, vol.25
, pp. 3497-3503
-
-
Cuyckens, F.1
Wassvik, C.2
Mortishire-Smith, R.J.3
Tresadern, G.4
Campuzano, I.5
Claereboudt, J.6
-
36
-
-
0019499173
-
Determination of mean serum level by assay of a single pooled sample
-
Hamilton RA, Garnett WR, Kline BJ (1981) Determination of mean serum level by assay of a single pooled sample. Clin Pharmacol Ther 29: 250-251.
-
(1981)
Clin Pharmacol Ther
, vol.29
, pp. 250-251
-
-
Hamilton, R.A.1
Garnett, W.R.2
Kline, B.J.3
-
37
-
-
0031873679
-
Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening
-
Hop CE, Wang Z, Chen Q, Kwei G (1998) Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening. J Pharm Sci 87: 901-903.
-
(1998)
J Pharm Sci
, vol.87
, pp. 901-903
-
-
Hop, C.E.1
Wang, Z.2
Chen, Q.3
Kwei, G.4
-
39
-
-
33846811132
-
An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-TOF instrument
-
Pringle SD, Giles K, Wildgoose JL, Williams JP, Slade SE, Thalassinos K, Bateman RH, Bowers MT, Scrivens JH (2007) An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-TOF instrument. Int J Mass Spectrom 261: 1-12.
-
(2007)
Int J Mass Spectrom
, vol.261
, pp. 1-12
-
-
Pringle, S.D.1
Giles, K.2
Wildgoose, J.L.3
Williams, J.P.4
Slade, S.E.5
Thalassinos, K.6
Bateman, R.H.7
Bowers, M.T.8
Scrivens, J.H.9
|