Analysis of children with type 1 diabetes in Korea: High prevalence of specific anti-islet autoantibodies, immunogenetic similarities to Western populations with "unique" haplotypes, and lack of discrimination by aspartic acid at position 57 of DQB

Clinical Immunology

Volumn 113, Issue 3, 2004, Pages 318-325

  Yu, Jeesuk ^a   Shin, Chung Ho ^b   Yang, Sei Won ^b   Park, Myoung Hee ^b   Eisenbarth, George S ^c  

^a Dankook University College of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

GAD65; HLA; ICA512; Insulin; Type 1 diabetes mellitus (T1DM)

Indexed keywords

ASPARTIC ACID; HLA DQ ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; HLA DR1 ANTIGEN; INSULIN RECEPTOR ANTIBODY;

ADOLESCENT; ADULT; ALLELE; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ANTIGENIC VARIATION; ARTICLE; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MARKER; DISEASE PREDISPOSITION; EARLY DIAGNOSIS; FAMILIAL INCIDENCE; GENE FREQUENCY; GENE LOCUS; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HAPLOTYPE; HETEROZYGOSITY; HLA SYSTEM; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; ONSET AGE; PRIORITY JOURNAL; SCREENING TEST;

ADOLESCENT; ADULT; ASPARTIC ACID; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; EUROPE; HAPLOTYPES; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; INFANT; ISLETS OF LANGERHANS; KOREA; PREVALENCE;

EID: 7044250867     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clim.2004.08.009     Document Type: Article

References (39)

1. G.S. Eisenbarth Type I diabetes mellitus. A chronic autoimmune disease N. Engl. J. Med. 314 1986 1360 1368
2. Diabetes Epidemiology Research International Group Geographic patterns of childhood insulin-dependent diabetes mellitus Diabetes 37 1988 1113 1119
3. K.W. Ko, S.W. Yang, and N.H. Cho The incidence of IDDM in Seoul from 1985 to 1988 Diabetes Care 17 1994 1473 1475
4. D.P. Singal, and M.A. Blajchmann Histocompatibility (HLA) antigens, lymphotoxic antibodies and tissue antibodies in patients with diabetes mellitus Diabetes 22 1973 429 432
5. H.A. Erlich, A. Zeidler, J. Chang, S. Shaw, L.J. Raffel, W. Klitz, Y. Beshkov, G. Costin, S. Pressman, T.L. Bugawan, and J.I. Rotter HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families Nat. Genet. 3 1993 358 364
6. J.A. Noble, A.M. Valdes, M. Cook, W. Klitz, G. Thomson, and H.A. Erlich The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families Am. J. Hum. Genet. 59 1996 1134 1148
7. J.X. She Susceptibility to type 1 diabetes: HLA-DQ and DR revisited Immunol. Today 17 1996 323 329
8. H.S. Huang, J.T. Peng, J.Y. She, L.P. Zhang, C.C. Chao, K.H. Liu, and J.X. She HLA-encoded susceptibility to insulin-dependent diabetes mellitus is determined by DR and DQ genes as well as their linkage disequilibria in a Chinese population Hum. Immunol. 44 1995 210 219
9. J.S. Dorman, R.E. LaPorte, R.A. Stone, and M. Trucco Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain Proc. Natl. Acad. Sci. U. S. A. 87 1990 7370 7374
10. G.F. Bottazzo, A. Florin-Christensen, and D. Doniach Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies Lancet 2 1974 1279 1283
11. P.J. Bingley, M.R. Christie, E. Bonifacio, R. Bonfanti, M. Shattock, M.T. Fonte, G.F. Botazzo, and E.A. Gale Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives Diabetes 43 1994 1304 1310
12. C.F. Verge, D. Stenger, E. Bonifacio, P.G. Colman, C. Pilcher, P.J. Bingley, and G.S. Eisenbarth Combined use of autoantibodies (IA-2ab, Gadab, IAA, ICA) in type 1 diabetes: combinatorial islet autoantibody workshop Diabetes 47 1998 1857 1866
13. D.U. Rabin, S.M. Pleasic, R. Palmer-Crocker, and J.A. Shapiro Cloning and expression of IDDM-specific human autoantigens Diabetes 41 1992 183 186
14. D.F. Bu, M.G. Erlander, B.C. Hitz, N.J. Tillakaratne, D.L. Kaufman, C.B. Wagner-McPherson, G.A. Evans, and A.J. Tobin Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene Proc. Natl. Acad. Sci. U. S. A. 89 1992 2115 2119
15. S. Baekkeskov, T. Dyrberg, and Å. Lernmark Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat Science 224 1984 1348 1350
16. S. Baekkeskov, H.J. Aanstoot, S. Christgau, A. Reetz, M. Solimena, M. Cascalho, F. Folli, H. Richter-Olesen, and P. De Camilli Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase Nature 347 1990 151 156
17. J.P. Palmer, C.M. Asplin, P. Clemons, K. Lyen, O. Tatpati, P.K. Raghu, and T.L. Paquette Insulin antibodies in insulin-dependent diabetics before insulin treatment Science 222 1983 1337 1339
18. A.J.K. Williams, P.J. Bingley, E. Bonifacio, J.P. Palmer, and E.A.M. Gale A novel micro-assay for insulin autoantibodies J. Autoimmun. 10 1997 473 478
19. A.G. Ziegler, M. Hummel, M. Schenker, and E. Bonifacio Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes. The 2-year analysis of the German BABYDIAB study Diabetes 48 1999 460 468
20. Expert committee on the diagnosis and classification of diabetes mellitus Report of the expert committee on the diagnosis and classification of diabetes mellitus Diabetes Care 20 1997 1183 1197
21. C.E. Grubin, T. Daniels, B. Toivola, M. Landin-Olsson, W.A. Hagopian, L. Li, A.E. Karlsen, E. Boel, B. Michelsen, and Å. Lernmark A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM Diabetologia 37 1994 344 350
22. L. Yu, D. Robles, N. Abiru, P. Kaur, M. Rewers, K. Kelemen, and G.S. Eisenbarth Early expression of anti-insulin autoantibodies of human and the NOD mouse: evidence for early determination of subsequent diabetes Proc. Natl. Acad. Sci. U. S. A. 97 2000 1701 1706
23. M.H. Park, D.H. Whang, and S.J. Kang High resolution HLA-DQB1 typing by combination of PCR-RFLP and PCR-SSCP Hum. Immunol. 60 1999 901 907
24. S. Mitsunaga, T. Oguchi, K. Tokunaga, T. Akaza, K. Tadokoro, and T. Juji High resolution HLA-DQB1 typing by combination of group-specific amplification and restriction fragment length polymorphism Hum. Immunol. 42 1995 307 314
25. M. Bannai, K. Tokunaga, L. Lin, S. Kuwata, T. Mazda, I. Amaki, K. Fujisawa, and T. Juji Discrimination of human HLA-DRB1 alleles by PCR-SSCP (single-strand conformation polymorphism) method Eur. J. Immunogenet. 21 1994 1 9
26. O.J. Kwon, C. Brautbar, N. Weintrob, E. Sprecher, C. Saphirman, K. Bloch, O. Pinhas-Hamiel, S. Assah, P. Vardi, and S. Israel Immunogenetics of HLA class II in Israeli Ashkenazi Jewish, Israeli non-Ashkenazi Jewish, and in Israeli Arab IDDM patients Hum. Immunol. 62 2001 85 91
27. T. Awata, T. Kuzuya, A. Matsuda, Y. Iwamoto, and Y. Kanazawa Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects Diabetologia 35 1992 419 424
28. B.H. Chen, C.H. Chiang, S.R. Lin, M.G. Chao, and S.T. Tsai The influence of age at onset and gender on the HLA-DQA1, DQB1 association in Chinese children with insulin dependent diabetes mellitus Hum. Immunol. 60 1999 1131 1137
29. Y. Sera, E. Kawasaki, N. Abiru, M. Ozaki, T. Abe, H. Takino, H. Kondo, H. Yamasaki, Y. Yamaguchi, S. Akazawa, S. Nagataki, Y. Uchigata, N. Matsuura, and K. Egunchi Autoantibodies to multiple islet autoantigens in patients with abrupt onset type 1 diabetes and diabetes diagnosed with urinary glucose screening J. Autoimmun. 13 1999 257 265
30. T. Awata, T. Kuzuya, A. Matsuda, Y. Iwamoto, Y. Kanazawa, M. Okuyama, and T. Juji High frequency of aspartic acid at position 57 of HLA-DQ β-chain in Japanese IDDM patients and nondiabetic subjects Diabetes 39 1990 266 269
31. H. Ikegami, Y. Kawaguchi, E. Yamato, S. Kuwata, K. Tokunaga, Y. Noma, K. Shima, and T. Ogihara Analysis by the polymerase chain reaction of histocompatibility leukocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus J. Clin. Endocrinol. Metab. 75 1992 1381 1385
32. M.A. Penny, D. Jenkins, C.H. Mijovic, K.H. Jacobs, D.A. Cavan, V.T. Yeung, C.S. Cockram, B.R. Hawkins, J.A. Fletcher, and A.H. Barnett Susceptibility to IDDM in a Chinese population. Role of HLA class II alleles Diabetes 41 1992 914 919
33. C.B. Sanjeevi, V. Seshiah, E. Moller, and O. Olerup Different genetic backgrounds for malnutrition-related diabetes and type 1 (insulin-dependent) diabetes mellitus in south Indians Diabetologia 35 1992 283 286
34. C.H. Mijovic, D. Jenkins, K.H. Jacobs, M.A. Penny, J.A. Fletcher, and A.H. Barnett HLA-DQA1 and -DQB1 alleles associated with genetic susceptibility to IDDM in a black population Diabetes 40 1991 748 753
35. R. Buzzetti, L. Nistico, J.F. Osborn, C. Giovannini, A. Chersi, and R. Sorrentino HLA-DQA1 and DQB1 gene polymorphisms in type I diabetic patients from central Italy and their use for risk prediction Diabetes 42 1993 1173 1178
36. A.C. Thai, W.Y. Ng, K.Y. Loke, W.R. Lee, K.F. Lui, and J.S. Cheah Anti-GAD antibodies in Chinese patients with youth and adult-onset IDDM and NIDDM Diabetologia 40 1997 1425 1430
37. R. Turner, I. Stratton, V. Horton, S. Manley, P. Zimmet, I.R. Mackay, M. Shattock, G.F. Bottazzo, and R. Holman UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group Lancet 350 1997 1288 1293
38. C.F. Verge, R. Gianani, E. Kawasaki, L. Yu, M. Pietropaolo, R.A. Jackson, H.P. Chase, and G.S. Eisenbarth Prediction of type I diabetes in first-degree relatives using a combination of insulin. GAD, and ICA512bdc/IA-2 autoantibodies Diabetes 45 1996 926 933
39. J. Yu, L. Yu, T.L. Bugawan, H.A. Erlich, K. Barriga, M. Hoffman, M. Rewers, and G.S. Eisenbarth Transient antiislet autoantibodies: infrequent occurrence and lack of association with "Genetic" risk factors J. Clin. Endocrinol. Metab. 85 2000 2421 2428