TLR9 ligand induces the generation of CD20+ plasmablasts and plasma cells from CD27+ memory B-cells

Frontiers in Immunology

Volumn 2, Issue DEC, 2011, Pages

  Geffroy Luseau, Alexandrine ^a,b,c   Chiron, David ^a,b,d   Descamps, Géraldine ^a,b   Jégo, Gaëtan ^a,b,e   Amiot, Martine ^a,b   Pellat Deceunynck, Catherine ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c Atlantic Bone Screen   (France)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e Institut Médical de Génétique et d Immunologie   (France)

Author keywords

CD20; CpG; Plasma cells; Survival

Indexed keywords

EID: 84874445022     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2011.00083     Document Type: Article

References (34)

1. Arpin, C., Banchereau, J., and Liu, Y. J. (1997) Memory B cells are biased towards terminal differentiation: a strategy that may prevent repertoire freezing. J. Exp. Med. 186, 931-940.
2. Arpin, C, Dechanet, J., Van Kooten, C., Merville, P., Grouard, G., Brière, F., Banchereau, J., and Liu, Y. J. (1995). Generation of memory B cells and plasma cells in vitro. Science 268, 720-722.
3. Banwait, R., O'Regan, K., Campigotto, E, Harris, B., Yarar, D., Bagshaw, M., Leleu, X., Leduc, R., Ramaiya, N., Weller, E., and Ghobrial, I. M. (2011). The role of 18F-FDG PET/CT imaging in Waldenstrom macroglobulinemia. Am. J. Hematol. 86,567-572.
4. Bataille, R., Jégo, G., Robillard, N., Barillé-Nion, S., Harousseau, J. L., Moreau, P., Amiot, M., and Pellat-Deceunynck, C. (2006). The phenotype of normal, reactive and malignant plasma cells. Identification of "many and multiple myelomas" and of new targets for myeloma therapies. Haematologica 91,1234-1240.
5. Bernasconi, N. L., Traggiai, E., and Lan-zavecchia, A. (2002). Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298, 2199-2202.
6. Bohnhorst, J., Rasmussen, T., Moen, S. H., Flottum, M., Knudsen, L., Borset, M., Espevik, T., and Sundan, A. (2006). Toll-like receptors mediate proliferation and survival of multiple myeloma cells. Leukemia 20, 1138-1144.
7. Chen-Kiang, S. (2003). Cell-cycle control of plasma cell differentiation and tumorigenesis. Immunol. Rev. 194, 39-47.
8. Chiron, D., Pellat-Deceunynck, C., Maillasson, M., Bataille, R., and Jego, G. (2009). Phosphorothioate-modified TLR9 ligands protect cancer cells against TRAIL-induced apoptosis. J. Immunol. 183, 4371-4377.
9. Chng, W. J., Schop, R. F., Price-Troska, T., Ghobrial, I., Kay, N., Jelinek, D. E, Gertz, M. A., Dispenzieri, A., Lacy, M., Kyle, R. A., Greipp, P. R., Tschumper, R. C., Fonseca, R., and Bergsagel, P. L. (2006). Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lym-phocytic leukemia than multiple myeloma. Blood 108, 2755-2763.
10. De Vos, J., Hose, D., Reme, T., Tarte, K., Moreaux, J., Mahtouk, K., Jourdan, M., Goldschmidt, H., Rossi, J. F., Cre-mer, E W., and Klein, B. (2006). Microarray-based understanding of normal and malignant plasma cells. Immunol. Rev. 210, 86-104.
11. Dechanet, J., Merville, P., Durand, I., Banchereau, J., and Miossec, P. (1995). The ability of synovio-cytes to support terminal differentiation of activated B cells may explain plasma cell accumulation in rheumatoid synovium. J. Clin. Invest. 95,456-463.
12. Geffroy-Luseau, A., Jégo, G., Bataille, R., Campion, L., and Pellat-Deceunynck, C. (2008). Osteoclasts support the survival of human plasma cells in vitro. Int. Immunol. 20,775-782.
13. Hodge, L. S., Novak, A. J., Grote, D. M., Braggio, E., Ketterling, R. P., Manske, M. K., Price Troska, T. L., Ziesmer, S. C., Fonseca, R., Witzig, T. E., Morice, W. G., Gertz, M. A., and Ansell, S. M. (2011). Establishment and characterization of a novel Waldenstrom macroglobulinemia cell line, MWCL-1. Blood 117, e190-197.
14. Jahrsdörfer, B., Hartmann, G., Racila, E., Jackson, W., Mühlenhoff, L., Mein-hardt, G., Endres, S., Link, B. K., Krieg, A. M., and Weiner, G. J. (2001). CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens. J. Leukoc. Biol. 69, 81-88.
15. Jego, G., Bataille, R., Geffroy-Luseau, A., Descamps, G., and Pellat-Deceunynck, C. (2006). Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through toll-like receptors. Leukemia 20, 1130-1137.
16. Jego, G., Bataille, R., and Pellat-Deceunynck, C. (2001). Interleukin-6 is a growth factor for nonmalig-nant human plasmablasts. Blood 97, 1817-1822.
17. Jego, G., Robillard, N., Puthier, D., Amiot, M., Accard, F., Pineau, D., Harousseau, J. L., Bataille, R., and Pellat-Deceunynck, C. (1999). Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells. Blood 94, 701-712.
18. Jourdan, M., Caraux, A., Caron, G., Robert, N., Fiol, G., Rème, T., Bol-loré, K., Vendrell, J. P., Le Gallou, S., Mourcin, F., De Vos, J., Kassambara, A., Duperray, C., Hose, D., Fest, T., Tarte, K., and Klein, B. (2011). Characterization of a transitional preplas-mablast population in the process of human B cell to plasma cell differentiation.J. Immunol. 187,3931-3941.
19. Jourdan, M., Caraux, A., De Vos, J., Fiol, G., Larroque, M., Cognot, C., Bret, C., Duperray, C., Hose, D., and Klein, B. (2009). An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phe-notypic and molecular characterization. Blood 114,5173-5181.
20. Kyle, R. A., and Rajkumar, S. V. (2008). Multiple myeloma. Blood 111,2962-2972.
21. Mankaï, A., Buhé, V., Hammadi, M., Youinou, P., Ghedira, I., Berthou, C., and Bordron, A. (2009). Improvement of rituximab efficiency in chronic lymphocytic leukemia by CpG-mediated upregulation of CD20 expression independently of PU.1. Ann. N. Y. Acad. Sci. 1173, 721-728.
22. Martín-Jiménez, P., García-Sanz, R., Balanzategui, A., Alcoceba, M., Ocio, E., Sanchez, M. L., González, M., and San Miguel, J. (2007). Molecular characterization of heavy chain immunoglobulin gene rearrangements in Waldenström's macroglobulinemia and IgM monoclonal gam-mopathy of undetermined significance. Haematologica 92, 635-642.
23. Medina, F., Segundo, C., Campos-Caro, A., Gonzalez-Garcia, I., and Brieva, J. A. (2002). The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression. Blood 99, 2154-2161.
24. Ménoret, E., Gomez-Bougie, P., Sur-get, S., Trichet, V., Oliver, L., Pellat-Deceunynck, C., and Amiot, M. (2010). Mcl-1128-350 fragment induces apoptosis through direct interaction with Bax. FEBS Lett. 584, 487-492.
25. Moreaux, J., Klein, B., Bataille, R., Descamps, G., Maïga, S., Hose, D., Goldschmidt, H., Jauch, A., Rème, T., Jourdan, M., Amiot, M., and Pellat-Deceunynck, C. (2011). A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines. Haematologica 96,574-582.
26. Moser, K., Tokoyoda, K., Radbruch, A., MacLennan, I., and Manz, R. A. (2006). Stromal niches, plasma cell differentiation and survival. Curr. Opin. Immunol. 18, 265-270.
27. Odendahl, M., Mei, H., Hoyer, B. F., Jacobi, A. M., Hansen, A., Muehling-haus, G., Berek, C., Hiepe, F., Manz, R., Radbruch, A., and Dörner, T. (2005). Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response. Blood 105, 1614-1621.
28. Pellat-Deceunynck, C., Bataille, R., Robillard, N., Harousseau, J. L., Rapp, M. J., Juge-Morineau, N., Wij-denes, J., and Amiot, M. (1994). Expression of CD28 and CD40 in human myeloma cells: a comparative study with normal plasma cells. Blood 84, 2597-2603.
29. Puthier, D., Pellat-Deceunynck, C., Bar-illé, S., Robillard, N., Rapp, M. J., Juge-Morineau, N., Harousseau, J. L., Bataille, R., and Amiot, M. (1999). Differential expression of Bcl-2 in human plasma cell disorders according to proliferation status and malignancy. Leukemia 13, 289-294.
30. Radbruch, A., Muehlinghaus, G., Luger, E. O., Inamine, A., Smith, K. G., Dorner, T., and Hiepe, E (2006). Competence and competition: the challenge of becoming a long-lived plasma cell. Nat. Rev. Immunol. 6, 741-750.
31. Robillard, N., Avet-Loiseau, H., Garand, R., Moreau, P., Pineau, D., Rapp, M. J., Harousseau, J. L., and Bataille, R. (2003). CD20 is associated with a small mature plasma cell morphology and t(1 1; 14) in multiple myeloma. Blood 103, 1070-1071.
32. Robillard, N., Pellat-Deceunynck, C., and Bataille, R. (2005). Pheno-typic characterization of the human myeloma cell growth fraction. Blood 105,4845-4848.
33. Shapiro-Shelef, M., and Calame, K. (2005). Regulation of plasma-cell development. Nat. Rev. Immunol. 5, 230-242.
34. Vikstrom, I., and Tarlinton, D. M. (2011). B cell memory and the role of apoptosis in its formation. Mol. Immunol. 48,1301-1306.