COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependence

Addiction Biology

Volumn 18, Issue 2, 2013, Pages 344-356

  Schellekens, Arnt F A ^a,b   Franke, Barbara ^a   Ellenbroek, Bart ^c   Cools, Alexander ^a   De Jong, Cor A J ^b   Buitelaar, Jan K ^a   Verkes, Robbert Jan ^a  

^a RADBOUD UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

Author keywords

Alcohol dependence; childhood adversity; COMT; dopamine; DRD2; gene environment interaction

Indexed keywords

CATECHOL METHYLTRANSFERASE; METHIONINE; VALINE;

ABUSE; ADULT; ALCOHOLISM; ALLELE; ANALYSIS OF VARIANCE; ANKK1 TAQ1A GENE; ARTICLE; CHILD NEGLECT; CHILDHOOD TRAUMA QUESTIONNAIRE; CONTROLLED STUDY; DRD2 GENE; EMOTIONAL ABUSE; EXPERIENCE; GENE; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HYPOTHESIS; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARENTAL ACCEPTANCE AND REJECTION QUESTIONNAIRE; PHYSICAL ABUSE; PRIORITY JOURNAL; PSYCHOLOGICAL ABUSE; QUESTIONNAIRE; RISK; SEXUAL ABUSE; STATISTICAL ANALYSIS; STRESSFUL AND TRAUMATIC EVENTS QUESTIONNAIRE;

ADOLESCENT; ADULT; AGE OF ONSET; ALCOHOLISM; ALLELES; AMINO ACID SUBSTITUTION; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CATECHOL O-METHYLTRANSFERASE; CHILD; CHILD ABUSE; DOPAMINE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIFE CHANGE EVENTS; LOGISTIC MODELS; MALE; METHIONINE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, DOPAMINE D2; SELF REPORT; SEVERITY OF ILLNESS INDEX; STRESS, PSYCHOLOGICAL; VALINE;

EID: 84874443235     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2012.00438.x     Document Type: Article

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