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Volumn 11, Issue 2, 2013, Pages 140-148

Synergistic effect of olaparib with combination of cisplatin on PTEN-deficient lung cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; OLAPARIB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAD51 PROTEIN;

EID: 84874411631     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-12-0401     Document Type: Article
Times cited : (57)

References (45)
  • 1
    • 77956380540 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics
    • Jin-xue He, Chun-hao Yang, Ze-hong Miao. Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics. Acta Pharmacologica Sinica 2010;31:1172-80.
    • (2010) Acta Pharmacologica Sinica , vol.31 , pp. 1172-80
    • Jin-xue, H.1    Chun-Hao, Y.2    Ze-hong, M.3
  • 2
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase
    • Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase. Nature 2005;434:913-7.
    • (2005) Nature , vol.434 , pp. 913-7
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3    Parker, K.M.4    Flower, D.5    Lopez, E.6
  • 3
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21.
    • (2005) Nature , vol.434 , pp. 917-21
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3    Tutt, A.N.4    Johnson, D.A.5    Richardson, T.B.6
  • 4
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
    • McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S, et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res 2006;66:8109-15.
    • (2006) Cancer Res , vol.66 , pp. 8109-15
    • McCabe, N.1    Turner, N.C.2    Lord, C.J.3    Kluzek, K.4    Bialkowska, A.5    Swift, S.6
  • 5
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009;361:123-34.
    • (2009) N Engl J Med , vol.361 , pp. 123-34
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3    Tutt, A.4    Wu, P.5    Mergui-Roelvink, M.6
  • 6
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial. Lancet 2010;376:235-44.
    • (2010) Lancet , vol.376 , pp. 235-3744
    • Tutt, A.1    Robson, M.2    Garber, J.E.3    Domchek, S.M.4    Audeh, M.W.5    Weitzel, J.N.6
  • 7
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • Audeh MW, Carmichael J, Penson RT, Friedlander M, Powell B, Bell-McGuinn KM, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial. Lancet 2010;376:245-51.
    • (2010) Lancet , vol.376 , pp. 245-3751
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3    Friedlander, M.4    Powell, B.5    Bell-McGuinn, K.M.6
  • 8
    • 77957555168 scopus 로고    scopus 로고
    • Synergistic chemosensitivity of triplenegative breast cancer cell lines to poly (ADP-ribose) polymerase inhibition, gemcitabine, and cisplatin
    • Hastak K, Alli E, Ford JM. Synergistic chemosensitivity of triplenegative breast cancer cell lines to poly (ADP-ribose) polymerase inhibition, gemcitabine, and cisplatin. Cancer Res 2010;70:7970-80.
    • (2010) Cancer Res , vol.70 , pp. 7970-7080
    • Hastak, K.1    Alli, E.2    Ford, J.M.3
  • 9
    • 0035874894 scopus 로고    scopus 로고
    • Homology-directed DNA repair, mitomycin-C resistance, and chromosome stability is restored with correction of a Brca1 mutation
    • Moynahan ME, Cui TY, Jasin M. Homology-directed DNA repair, mitomycin-C resistance, and chromosome stability is restored with correction of a Brca1 mutation. Cancer Res 2001;61:4842-50.
    • (2001) Cancer Res , vol.61 , pp. 4842-50
    • Moynahan, M.E.1    Cui, T.Y.2    Jasin, M.3
  • 10
    • 0034604716 scopus 로고    scopus 로고
    • The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
    • Bhattacharyya A, Ear US, Koller BH, Weichselbaum RR, Bishop DK. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin. J Biol Chem 2000;275:23899-903.
    • (2000) J Biol Chem , vol.275 , pp. 23899-903
    • Bhattacharyya, A.1    Ear, U.S.2    Koller, B.H.3    Weichselbaum, R.R.4    Bishop, D.K.5
  • 11
    • 34547617889 scopus 로고    scopus 로고
    • BRCA1-and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II
    • Treszezamsky AD, Kachnic LA, Feng Z, Zhang J, Tokadjian C, Powell SN, et al. BRCA1-and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II. Cancer Res 2007;67:7078-81.
    • (2007) Cancer Res , vol.67 , pp. 7078-81
    • Treszezamsky, A.D.1    Kachnic, L.A.2    Feng, Z.3    Zhang, J.4    Tokadjian, C.5    Powell, S.N.6
  • 12
    • 65949124480 scopus 로고    scopus 로고
    • Defective repair of oxidative DNA damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase
    • Alli E, Sharma VB, Sunderesakumar P, Ford JM. Defective repair of oxidative DNA damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase. Cancer Res 2009;69:3589-96.
    • (2009) Cancer Res , vol.69 , pp. 3589-96
    • Alli, E.1    Sharma, V.B.2    Sunderesakumar, P.3    Ford, J.M.4
  • 13
    • 80052168685 scopus 로고    scopus 로고
    • The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
    • Helleday T. The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings. Mol Oncol 2011;5:387-93.
    • (2011) Mol Oncol , vol.5 , pp. 387-93
    • Helleday, T.1
  • 14
    • 55749095538 scopus 로고    scopus 로고
    • Poly (ADPribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA
    • Guggenheim ER, Ondrus AE, Movassaghi M, Lippard SJ. Poly (ADPribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA. Bioorg Med Chem 2008;16: 10121-8.
    • (2008) Bioorg Med Chem , vol.16 , pp. 10121-8
    • Guggenheim, E.R.1    Ondrus, A.E.2    Movassaghi, M.3    Lippard, S.J.4
  • 15
    • 77954829745 scopus 로고    scopus 로고
    • Recognition of platinum-DNA damage by poly (ADP-ribose) polymerase-1
    • Zhu G, Chang P, Lippard SJ. Recognition of platinum-DNA damage by poly (ADP-ribose) polymerase-1. Biochemistry 2010;49:6177-83.
    • (2010) Biochemistry , vol.49 , pp. 6177-4983
    • Zhu, G.1    Chang, P.2    Lippard, S.J.3
  • 16
    • 52449111109 scopus 로고    scopus 로고
    • Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin
    • Evers B, Drost R, Schut E, de Bruin M, van der Burg E, Derksen PW, et al. Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin. Clin Cancer Res 2008;14:3916-25.
    • (2008) Clin Cancer Res , vol.14 , pp. 3916-25
    • Evers, B.1    Drost, R.2    Schut, E.3    De Bruin, M.4    Van Der Burg, E.5    Derksen, P.W.6
  • 17
    • 79951819983 scopus 로고    scopus 로고
    • Tumor growth inhibition by olaparib in BRCA2 germline-mutated patientderived ovarian cancer tissue xenografts
    • Kortmann U, McAlpine JN, Xue H, Guan J, Ha G, Tully S, et al. Tumor growth inhibition by olaparib in BRCA2 germline-mutated patientderived ovarian cancer tissue xenografts. Clin Cancer Res 2011;17: 783-91.
    • (2011) Clin Cancer Res , vol.17 , pp. 783-1791
    • Kortmann, U.1    McAlpine, J.N.2    Xue, H.3    Guan, J.4    Ha, G.5    Tully, S.6
  • 18
    • 49249119415 scopus 로고    scopus 로고
    • A synthetic lethal therapeutic approach: Poly (ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
    • Ashworth A. A synthetic lethal therapeutic approach: Poly (ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol 2008;26:3785-90.
    • (2008) J Clin Oncol , vol.26 , pp. 3785-90
    • Ashworth, A.1
  • 19
  • 20
    • 77955092315 scopus 로고    scopus 로고
    • PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers
    • Jin G, Kim MJ, Jeon HS, Choi JE, Kim DS, Lee EB, et al. PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers. Lung Cancer 2010;69:279-83.
    • (2010) Lung Cancer , vol.69 , pp. 279-683
    • Jin, G.1    Kim, M.J.2    Jeon, H.S.3    Choi, J.E.4    Kim, D.S.5    Lee, E.B.6
  • 21
    • 65949086609 scopus 로고    scopus 로고
    • PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR
    • Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, et al. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res 2009;69:3256-61.
    • (2009) Cancer Res , vol.69 , pp. 3256-61
    • Sos, M.L.1    Koker, M.2    Weir, B.A.3    Heynck, S.4    Rabinovsky, R.5    Zander, T.6
  • 22
    • 0036094196 scopus 로고    scopus 로고
    • Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation
    • Soria JC, Lee HY, Lee JI,Wang L, Issa JP,Kemp BL, et al. Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res 2002;8:1178-84.
    • (2002) Clin Cancer Res , vol.8 , pp. 1178-84
    • Soria, J.C.1    Lee, H.Y.2    Lee, J.I.3    Wang, L.4    Issa, J.P.5    Kemp, B.L.6
  • 23
    • 23444461754 scopus 로고    scopus 로고
    • PTEN expression in non-small cell lung cancer: Evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
    • Marsit CJ, Zheng S, Aldape K, HindsPW, Nelson HH, Wiencke JK, et al. PTEN expression in non-small cell lung cancer: Evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration. Hum Pathol 2005;36:768-76.
    • (2005) Hum Pathol , vol.36 , pp. 768-76
    • Marsit, C.J.1    Zheng, S.2    Aldape, K.3    Hinds, P.W.4    Nelson, H.H.5    Wiencke, J.K.6
  • 24
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in maintaining chromosomal integrity
    • Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 2007;128:157-70.
    • (2007) Cell , vol.128 , pp. 157-70
    • Shen, W.H.1    Balajee, A.S.2    Wang, J.3    Wu, H.4    Eng, C.5    Pandolfi, P.P.6
  • 25
    • 51849086880 scopus 로고    scopus 로고
    • PTEN: A new guardian of the genome
    • Yin Y, Shen WH. PTEN: A new guardian of the genome. Oncogene 2008;27:5443-53.
    • (2008) Oncogene , vol.27 , pp. 5443-53
    • Yin, Y.1    Shen, W.H.2
  • 26
    • 77954358148 scopus 로고    scopus 로고
    • PTEN Loss compromises homologous recombination repair in astrocytes: Implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors
    • McEllin B, Camacho CV, Mukherjee B, Hahm B, Tomimatsu N, Bachoo RM, et al. PTEN Loss compromises homologous recombination repair in astrocytes: Implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. Cancer Res 2010;70:5457-64.
    • (2010) Cancer Res , vol.70 , pp. 5457-7064
    • McEllin, B.1    Camacho, C.V.2    Mukherjee, B.3    Hahm, B.4    Tomimatsu, N.5    Bachoo, R.M.6
  • 28
    • 0034527287 scopus 로고    scopus 로고
    • Rational approach to the clinical protocol design for drug combinations: A review
    • Chang TT, Chou TC. Rational approach to the clinical protocol design for drug combinations: A review. Acta Paediatr Taiwan 2000;41: 294-302.
    • (2000) Acta Paediatr Taiwan , vol.41 , pp. 294-302
    • Chang, T.T.1    Chou, T.C.2
  • 29
    • 0017706693 scopus 로고
    • A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems
    • Chou TC, Talaly P. A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems. J Biol Chem 1977;252:6438-42.
    • (1977) J Biol Chem , vol.252 , pp. 6438-42
    • Chou, T.C.1    Talaly, P.2
  • 33
    • 79955588797 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
    • Strom CE, Johansson F, Uhl-en M, Szigyarto CA, Erixon K, Helleday T, et al. Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate. Nucleic Acids Res 2011;39:3166-75.
    • (2011) Nucleic Acids Res , vol.39 , pp. 3166-3975
    • Strom, C.E.1    Johansson, F.2    Uhl-en, M.3    Szigyarto, C.A.4    Erixon, K.5    Helleday, T.6
  • 35
    • 84863116161 scopus 로고    scopus 로고
    • PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: Implications for radiotherapy and chemotherapy
    • Fraser M, Zhao H, Luoto KR, Lundin C,Coackley C, Chan N, et al. PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: Implications for radiotherapy and chemotherapy. Clin Cancer Res 2012;18:1015-27.
    • (2012) Clin Cancer Res , vol.18 , pp. 1015-1827
    • Fraser, M.1    Zhao, H.2    Luoto, K.R.3    Lundin, C.4    Coackley, C.5    Chan, N.6
  • 36
    • 66149141021 scopus 로고    scopus 로고
    • PTEN and the PI3-kinase pathway in cancer
    • Chalhoub N, Baker SJ. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 2009;4:127-50.
    • (2009) Annu Rev Pathol , vol.4 , pp. 127-50
    • Chalhoub, N.1    Baker, S.J.2
  • 37
    • 20244388673 scopus 로고    scopus 로고
    • Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
    • Syljuasen RG, Sørensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, et al. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol 2005;25:3553-62.
    • (2005) Mol Cell Biol , vol.25 , pp. 3553-62
    • Syljuasen, R.G.1    Sørensen, C.S.2    Hansen, L.T.3    Fugger, K.4    Lundin, C.5    Johansson, F.6
  • 39
    • 78549251695 scopus 로고    scopus 로고
    • Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
    • Hashimoto Y, Ray Chaudhuri A, Lopes M, Costanzo V. Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol 2010;17:1305-11.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 1305-1711
    • Hashimoto, Y.1    Ray Chaudhuri, A.2    Lopes, M.3    Costanzo, V.4
  • 40
    • 84858774472 scopus 로고    scopus 로고
    • The ups and downs of DNA repair biomarkers for PARP inhibitor therapies
    • Wang X, Weaver DT. The ups and downs of DNA repair biomarkers for PARP inhibitor therapies. Am J Cancer Res 2011;1:301-27.
    • (2011) Am J Cancer Res , vol.1 , pp. 301-27
    • Wang, X.1    Weaver, D.T.2
  • 41
    • 77954032829 scopus 로고    scopus 로고
    • Poly(ADP)-ribose polymerase inhibition: Frequent durable responses in BRCA carrier ovarian cancer correlating with platinumfree interval
    • Fong PC, Yap TA, Boss DS, Carden CP, Mergui-Roelvink M, Gourley C, et al. Poly(ADP)-ribose polymerase inhibition: Frequent durable responses in BRCA carrier ovarian cancer correlating with platinumfree interval. J Clin Oncol 2010;28:2512-9.
    • (2010) J Clin Oncol , vol.28 , pp. 2512-289
    • Fong, P.C.1    Yap, T.A.2    Boss, D.S.3    Carden, C.P.4    Mergui-Roelvink, M.5    Gourley, C.6
  • 42
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
    • (2004) Science , vol.304 , pp. 1497-500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 43
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-39
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 44
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4 "ALK fusion gene in nonsmall-cell lung cancer
    • Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, et al. Identification of the transforming EML4-ALK fusion gene in nonsmall-cell lung cancer. Nature 2007;448:561-6.
    • (2007) Nature , vol.448 , pp. 561-6
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3    Takada, S.4    Yamashita, Y.5    Ishikawa, S.6
  • 45
    • 79959986415 scopus 로고    scopus 로고
    • PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer
    • Paul I, Savage KI, Blayney JK, Lamers E, Gately K, Kerr K, et al. PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. J Pathol 2011;224: 564-74.
    • (2011) J Pathol , vol.224 , pp. 564-22474
    • Paul, I.1    Savage, K.I.2    Blayney, J.K.3    Lamers, E.4    Gately, K.5    Kerr, K.6


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